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Search Results: 1 - 10 of 224205 matches for " Mali Prabha R "
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DIURETIC ACTIVITY OF PISTIA STRATIOTES LEAF EXTRACT IN RATS
Tripathi Pallavi,Arora Sandeep,Gupta Rajiv,Mali Prabha R
International Research Journal of Pharmacy , 2011,
Abstract: The leaf extracts of Pistia stratiotes were subjected to screening of antidiabetic and diuretic activity in rats. The oral administration of the extracts (200mg/kg body weight) produced significant antihyperglycemic (P*<0.001) action, as well as Diuretic action. The antihyperglycemic action of the extracts may be due to the blocking of glucose absorption. From the obtained result it was concluded that Pistia stratiotes possess potent antidiabetic and diuretic activity.
STUDIES ON ANTIASTHMATIC ACTIVITY OF AQUEOUS EXTRACT OF ROOTS OF MIMOSA PUDICA LINN
Mali Prabha R,Patil Chandrashekhar D,Rahila Sheikh,Mali Pratibha R
International Research Journal of Pharmacy , 2011,
Abstract: The present study designed to evaluate the antiasthmatic activity of aqueous extract of Mimosa pudica (AEMP) on in vitro and in vivo animal models. Histamine induced contraction in isolated goat tracheal chain showed that aqueous extract of Mimosa pudica (AEMP) inhibited the contractile effect of histamine (P<0.05). A dose dependent contraction of goat tracheal chain is observed. Treatment with AECP protected 74% from degranulation of mast cell as compared to control group. AEMP showed excellent protection in guinea pigs against the histamine-induced bronchospasm. Thus, AECP showed antihistaminic, mast cell stabilizing and protected guinea pigs against histamine induced PCD and hence possesses potential role in the treatment of asthma.
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF FAMOTIDINE USING NATURAL POLYMERS
Jagtap Leena S,Swami Seema P,Mali Prabha R,Tripathi Pallavi S
International Research Journal of Pharmacy , 2011,
Abstract: In the present investigation effervescent floating matrix tablets of famotidine are formulated to achieve gastric retention for a period of 8 to 10 hrs. Famotidine is H2 receptor antagonist widely prescribed in gastric ulcer, Duodenal ulcer, Zollinger Ellison syndrome & Gastro-esophageal reflux disease. Famotidine has low oral bioavailability of 35% & short biological half life of 2 – 3 hrs. This favors development of sustained release dosage form. Besides this, it is primarily absorbed from stomach. Local delivery increase stomach wall receptor site bioavailability and increase efficacy of drug to reduce acid secretion. Hence the principle of Floating drug delivery system was applied to improve systemic as well as local drug delivery. Natural polysaccharides such as xanthan gum and chitosan were used to achieve sustained release of the drug. Thus it can be concluded that floating matrix famotidine tablets so formulated achieved desired gastric retention for 8 to 10 hrs and sustained the drug release. Thus one tablet daily is sufficient to reduce gastric acidity as compared to conventional tablets in hyperacidity conditions.
RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN SOLID DOSAGE FORM
Sheikh Rahila J,Puranik Manisha P,Bavadkar Deepali N,Mali Prabha R
International Research Journal of Pharmacy , 2011,
Abstract: A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of Valsartan and Hydrochlorothiazide in solid dosage form. The method was carried out on a C18 Intersil (250 X 4.6 i.d., particle size 10μm) column with a mobile phase consisting of 0.02M Potassium dihydrogen orthophosphate:Methanol:Triethylamine [25:75:0.2 %v/v/v, pH 6.0]at a flow rate of 1.0 mL/min. Detection was carried out at 259 nm. The retention time of Valsartan and Hydrochlorothiazide was found to be 4.15 and 3.20 min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation and can be used for the estimation of these drugs in combined pharmaceutical dosage forms.
BIOPHARMACEUTICAL CLASSIFICATION SYSTEM AND BIOWAVER: AN OVERVIEW
Puranik Prashant K,Kasar Sagar Ashok,Gadade Deepak Dilip,Mali Prabha R
International Research Journal of Pharmacy , 2011,
Abstract: The biopharmaceutical classification system (BCS) has been developed to provide a scientific approach for classifying drug compounds based on solubility as related to dose and intestinal permeability in combination with the dissolution properties of the oral immediate release dosage form. BCS is to provide a regulatory tool for replacing certain bioequivalence (BE) studies by accurate in vitro dissolution tests. This review gives three dimensionless numbers which are used in BCS are absorption number, dissolution number, dose number.Biowaver is an important tool for formulation development. Bioavailability (BA) and BE play a central role in pharmaceutical product development, and BE studies are presently being conducted for New Drug Applications (NDAs) of new compounds, in supplementary NDAs for new medical indications and product line extensions, in Abbreviated New Drug Applications (ANDAs) of generic products, and in applications for scale-up and post-approval changes. The principles of the BCS classification system can be applied to NDA and ANDA approvals as well as to scale-up and post approval changes in drug manufacturing. BCS classification can therefore save pharmaceutical companies a significant amount in development time and reduce costs. The aim of the present review is to present the status of BCS and discuss its future application in pharmaceutical product development.
