oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

时间不限

2017 ( 69 )

2016 ( 249 )

2015 ( 1059 )

2014 ( 1414 )

自定义范围…

匹配条件: “Mahesh Kumar Kataria” ,找到相关结果约21418条。
列表显示的所有文章,均可免费获取
第1页/共21418条
每页显示
BIOPHARMACEUTICS DRUG DISPOSITION CLASSIFICATION SYSTEM: AN EXTENSION OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM
Kataria Mahesh Kumar,Bhandari Anil
International Research Journal of Pharmacy , 2012,
Abstract: The Biopharmaceutics Classification System (BCS) was developed for prediction of in vivo pharmacokinetic performance of drug products from measurements of permeability and solubility. If the permeability criteria changed with metabolism criteria than it may be useful in predicting overall drug disposition, including routes of drug elimination and the effects of efflux and absorptive transporters on oral drug absorption, importance of food effects, and transporter effects on post absorption systemic drug concentrations following oral and intravenous dosing known as Biopharmaceutics drug disposition classification system (BDDCS). The drugs that have high permeability but poor metabolism are generally hydrophilic molecules with low molecular weight are likely to be absorbed by active transport mechanisms. Suggesting that drugs have extensive metabolism are highly absorbed. BDDCS using elimination criteria may expand the number of Class 1 drugs eligible for a biowaiver of in vivo bioequivalence (BE) studies and provide predictability of drug disposition profiles for Classes 2, 3, and 4 compounds.
MICROENCAPSULATION: ADVANCEMENTS IN APPLICATIONS
Arsh Chanana,Mahesh Kumar Kataria,Monish Sharma,Ajay Bilandi
International Research Journal of Pharmacy , 2013,
Abstract: Microcapsule is a tiny sphere including core material/internal phase or fill, coated with/surrounded by wall know as shell, coating or membrane. The usual size range of the microcapsule lies between 1 to 1000 μm. The technique is usually applied for targeted drug delivery, protection of the molecule and stability if the core material. Microencapsulation system offers potential advantages over conventional drug delivery systems and also established as unique carrier systems for many pharmaceuticals. This article contains the traditional and the recent pharmaceutical applications of microecapsules. The microcapsules are widely applied in pharmaceutical for Novel drug Delivery System (NDDS), latest formulations, Delivery of DNA Vaccines, Pro Drug Approach, Biodegradable and biocompatible material. Other then pharmaceutical microcapsules are widely used in delivery of probiotic, pesticide industry, food technology, beverages and cell immobilization etc. Although significant advances have been made in the field of microencapsulation, still many challenges need to be rectified during the appropriate selection of core materials, coating materials and process techniques.
TABLET COATING TECHNIQUES: CONCEPTS AND RECENT TRENDS
Gupta Ankit,Bilandi Ajay,Kataria Mahesh Kumar,Khatri Neetu
International Research Journal of Pharmacy , 2012,
Abstract: Tablet coating is a common pharmaceutical technique of applying a thin polymer-based lm to a tablet or a granule containing active pharmaceutical ingredients (APIs). Solid dosage forms are coated for a number of reasons, the most important of which is controlling the release profiles. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Tablets are usually coated in horizontal rotating pans with the coating solution sprayed onto the free surface of the tablet bed. The advantages of tablet coating are taste masking, odour masking, physical and chemical protection, protects the drug from the gastric environment etc. There are various techniques for tablet coating such as sugar coating, film coating, and enteric coating. Recent trends in pharmaceutical technologies are the development of coating methods which overcomes the various disadvantages associated with solvent based coatings. In these latest technologies coating materials are directly coated onto the surface of solid dosage forms without using any solvent. Various solventless coatings are available such as electrostatic dry coating, magnetically assisted impaction coating, compression coating, hot melt coating, powder coating, and supercritical fluid coating. Supercell Coating Technology is a revolutionary tablet coating that accurately deposits controlled amounts of coating materials on tablets even if they are extremely hygroscopic or friable. Magnetically assisted impaction coating, electrostatic dry coating in solventless coatings, aqueous film coating and Supercell coating technology are also available recent technique of coating. An ideal tablet should be free from any visual defect or functional defect. The advancements and innovations in tablet manufacture have not decreased the problems, often encountered in the production, instead have increased the problems, mainly because of the complexities of tablet presses; and/or the greater demands of quality. This review deal in detail about history, recent tablet coating technique and remedies associated with the tablet coating.
