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Search Results: 1 - 10 of 1529 matches for " Maja Popovi? "
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Ion-beam irradiation effects on reactively sputtered CrN layers
Mirjana Novakovi?,Maja Popovi,Nata?a Bibi?
Processing and Application of Ceramics , 2011,
Abstract: This paper presents a study of microstructural changes induced in CrN layers by irradiation with 120 keV argon ions. The layers were deposited on (100) Si wafers, at different nitrogen partial pressures (2×10^-4, 3.5×10^-4 and 5×10^-4 mbar), to a total thickness of 260–280 nm. During deposition the substrates were held at 150°C. After deposition the samples were irradiated with argon ions to the fluences of 1×10^15 and 1×10^16 ions/cm2, under the vacuum of 7×10^-6 mbar. Characterisation of the samples structure and morphology were performed by X-ray diffraction (XRD) analysis and cross-sectional transmission electron microscopy (XTEM), and the concentration profiles were determined by Rutheford backscattering (RBS) spectrometry. It was found that the layer composition strongly depends on the nitrogen partial pressure during deposition. A pure stoichiometric CrN phase was achieved for the highest nitrogen partial pressure (5×10^-4 mbar). Argon ions irradiation induces microstructural changes in the CrN layers such as variation of the lattice constants, micro-strain and mean grain size.
Concept of expert system for modal split in transportation planning
PopoviMaja M.,Jovi? Jadranka J.
Yugoslav Journal of Operations Research , 2006, DOI: 10.2298/yjor0601107p
Abstract: The objective of this paper is to develop a concept of expert system based on the survey of experts' opinions and their experience concerning relations in modal split, on the basis of parameters of transport system demand and transport supply, defined through PT travel time and city size, i.e. mean trip length. This expert system could be of use both to experts and less experienced planners who could apply the knowledge contained in this expert system for further improvement, on operational as well as on strategic level.
ATYPICAL, CHOLESTATIC FORM OF HEPATITIS A WITH AN EXTRAHEPATIC, CUTANEOUS MANIFESTATION – A CASE REPORT
Lidija Popovi? Dragonji?,Dane Krtini?,Maja Jovanovi?,Miodrag Vrbi?
Acta Medica Medianae , 2012,
Abstract: Hepatitis A sometimes can present through atypical forms and merged extrahepatic manifestations. Most atypical forms include relapsing hepatitis and cholestatic hepatitis. Extrahepatic manifestations of HAV are rare, and include evanescent skin rash and transient arthralgias. A 25-year-old male, previously healthy, developed acute hepatitis. Hepatitis A virus was serologically confirmed. No skin efflorescences were seen at the beginning. Over the course of the illness which extended up to fifteen weeks, bilirubin and aminotransferase levels were continuously highly elevated. Nine weeks after the initial presentation he developed a painless, non-pruritic, purpura-like maculopapular erythematous rash over both lower extremities. Five weeks later, the rash had completely disappeared and the patient’s clinical status much improved. This case demonstrates two unusual and unrelated manifestations: prolonged cholestatic form of hepatitis and cutaneous vasculitis. Possible unusual manifestations of this disease should be a reminder of a brief diagnostic examination, which is usually not done in hepatitis A.
Qualitative and quantitative parameters of swine cell immunity
PopoviMaja,Valpoti? H.,Kardum-Paro Marijana,Pavi?i? ?.
Acta Veterinaria , 2008, DOI: 10.2298/avb0803149p
Abstract: Flow cytometry is a modern analytic method for qualitative and quantitive analyses of procaryotic and eukaryotic cells. Classical analytical methods examine one characteristic as an average for an examined cell population. Flow cytometry simultaneously measures several biochemical and physical parameters of every single cell in a heterogenic cell sample. Flow cytometry is routinely used all over the world in professional laboratories in veterinary medicine. For that purpose on the Veterinary Faculty of University in Zagreb, a machine for flow cytometry was standardized for use in veterinary medicine, especially for immunophenotyping of haemopoetic cells of domestic animals. In this manuscript we showed the standardisation method on a swine model, on samples of peripheral blood for the immunophenotypification of CD45+, CD3+ and CD21+ cells. .
HIGH SENSITIVITY C-REACTIVE PROTEIN AS PREDICTION FACTOR OF DISEASE PROGRESSION IN PATIENTS WITH CHRONIC HEPATITIS C AND MILD LIVER STEATOSIS
Lidija Popovi?-Dragonji?,Maja Jovanovi?,Miodrag Vrbi?,Ljiljana Konstantinovi?
