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Search Results: 1 - 10 of 1484 matches for " Magda Shaheen "
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MRN-100, An Iron-Based Compound, Possesses Anti-HIV Activity In Vitro
Mamdooh Ghoneum,Magda Shaheen
Evidence-Based Complementary and Alternative Medicine , 2010, DOI: 10.1093/ecam/nen019
Abstract: We examined the in vitro anti-human immunodeficiency virus (HIV) activity of MRN-100, an iron-based compound derived from bivalent and tervalent ferrates. MRN-100 action against HIV-1 (SF strain) was tested in primary cultures of peripheral blood mononuclear cells (MNC) by analyzing p24 antigen production and percent survival of MNC infected with HIV. MRN-100 at a concentration of 10% (v/v) inhibited HIV-1 replication in 11 out of 14 samples (79%). The percentage of suppression of p24 antigen was ?12.3 to 100% at 10 days post-treatment. MRN-100 also exhibited a significant protective effect in the survival of HIV-1-infected MNC. MNC survival post-treatment was dose dependent, 70.4% ± 8.4, 83.6% ± 10.7 and 90% ± 11.4, at concentrations 2.5, 5 and 10% (v/v), respectively, as compared with 53% ± 4 for HIV-1-infected MNC without treatment. The effect was detected as early as 4 days and continued up to 11 days. Treatment with MRN-100 caused no significant change in proliferative response of MNC alone or cocultured with different mitogens: PHA and Con-A (activators of T cell function) and PWM (activator of CD4+ T cell-dependent B cells). We concluded that MRN-100 possesses anti-HIV activity in vitro and without an increase in lymphocyte proliferation, MRN-100 may be a useful agent for treating patients with acquired immunodeficiency syndrome.
Creativity and Education  [PDF]
Robina Shaheen
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.13026
Abstract: This paper starts with a brief background of the link between creativity and education, including the beginning of the most recent interest in the two. There is a short summary of the reasons for this renewed interest. This is followed by a discussion into the dissatisfactions over current education and its changing role in the light of increasing importance being accorded to creativity. Lastly, evidence in educational policy documents from around the world is presented to show the steps being taken for implementation of creativity in education.
On the Signed Domination Number of the Cartesian Product of Two Directed Cycles  [PDF]
Ramy Shaheen
Open Journal of Discrete Mathematics (OJDM) , 2015, DOI: 10.4236/ojdm.2015.53005
Abstract: Let D be a finite simple directed graph with vertex set V(D) and arc set A(D). A function \"\"?is called a signed dominating function (SDF) if \"\"?for each vertex \"\". The weight \"\"?of f is defined by \"\". The signed domination number of a digraph D is \"\". Let Cm × Cn denotes the cartesian product of directed cycles of length m and n. In this paper, we determine the exact values of gs(Cm × Cn) for m = 8, 9, 10 and arbitrary n. Also, we give the exact value of gs(Cm × Cn) when m, \"\"?(mod 3) and bounds for otherwise.
Moral Judgment: Truth, Order and Consequence  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.65061
Abstract: Often we make snap moral judgments based on limited information. For instance upon reading a newspaper headline we very quickly decide on whether the implied outcome is good or bad. However, in situations like this we are also likely to revise our judgments when we read the main story and the conclusion of the article. One question yet to be answered is whether we adjust our moral judgments in a systematic way as we gain more details about a moral scenario. Two experiments (lab-based, online) addressed this question along with the influence of other factors on moral judgments (the origin of the moral scenario, the severity of the consequence of the scenario). Across both experiments, moral judgments were: 1) generally adjusted downwards as more information was presented; 2) more severe for headlines than the main story or the conclusion; 3) more severe for scenarios that were fabricated than real life stories; 4) more severe when the conclusion involved a severe consequence than a non-severe consequence.
