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Search Results: 1 - 10 of 586 matches for " Manas Raychaudhuri "
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Algunos correlatos perceptivos de la sensibilidad estética
Manas Raychaudhuri
Revista Latinoamericana de Psicología , 1972,
Abstract: This study investigated the supposed relationship between aesthetic- artistic sensítivity, and a number of perceptual attributes such as tolerance of ambiguity, preference for complexíry, perceptual independence and projectíon of dynamism on unstructured stimuli. Two groups of aesthetic (N=30) and non aesthetic (N=30) Ss were given the Revised Art (RA) , Conformance (CF), Movement (MV) scales of the Welsh Figure Preference Test (WFTP) and the Rorschach inkblots (for M only) individually. The results provide support for the hypothesized linking of the aforesaid perpectual characterístic to aesthetic-artístic sensitivity.
Kinetic Monte Carlo Study of the Type 1/Type 2 Choice in Apoptosis Elucidates Selective Killing of Cancer Cells under Death Ligand Induction  [PDF]
Subhadip Raychaudhuri
Open Journal of Apoptosis (OJApo) , 2015, DOI: 10.4236/ojapo.2015.41003
Abstract: Death ligand mediated apoptotic activation is a mode of cell death that is widely used in cellular and physiological situations. Interest in studying death ligand induced apoptosis has increased due to the promising role of recombinant soluble forms of death ligands (mainly recombinant TRAIL) in anti-cancer therapy. A clear elucidation of how death ligands activate the type 1 and type 2 apoptotic pathways in healthy and cancer cells may help develop better chemotherapeutic strategies. In this work, we use kinetic Monte Carlo simulations to address the problem of type 1/ type 2 choice in death ligand mediated apoptosis of cancer cells. Our study provides insights into the activation of membrane proximal death module that results from complex interplay between death and decoy receptors. Relative abundance of death and decoy receptors was shown to be a key parameter for activation of the initiator caspases in the membrane module. Increased concentration of death ligands frequently increased the type 1 activation fraction in cancer cells, and, in certain cases changed the signaling phenotype from type 2 to type 1. Results of this study also indicate that inherent differences between cancer and healthy cells, such as in the membrane module, may allow robust activation of cancer cell apoptosis by death ligand induction. At the same time, large cell-to-cell variability through the type 2 pathway was shown to provide protection for healthy cells. Such elucidation of selective activation of apoptosis in cancer cells addresses a key question in cancer biology and cancer therapy.
Polarizabilities of Impurity Doped Quantum Dots under Pulsed Field: Role of Additive White Noise  [PDF]
Surajit Saha, Manas Ghosh
Open Journal of Microphysics (OJM) , 2015, DOI: 10.4236/ojm.2015.51001
Abstract: We make a rigorous exploration of the profiles of a few diagonal and off-diagonal components of linear (αxx, αyy, αxy andαyx), first nonlinear (βxxx, βyyy, βxyy andβyxx), and second nonlinear (γxxxx, γyyyy, γxxyyandγyyxx) polarizabilities of quantum dots under the influence of external pulsed field. Simultaneous presence of additive white noise has also been considered. The quantum dot contains dopant described by a Gaussian potential. The numbers of pulse and the dopant location have been found to fabricate the said profiles jointly. The β components display greater complexity in their profiles in comparison with the α and γ counterparts. The presence of noise prominently enhances the influence of dopant coordinate on the polarizability profiles, particularly for α and γ components. However, for β components, the said influence becomes quite evident both in the presence and absence of additive noise. The study reveals some means of achieving stable, enhanced, and often maximized output of noise-driven linear and nonlinear polarizabilities.
