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Search Results: 1 - 10 of 207848 matches for " Manuel Díaz-Rubio "
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The burden and management of patients with IBS: results from a survey in Spanish gastroenterologists
Almansa,Cristina; Díaz-Rubio,Manuel; Rey,Enrique;
Revista Espa?ola de Enfermedades Digestivas , 2011, DOI: 10.4321/S1130-01082011001100003
Abstract: backgrounds: irritable bowel syndrome (ibs) is a common and complex disorder. though it is estimated that ibs constitutes an important part of the gastroenterology (gi) practice, the burden of this problem in the gi outpatients clinics in spain is unclear. aim: the aim of this study is to obtain a "shot" of the burden and management of this syndrome in the daily gi practice. methods: 508 general gastroenterologists from all over the country were approached and asked to complete a survey that included questions about their daily practice and the definition, diagnosis and treatment of ibs. results: 55% of the surveyed physicians estimate that ibs constitute between a quarter and a half of all their consultations; and pointed out that most of these patients were referred from primary care. overall, the spanish gastroenterologists show an adequate knowledge of the different diagnostic criteria, though they do not always follow the current guidelines. up to 55% of the physicians always perform a complementary test to support their diagnosis and 40% order a diagnostic test only in older patients (> 50 years) or in presence of alarm symptoms. interestingly, 80% of the gastroenterologists start empirical treatment based on the patients' symptoms. conclusions: though spanish gastroenterologists seem to have an adequate theoretical knowledge of the disease, they do not systematically follow current guidelines and tend to manage ibs symptoms based on their own criteria.
Mycobacterium avium subspecies paratuberculosis and its relationship with Crohn’s disease
Juan Luis Mendoza, Raquel Lana, Manuel Díaz-Rubio
World Journal of Gastroenterology , 2009,
Abstract: The hypothesis postulating that Mycobacterium avium paratuberculosis (MAP) is the cause of Crohn’s disease (CD) has been circulating for many years. Advances in molecular techniques, such as polymerase chain reaction and culture methods, have enabled researchers to demonstrate that there is an association between MAP and CD. Recently, genome-wide association studies have identified novel susceptibility genes for CD, which are critical for generation of an adaptive immune response that is protective against intracellular pathogens, including M. tuberculosis infection. However, the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients. Accordingly, this review sought neither to confirm nor refute this, but instead to survey recent literature on the role of MAP in CD.
The burden and management of patients with IBS: results from a survey in Spanish gastroenterologists Manejo clínico de los pacientes con síndrome de intestino irritable: resultados de una encuesta entre gastroenterólogos espa oles
Cristina Almansa,Manuel Díaz-Rubio,Enrique Rey
Revista Espa?ola de Enfermedades Digestivas , 2011,
Abstract: Backgrounds: irritable bowel syndrome (IBS) is a common and complex disorder. Though it is estimated that IBS constitutes an important part of the gastroenterology (GI) practice, the burden of this problem in the GI outpatients clinics in Spain is unclear. Aim: the aim of this study is to obtain a "shot" of the burden and management of this syndrome in the daily GI practice. Methods: 508 general gastroenterologists from all over the country were approached and asked to complete a survey that included questions about their daily practice and the definition, diagnosis and treatment of IBS. Results: 55% of the surveyed physicians estimate that IBS constitute between a quarter and a half of all their consultations; and pointed out that most of these patients were referred from primary care. Overall, the Spanish gastroenterologists show an adequate knowledge of the different diagnostic criteria, though they do not always follow