Acta Medica Medianae , 2010,
Abstract: Chronic hepatitis C (CHC) is a major cause of liver cirrhosis and hepatocellular carcinoma. Steatosis occurs in almost 50% of patients with CHC, who make a faster progression to cirrhosis. The "atypical " patients are registred too, with normal values of blood sugar, cholesterol, triglycerides, BMI, body weight having non-alcoholic steatohepatitis (NASH) and CHC. The hsCRP levels rise before and simultaneously with the chronic hepatitis and cirrhosis progression, therefore, it is a useful prognostic parameter. According to our knowledge, there are no sufficient data concerning hsCRP concentrations in CHC patients, although it predicts or detects different grades of cirrhosis. For that reason, the aim of our research was to assess the hsCRP in patients with CHC.The investigation involved 45 patients (28 males and 17 females), mean age 41±15 years, with CHC, without any accompanying disease. The control group consisted of 45 healthy volunteers (22 males, 23 females), mean age 34±10 years. The CHC patients' group was divided into two subgroups, the first, which consisted of 23 patients with evidenced histological signs of mild steatosis, and the second one, comprising 22 patients without the mentioned signs; hsCRP concentrations were measured in each patients' (sub)group.The findings indicate that the hsCRP value had a statistically significant increase in the CHC patients' group compared to the control group (p<0.05). In the CHC and mild liver steatosis patients subgroup, even more statistically significant hsCRP increase occured compared to the other subgroup (p<0.001).It can be concluded, based on the acquired results, that hsCRP should be considered as a CHC progression prognostic factor, in order to make a well-timed and special therapeutic approach to the CHC individuals even more prone to the disease progression.
Structural changes induced by argon ion irradiation in TiN thin films
Maja Popovi,Mirjana Novakovi?,Zlatko Rako?evi?,Nata?a Bibi?
Processing and Application of Ceramics , 2011,
Abstract: In this work, the effects of 120 keV Ar+ ion implantation on the structural properties of TiN thin films were investigated. TiN layers were deposited by d.c. reactive sputtering on Si(100) wafers at room temperature or at 150°C. The thickness of TiN layers was ~240 nm. After deposition the samples were irradiated with 120 keV argon ions to the fluencies of 1×10^15 and 1×10^16 ions/cm2. Structural characterisation was performed with Rutherford backscattering spectroscopy (RBS), cross-sectional transmission electron microscopy (XTEM), grazing angle X-ray diffraction (XRD) and atomic force microscopy (AFM). It was found that the argon ion irradiation induced the changes in the lattice constant, mean grain size, micro-strain and surface morphology of the TiN layers. The observed micro-structural changes are due to the formation of the high density damage region in the TiN thin film structure.
Endoscopically removed giant submucosal lipoma
Jovanovi? Ivan,Pavlovi? Aleksandra,Popovi? Dragan,Pavlov Maja
Vojnosanitetski Pregled , 2007, DOI: 10.2298/vsp0706417j
Abstract: Background. Although uncommon, giant submucosal colon lipomas merit attention as they are often presented with dramatic clinical features such as bleeding, acute bowel obstruction, perforation and sometimes may be mistaken for malignancy. There is a great debate in the literature as to how to treat them. Case report. A patient, 67-year old, was admitted to the Clinic due to a constipation over the last several months, increasing abdominal pain mainly localized in the left lower quadrant accompanied by nausea, vomiting and abdominal distension. Physical examination was unremarkable and the results of the detailed laboratory tests and carcinoembryonic antigen remained within normal limits. Colonoscopy revealed a large 10 cm long, and 4 to 5 cm in diameter, mobile lesion in his sigmoid colon. Conventional endoscopic ultrasound revealed 5 cm hyperechoic lesion of the colonic wall. Twenty MHz mini-probe examination showed that lesion was limited to the submucosa. Since polyp appeared too large for a single transaction, it was removed piecemeal. Once the largest portion of the polyp has been resected, it was relatively easy to place the opened snare loop around portions of the residual polyp. Endoscopic resection was carried out safely without complications. Histological examination revealed the common typical histological features of lipoma elsewhere. The patient remained stable and eventually discharged home. Four weeks later he suffered no recurrent symptoms. Conclusion. Colonic lipomas can be endoscopically removed safely eliminating unnecessary surgery.
