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Search Results: 1 - 10 of 219803 matches for " Manjunath C. Nanjappa "
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Myocardial FFR (Fractional Flow Reserve) in patients with angiographically intermediate coronary artery stenosis - an initial institutional experience
Jagadish H. Ramaiah,Raghu T. Ramegowda,Srinivas B. Chikkaswamy,Manjunath C. Nanjappa
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130202
Abstract: Background: The clinical significance of coronary artery stenosis of intermediate severity can be difficult to determine. The management of intermediate coronary lesions, defined by a diameter stenosis of I40% to U70%, continues to be a therapeutic dilemma for cardiologists. The 2-dimensional representation of the arterial lesion provided by angiography is limited in distinguishing intermediate lesions that require stenting from those that simply need appropriate medical therapy. In the era of drug-eluting stents, some might propose that stenting all intermediate coronary lesions is an appropriate solution. However, the possibility of procedural complications such as coronary dissection, no reflow phenomenon, in-stent restenosis, and stent thrombosis requires accurate stratification of patients with intermediate coronary lesions to appropriate therapy. Myocardial fractional flow reserve (FFR) is an index of the functional severity of coronary stenosis that is calculated from pressure measurements made during coronary angiography. The objective of the study is to evaluate the usefulness of FFR in patients with angiographically intermediate coronary artery stenosis. Methods: 20 patients with intermediate coronary stenosis and chest pain of uncertain origin. The Exercise Electrocardiography (TMT), Myocardial Perfusion Imaging study (MPI), Quantitative Coronary Angiography (QCA) were compared with the results of FFR measurements. Results: 20 patients were undergone FFR measurement during the study period. With the mean age of 57.25 à11.2 and male patients were 16 (80%), female patients 4 (20%), in all 13 patients with an FFR of <0.75, reversible myocardial ischemia was demonstrated unequivocally on at least one noninvasive test. In contrast, 5 of 7 patients with an FFR of >0.75 tested negative for reversible myocardial ischemia on TMT and MPI study. No revascularization procedures were performed in 7 (35%) patients, and no adverse cardiovascular events were noted in all these patients during 6 months of follow-up. Conclusions: In patients with coronary stenosis of intermediate severity, FFR appears to be a useful index of the functional severity of the stenosis and the need for coronary revascularization. [Int J Res Med Sci 2013; 1(1.000): 4-11]
Infective Endocarditis: A Rare Organism in an Uncommon Setting
Rajiv Ananthakrishna,Ravindranath K. Shankarappa,Naveena Jagadeesan,Ravi S. Math,Satish Karur,Manjunath C. Nanjappa
Case Reports in Infectious Diseases , 2012, DOI: 10.1155/2012/307852
Abstract: Facklamia hominis is a rare causative organism of infective endocarditis (IE). Only few cases of infection due to F. hominis have been reported in the literature. We describe a case of IE due to Gram-positive, alpha-haemolytic, catalase-negative coccus F. hominis in an adult patient with rheumatic mitral stenosis. Isolated mitral stenosis is an uncommon valve lesion predisposing to IE. The following paper is being presented to emphasize the possibility of IE due to F. hominis, and laboratories need to be alert of the potential significance in appropriate clinical setting. 1. Introduction Infective endocarditis (IE) is one of the major complications in individuals with structural heart disease. The majority of cases of IE are caused by Streptococci, Staphylococci, Enterococci, and fastidious Gram-negative coccobacilli. In their absence, unusual organisms should be considered. Facklamia hominis is one such rare organism [1]. Facklamia species are Gram-positive, alpha-haemolytic, catalase negative cocci, which resemble Streptococcus viridians on 5% sheep blood agar. Only few cases of infection due to F. hominis have been reported in the literature. We present a case of IE due F. hominis in an adult patient with rheumatic mitral stenosis. Isolated mitral stenosis is an uncommon valve lesion predisposing to IE. The following paper is being presented to emphasize the possibility of IE due to F. hominis, and laboratories need to be alert of the potential significance in appropriate clinical setting. 2. Case Report A 35-year-old male with rheumatic heart disease was admitted to our hospital for evaluation of fever of 3-weeks duration. He had been empirically treated for enteric fever by a primary care physician. The patient had received oral ciprofloxacin for 1 week prior to admission. He was on regular benzathine penicillin prophylaxis and had undergone balloon mitral valvotomy 15 years earlier. The temperature at presentation was 101°F. The patient was hemodynamically stable. Cardiovascular system examination revealed a middiastolic murmur at the apex. The rest of the systemic examination was unremarkable. Three separate sets of blood cultures were obtained for possible IE. Blood cultures were performed using BacT/ALERTR FA bottles (Biomerieux). These bottles were incubated in the Bact/ALERT microbial detection system. Pending culture reports, empirical intravenous treatment with crystalline penicillin (24?million units/24?hr IV, every 4?hr in six equally divided doses) and gentamicin (1?mg/kg IV every 8?hr) was initiated. Results routine blood tests were:
Expect the Unexpected: A Unique Association of Bicuspid Aortic Valve, with Severe Aortic Stenosis and Dilation of Ascending Aorta, with Cervical Vagus Nerve Schwannoma  [PDF]
Shivanand Patil, Rangaraj Ramalingam, Kasamshetty Subramanyam, Deepak Pujar, Cholenahally Nanjappa Manjunath
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.64035
Hoarseness of voice is a common symptom of many laryngeal and extralaryngeal conditions. It is very crucial to identify the culprit behind it, keeping in mind all the various differentials. We re-port a case of a 35-year-old woman presenting with complaint of hoarseness of voice. Upon car-diac evaluation, the patient was diagnosed with bicuspid aortic valve, with severe aortic stenosis and dilation of ascending aorta. We suspected that the plausible reason for hoarseness of voice was compression of recurrent laryngeal nerve due to dilation of aorta, i.e., Ortner’s syndrome. But to our surprise, CT of aorta and neck revealed extensive elongated cervical vagus nerve schwannoma. Such type of association is unique and new to voluminous medical literature.
Coronary Dissection, No Flow, Cardiac Arrest
Arunkumar Panneerselvam MD, DM, AFSCAI,Prabhavathi Bhat MD, DM,Manjunath Cholenahally Nanjappa MD, DM
European Journal of Cardiovascular Medicine , 2011,
Abstract: Coronary angioplasty with stenting is a safe procedure in experienced hands. Anticipating and tackling complications is the key to successful coronary intervention. We present a 63-year-old man with unstable angina, who underwent angioplasty and stenting to left anterior descending artery. A dissection was noted at the distal end of the stent and this was covered with another stent.Following stenting another dissection was noted distal to the second stent and a third stent was deployed. Subsequently, there was no-flow and patient had a cardiac arrest from which he was resuscitated. Finally TIMI III flow was achieved and further in hospital course was uneventful.Dissection, no flow and cardiac arrest are the dreaded complications of angioplasty and all three occurred in this patient. Steps to prevent these complications and management options are discussed.
Total dose infusion of fractionated iron dextran complex in management of anaemia in antenatal cases
Manjunath S,Veena H C
International Journal of Reproduction, Contraception, Obstetrics and Gynecology , 2013, DOI: 10.5455/2320-1770.ijrcog20130918
Abstract: Background: Iron deficiency anemia is common clinical manifestation in pregnancy. It can be easily prevented or corrected by early diagnosis and proper treatment successfully. This study was done to know the efficacy, effectiveness, rise in hemoglobin level and adverse effects of newly available low molecular weight iron dextran complex. Methods: A prospective clinical trial was conducted in randomly selected 50 antenatal women who attended the OPD of OBG department and were moderately anemic and fulfilled the inclusion criteria of the study Results: All the 50 women were moderately anemic with hemoglobin level between 7-9 gm%. After total dose infusion of low molecular weight fractionated iron dextran complex, hemoglobin level was measured at 4 weeks and at term. The mean hemoglobin level rose to 9.5 gm/dl by 4 weeks after infusion and to 11.53 gm/dl at term, which was statistically significant (p<0.0001). Only one patient developed non-cardiac chest pain during the test dose and two patients developed urticaria during total dose infusion. Conclusion: The study showed a statistically significant increase in hemoglobin level after total dose infusion of low molecular weight iron dextran complex with a good safety profile and minimal hospital stay. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 355-358]
A Comparative Study Of Motor Abilities Among Sportsman And Non Sportsman
Asundi Manjunath Kallappa,C. R. Bhairaddy
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Motor abilities are one of the facts of a person's all round harmonious development. Motor abilities are the cultural phenomenon of great complexity and magnitude, which is historically, preconditioned level of health and comprehensive development of a person. Aim of the study was to find out the motor abilities among sportsman and non-sportsman. For this investigation, the investigator has taken total 50 male sportsman and 50 male non sportsman of universities and colleges in Gulbarga division, between the age group 18 to 35 years, selected on random basis, AAHPER- youth fitness test revised (1970) were employed as tools for collection of data. For Comparison statistical analysis was done by calculating mean, standard deviation and't' value through SPSS package. It was concluded that the two groups significantly differ on the five variables/ components of motor abilities namely pull up, sit up, shuttle run flexibility, endurance and two groups showed different dimensions.
