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Search Results: 1 - 10 of 144335 matches for " Make B "
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Undertreatment of COPD: a retrospective analysis of US managed care and Medicare patients
Make B,Dutro MP,Paulose-Ram R,Marton JP
International Journal of COPD , 2012,
Abstract: Barry Make1, Michael P Dutro2, Ryne Paulose-Ram2, Jen P Marton2, Douglas W Mapel31National Jewish Health, Denver, CO, 2Pfizer Inc, New York, NY, 3Lovelace Clinic Foundation, Albuquerque, NM, USABackground: We investigated a large population of patients with chronic obstructive pulmonary disease (COPD) to determine their frequency of medication use and patterns of pharmacotherapy.Methods: Medical and pharmacy claims data were retrospectively analyzed from 19 health plans (>7.79 million members) across the US. Eligible patients were aged ≥40 years, continuously enrolled during July 2004 to June 2005, and had at least one inpatient or at least two outpatient claims coded for COPD. As a surrogate for severity of illness, COPD patients were stratified by complexity of illness using predefined International Classification of Diseases, Ninth Revision, Clinical Modification, Current Procedural Terminology, Fourth Edition, and Healthcare Common Procedure Coding System codes.Results: A total of 42,565 patients with commercial insurance and 8507 Medicare patients were identified. Their mean age was 54.7 years and 74.8 years, and 48.7% and 46.9% were male, respectively. In total, 66.3% of commercial patients (n = 28,206) were not prescribed any maintenance COPD pharmacotherapy (59.1% no medication; 7.2% inhaled short-acting 2-agonist only). In the Medicare population, 70.9% (n = 6031) were not prescribed any maintenance COPD pharmacotherapy (66.0% no medication; 4.9% short-acting 2-agonist only). A subset of patients classified as high-complexity were similarly undertreated, with 58.7% (5358/9121) of commercial and 68.8% (1616/2350) of Medicare patients not prescribed maintenance COPD pharmacotherapy. Only 18.0% and 9.8% of diagnosed smokers in the commercial and Medicare cohorts had a claim for a smoking cessation intervention and just 16.6% and 23.5%, respectively, had claims for an influenza vaccination.Conclusion: This study highlights a high degree of undertreatment of COPD in both commercial and Medicare patients, with most patients receiving no maintenance pharmacotherapy or influenza vaccination.Keywords: managed care, chronic obstructive pulmonary disease, health care utilization, quality of care
Undertreatment of COPD: a retrospective analysis of US managed care and Medicare patients
Make B, Dutro MP, Paulose-Ram R, Marton JP, Mapel DW
International Journal of Chronic Obstructive Pulmonary Disease , 2012, DOI: http://dx.doi.org/10.2147/COPD.S27032
Abstract: dertreatment of COPD: a retrospective analysis of US managed care and Medicare patients Original Research (3403) Total Article Views Authors: Make B, Dutro MP, Paulose-Ram R, Marton JP, Mapel DW Published Date January 2012 Volume 2012:7 Pages 1 - 9 DOI: http://dx.doi.org/10.2147/COPD.S27032 Received: 08 October 2011 Accepted: 19 November 2011 Published: 18 January 2012 Barry Make1, Michael P Dutro2, Ryne Paulose-Ram2, Jen P Marton2, Douglas W Mapel3 1National Jewish Health, Denver, CO, 2Pfizer Inc, New York, NY, 3Lovelace Clinic Foundation, Albuquerque, NM, USA Background: We investigated a large population of patients with chronic obstructive pulmonary disease (COPD) to determine their frequency of medication use and patterns of pharmacotherapy. Methods: Medical and pharmacy claims data were retrospectively analyzed from 19 health plans (>7.79 million members) across the US. Eligible patients were aged ≥40 years, continuously enrolled during July 2004 to June 2005, and had at least one inpatient or at least two outpatient claims coded for COPD. As a surrogate for severity of illness, COPD patients were stratified by complexity of illness using predefined International Classification of Diseases, Ninth Revision, Clinical Modification, Current Procedural Terminology, Fourth Edition, and Healthcare Common Procedure Coding System codes. Results: A total of 42,565 patients with commercial insurance and 8507 Medicare patients were identified. Their mean age was 54.7 years and 74.8 years, and 48.7% and 46.9% were male, respectively. In total, 66.3% of commercial patients (n = 28,206) were not prescribed any maintenance COPD pharmacotherapy (59.1% no medication; 7.2% inhaled short-acting 2-agonist only). In the Medicare population, 70.9% (n = 6031) were not prescribed any maintenance COPD pharmacotherapy (66.0% no medication; 4.9% short-acting 2-agonist only). A subset of patients classified as high-complexity were similarly undertreated, with 58.7% (5358/9121) of commercial and 68.8% (1616/2350) of Medicare patients not prescribed maintenance COPD pharmacotherapy. Only 18.0% and 9.8% of diagnosed smokers in the commercial and Medicare cohorts had a claim for a smoking cessation intervention and just 16.6% and 23.5%, respectively, had claims for an influenza vaccination. Conclusion: This study highlights a high degree of undertreatment of COPD in both commercial and Medicare patients, with most patients receiving no maintenance pharmacotherapy or influenza vaccination.
