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Search Results: 1 - 10 of 168082 matches for " Maha E. Soliman "
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Improvement of Hematopoietic and Immunologic Findings in Sublethal Gamma Irradiated Rats Treated with Bone Marrow Transplantation and Wheat Germ Oil  [PDF]
Maha G. Soliman, Omaima M. Ashry, Mervat A. E. Ahmed, Yasmine H. Abd El-Naby
Journal of Immune Based Therapies, Vaccines and Antimicrobials (JIBTVA) , 2015, DOI: 10.4236/jibtva.2015.42002
Abstract: The objective of this study was to evaluate the efficacy of the wheat germ oil (WGO) and bone marrow transplantation (BMT) in boosting the immuno response and protecting from oxidative stress in irradiated rats. BM was given by intravenous injection to male rats, one hour post gamma irradiation at the dose level of 5 Gy. Rats were orally administrated with 54 mg/Kg body wt of wheat germ oil daily for 2 weeks before irradiation. After 14 days, results revealed that total body irradiation induced significant decreases in RBCs, WBCs and lymphocytes, as well as Glutathione (GSH) and zinc superoxide dismutase (Zn/SOD), splenocyte count, bone marrow lymphocyte count and viability. Tumor necrosis factor alpha (TNF-α) and interleukin 2 (IL-2) also recorded significant decrease while interleukin 6 (IL-6) and lipid peroxidation marker malondialdehde (MDA) in serum and spleen were conversely elevated. In irradiated animals receiving BMT and WGO, values of MDA in serum and tissue were significantly depressed as compared with the irradiated group, while lymphocytes, bone marrow viability percentage, splenocytes percentage, IL-2, IL-6 and GSH were significantly elevated. The curative action of WGO enforcing significant innate response could trigger and augment adaptive immune response by BMT, thus protecting immune system from radiation induced damage as well as oxidative stress.
Exploring Hepatotoxicity of Benomyl: Histological and Histochemical Study on Albino Rats
Saber A. Sakr,Hany A. Abdel Samei,Maha E. Soliman
Journal of Medical Sciences , 2004,
Abstract: Benomyl, a fungicide of the benzimidazole group applied against a wide range of fungal diseases of crops and vegetables. The effects of benomyl on the hepatic tissue of albino rats were investigated. Treating rats with benomyl at a dose level of 1/10 LD50 three times/week for three weeks induced various histopathological changes in the liver, such as hepatic tissue impairment, cytoplasmic vacuolization of the hepatocytes, leucocytic infiltrations, congestion of blood vessels and fatty degeneration. Histochemical investigations revealed reduction in total carbohydrates, total proteins and nucleic acids (DNA, RNA) in the hepatic cells. These alterations were time-dependent and were obvious in animals treated with benomyl for 3 weeks. It is speculated that one or more metabolites of benomyl may be responsible for the hepatotoxicity recorded in the present work.
Factors Affecting Dynamics of Metacercarial Productivity of Fasciola gigantica from its Snail Host
Ismail M. Shalaby,Mohamed G. Hassan,Maha F.M. Soliman,Nour E. Sherif
Pakistan Journal of Biological Sciences , 2004,
Abstract: Experimental infections of preadult and adult Lymnaea cailliaudi snails using the same isolates of Fasciola gigantica miracidia were performed under laboratory conditions to determine whether the temperature, intensity of infection and age of snail host of F. gigantica in Egypt had an effect on the dynamics of metacercarial productivity. Preadult snails were divided into 3 groups kept at 18-20, 24-26 and 29-31 C, respectively and the adult snails were represented by a single group kept at 24-26 C to compared to its corresponding preadults ones. Each group was divided into four subgroups a, b, c and d, each one was subjected to 1, 2, 3 and 5 miracidial exposures, respectively. Two miracidial infections per snail produced more metacercariae compared to that of 1, 3 or 5 miracidial infections. Prepatent period of F. gigantica inside its snail host was inversely related to temperature and markedly affected by age rather than the number of miracidia inoculated. In contrary, Patent periods were significantly affected by the intensity of miracidial infection. Temperature above 24 C was suitable for high metacercarial production and a significant increasing in the percentage of the floating metacercariae was found at high temperature. Adult snails showed less susceptibility to infection as they never infected with single miracidia and produced few metacercariae with more than single miracidial infection.
Epidemiological review of human and animal fascioliasis in Egypt
Maha F.M. Soliman
Journal of Infection in Developing Countries , 2008,
Abstract: One of the neglected food-borne-diseases in the international public health arena is fascioliasis. It is a serious infectious parasitic disease infecting humans and animals worldwide and tops all the zoonotic helminthes. Human cases are being increasingly reported from Europe, the Americas, Oceania, Africa and Asia. Hence, human fascioliasis is considered now as a zoonosis of major global and regional importance. In Egypt, animal and human fascioliasis is an endemic clinical and epidemiological health problem. Doubtless, understanding the epidemiology of the parasitic diseases and factors affecting their incidence provides the foundation upon which effective prevention and control programs should be established. This article reviews the history, life cycles, transmission, incidence, geographical distribution, and environmental and human determinants that contribute to the epidemiological picture of fascioliasis with special reference to Egypt.