the current guidelines. Up to 55% of the physicians always perform a complementary test to support their diagnosis and 40% order a diagnostic test only in older patients (> 50 years) or in presence of alarm symptoms. Interestingly, 80% of the gastroenterologists start empirical treatment based on the patients' symptoms. Conclusions: though Spanish gastroenterologists seem to have an adequate theoretical knowledge of the disease, they do not systematically follow current guidelines and tend to manage IBS symptoms based on their own criteria. Introducción: el síndrome de intestino irritable (SII) es un trastorno frecuente, aunque la magnitud de este problema y su complejidad en las consultas de digestivo en Espa a no están bien caracterizadas. Objetivo: obtener conocimiento sobre cómo manejan clínicamente el SII los especialistas de aparato digestivo en Espa a. Método: encuesta transversal realizada a 508 especialistas de aparato digestivo de toda Espa a que incluía preguntas generales acerca de su práctica clínica diaria y específicas sobre la definición, el diagnóstico y el tratamiento del SII. Resultados: el 55% de los gastroenterólogos encuestados estima que los pacientes con SII representan entre un 25-50% del volumen de sus consultas; la mayoría referidos desde primaria para diagnóstico. En general los gastroenterólogos espa oles refieren conocer los criterios diagnósticos clínicos, aunque la mayoría no basa su diagnóstico en ellos y suele solicitar alguna prueba complementaria para descartar organicidad. Pese a ello, un 80% de especialistas suele comenzar tratamiento enfocado al control de los síntomas sin esperar al resultado de
Translation, cultural adaptation and validation of a Spanish version of the Irritable Bowel Syndrome Severity Score Traducción, adaptación cultural y validación al espa ol del cuestionario de gravedad del síndrome de intestino irritable (Irritable Bowel Syndrome Severity Score)
Cristina Almansa,Raquel García-Sánchez,Marta Barceló,Manuel Díaz-Rubio
Revista Espa?ola de Enfermedades Digestivas , 2011,
Abstract: Background: the Irritable Bowel Syndrome Severity Score (IBSSS) is a questionnaire only available in English that classifies IBS patients according to the severity of their symptoms and can be used to guide and monitor the treatment. Aims: to adapt and validate into Spanish the English version of the IBSSS questionnaire. Methods: the Spanish version of the questionnaire was obtained through a process of translation-evaluation of the comprehensibility and back translation. In a later phase we evaluated the applicability (n = 15), reproducibility (n = 31) and sensitivity to change (n = 40) of the Spanish version of the questionnaire. Finally we evaluated an alternative version of the ISBSS using a numerical scoring system instead of the original analog visual scale (n = 40). Results: the Spanish version of the IBSSS showed an excellent reproducibility (r = 0.81 for global score) and an adequate sensitivity to change: a decrease of 45 points or more identified worsening of IBS with a 70.6% sensitivity and 87.5% specificity; an increase of 45 points or more identified improvement of IBS with a 85.7% sensitivity and 87.5% specificity. The severity score was practically the same regardless of the scoring system used (r = 0.96). Conclusions: the Spanish version of the IBSSS is a reproducible tool that is able to identify relevant changes over the course of the disease. The use of a numerical scoring system is a valid alternative to the visual scale that improves the applicability of the questionnaire to situations when the written communication is limited or not possible. Introducción: el "Irritable Bowel Syndrome Severity Score" (IBSSS) es un cuestionario disponible solo en inglés, que permite clasificar a los pacientes con SII en función de su gravedad y sirve como guía para orientar y valorar la respuesta al tratamiento. Objetivos: adaptar y validar para su uso en pacientes espa oles la versión inglesa del cuestionario de severidad del SII. Método: la versión espa ola del cuestionario se obtuvo mediante un proceso de traducción-valoración de la comprensibilidad y retrotraducción. En una segunda fase se evaluaron la aplicabilidad (n = 15), reproducibilidad (n = 31) y sensibilidad al cambio (n = 40) de la versión en castellano del cuestionario. Finalmente, se confirmó la validez de una versión alternativa del cuestionario (n = 40) aplicando una escala de respuestas numérica en lugar de la original escala analógica visual. Resultados: el IBSSS mostró una excelente reproducibilidad (r = 0,81 para la puntuación global) y una adecuada sensibilidad al cambio; una
