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Search Results: 1 - 10 of 531129 matches for " Malykhina M. P. "
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INTELLIGENT SYSTEM FOR DATABASE DESIGN OF EFFECTIVE STRUCTURES Интеллектуальная система для проектирования баз данных эффективной структуры
Malykhina M. P.,Bujanov M. V.
Polythematic Online Scientific Journal of Kuban State Agrarian University , 2013,
Abstract: The article deals with the automated system that will allow users to make the structure of the existing database efficiently by sequential normalization with the use of explanatory system
ASPECTS OF PRACTICAL USE OF COLOR DIFFERENCE FOR RECOGNITION AND SELECTION OF BOUNDARY LINE ON IMAGES Аспекты практического применения цветового различия для распознавания и выделения границ изображений
Malykhina M. P.,Shichkin D. A.
Polythematic Online Scientific Journal of Kuban State Agrarian University , 2013,
Abstract: Selection of borders on images through color difference is reviewed in this article. The existing approaches are considered, the problems are set. We also show the reasons of shifting to other approaches
EVALUATION OF EFFICIENCY OF HYBRIDIZATION OF THE INTELLIGENT METHODS ON THE EXAMPLE OF THE NEURAL NETWORK EXPERT SYSTEM BASED ON PRECEDENTS Оценка эффективности гибридизации интеллектуальных методов на примере нейросетевой экспертной системы на основе прецедентов
Malykhina M. P.,Begman Y. V.
Polythematic Online Scientific Journal of Kuban State Agrarian University , 2013,
Abstract: The article discusses the ways of working of an intelligent system based on hybridization of several technologies of intelligent computations. A model of the hybrid system is represented. The effectiveness of the proposed approach has been proved
Estrous Cycle Dependent Fluctuations of Regulatory Neuropeptides in the Lower Urinary Tract of Female Rats upon Colon-Bladder Cross-Sensitization
Xiao-Qing Pan, Anna P. Malykhina
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094872
Abstract: Co-morbidity of bladder, bowel, and non-specific pelvic pain symptoms is highly prevalent in women. Little evidence is present on modulation of pelvic pain syndromes by sex hormones, therefore, the objective of this study was to clarify the effects of hormonal fluctuations within the estrous cycle on regulatory neuropeptides in female rats using a model of neurogenic bladder dysfunction. The estrous cycle in female rats (Sprague-Dawley, 230–250 g) was assessed by vaginal smears and weight of uterine horns. Neurogenic bladder dysfunction was induced by a single inflammatory insult to the distal colon. Protein expression of calcitonin gene related peptide (CGRP), substance P (SP), nerve growth factor (NGF), and brain derived neurotrophic factor (BDNF) in the pelvic organs, sensory ganglia and lumbosacral spinal cord was compared in rats in proestrus (high estrogen) vs diestrus (low estrogen). Under normal physiological conditions, concentration of SP and CGRP was similar in the distal colon and urinary bladder during all phases of the estrous cycle, however, acute colitis induced a significant up-regulation of CGRP content in the colon (by 63%) and urinary bladder (by 54%, p≤0.05 to control) of rats in proestrus. These changes were accompanied by a significant diminution of CGRP content in L6-S2 DRG after colonic treatment, likely associated with its release in the periphery. In rats with high estrogen at the time of testing (proestrus), experimental colitis caused a significant up-regulation of BDNF colonic content from 26.1±8.5 pg/ml to 83.4±32.5 pg/ml (N = 7, p≤0.05 to control) and also induced similar effects on BDNF in the urinary bladder which was also up-regulated by 5-fold in rats in proestrus (p≤0.05 to respective control). Our results demonstrate estrous cycle dependent fluctuations of regulatory neuropeptides in the lower urinary tract upon colon-bladder cross-sensitization, which may contribute to pain fluctuations in female patients with neurogenic bladder pain.
Differential Binding of IgG and IgA to Mucus of the Female Reproductive Tract
Kelly M. Fahrbach, Olga Malykhina, Daniel J. Stieh, Thomas J. Hope
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076176
Abstract: Cells of the endocervix are responsible for the secretion of mucins, which provide an additional layer of protection to the female reproductive tract (FRT). This barrier is likely fortified with IgA as has previously been shown in the gastrointestinal tract and lungs of mice. Mucus associated IgA can facilitate clearance of bacteria. While a similar function for IgG has been proposed, an association with mucus has not yet been demonstrated. Here we find that IgA and IgG are differentially associated with the different types of mucus of the FRT. We observed that while both IgA and IgG are stably associated with cervical mucus, only IgG is associated with cervicovaginal mucus. These findings reveal that antibodies can bind tightly to mucus, where they can play a significant role in the fortification of the mucus barriers of the FRT. It may be possible to harness this interaction in the development of vaccines designed to protect the FRT mucosal barriers from sexually transmitted diseases such as HIV.
VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity
Anna P Malykhina, Qi Lei, Chris S Erickson, Miles L Epstein, Marcia R Saban, Carole A Davis, Ricardo Saban
BMC Physiology , 2012, DOI: 10.1186/1472-6793-12-15
Abstract: In addition to C57BL/6J, ChAT-cre mice were used for visualization of bladder cholinergic nerves. The direct effect of VEGF on the density of sensory nerves expressing the transient receptor potential vanilloid subfamily 1 (TRPV1) and cholinergic nerves (ChAT) was studied one week after one or two intravesical instillations of the growth factor.To study the effects of VEGF on bladder function, mice were intravesically instilled with VEGF and urodynamic evaluation was assessed. VEGF-induced alteration in bladder dorsal root ganglion (DRG) neurons was performed on retrogradly labeled urinary bladder afferents by patch-clamp recording of voltage gated Na+ currents. Determination of VEGF-induced changes in sensitivity to abdominal mechanostimulation was performed by application of von Frey filaments.In addition to an overwhelming increase in TRPV1 immunoreactivity, VEGF instillation resulted in an increase in ChAT-directed expression of a fluorescent protein in several layers of the urinary bladder. Intravesical VEGF caused a profound change in the function of the urinary bladder: acute VEGF (1 week post VEGF treatment) reduced micturition pressure and longer treatment (2 weeks post-VEGF instillation) caused a substantial reduction in inter-micturition interval. In addition, intravesical VEGF resulted in an up-regulation of voltage gated Na+ channels (VGSC) in bladder DRG neurons and enhanced abdominal sensitivity to mechanical stimulation.For the first time, evidence is presented indicating that VEGF instillation into the mouse bladder promotes a significant increase in peripheral nerve density together with alterations in bladder function and visceral sensitivity. The VEGF pathway is being proposed as a key modulator of neural plasticity in the pelvis and enhanced VEGF content may be associated with visceral hyperalgesia, abdominal discomfort, and/or pelvic pain.It is highly likely that neurogenic dysfunction of the urinary bladder is involved in various disorders of
Dielectric Property Studies of Biologically Compatible Brushite Single Crystals Used as Bone Graft Substitute  [PDF]
M. P. Binitha, P. P. Pradyumnan
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.42016