Physiological and Histopathological studies on Bisphenol-A compound as
Eman G.E.Helal *; Mohamed M.M. Badawi **; Maha G. Soliman *; Nadia A. Abdel-Kawi *; Hewaida A. E. Fadel ***; Nashwa M. G. Abozaid
Egyptian Journal of Hospital Medicine , 2013,
Abstract: Back ground: Xenoestrogens are compounds like estrogens in effect but not in structure which are mimicking the action of endogenous estrogen and activate estrogen receptor. Xenoestrogens are chemically distinct industrial products potentially able to disrupt the endocrine system by mimicking the action of endogenous steroid hormones. Among such compounds, the ubiquitous environmental contaminants bisphenol-A (BPA) may promote adverse effects in humans triggering estrogenic signals in target tissues. Bisphenol- A is widely used in food and drinks packaging. Aim of the work: The present study is carrying out to evaluate the effect of bisphenol-A on sexual hormonal pattern in male albino rats. Material and Methods: 64adult male Sprague – Dawley rats (100-120 g) were divided to four groups (16 rats/group).Group (1): control group without any treatment. Group(2): positive control group was injected subcutaneously (s.c) with sesame oil daily. Group (3): received BPA daily with low dose (10 mg/kg/day s.c). Group (4): received BPA daily with high dose (30 mg/kg/day s.c). The experiment durated 30 days, half rats of each group were sacrificed after 15 days of treatment and the other half of groups after 30 days. The blood was collected, serum was separated and used for estimation of (hormonal levels, prolactin, gonadotrophin and testosterone) and some biochemical parameters (liver enzymes, kidney function, protein and lipid profile). Testis, liver and kidney were taken for the histopathological examination. Results: Biochemical results showed significant elevation in prolactin and FSH levels and significant reduction in LH and testosterone levels in all groups compared to the control group. Increased serum enzymes (ASAT, ALAT& ALP) levels with increased concentration of urea and creatinine were detected in all the treated groups compared to the control group. Decline in protein profile and elevation in the concentration of lipid profile, while HDL was decreased in all the treated groups. Histopathological results showed dystrophic changes in the form of congestion in the blood vessels of the testis, liver and kidney of rats with thickening of walls of the blood vessels especially in the testis. In liver, focal inflammatory areas, with dilated and congested central and portal veins were found. Vacuolar degenerative changes in hepatocytes were seen. In the kidney, mild nephritis, sclerotic changes in glomerular tuft, hyaline casts in the lumen of epithelial cells which lining convoluted tubule were noticed. Conclusion: From the previous results we concluded that b
Evaluation of the Protective Effect of Two Antioxidative Agents in Mice Experimentally Infected with Schistosoma mansoni: Haematological and Histopathological Aspects
Maha F.M. Soliman,Nahla S. El-Shenawy
Pakistan Journal of Biological Sciences , 2003,
Abstract: The effect of antioxidative agents, Nigella sativa oil and melatonin, in protection against the oxidative processes induced by schistosomiasis was studied on haematological parameters, granuloma formation and tissue reaction of liver, intestine and kidney of mice experimentally infected with Schistosoma mansoni. N. sativa oil (1.14 g kg-1 orally) or melatonin (3.55 mg kg-1 i.p.) was administrated daily for 30 days starting from 1st day of infection. Haematological results revealed that treatment with melatonin and N. Sativa oil caused significant decrease in total leukocyte count while, RBCs, Hb content and PCV were increased significantly with N. sativa- treatment as compared with infected and melatonin-treated group. Morphometeric and histopathological findings of liver revealed a modulation in the pathological profile of schistosomiasis by reducing the severity of histopathological changes and attenuating hepatic granuloma. N. sativa oil did not interfere on the granuloma evolution in intestine, although, melatonin markedly reduced the fibrotic areas. Also, these antioxidants markedly ameliorated most of the pathological changes occurred in kidney. The effects of the antioxidants may be attributed partly to their early administration before the stimulation of the immune system or due to a modulation in the immune response in general.