Effect of Duration of Light:Dark Cycles on in vitro Shoot Regeneration of Tomato
Poonam Bhatia,Nanjappa Ashwath
Asian Journal of Plant Sciences , 2005,
Abstract: Cotyledonary explants of the Red Coat cultivar were exposed to light:dark cycles in regeneration medium (MS basal+15 M zeatin) for four weeks, with the view of elucidating the role of light in direct shoot regeneration. Light has not been found essential for shoot regeneration in tomato. However, maximum shoot regeneration response (60%) could only occur in the explants exposed to 16 h light and 8 h dark. The response declined at 2 h dark (47%) or 24 h light (40%). Comparable number of shoots was produced in the 16 h light (3.3) and 24 h dark (3.2) treatments, but in 24 h light treatment the number of shoots produced per explant was less (2.7). Shoots with maximum height were observed in 24 h light (6.3 mm) followed by 16 h light (4.5 mm) and 24 h dark (3.9 mm). The shoots regenerated in the dark were not etiolated. Mimicking of light regulated processes by exogenous application of high concentration of cytokinin can be the possible reason for the non-etiolated behaviour of the dark regenerated shoots. Although light was not essential for shoot regeneration, appropriate light:dark cycles were required for proper chlorophyll development.
Effect of Medium pH on Shoot Regeneration from the Cotyledonary Explants of Tomato
Poonam Bhatia,Nanjappa Ashwath
Biotechnology , 2005,
Abstract: To optimise medium pH for in vitro shoot regeneration and shoot growth from the cotyledon explants of tomato cv. Red Coat, the explants were inoculated onto MS medium which was maintained at a wide range of pH (4.5-7.5). Percentage shoot regeneration and number of shoots produced per explant were not significantly affected by the medium pH. The proportion of explants that produced callus and callus diameter remained unaffected by the medium pH. In contrast, the shoot height was significantly affected and taller shoots were only produced at a pH range of 5.5-6.0. Lower (4.5-5) and higher (6.5-7.5) medium pH significantly reduced shoot height. The results suggest that the explants of tomato Cv. Red Coat are moderately tolerant to a wide range of medium pH, as most of the traits studied remained unaffected by the change in media pH. However, the best regeneration and growth occurred only in the pH range 5.5-6.0.
Improving the Quality of in vitro Cultured Shoots of Tomato (Lycopersicon esculentum Mill. cv. Red Coat)
Poonam Bhatia,Nanjappa Ashwath
Biotechnology , 2008,
Abstract: Effects of activated charcoal (0, 1, 5 and 10 mg L-1), ascorbic acid (30, 60, 120, 240 and 480 μM) and casein hydrolysate (0, 50, 100, 200, 500 and 1000 mg L-1) were evaluated for morphogenesis of Lycopersicon esculentum cv. Red Coat cotyledons. The media containing higher concentrations of activated charcoal and ascorbic acid produced longer shoots. Addition of casein hydrolysate significantly reduced callus response.
A Hirshfeld Surface Analysis and Crystal Structure of 2’-[1-(2-Fluoro-Phenyl)-1H-tetrazol-5-Yl]-4-Methoxy-Biphenyl-2-Carbaldehyde  [PDF]
S. Madan Kumar, B. C. Manjunath, G. S. Lingaraju, M. M. M. Abdoh, M. P. Sadashiva, N. K. Lokanath
Crystal Structure Theory and Applications (CSTA) , 2013, DOI: 10.4236/csta.2013.23017

The title compound, C21H15FN4O2 is synthesized and characterized by 1H NMR, LC-MS and finally confirmed by single crystal X-ray diffraction method. This molecule crystallizes in the monoclinic crystal system and space group P21/c, with crystal parameters a = 9.4386(5) A, b = 20.8082(1) A, c = 9.4338(6) A, β = 99.566(2)0, Z = 4 and V = 1826.98(19) A3. The mean planes of fluro-phenyl moiety makes a dihedral angle of 21.51 (7)

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