The electrical characterization of bone is essential for the better understanding of the role of electrical stimulation in bone remodeling. Calcium Hydrogen Phosphate Dihydrate or brushite (CaHPO4 2H2O) has been used in bone substitution owing to their fast resorption under physiological condition. Brushite is a suitable matrix for osteoconductive bone grafts. In this work, Calcium Hydrogen Phosphate single crystals have been grown by single diffusion gel growth technique. The powder XRD studies revealed the monoclinic structure of the grown crystals. The vibrational analysis of the crystals is done with FTIR spectroscopy and the major functional groups and their assigned vibrations are discussed. The frequency dependence of dielectric constant and ac conductivity at different temperatures have been studied in detail. This study shows decrease in the dielectric constant with the increase in frequency and temperature. The variation of ac conductivity is found to be increasing with frequency and decreasing with temperature.

An Investigation into the Role of Capping on Second Harmonic Generation from Nonlinear Organic Polymer and Guest-Host Thin Films by In-Situ Poling  [PDF]
P. M. Ushasree, M. Szablewski
Optics and Photonics Journal (OPJ) , 2016, DOI: 10.4236/opj.2016.65013
Abstract: In attempts to fabricate thermally stable second-order nonlinear polymer thin films, we have investigated the second harmonic generation (SHG) from both nonlinear polymer and guest-host thin films. We have also investigated the role of capping on the SHG, temporal stability and relaxation of dipole alignment. Corona poling techniques were employed to orient the dopants into the noncentrosymmetric structure required to obtain the SHG. The effect of capping with a polymeric encapsulant below the glass transition temperature of the polymers on the unpoled and corona poled thin films was studied. Capping of the nonlinear polymer and guest host thin films have resulted in high SHG with good temporal stability. SHG signal falls drastically during the first 8 days after poling while no further significant decay in SHG signal was observed after about 33 days. Our investigations have identified the characteristics required for a good encapsulant on a non-con-ductive surface.
Validation of PSIAC Model for Sediment Yields Estimation in Ungauged Catchments of Tanzania  [PDF]
P. M. Ndomba
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.47104

The main objective of this paper is to report on preliminary validation results of the newly applied sediment yields estimation model in Tanzania, the Pacific Southwest Inter-Agency Committee (PSIAC). This is a follow-up research on the call to customize simple and/or multi-processes sediment yields estimation models such as PSIAC in the region. The PSIAC approach is based on a sediment yield classification scheme employing individual drainage basin characteristics: surface geology, soils, climate, runoff, topography, ground cover, land use, upland erosion, channel erosion, and sediment transport. In this study, PSIAC model is built from readily available environmental variables sourced from Government ministries/agencies and public domain global spatial data. The sediment classification exercise was verified with field observations. The set up model was then validated by 31 small dams’ siltation surveys and previous sedimentation study findings. PSIAC model performance for major part of central Tanzania was good during calibration (BIAS = 7.88%) and validation (BIAS = 18.12%). Another observation was that uncalibrated model performs fairly well, though performance improves with calibration. The extension of the uncalibrated PSIAC model to 3 selected large basins of Tanzania, with drainage areas size up to 223,000 km2, registered a satisfactory performance in one of them with fair performance in the rest. For large

Heat Flux Modulation in Domino Dynamo Model  [PDF]
M. Reshetnyak, P. Hejda
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.32B013

Using the domino dynamo model, we show how specific axisymmetric and equatorial symmetric forms of the heat flux variations at the core-mantle boundary change the frequency of the geomagnetic field reversals. In fact, we are able to demonstrate the effect known from the modern 3D planetary dynamo models using an ensemble of interacting spins, which obey equations of the Langevin type with a random force. We also consider applications to the giant planets and offer explanations of some specific episodes of the geomagnetic field in the past.

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