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Search Results: 1 - 10 of 1178 matches for " Magda Zammataro "
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Targeting Chronic Pain with Epigenetic Drugs: Focus on mGlu2 Receptors
Santina Chiechio,Magda Zammataro,Robert W. Gereau IV,Agata Copani
Molecular and Cellular Pharmacology , 2009,
Abstract: Histone deacetylase (HDAC) enzymes regulate gene expression by affecting chromatin structure and/or the activity of transcription factors. We have recently demonstrated that histone deacetylase inhibitors (HDACIs) behave as epigenetic agents capable of inducing analgesia by up-regulating metabotropic glutamate type 2 (mGlu2) receptors. Specifically, the regulation of mGlu2 receptor expression appears to involve the acetylation of the NF-κB transcription factor. mGlu2 and mGlu3 receptors belong to class II metabotropic glutamate receptors. These receptors are coupled to Gi/o proteins and play an important role in mediating antinociception in a variety of inflammatory and chronic pain models. We have shown that the HDACI-mediated mGlu2 receptor up-regulation occurs in the dorsal horn of the spinal cord and in the dorsal root ganglia, supporting a predominant role for mGlu2 receptors as mediators of analgesia in experimental animal models of chronic pain. We suggest that drugs that increase the expression of mGlu2 receptors, such as HDACIs or acetylating drugs (e.g. L-acetylcarnitine), may be effective in patients with chronic pain that are refractory to conventional analgesics.
mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
Magda Zammataro, Santina Chiechio, Michael C Montana, Anna Traficante, Agata Copani, Ferdinando Nicoletti, Robert W Gereau
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-6
Abstract: In this study we used mGlu2 or mGlu3 knock-out mice to dissect the specific role for these two receptors in the endogenous control of inflammatory pain and their specific contribution to the analgesic activity of mixed mGlu2/3 receptor agonists.Our results showed that mGlu2-/- mice display a significantly greater pain response compared to their wild type littermates. Interestingly the increased pain sensitivity in mGlu2-/- mice occurred only in the second phase of the formalin test. No differences were observed in the first phase. In contrast, mGlu3-/- mice did not significantly differ from their wild type littermates in either phase of the formalin test.When systemically injected, a single administration of the mGlu2/3 agonist, LY379268 (3 mg/kg, ip), showed a significant reduction of both phases in wild-type mice and in mGlu3-/- but not in mGlu2-/- mice. However tolerance to the analgesic effect of LY379268 (3 mg/kg, ip) in mGlu3-/- mice developed following 5 consecutive days of injection.Taken together, these results demonstrate that: (i) mGlu2 receptors play a predominant role over mGlu3 receptors in the control of inflammatory pain in mice; (ii) the analgesic activity of mixed mGlu2/3 agonists is entirely mediated by the activation of the mGlu2 subtype and (iii) the development of tolerance to the analgesic effect of mGlu2/3 agonists develops despite the lack of mGlu3 receptors.Metabotropic glutamate (mGlu) receptors are considered promising targets in the treatment of chronic pain. All mGlu receptor subtypes (mGlu1-8), except mGlu6, are widely distributed along the pain neuraxis, and modulate cellular mechanisms of nociceptive sensitization that underlie the development of chronic pain [1-3]. We and others have focused on the role of group-II mGlu receptors (mGlu2 and mGlu3), which are coupled to Gi proteins and depress pain transmission at synapses between primary afferent fibers and second order sensory neurons in the dorsal horn of the spinal cord [4,5]. mG
Moral Judgment: Truth, Order and Consequence  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.65061
Abstract: Often we make snap moral judgments based on limited information. For instance upon reading a newspaper headline we very quickly decide on whether the implied outcome is good or bad. However, in situations like this we are also likely to revise our judgments when we read the main story and the conclusion of the article. One question yet to be answered is whether we adjust our moral judgments in a systematic way as we gain more details about a moral scenario. Two experiments (lab-based, online) addressed this question along with the influence of other factors on moral judgments (the origin of the moral scenario, the severity of the consequence of the scenario). Across both experiments, moral judgments were: 1) generally adjusted downwards as more information was presented; 2) more severe for headlines than the main story or the conclusion; 3) more severe for scenarios that were fabricated than real life stories; 4) more severe when the conclusion involved a severe consequence than a non-severe consequence.
Dynamic Moral Judgments and Emotions  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.68090
Abstract: We may experience strong moral outrage when we read a news headline that describes a prohibited action, but when we gain additional information by reading the main news story, do our emotional experiences change at all, and if they do in what way do they change? In a single online study with 80 participants the aim was to examine the extent to which emotional experiences (disgust, anger) and moral judgments track changes in information about a moral scenario. The evidence from the present study suggests that we systematically adjust our moral judgments and our emotional experiences as a result of exposure to further information about the morally dubious action referred to in a moral scenario. More specifically, the way in which we adjust our moral judgments and emotions appears to be based on information signalling whether a morally dubious act is permitted or prohibited.