In HCMV-exposed HUVEC, P52/RelB regulatory factors mediate activation of the human PAR1 gene promoter
Popovi? M.,Paska? Svetlana,?ivkovi? Maja,?uri?-Deli? Tamara
Archives of Biological Sciences , 2009, DOI: 10.2298/abs0904613p
Abstract: We studied the effect of HCMV (AD-169) on the regulation of PAR1 reporter activity in HUVEC. In HUVEC, HCMV significantly induced activation of PAR1 reporter constructs carrying AP-2-like and two complexes of AP-2/Sp1-binding elements. Shorter constructs with no AP-2-like binding elements had lower activity upon virus inoculation. Moreover, activity of the shortest construct without binding elements was not significantly increased in virus-exposed cells. Furthermore, in HCMV-exposed cells, activity of the PAR1 reporter was significantly augmented upon p52/RelB transfection. Taken together, the data indicate that activity of the PAR1 promoter is highly dependent on AP-2/Sp1 bind-ing elements and mediated by p52/RelB regulatory factors. Key words: HCMV, PAR1 gene reporter, HUVEC.
In vitro cultivation of porcine limbal stem cells
Maja Popovi,Mirna Tominac,Ksenija Vlahovi?,Dubravko Kezi?
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2009.s3.125
Abstract: Similarly as in other organ structures stem cells are present in cornea residing basal epithelial layer termed palisade of Voight. A growing interest in allografts and xenografts implies a thorough study of regenerative potentials of these cells, as well as a clear description of their patterns in in vitro tissue cultures to be grafted. Recently we have developed a simple method for cultivation of porcine corneal epithelial stem cells obtained by biopsy from the limbal region. Eight enucleated eyes were obtained from four slaughtered pigs. 5 mm2 samples of limbal epithelium were taken by keratotomy method. The primary cultures of these cells showed phenotypic and morphometric characteristics of porcine corneal epithelial cells following May-Grunwald-Giemsa staining. After 5d of sowing they reached 80% of confluence. With the Night & Day lenses a total confluence was achieved 5d earlier in comparison to the cells that were grown in the secondary cultures. Accordingly, the use of porcine limbal stem cells has potentials in veterinary medicine (as novel approach in reparative/regenerative medicine of pets, horses and selected breeds), but also are in accordance with the extensive studies on the potential use of xenografts, mainly swine tissues/organs, in humans.
Anti-idiotypic antibodies: a new approach in prion research
Anja Colja Venturini, Maja Bresjanac, Tanja Vranac, Simon Koren, Mojca Narat, Mara Popovi, Vladka ?urin ?erbec
BMC Immunology , 2009, DOI: 10.1186/1471-2172-10-16
Abstract: The preparation of anti-idiotypic monoclonal antibodies was achieved with well-defined strategies of immunization, selection and subsequent characterization. Our results demonstrate that it is possible to induce a strong anti-idiotypic immune response against the V5B2 monoclonal antibody in both xenogeneic and syngeneic experimental systems. From the competition seen between polyclonal and monoclonal anti-idiotypic antibodies and the original immunogen, the P1 peptide, and even more importantly, the ultimate target antigen, PrPSc, we conclude that selected antibodies bind to the antigen-combining site of the V5B2 monoclonal antibody and might even resemble the PrPSc-specific epitope. The involvement of both antigen-combining sites in the interaction between V5B2 and the most promising monoclonal anti-idiotypic antibody was further supported by molecular docking.The results of the present study not only provide an example of the successful production of Ab2 monoclonal antibodies based on a well planned strategy for selection, but should also provide a new experimental approach that is applicable to the field of prion diseases.According to the Network Theory of Niels Jerne, the immune system is a network of interacting idiotypes that is involved in the regulation of immune responses [1]. Anti-idiotypic (Ab2) antibodies are a special set of antibodies that can react with idiotopes, which represent unique antigenic determinants on the surface of an antibody. Each antibody constitutes a small set of idiotopes that form its own idiotype. Private idiotopes have been shown to be associated with the complementarity-determining regions (CDRs), which, in addition to various rearrangements of V-(D)-J gene segments, also reflect random somatic mutations and/or N-region additions with a low probability of repetition in another individual. Unlike private idiotopes, recurrent idiotopes are encoded by germline genes, which can generally tolerate some somatic mutations without the lo
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