Realizing the promise of breast cancer vaccines
Jackson E, Soliman H
Vaccine: Development and Therapy , 2012, DOI: http://dx.doi.org/10.2147/VDT.S25532
Abstract: lizing the promise of breast cancer vaccines Review (1280) Total Article Views Authors: Jackson E, Soliman H Published Date August 2012 Volume 2012:2 Pages 35 - 41 DOI: http://dx.doi.org/10.2147/VDT.S25532 Received: 09 May 2012 Accepted: 02 July 2012 Published: 22 August 2012 Erica Jackson, Hatem Soliman University of South Florida/Moffitt Cancer Center and Research Institute, Tampa, FL, USA Abstract: Breast cancer vaccines are being developed to stimulate adaptive antitumor immune responses in patients. These vaccines have the potential to treat breast cancer with minimal side effects and toxicity. However, many obstacles still need to be overcome to fully realize the vaccines' clinical benefit. A review of the literature was conducted to assess the use of vaccines in targeting transformed cells. Four vaccines currently under study were discussed, each summarizing the different vaccine platforms used to introduce target antigen to the patient's immune system. The advantages and disadvantages of each method were discussed, although no one method was found to be superior. Additional issues addressed included overcoming tumor-induced immunosuppression, immune evasion of transformed cells, the use of vaccines in combination therapy, and the challenges of using these vaccines in various clinical settings. Vaccines may be most effective in patients with minimal residual disease, as opposed to using them in the metastatic setting. Also, specific clinical trial design considerations for the use of vaccines in cancer patients, such as time-to-failure end points, were discussed. Understanding these various elements will be important to the translation of breast cancer vaccine therapy into routine clinical practice.
Realizing the promise of breast cancer vaccines
Jackson E,Soliman H
Vaccine: Development and Therapy , 2012,
Abstract: Erica Jackson, Hatem SolimanUniversity of South Florida/Moffitt Cancer Center and Research Institute, Tampa, FL, USAAbstract: Breast cancer vaccines are being developed to stimulate adaptive antitumor immune responses in patients. These vaccines have the potential to treat breast cancer with minimal side effects and toxicity. However, many obstacles still need to be overcome to fully realize the vaccines' clinical benefit. A review of the literature was conducted to assess the use of vaccines in targeting transformed cells. Four vaccines currently under study were discussed, each summarizing the different vaccine platforms used to introduce target antigen to the patient's immune system. The advantages and disadvantages of each method were discussed, although no one method was found to be superior. Additional issues addressed included overcoming tumor-induced immunosuppression, immune evasion of transformed cells, the use of vaccines in combination therapy, and the challenges of using these vaccines in various clinical settings. Vaccines may be most effective in patients with minimal residual disease, as opposed to using them in the metastatic setting. Also, specific clinical trial design considerations for the use of vaccines in cancer patients, such as time-to-failure end points, were discussed. Understanding these various elements will be important to the translation of breast cancer vaccine therapy into routine clinical practice.Keywords: breast cancer, vaccine, immunotherapy, immune tolerance, peptide vaccine, dendritic cell vaccine
Asymptotic Stability of Solutions of Lotka-Volterra Predator-Prey Model for Four Species  [PDF]
A. A. Soliman, E. S. Al-Jarallah
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.64063
Abstract: In this paper, we consider Lotka-Volterra predator-prey model between one and three species. Two cases are distinguished. The first is Lotka-Volterra model of one prey-three predators and the second is Lotka-Volterra model of one predator-three preys. The existence conditions of nonnega-tive equilibrium points are established. The local stability analysis of the system is carried out.
Evaluation of Surface Roughness and Streptococcus mutans Adhesion to Bulk-Fill Resin Composites Polished with Different Systems  [PDF]
Wafaa E. Soliman, Ashraf I. Ali, Walid F. Elkhatib
Advances in Microbiology (AiM) , 2019, DOI: 10.4236/aim.2019.91007
Abstract: Purpose: Bacterial adhesion represents the initial step in biofilm formation, dental caries and decay. This study aimed to evaluate and compare surface roughness and bacterial adhesion to bulk fill resin composites polished with different systems. Methods: Filtek Z350 XT (Incremental-fill resin composite), Filtek Bulk-fill Posterior (Bulk-fill resin composite), and Tetric N Ceram (Bulk-fill resin composite) were used as resin composites. The polishing systems used in this study were Sof-Lex multi-step, PoGo one step, and Mylar strip. Scanning electron microscope (SEM) was used to examine the surface roughness and adhesion of Streptococcus mutans ATCC 25175 standard strain to bulk-fill resin composites. Results: The type of restorative materials did not affect the surface roughness or bacterial adhesion (p > 0.05) but the polishing systems were significant (p < 0.05) influencing factors. Furthermore, Pearson correlation revealed a statistically significant (p < 0.001) association (R = 0.943) between surface roughness and bacterial adhesion to the tested surfaces. Conclusion: Regardless of the restorative material, Mylar polishing system revealed the smoothest surface and the lowest adhesion of S. mutans as compared to Pogo one step and Sof-Lex multi-step polishing systems.
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