A Rapid Extractive Spectrophotometric Method for the Determination of Tin with 6-Chloro-3-hydroxy-2-(2′-thienyl)-4-oxo-4H-1-benzopyran
Ramesh Kataria,Harish Kumar Sharma
Advances in Chemistry , 2014, DOI: 10.1155/2014/750973
Abstract: An extractive spectrophotometric method for the determination of the trace amounts of tin has been carried out by employing 6-chloro-3-hydroxy-2-(2′-thienyl)-4-oxo-4H-1-benzopyran (in acetone) (CHTB) for the complexation of the metal ion in HCl medium. The colored species thus produced is quantitatively extracted into dichloromethane and shows the maximum absorbance at 432–437?nm. The method obeys Beer’s law in the range 0.0–1.3?μg?mL?1 of tin with molar absorptivity and Sandell’s sensitivity of ?L?mol?1?cm?1 and 0.0020?μg?Sn?cm?2, respectively, at 435?nm. The method is highly selective and free from the interference of a large number of elements including platinum metals. The ratio of metal to ligand in the extracted species is 1?:?2. Utilizing this method, the analysis of various synthetic and technical samples including gun metal and tin can have been carried out satisfactorily. 1. Introduction Tin does not occur free in nature and is found almost exclusively as tin oxide known as cassiterite or tin stone. Tin although a toxic metal, still it is being widely employed in manufacturing important alloys [1] and as solders for the joining of electronic components. The excess use of tin in daily life as fungicides in crops, in food packaging, and as stabilizer for polyvinyl chloride may introduce the inorganic tin {Sn(II) and Sn(IV)} in the environment. Out of these two, Sn(II) seems to be more toxic as compared to Sn(IV) [2]. In the literature, there are numerous analytical methods for the measurement of tin which are based on sophisticated instruments [3–10]. These methods are highly sensitive but generally tedious and prone to serious interferences from other elements. In contrast spectrophotometric methods are preferred due to their simplicity and speed in routine analysis. The reported studies have shown that a large number of reagents such as methyl orange [11], benzopyran derivatives [1, 12, 13], 2-(5-nitro-2-pyrilazo)-5-[N-n-propyl-N-(3-sulfopropyl)amino-phenoyl] [14], pyrocatechol violet [15–18], phenylfluorone [19, 20], dibromohydroxyphenylfluorone [21], arsenazo-M [22], isoamyl xanthate [23], diacetyl-monoxime-p-hydroxybenzoyl-hydrazine [24], bromopyrogallol red [25], potassium ethylxanthate [26], ferron [27], and 5,7-dichloro-8-quinolinol [28] have been used for the spectrophotometric determination of tin(II,IV) content. Among these many reagents [18, 21, 23, 26–28] are nonselective as they suffer from the interference, have low sensitivity [11, 12, 23, 24, 26–28], and some of them are time consuming, as they require time for full color
Reliable and Efficient Routing Using Adaptive Genetic Algorithm in Packet Switched Networks
Rakesh Kumar,Mahesh Kumar
International Journal of Computer Science Issues , 2012,
Abstract: To identify the optimal route is a complex task in packet switched network because optimization depends upon a number of parameters. In this paper Genetic Algorithm is used to locate the optimal route. Genetic Algorithm starts with a number of solutions where each solution is represented in the form of chromosome using the permutation encoding scheme. The success of Genetic Algorithm depends upon the number of operators such as selection, mutation and crossover. Needless to say crossover is most innovative. In this paper crossover operators proposed namely 1-point, 2-point, and adaptive, have been customized according to the need of computer network. The fitness of each solution is evaluated in terms of historical reliability factor, node success/failure and delay. The performance of the proposed approach has been compared with Dijkstra Algorithm and improvement has been observed.
Towards Expeditious and Unswerving Routing to Corroborate Nascent Internet
Shishir Kumar,Mahesh Kumar
Computer Science , 2009,
Abstract: The internet is now-a-days experiencing a stress due to some inherent problems with the main interdomain routing protocol, boarder gateway protocol (BGP), the amount of time it takes to converge, number of update message exchanged followed by a failure to stabilize, the amount of time required to get a valid alternate path following the failure, the way size of routing table increasing, and security issues like integrity and privacy of routing tables and routing updates exchanged among the routers, are of our primary concern. In our proposed research work we plan to address aforementioned issues related to internet routing specially in boarder gateway protocol to enable BGP to offer expeditious unswerving routing to corroborate nascent internet. We plan to make some changes in the design of boarder gateway protocol and may introduce addition of extra features in BGP to help support above mentioned objective.