Fuzzy Controlled Ultra-Capacitor Based DVR (UCAP-DVR) for Power Quality Enhancement  [PDF]
R. Bhavani, Dr. N. Rathina Prabha
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.713338
Abstract: In recent years, a rapid decrease in the cost of various energy storage technologies and their integration into grid becomes a reality with the advent of smart grid. The Dynamic Voltage Restorer (DVR) is a custom power device that has an excellent dynamic capability used to provide voltage sag, swell compensation in distribution systems. Among the energy storage devices, Ultra-Capacitors (UCAP) have ideal characteristics such as high power and low energy density essential for the compensation of voltage sag and swell, which require high power for short interval of time. This paper presents an integration of rechargeable UCAP with DVR. This UCAP-DVR presents a modular, flexible system configuration that will have an active power capability and also provide deep, extended mitigation for power quality problems. The DVR is integrated into UCAP via bidirectional DC-DC converter which supports a rigid dc-link voltage for DVR and also helps in compensating temporary voltage sag and swell. FUZZY LOGIC Controller is used to enhance the performance of UCAP-DVR. The simulation model for the proposed system has been developed in MAT-LAB and the performance over conventional DVR is compared with the results obtained.
Foster Kennedy syndrome
Bhura Prabha,Mishra R
Indian Journal of Ophthalmology , 1973,
Abstract:
A Study On The Use Of “pull Quotes” In Framing The News In The Sites www.thehindu And www.thenewindianexpress About The Fall Of Ltte In Sri Lanka For A Period From 1st January To 31st May 2009
Rama Prabha. R
Indian Streams Research Journal , 2012,
Abstract: The role of media be it Online, Print and Audio-Visual becomes engrained in the public consciousness over a period of time. It is vital in generating a democratic culture that extends beyond the political system. It is through the media that people share their experience, learn and become aware. Hence, it is rightly called media as the fourth pillar of democracy, the Fourth Estate.Media plays an influential role in portraying other countries image in a striking way. The mass media can contribute to people's understanding or Misunderstanding of each other's country. Mass media play a crucial role in constructing the image of various societies and their people, as good or bad. The professional way of news reporting with sense of objectivity will take care of many problems of journalism. The role of media in portraying the image about the people, culture, crisis etc cannot be ignored. The Media can either propagate messages of intolerance and disinformation or serve as a tool of conflict resolution, which is a part of conflict news reporting. This study tries to explore the role of media in reporting a conflict.
Integrated Hidden Markov Model and Bayes Packet Classifier for effective Mitigation of Application DDoS attacks
S Prabha,R Anitha
International Journal of Computer Science Issues , 2011,
Abstract: Resisting distributed denial of service (DDoS) attacks become more challenging with the availability of resources and techniques to attackers. The application-layer-based DDoS attacks utilize legitimate HTTP requests to overwhelm victim resources are more undetectable and are protocol compliant and non-intrusive. Focusing on the detection for application layer DDoS attacks, the existing scheme provide an access matrix which capture the spatial-temporal patterns of a normal flash crowd on non stationary object. The access matrix captures the spatial-temporal patterns of the normal flash crowd and the anomaly detector based on hidden Markov model (HMM) described the dynamics of Access Matrix (AM) to detect the application DDoS attacks. However current application layer attacks have high influence on the stationary object as well. In addition the detection threshold for non stationary object should be reevaluated to improve the performance of false positive rate and detection rate of the DDoS attacks.
In vitro anthelmintic activity of Baliospermum montanum muell. arg roots
Mali R,Wadekar R
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Alcohol and aqueous extracts from the roots of Baliospermum montanum Muell. Arg were investigated for their anthelmintic activity against Pheretima posthuma and Ascardia galli . Various concentrations (10-100 mg/ml) of each extract were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. Both the extracts exhibited significant anthelmintic activity at highest concentration of 100 mg/ml. Piperazine citrate (10 mg/ml) was included as standard reference and distilled water as control.
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