Requirement Development for Electrical Vehicles Using Simulation Tools
Wei Zhan,Make McDermott,Behbood Zoghi,Muhammad Hasan
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
Identifying and characterizing COPD patients in US managed care. A retrospective, cross-sectional analysis of administrative claims data
Douglas W Mapel, Michael P Dutro, Jen? P Marton, Kimberly Woodruff, Barry Make
BMC Health Services Research , 2011, DOI: 10.1186/1472-6963-11-43
Abstract: This retrospective, cross-sectional analysis of US managed care administrative claims data describes a practical way to identify COPD patients. We analyze 7.79 million members for potential inclusion in the COPD cohort, who were continuously eligible during a 1-year study period. A younger commercial population (7.7 million) is compared with an older Medicare population (0.115 million). We outline a novel approach to stratifying COPD patients using "complexity" of illness, based on occurrence of claims for given comorbid conditions. Additionally, a unique algorithm was developed to identify and stratify COPD exacerbations using claims data.A total of 42,565 commercial (median age 56 years; 51.4% female) and 8507 Medicare patients (median 75 years; 53.1% female) were identified as having COPD. Important differences were observed in comorbidities between the younger commercial versus the older Medicare population. Stratifying by complexity, 45.0%, 33.6%, and 21.4% of commercial patients and 36.6%, 35.8%, and 27.6% of older patients were low, moderate, and high, respectively. A higher proportion of patients with high complexity disease experienced multiple (≥2) exacerbations (61.7% commercial; 49.0% Medicare) than patients with moderate- (56.9%; 41.6%), or low-complexity disease (33.4%; 20.5%). Utilization of healthcare services also increased with an increase in complexity.In patients with COPD identified from Medicare or commercial claims data, there is a relationship between complexity as determined by pulmonary and non-pulmonary comorbid conditions and the prevalence of exacerbations and utilization of healthcare services. Identification of COPD patients at highest risk of exacerbations using complexity stratification may facilitate improved disease management by targeting those most in need of treatment.Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death among US adults and is projected to be the third by 2020 [1-3], although the dise
High-conductivity graphene nanocomposite via facile, covalent linkage of gold nanoparticles to graphene oxide
YuJie Zhang,MaKe Geng,Huan Zhang,Yao He,Cheng Peng,Qing Huang,ChunHai Fan
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-5333-6
Abstract: Graphene and its derivative, graphene oxide (GO) have been substantively used as the main framework for dispersing or building nanoarchitectures because of their excellent properties in electronics and catalysis. The requirement to obtain superior graphene-metal hybrid nanomaterials has led us to explore a facile way to design 4-aminobenzenethiol/1-hexanethiolate-protected gold nanoparticles (aAuNPs)-functionalized graphene oxide composite (aAuNPs-GO) in solution. We demonstrate that when aAuNPs with amino groups are exposed to GO, well-dispersed coverage of Au nanoparticles are mainly observed on the edge of GO sheet. In contrast, when 1-hexanethiolate-protected gold nanoparticles (hAuNPs) without amino groups are exposed to GO, hAuNPs simply aggregate on the surface of GO. This indicates that amino groups located on the surface of Au nanoparticles are an essential prerequisite for attachment of nearly monodispersed aAuNPs. The strategy described here for the fabrication of aAuNPs-GO provides a straightforward approach to develop graphene-based nanocomposites with undamaged sheets structure and good solubility and also improve the conductivity of GO sheets evidently.
Inquérito epidemiológico sobre características da popula o canina e felina de um bairro próximo à zona rural em Cuiabá-MT, visando o controle da raiva animal
Caramori Junior Jo?o Garcia,Lubas Marco Ant?nio da Silva,Kawatake Make Silva,Sales Katia Gouvea
Revista da Sociedade Brasileira de Medicina Tropical , 2003,
Abstract: Foram avaliados os questionários respondidos por 476 alunos, com idade entre 15 e 20 anos, de uma escola do bairro Pedra 90 em Cuiabá-MT, objetivando conhecer as características da popula o canina e felina daquele local. Dos 476 domicílios, em 371 (78%), foram registrados 513 c es e 307 gatos. Dos 513 c es, 289 (56,3%) eram machos e 224 (43,7%) fêmeas. Dos 307 gatos, 182 (59,3%) eram machos e 125 (40,7%) fêmeas. Os proprietários de 474 (92,4%) c es e 267 (86,9%) gatos afirmaram ter vacinado seus animais contra raiva.