Behavioral Economics: Where Is It Heading?  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.69109
Abstract: The addition of “behavioral” to economics has given rise to a highly successful field of research. But, is it just a fashionable new trend or is it here to stay? More to the point, how does it differ from its close relative psychology? To answer these questions, the present article considers what behavioral economics is, and where it started, with the aim of trying to forecast what the status of it will be in the future. In forecasting where behavioral economics might be heading, the argument proposed here is that the best clues can be found in psychological research. If, as has been proposed here, behavioral economics partners research trends in psychology, then the futures of both will almost certainly be moving in the same direction. Both are beginning to, and will start to rely on online tools/mobile phone applications to collect richer data revealing dynamic tends over long time horizons, and as technology continues to facilitate ways of looking at group behaviour online, then larger scale studies examining interactions amongst multiple groups of people will become the norm rather than the exception. More specifically this article speculates on the future research focus of researchers in behavioral economics and the extent to which this will overlap with psychological research on judgment and decision-making.
Subjective Burden on Family Carers of Hemodialysis Patients  [PDF]
Magda M. Bayoumi
Open Journal of Nephrology (OJNeph) , 2014, DOI: 10.4236/ojneph.2014.42011

Background: Hemodialysis (HD) is an important objective burden (task) on patient with end stage renal disease (ESRD) and the caregiver has a subjective burden which contributes to lifestyle changes, which result in depression, anxiety declining physical health, social isolation and financial strain. Aim: To evaluate the subjective burden on family caregiver who cares patient on maintenance hemodialysis therapy. Methods: Fifty main family caregivers for each patient on HD and the instrument were used by Caregiver Burden Interview (CBI) completed by caregiver as a major of subjective response to care giving. Results: The present study findings demonstrated that main age of caregiver was 40 (11.0) years, two thirds of females, and they were mostly married (78.0%) with children. The total family caregiver burden reported was 43.3 (21.7), role strain 50.0 (25.4) and the personal strain 39.5 (19.7). The total caregivers’ burden significantly positively correlated with the patients’ age (r = 0.461) and negatively correlated with patients’ level of education (r = ?0.290). Moreover the role strain, personal strain and total caregiver burden scores were statistically and significantly negatively correlated with their age (r = ?0.444) and level of education (r = ?0.416) and the total burden scores were ranked as moderately to severely burdened all family caregivers. Conclusion: Caregivers’ appraisal, coping strategies, interpersonal relationship issues, and social support would need to be considered for caregivers of patients maintained on HD.

The Theoretical Principles of the Body-Centered Therapy to Promote Affective Attunement in Children with Autism Spectrum Disorder  [PDF]
Magda Di Renzo
Journal of Behavioral and Brain Science (JBBS) , 2017, DOI: 10.4236/jbbs.2017.712039
Abstract: Background: The roots of autism spectrum disorders become evident in first attunement mechanisms between mother and child that allow a first level of mentalizing. Neurosciences and current developmental theories confirm the existence of defensive mechanisms related to body and affectivity that psychodynamic theories had already highlighted. Reading child’s behavior not only by administering tests but also through careful clinical observations allows a better understanding of the communication and social difficulties present in autistic children. The identification of the zone of proximal development can promote a therapeutic intervention that respects the individuality of the child and the specificity of his relational approach to the world. Conclusion: The paper presents the theoretical principles of a body-centered therapy to promote the attunement processes necessary to activate cognitive resources.
Cabanagem, cidadania e identidade revolucionária: o problema do patriotismo na Amaz?nia entre 1835 e 1840
Ricci, Magda;
Tempo , 2007, DOI: 10.1590/S1413-77042007000100002
Abstract: cabanagem was a social revolution that decimated the amazonia's population in a wide territory. in contrast to this wide and international scenery, cabanagem was, and it still is, analyzed as regional movement, typical of the regency period. however, the "patriot" cabanos created, throughout the movement, a feeling of common identity shared by people of the different etnias cultures which it extrapolated these initial caracteristics. this whole process is the central object of this article.
Does Demand Volatility Lower Growth and Raise Inflation? Evidence from the Caribbean
Kandil, Magda;
Economía mexicana. Nueva época , 2009,
Abstract: the paper investigates asymmetry in the allocation of aggregate demand shocks between real output growth and price inflation over the business cycle in a sample of fifteen caribbean countries. in most countries, the evidence indicates the existence of a kinked supply curve, which implies that positive demand shocks feed predominantly into prices while negative demand shocks mainly affect output. this suggests that the high variability of aggregate demand in caribbean countries, frequently exposed to shocks, tends to create an upward bias on inflation and a downward bias on real output growth, on average, over time. the analysis highlights the benefits of eliminating structural rigidities responsible for the kinked nature of the supply curve, and points to the dangers of pro-cyclical macroeconomic policies.
Novas práticas de leitura e escrita: letramento na cibercultura
Soares, Magda;
Educa??o & Sociedade , 2002, DOI: 10.1590/S0101-73302002008100008
Abstract: in the context of two different cultures - print culture and electronic culture, or cyberculture -, this article seeks a clearer comprehension of literacy opposing typographic and digital technologies of reading and writing. through the differences regarding the writing space and the mechanisms of producing, reproducing and diffusing ideas, it argues that different kinds of literacy - that is, different social, cognitive and discursive effects - have resulted from such different modalities of written communication. since literacy is not a single, homogeneous phenomenon, it finally suggests this word should be used in its plural rather than singular form: literacies.
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