Translation, cultural adaptation and validation of a Spanish version of the Irritable Bowel Syndrome Severity Score
Almansa,Cristina; García-Sánchez,Raquel; Barceló,Marta; Díaz-Rubio,Manuel; Rey,Enrique;
Revista Espa?ola de Enfermedades Digestivas , 2011, DOI: 10.4321/S1130-01082011001200002
Abstract: background: the irritable bowel syndrome severity score (ibsss) is a questionnaire only available in english that classifies ibs patients according to the severity of their symptoms and can be used to guide and monitor the treatment. aims: to adapt and validate into spanish the english version of the ibsss questionnaire. methods: the spanish version of the questionnaire was obtained through a process of translation-evaluation of the comprehensibility and back translation. in a later phase we evaluated the applicability (n = 15), reproducibility (n = 31) and sensitivity to change (n = 40) of the spanish version of the questionnaire. finally we evaluated an alternative version of the isbss using a numerical scoring system instead of the original analog visual scale (n = 40). results: the spanish version of the ibsss showed an excellent reproducibility (r = 0.81 for global score) and an adequate sensitivity to change: a decrease of 45 points or more identified worsening of ibs with a 70.6% sensitivity and 87.5% specificity; an increase of 45 points or more identified improvement of ibs with a 85.7% sensitivity and 87.5% specificity. the severity score was practically the same regardless of the scoring system used (r = 0.96). conclusions: the spanish version of the ibsss is a reproducible tool that is able to identify relevant changes over the course of the disease. the use of a numerical scoring system is a valid alternative to the visual scale that improves the applicability of the questionnaire to situations when the written communication is limited or not possible.
Chest pain of esophageal origin Dolor torácico de origen esofágico
M. Díaz-Rubio
Revista Espa?ola de Enfermedades Digestivas , 2004,
Abstract:
Atypical symptoms of gastro-esophageal reflux during pregnancy
Rey,Enrique; Rodríguez-Artalejo,Fernando; Herraiz,Miguel ángel; álvarez-Sánchez,ángel; Escudero,Manuel; Díaz-Rubio,Manuel;
Revista Espa?ola de Enfermedades Digestivas , 2011, DOI: 10.4321/S1130-01082011000300004
Abstract: background: pregnancy is associated with an increased incidence of heartburn. however, there is no information for other symptoms related to gastro-esophageal reflux (gor). aim: to assess the prevalence of atypical symptoms of gor during pregnancy, and to examine its association with typical gor symptoms. methods: we report data for 263 women with a pregnancy of less than 12 weeks. they were interviewed at the end of each trimester of pregnancy and at 1-year post-partum, using the gastro esophageal reflux questionnaire (gerq). in the first interview, information about symptoms in the year before pregnancy was also collected with gerq. results: women suffered atypical gor symptoms during pregnancy more frequently than in the year before: non-cardiac chest pain (nccp) (9.1 vs. 1.9%), dysphagia (12.6 vs. 2.3%), globus (33.1 vs. 4.6%), cough (26.6 vs. 6.8%), belching (66.2 vs. 19.4%) and hiccups (19.0 vs. 8.4%). atypical gor symptoms in pregnancy showed an association with suffering the same symptom before pregnancy and nccp, globus, belching and hiccups with suffering typical gor symptoms in the first trimester. conclusions: atypical gor symptoms are highly prevalent in pregnancy, and are associated with atypical symptoms before pregnancy and with typical symptoms of gor in the first trimester.
Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
Alfonso Martínez, Jose Santiago, Jezabel Varadé, Ana Márquez, José Lamas, Juan Mendoza, Hermenegildo de la Calle, Manuel Díaz-Rubio, Emilio G de la Concha, Benjamín Fernández-Gutiérrez, Elena Urcelay
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-329
Abstract: Six polymorphisms distributed through the SEPS1 gene (rs11327127, rs28665122, rs4965814, rs12917258, rs4965373 and rs2101171) were genotyped in more than two thousand patients suffering from type 1 diabetes, rheumatoid arthritis or inflammatory bowel diseases and 550 healthy controls included in the case-control study.Lack of association of SEPS1 polymorphisms or haplotypes precludes a major role of this gene increasing predisposition to these inflammatory diseases.The human gene SEPS1, located on chromosome 15q26.3, encodes selenoprotein S which participates in the retro-translocation of misfolded proteins from the endoplasmic reticulum (ER) to the cytosol for their degradation [1]. This ER membrane protein functions in stress responses to prevent the deleterious consequences of accumulation of misfolded proteins, accumulation that has been linked to immune and inflammatory processes [2]. A study identified the strong association of the proximal promoter SEPS1 polymorphism at -105G/A with circulating levels of three pro-inflammatory cytokines, interleukin (IL)-6, IL-1β and TNF-α [3]. Moreover, these authors reported that the mutant variant significantly reduced the promoter activity of the SEPS1 gene in stressed HepG2 cells and that the suppression of this gene by short interfering RNA increased the release of pro-inflammatory cytokines in a macrophage cell line. A regulatory loop has been recently proposed whereby cytokines stimulate the expression of SEPS1, which in turn diminishes cytokine production [4].The murine homolog gene of the human SEPS1 is the Tanis gene, which encodes a serum amyloid A receptor [5]. Acute phase serum amyloid A proteins (SAAs) are multifunctional apolipoproteins produced in large amounts during the acute phase of inflammation and also during the development of chronic inflammatory diseases. SAAs are involved in the pathogenesis of several chronic inflammatory diseases, such as rheumatoid arthritis (RA) [6-9], multiple sclerosis (MS)[10
High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn’s disease
Juan L Mendoza, Amparo San-Pedro, Esther Culebras, Raquel Cíes, Carlos Taxonera, Raquel Lana, Elena Urcelay, Fernando de la Torre, Juan J Picazo, Manuel Díaz-Rubio
World Journal of Gastroenterology , 2010,
Abstract: AIM: To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis (MAP) in patients with inflammatory bowel disease [Crohn’s disease (CD) and ulcerative colitis (UC)].METHODS: Thirty patients with CD (15 with at least one NOD2/CARD15 mutation), 29 with UC, and 10 with no inflammatory bowel disease (IBD). were tested for MAP by polymerase chain reaction (specific IS900 fragment) and blood culture.RESULTS: MAP DNA was detected in all original blood samples and 8-wk blood cultures (CD, UC and non-IBD). Positive MAP DNA status was confirmed by dot blot assays. All 69 cultures were negative by acid-fast Ziehl-Neelsen staining. Viable MAP, in spheroplast form, was isolated from the 18-mo blood cultures of all 30 CD patients, one UC patient, and none of the non-IBD controls. No association was found between positive MAP cultures and use of immunosuppressive drugs or CD-associated single nucleotide polymorphisms.CONCLUSION: MAP is widely present in our area and MAP DNA can be recovered from the blood of CD, UC and non-IBD patients. However, MAP spheroplasts were only found in CD patients.
Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease
José A. Agúndez, Elena García-Martin, María L. Maestro, Francisca Cuenca, Carmen Martínez, Luis Ortega, Miguel Carballo, Marta Vidaurreta, Marta Agreda, Gabriela Díaz-Zelaya, Avelina Suárez, Manuel Díaz-Rubio, José M. Ladero
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037998
Abstract: Background/Aims Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. Methods We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma. The distribution of the analysed SNP in hepatocellular carcinoma patients was compared with that found in untreated chronic hepatitis C patients. All patients were white and most were Spaniards. Results In multivariate analysis ALT values were higher (P = 0.001) and GGT values were lower (P<0.001) in chronic hepatitis C patients homozygotes for the major rs12979860C allele as compared with carriers of the mutated rs12979860T allele. Steatosis was more frequent (Odds ratio = 1.764, 95% C.I. 1.053–2.955) and severe (P = 0.026) in carriers of the rs12979860T allele. No relation was found between the analysed SNP and METAVIR scores for necroinflammation and fibrosis, and there were no differences in the distribution of the analysed SNP between hepatocellular carcinoma and untreated chronic hepatitis C patients. Conclusion The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.
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