Cellotape Birefringent Filter: Some New Demonstrations  [PDF]
Ayantika Khanra, Barun Raychaudhuri
Optics and Photonics Journal (OPJ) , 2016, DOI: 10.4236/opj.2016.67016
Abstract: An easy method is put forward to estimate the optical bandwidth and the wavelength of maximum transmission of Lyot optical filter by measuring the change in phase retardation of birefringent plates as function of thickness. The objective is to demonstrate the experiment with common undergraduate laboratory equipment and thereby provide with an educational aid. The filter is fabricated with cellotape using its birefringence property. The accuracy of measurement is cross-checked with precision spectroradiometric measurements. Some simplification is suggested in the theoretical derivation of the transmitted intensity and a possibility of realizing tunable filter by changing the angle of incidence is indicated.
Biologics : Target - specific treatment of systemic and cutaneous autoimmune diseases
Raychaudhuri Siba,Raychaudhuri Smriti
Indian Journal of Dermatology , 2009,
Abstract: Biologics are becoming important in the treatment of systemic and cutaneous autoimmune diseases. They are designed to target specific components of immune system. As the new drugs are capable of targeting proteins in a more specific fashion, yet have lower risks of systemic side-effects, they have considerable advantages over the older immunomodulators. The development of TNF-alpha blockers in the treatment of psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn′s disease and ankylosing spondylitis have been major breakthroughs. Likewise, B-cell depletion has proved to be equally revolutionary for the treatment of lupus, pemphigus, certain vasculitides etc. But all said and done, the development of these molecules and their clinical usage are still at evolving stages. Consensus needs be formed to further categorize the clinical profiles of the patients in whom biologics are to be used in the future, given that the long-term safety profiles of these agents are very much unknown at present.
SCID mouse model of psoriasis: A unique tool for drug development of autoreactive T-cell and TH-17 cell-mediated autoimmune diseases
Raychaudhuri Smriti,Raychaudhuri Siba
Indian Journal of Dermatology , 2010,
Abstract: In both skin and synovial tissues of psoriatic arthritis (PsA) patients, there are prominent lymphocytic infiltrates localized to the dermal papillae in the skin and the sublining layer stroma in the joint. T-cells, with a predominance of CD4+ lymphocytes, are the most significant lymphocytes in the tissues; in contrast, this ratio is reversed in the epidermis, synovial fluid compartment, and at the enthesis, where CD8+ T-cells are more common. This differential tropism of CD8+ T-cell suggests that the CD8+ T-cells may be driving the immune response in the joint and skin. This is supported by an association with MHC class I. The cytokine network in the psoriatic skin and synovium is dominated by monocyte and T-cell-derived cytokines: IL-1β, IL-2, IL-10, IFN-γ, and TNF-α. In PsA synovium, higher levels of IFN-γ, IL-2, and IL-10 have been detected than in psoriatic skin. An analysis of T-cell receptor beta-chain variable (TCRβV) gene repertoires revealed common expansions in both skin and synovial inflammatory sites, suggesting an important role for cognate T-cell responses in the pathogenesis of PsA and that the inciting antigen may be identical or homologous between the afflicted skin and synovium. Traditionally, T-cells have been classified as T helper 1 (Th1) or Th2 cells by production of defining cytokines, IFN- γ and IL-4, respectively. Recently, a new type of T-cell, Th17, has been linked to autoimmune inflammation. T-helper 17 (Th17) cells are a unique effector CD4+ T-cell subset characterized by the production of interleukin (IL)-17. Murine diseases that were previously considered to be pure Th1-mediated responses have been shown to contain mixed populations of Th1 and Th17 cells. Also, in humans, a critical immunoregulatory role of Th-17 cells in infectious and autoimmune diseases has been identified. It has been postulated that IL-17 may be important in psoriasis. Our initial observations demonstrate that IL-17 and its receptor system are important for PsA also. In in vivo and in vitro studies we have demonstrated that IL-17/IL-17R are enriched in skin, synovial tissue, and synovial fluid of psoriatic arthritis patients and Th17 cells are functionally significant in the pathogenesis of psoriasis and psoriatic arthritis. Here we will share our experience of the SCID mouse model of psoriasis in respect to its use in investigating psoriatic diseases and development of immune-based drugs for psoriasis, psoriatic arthritis, and other autoimmune diseases.