The clinical features of the overlap between COPD and asthma
Megan Hardin, Edwin K Silverman, R Graham Barr, Nadia N Hansel, Joyce D Schroeder, Barry J Make, James D Crapo, Craig P Hersh, the COPDGene Investigators
Respiratory Research , 2011, DOI: 10.1186/1465-9921-12-127
Abstract: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study.119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness.Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history.ClinicalTrials.gov: NCT00608764Chronic Obstructive Pulmonary Disease (COPD) affects over 10 million Americans. In the United States, COPD is the third leading cause of death [1] and is responsible for over $15 billion in annual healthcare costs [2]. World-wide, COPD is one of the few conditions in which mortality is rising, and it is estimated to become the third leading cause of death by 2020[3,4]. More than 40% of patients with COPD will additionally report a history of asthma, and this dual-diagnosis increases with age [5,6].There is increasing evidence that patients who have COPD and asthma experience more rapid disease progression than those with either disease alone. Airway hyperresponsiveness (AHR) and the diagnosis of asthma have been associated with greater decline in FEV1 in both smokers and nonsmokers [7-9] and asthma has been recognized as a risk factor for COPD [10]. The pre
Inquérito epidemiológico sobre características da popula??o canina e felina de um bairro próximo à zona rural em Cuiabá-MT, visando o controle da raiva animal
Caramori Junior, Jo?o Garcia;Lubas, Marco Ant?nio da Silva;Kawatake, Make Silva;Sales, Katia Gouvea;Guedes, Julio Capilé;Schmitt, Aline Concei??o;
Revista da Sociedade Brasileira de Medicina Tropical , 2003, DOI: 10.1590/S0037-86822003000300017
Abstract: questionnaires answered by 476 students (age 15-20 yrs) attending a local school in the neighborhood of pedra 90 in cuiabá-mt were analyzed in order to study the characteristics of feline and canine populations in the region. the results showed that 371 (78%) of the 476 families kept 513 dogs and 307 cats. of 573 dogs, 289 (56.3%) were male and 224 (43.7%) were female. of 307 cats, 182 (59.28%) were male and 125 (40.72%) were female. the owners of 474 (92.4%) dogs and 267 (86.9%) cats reported that their pets had been vaccinated against rabies.
Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
Nicholas D Giardino, Jeffrey L Curtis, Adin-Cristian Andrei, Vincent S Fan, Joshua O Benditt, Mark Lyubkin, Keith Naunheim, Gerard Criner, Barry Make, Robert A Wise, Susan K Murray, Alfred P Fishman, Frank C Sciurba, Israel Liberzon, Fernando J Martinez, the NETT Research Group
Respiratory Research , 2010, DOI: 10.1186/1465-9921-11-29
Abstract: Data from 1828 patients with moderate to severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), collected prior to rehabilitation and randomization, were used in linear regression models to test the association between anxiety symptoms, measured by the Spielberger State Trait Anxiety Inventory (STAI) and: (a) six-minute walk distance test (6 MWD), (b) cycle ergometry peak workload, (c) St. Georges Respiratory Questionnaire (SRGQ), and (d) UCSD Shortness of Breath Questionnaire (SOBQ), after controlling for potential confounders including age, gender, FEV1 (% predicted), DLCO (% predicted), and the Beck Depression Inventory (BDI).Anxiety was significantly associated with worse functional capacity [6 MWD (B = -0.944, p < .001), ergometry peak workload (B = -.087, p = .04)], quality of life (B = .172, p < .001) and shortness of breath (B = .180, p < .001). Regression coefficients show that a 10 point increase in anxiety score is associated with a mean decrease in 6 MWD of 9 meters, a 1 Watt decrease in peak exercise workload, and an increase of almost 2 points on both the SGRQ and SOBQ.In clinically stable patients with moderate to severe emphysema, anxiety is associated with worse exercise performance, quality of life and shortness of breath, after accounting for the influence of demographic and physiologic factors known to affect these outcomes.ClinicalTrials.gov NCT00000606Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death. Disability, functional limitations and decreased quality of life in patients with COPD are correlated with objective physiologic measures of disease severity [1-3]. However, a large proportion of the variance in functional status and quality of life associated with COPD is not explained by measures of pulmonary physiology. Psychological factors may play in important role in determining the impact of COPD on patient functioning. For example, anxiety in patients with COPD has been associated
The Mélange of Innovation and Tradition in Maltese Law: The Essence of the Maltese Mix?
B Andò
Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad , 2012,
Abstract: Aim of this paper is to provide valuable insights into the Maltese legal system with a special focus on private law. The assumption is that this legal system is the byproduct of the "mixing" of innovation and tradition, resulting from the interaction of English law and continental law. A major role in the development of the system is played by courts. Some examples (moral damages and pre-contractual liability) are considered which highlight the importance of the function displayed by Maltese judges. KEYWORDS: Tradition; English law; continental law; hybridity; mixed legal systems; Maltese courts; moral damages; pre-contractual liability; lacunae
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