Evaluation of clinical utility of serum enzymes of hepatic origin in clinically affected Marwari sheep of arid tract in India
Nalini Kataria,,A. Kumar Kataria,Ruchi Maan,Ajey K. Gahlot
Animal Biology & Animal Husbandry , 2010,
Abstract: The clinical utility of serum enzymes of hepatic origin was evaluated by determining theirlevels in the adult sheep of Marwari breed belonging to farmers’ stock of arid tract of Rajasthan state,India. The animals were grouped into healthy and affected which comprised of fasciola infected,pneumonia affected, having enterotoxa122emia, and drought affected. The serum enzymes includedwere sorbitol dehydrogenase, malate dehydrogenase, glucose-6-phosphate-dehydrogenase, glutamatedehydrogenase, ornithine carbamoyl transferase, gamma-glutamayl transferase, 5’nucleotidase, glucose-6-phosphatase, arginase, and aldolase. In clinically affected animals the levels of hepatic serumenzymes were significantly (p≤0.05) higher as compared to respective healthy levels. In fasciolainfected sheep the activities of all the enzymes were higher in comparison to healthy sheep. Degree ofincrease was least in pneumonia affected sheep. The G-6-Pase activity showed comparatively maximumchange in fasciola infected animals as compared to other enzymes. As the activities of all the serumenzymes of hepatic origin were found increased in affected animals, it was concluded that they all haddiagnostic significance exhibiting liver involvement. The increased activity was due to change of liverfunctions directly or indirectly.
MICROBIOLOGICAL ASSAY FOR VITAMIN B
Bishnoi Kapil*, , ,,Kataria Mahesh,Singhal Vipin,Gupta Deepika
International Research Journal of Pharmacy , 2012,
Abstract: Micronutrients added to foods are analyzed using various procedures depending on their nature and properties. The microbiological assays are better than chemical method because any suitable change in vitamin molecule which may not be detected by chemical method will be revealed by change in microbial activity. The microbiological assay of vitamins is based upon the comparison of the stimulation of growth of bacteria by measured concentration of vitamin with that produced by known concentration of standard preparation of Vitamin having known activity. Microbial assay of vitamin B-12, Calcium Pantothenate, Niacinamide can be done by individual transmittances method, which observes transmittance by spectrophotometer. The microbiological assay of antibiotics and vitamins were studied by using various strains of microbes.
Catching Of Stolen Vehicles With Unique Identification Code Using Embedded Systems
Mahesh Kumar Shakya
International Journal of Electronics Communication and Computer Technology , 2012,
Abstract: The main purpose of this concept is to catch the stolen vehicles by a latest technology. This research work is developing a smart logic to identify the stolen vehicle on check post or Toll base. Still there is no technique to identify the vehicle on check posts by any mean. To employ this technology in use, we issue one unique identification code to every vehicle. This unique number is stored in the silicon chip and the chip is installed in the vehicle. No one can change this number because this UID chip is installed in the engine of the vehicle. This vehicle number is not available in the market. Now the vehicle is equipped with the UID code. This code is also stored in the Data base of check post or Toll base. Now when any vehicle passed through the check post/Toll then at the check post/Toll RF passive vehicle reader generates a 125 kHz frequency for decoding RF tag( which has been installed in the vehicle). If the data base does not find the stolen UID code then security gate gets OPEN and if the stolen UID code is matched with the data base then security gate remains closed and alarm becomes ON automatically and finally the stolen vehicle is caught
Spectrum of Lesions in Cystoscopic Bladder Biopsies -A Histopathological Study
Mahesh Kumar U
Al Ameen Journal of Medical Sciences , 2012,
Abstract: Background: Diseases of the bladder, particularly inflammation (cystitis), constitute an important source of clinical signs and symptoms. Tumors of the bladder are an important source of both morbidity and mortality. Objectives: 1) To study the histopathological features of various lesions in bladder biopsies. 2) To study the frequency of different pathological lesions, particularly Transitional Cell Carcinoma (TCC) in urinary bladder biopsies. Results: Sixty cases of urinary bladder biopsies were received. Out of 60 patients, 43 were males and 17 were females. The spectrum of pathological lesions included inflammations, metaplastic lesions and tumours. Transitional cell carcinoma was the most common tumour seen in this study. A case of paraganglioma and malakoplakia were also seen. Conclusions: Our study has revealed that the bladder tumours are the commonest lesions in cystoscopic biopsies and TCC was the predominant tumour type
第1页/共21418条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.