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Evaluation of antiulcer activity of Boswellia serrata bark extracts using aspirin induced ulcer model in albino rats
Khaja Zeeyauddin,Mangamoori Lakshmi Narsu,Muna Abid,Mohammed Ibrahim
Journal of Medical and Allied Sciences , 2011,
Abstract: The effect of bark extracts of Boswellia serrata (Family Bursera-ceae) was evaluated in aspirin induced ulceration (200mg/kg) in albino rats. Antiulcer activity was evaluated by measuring ulcer index and percentage of ulcer healing. The petroleum ether (250mg/kg) and aqueous extracts (250mg/kg) of bark of Boswellia serrata plant showed significant antiulcer activity as evidenced by the data obtained. Histopathological findings also confirm the anti-ulcer activity of Boswellia serrata bark extracts in albino rats.
SUSTAINED RELEASE DEVICE CONTAINING ORNIDAZOLE FOR PERIODONTITIS
M. Shankraiah,C. Nagesh.,J. S. Venkatesh,M. Lakshmi Narsu.
International Research Journal of Pharmacy , 2011,
Abstract: The purpose of this study was to develop a sustained release device containing ornidazole for insertion within periodontal pockets. Cast films of ethyl cellulose with dibutyl phthalate as plasticizer, containing ornidazole were prepared. The films were evaluated for thickness, folding endurance, weight variation, content uniformity, tensile strength and in vitro antibacterial activity. In vitro release of ornidazole from the film was measured using UV spectrophotometer. The release data obtained were subjected for release kinetics study. The study revealed that drug release was found to be diffusion controlled with sustained release of ornidazole over a period of nine days within the periodontal pocket.
USE OF LIGNOCELLULOLYTIC MUTANTS OF PLEUROTUS OSTREATUS IN RUMINANT FEED FORMULATIONS
Vijaya Chalamcherla,Singaracharya Maringanti A.,Vijaya Lakshmi Muvva,Lakshmi Narasu Mangamoori
BioResources , 2009,
Abstract: Two lignolytic mutants (POM1 - U.V. irradiated and POM2 – X ray irradiated) of P. ostreatus wild type (POW) were developed and used in new feed formulations for ruminants. Paddy straw (10 kg) amended with coconut cake, glyricidia leaves, urea (2%), and rice bran (5%) along with mutant forms of P. ostreatus substantially increased the reducing sugars, crude protein, and In Vitro Dry Matter Digestibility (IVDMD), while reducing the lignin contents. Maximum amounts of reducing sugars (555 mg/100 ml) were reported in ration 1 with strain POW in 10 days of incubation period, while a minimum was recorded in POM1 (380 mg / 100 ml) in ration 1 in 30 days of incubation. U.V. irradiated mutant was responsible for accumulation of high crude protein (CP : 42.1 mg / 100 g) in ration 1 after 30 days of incubation. The percent lignin loss was more by mutant forms, and this loss was increased with increased incubation. As a consequence, IVDMD% has been gradually improved and maximized with feed formulations 3 (49.71%) and 1 (47.07%).
Design and synthesis of 1-aroyl-2-ylidene hydrazines under conventional and microwave irradiation conditions and their cytotoxic activities
Reddy, Lingam Venkata;Suman, Alishetty;Beevi, Syed Sultan;Mangamoori, Lakshmi Narasu;Mukkanti, Khagga;Pal, Sarbani;
Journal of the Brazilian Chemical Society , 2010, DOI: 10.1590/S0103-50532010000100015
Abstract: we report the design and synthesis of 1-aroyl-2-(alkenyl/aryl)idene hydrazines as hybrid molecules derived from mefenamic acid and substituted hydrazones. a number of compounds based on this new scaffold were prepared in good yields. the key intermediate n-acylhydrazine, prepared from mefenamic acid, was coupled with a variety of aldehydes under conventional as well as microwave irradiation conditions. the second approach, that requires short reaction time, can be carried out under a solvent free condition and does not require the use of an acid catalyst or solid support. some of the compounds synthesized showed cytotoxic activities in vitro.
A "green" synthesis of N-(quinoline-3-ylmethylene)benzohydrazide derivatives and their cytotoxicity activities
Reddy, Lingam Venkata;Nallapati, Suresh Babu;Beevi, Syed Sultan;Mangamoori, Lakshmi Narasu;Mukkanti, Khagga;Pal, Sarbani;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000900017
Abstract: we report some hybrid molecules based on n-(quinoline-3-ylmethylene)benzohydrazide template the synthesis of which was carried out using 2-chloroquinoline-3-carbaldehyde and a variety of substituted hydrazides in peg 400. the "green" solvent peg 400 was recovered and reused for several times in the present reaction and was found to be effective in terms of product yield. some of the compounds synthesized showed significant cytotoxic activity when tested in vitro
Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies
Mohammed Ibrahim, Mohammed Nane Khaja, Anjum Aara, Aleem Ahmed Khan, Mohammed Aejaz Habeeb, Yalavarthy Prameela Devi, Mangamoori Lakshmi Narasu, Chitoor Mohammed Habibullah
World Journal of Gastroenterology , 2008,
Abstract: AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats.METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats.RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo: extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities.CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury.