The spectrum of thyroid autoimmunity
Chatterjee Manas
Indian Journal of Dermatology , 2006,
Abstract: A 45 year old male presented with dry skin, facial puffiness, weight gain, constipation and lethargy for five months. He had been diagnosed as thyrotoxicosis fifteen years back and improved after oral antithyroid drugs. General examination revealed bradycardia, obesity, hoarseness, proptosis and acropachy. Dermatological examination revealed pretibal as well as generalised myxoedema with cold, hyperpigmented and xerotic skin. Hair was thin, coarse and brittle and nails brittle. Face appeared puffy, expressionless and eyelids wrinkled and drooping. Palms, soles had a yellowish hue. The neck revealed a diffusely enlarged thyroid. Hormone profile revealed reduced T3, T4 and raised TSH. Thyroperoxidase antibody was positive. ECG showed low voltage sinus bradycardia. X-ray hands substantiated thyroid acropachy. Skin biopsy confirmed pretibial myxoedema. He was diagnosed as Graves disease with past hyperthyroidism and present hypothyroid state and managed with oral thyroxine with improvement. The pretibial myxoedema was successfully managed with intralesional and topical steroids.
Gluteal primary cutaneus actinomycosis
Chatterjee Manas
Indian Journal of Dermatology , 2005,
Abstract: A 58 year old male presented with multiple areas of painless purulent discharge from the buttocks. He had pallor and dermatological examination revealed multiple subcutaneus nodules and discharging sinuses over the buttocks with hyperpigmentation and indurated puckered scarring. Examination of the pus revealed ′sulphur granules′ and Gram stain showed narrow bacillary forms and elongated hyphae with occasional branching. Skin biopsy revealed granular colonies in which ′ray fungus′ were seen. In brain-heart glucose agar in anerobic environment, white spidery colonies of Actinomyces israelii were grown at 37o C in 4 days, confirming primary cutaneus actinomycosis. He was managed with capsule doxycycline with regression of pus discharge in 6 weeks and therapy is planned for 18 months.
S-functions, reductions and hodograph solutions of the r-th dispersionless modified KP and Dym hierarchies
Manuel Manas
Physics , 2004, DOI: 10.1088/0305-4470/37/46/007
Abstract: We introduce an S-function formulation for the recently found r-th dispersionless modified KP and r-th dispersionless Dym hierarchies, giving also a connection of these $S$-functions with the Orlov functions of the hierarchies. Then, we discuss a reduction scheme for the hierarchies that together with the $S$-function formulation leads to hodograph systems for the associated solutions. We consider also the connection of these reductions with those of the dispersionless KP hierarchy and with hydrodynamic type systems. In particular, for the 1-component and 2-component reduction we derive, for both hierarchies, ample sets of examples of explicit solutions.
On the r-th dispersionless Toda hierarchy I: Factorization problem, symmetries and some solutions
M. Manas
Physics , 2004, DOI: 10.1088/0305-4470/37/39/010
Abstract: For a family of Poisson algebras, parametrized by by an integer number r, and an associated Lie algebraic splitting, we consider the factorization of given canonical transformations. In this context we rederive the recently found r-th dispersionless modified KP hierachies and r-th dispersionless Dym hierarchies, giving a new Miura map among them. We also found a new integrable hierarchy which we call the r-th dispersionless Toda hierarchy. Moreover, additional symmetries for these hierarchies are studied in detail and new symmetries depending on arbitrary functions are explicitly constructed for the r-th dispersionless KP, r-th dispersionless Dym and r-th dispersionless Toda equations. Some solutions are derived by examining the imposition of a time invariance to the potential r-th dispersionless Dym equation, for which a complete integral is presented and therefore an appropriate envelope leads to a general solution. Symmetries and Miura maps are applied to get new solutions and solutions of the r-th dispesionless modified KP equation.
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