Oct-4 expression maintained stem cell properties in prostate cancer-derived CD133+MDR1+ cells
S Rentala, LN Mangamoori
Tropical Journal of Pharmaceutical Research , 2009,
Abstract: Purpose: CD133 (prominin-1), a 5-transmembrane glycoprotein, has recently been considered an important marker that represents the subset population of cancer stem-like cells. The purpose of the present study is to isolate cancerous stem-like cells from normal healthy volunteers and prostate cancer patients (CD133+) which also express MDR1 and to ascertain the influence of Oct-4 on ‘stem-ness' and differentiation of these CD133+ cells towards epithelium. Methods: CD133+ cells were isolated using magnetic beads from normal healthy volunteers and prostate cancer patients (NV-CD133+and PC-CD133+). The isolated cells were analyzed using flow cytometry and Western blot technique for CD133, MDR1 and Oct-4. CD133+MDR1+ cells were cultured in presence and absence of antihuman Oct-4 blocking antibody. Results: PC-CD133+ cells displayed higher Oct-4 expression with the ability to self-renew and may represent a reservoir with differentiation potential for generating prostate cancer cells. Furthermore, PCCD133 + cells highly co-expressed the multiple drug-resistant marker MDR1. The treatment with Oct-4 blocking antibody can specifically block the capability of PC-CD133+ cells to differentiate into prostate epithelial cells bearing CD57. Conclusion: PC-CD133+ cells displayed a higher Oct-4 expression with the ability to self-renew and may represent a reservoir with differentiation potentials for progression of prostate cancer. The MDR1 expression of PC-CD133+ cells in vitro and in vivo is partially due to preferential activation of Oct-4 gene expression.
Using Magnetic Nanoparticles to Eliminate Oscillations in Saccharomyces cerevisiae Fermentation Processes  [PDF]
Lakshmi N. Sridhar
Journal of Sustainable Bioenergy Systems (JSBS) , 2012, DOI: 10.4236/jsbs.2012.23004
Abstract: This article provides computational evidence to show that functionalized magnetic nanoparticles can eliminate the wasteful oscillatory behavior in fermentation processes involving Saccharomyces cerevisiae. There has been a consi-derable amount of work demonstrating the existence of oscillations in fermentation processes. Recently Reference [1] computationally demonstrated very simple strategies to eliminate the oscillations in the fermentation process. In the case of the of the Saccharomyces cerevisiae fermentation process it was shown that the addition of a little bit of oxygen would be successful in eliminating the oscillation causing Hopf bifurcations. The work of [2,3] demonstrated that oxygen mass transfer could be enhanced by using functionalized magnetic nanoparticles. The aim of this work is to incorporate the model used by [3] regarding the enhancement of oxygen mass transfer in the cybernetic Jones Kompala model [4] describing the dynamics of the Saccharomnyces cerevisiae fermentation process and demonstrate that using the functionalized magnetic nanoparticles can by altering the mass transfer coefficient actually succeed in eliminating the oscillatory behavior that plagues the Saccharomyces cerevisiae fermentation process. This occurs because the oscillation causing Hopf bifurcations are sensitive to the amount of input oxygen and increasing the oxygen mass transfer coefficient causes the disappearance of the Hopf bifurcation points.
Global Optimization of Continuous Fermentation Involving Zymomonas mobilis  [PDF]
Lakshmi N. Sridhar
Journal of Sustainable Bioenergy Systems (JSBS) , 2013, DOI: 10.4236/jsbs.2013.31008
Abstract:

Global steady-state optimization of Zymomonas mobilis fermentation process problems is performed to demonstrate the existence of multiple optimum solutions necessitating the use of a global optimization strategy. It is shown that the steady-state equations for the Zymomonas mobilis fermentation process can be reduced to a single equation which when used as a constraint results in yielding only one optimum solution, the global one.

Unhealthy Cooking and Prevalence of Tuberculosis in Indian Women: A Case Study  [PDF]
Abha Lakshmi Singh, Saleha Jamal
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.37078
Abstract: Unhealthy cooking is one of the major cause of mortality and morbidity and a risk factor for occurrence of tuberculosis among Indian women. India is the TB burden country in the world and accounts for nearly 20 percent of global burden of tuberculosis. The present study establishes the association between unhealthy cooking conditions (use of biomass fuels/chulhas, cooking in multipurpose room, Non-ventilated kitchen, living in kutcha/semi-pucca houses) and prevalence of tuberculosis in women. This study is based on primary sources of data collected through questionnaire interviews from 2101 women respondents belonging to different income categories from Aligarh city. The study examines the socio-economic characteristics, cooking conditions, monitoring of indoor air quality of different types of kitchen locations using different types of fuels. Symptomatic linkages of tuberculosis with type of fuel use, kitchen locations and house type were analysed. The results show that the women using biomass fuels/chulhas cooking in non-ventilated kitchens and multipurpose room, living in kutcha/semi pucca houses were most prone to tuberculosis.
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