Dynamic Moral Judgments and Emotions  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.68090
Abstract: We may experience strong moral outrage when we read a news headline that describes a prohibited action, but when we gain additional information by reading the main news story, do our emotional experiences change at all, and if they do in what way do they change? In a single online study with 80 participants the aim was to examine the extent to which emotional experiences (disgust, anger) and moral judgments track changes in information about a moral scenario. The evidence from the present study suggests that we systematically adjust our moral judgments and our emotional experiences as a result of exposure to further information about the morally dubious action referred to in a moral scenario. More specifically, the way in which we adjust our moral judgments and emotions appears to be based on information signalling whether a morally dubious act is permitted or prohibited.
Behavioral Economics: Where Is It Heading?  [PDF]
Magda Osman
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.69109
Abstract: The addition of “behavioral” to economics has given rise to a highly successful field of research. But, is it just a fashionable new trend or is it here to stay? More to the point, how does it differ from its close relative psychology? To answer these questions, the present article considers what behavioral economics is, and where it started, with the aim of trying to forecast what the status of it will be in the future. In forecasting where behavioral economics might be heading, the argument proposed here is that the best clues can be found in psychological research. If, as has been proposed here, behavioral economics partners research trends in psychology, then the futures of both will almost certainly be moving in the same direction. Both are beginning to, and will start to rely on online tools/mobile phone applications to collect richer data revealing dynamic tends over long time horizons, and as technology continues to facilitate ways of looking at group behaviour online, then larger scale studies examining interactions amongst multiple groups of people will become the norm rather than the exception. More specifically this article speculates on the future research focus of researchers in behavioral economics and the extent to which this will overlap with psychological research on judgment and decision-making.
Schizophrenia proteomics: biomarkers on the path to laboratory medicine?
Shaheen Lakhan
Diagnostic Pathology , 2006, DOI: 10.1186/1746-1596-1-11
Abstract: Affecting nearly 1% of the world's population, schizophrenia is marked by chronic psychosis and social, occupational, behavioral, and cognitive impairment. This debilitating psychiatric disorder requires a disproportionate share of medical resources due to its early onset and chronic and severe nature. Schizophrenia is a lifelong disorder that usually manifests after puberty and before 25 years of age, with equal risks across gender. The illness is episodic and places the sufferer at an increased risk of suicide.Proteomics studies have focused extensively on cancer diagnosis and non-invasive monitoring, primarily via serum samples. Many have revealed potential biomarkers or biochemical molecules that identify a specific disease state and are capable of being detected or measured. For example, tumor marker CA125 (MUC16) provides useful information on disease resistance, treatment response, and even early detection in ovarian cancer screening, and efforts are underway for its clinical application [1].Not surprisingly, the standards for viable biomarkers are high. Ideally, a diagnostic marker meets seven conditions: 1) it detects a fundamental feature of the disease with high sensitivity and specificity; 2) is validated in post-mortem confirmed cases; 3) standardized with sound bioinformatics; 4) specific for the disease compared with related disorders; 5) reliable in many testing environments/labs; 6) noninvasive; 7) simple to perform; and 8) inexpensive [adapted from [2]].Despite the significant rates of self-harm behavior associated with schizophrenia, its relatively high prevalence in the general population and the existence of a substantial untreated population, no biomarker has yet been discovered for the disorder.This article describes the ability of proteomic approaches to accurately identify novel biomarkers, which may provide a substantial insight into schizophrenia pathogenesis. In addition, proteomic investigations could lead to the discovery of diagnostic
Diversification of U.S. medical schools via affirmative action implementation
Shaheen Lakhan
BMC Medical Education , 2003, DOI: 10.1186/1472-6920-3-6
Abstract: Selection based solely on academic qualifications such as GPA and MCAT scores does not achieve racial and ethnic diversity in medical school, nor does it adequately predict success as practicing physicians. However, race-conscious preference yields greater practice in underserved and often minority populations, furthers our biomedical research progression, augments health care for minority patients, and fosters an exceptional medical school environment where students are better able to serve an increasingly multicultural society.The implementation of race-conscious affirmative action results in diversity in medicine. Such diversity has shown increased medical practice in underserved areas, thereby providing better health care for the American people."Mend it, but don't end it."President William Jefferson Clinton [1]America's extremely discriminatory past fostered the exclusive practice of medicine by white men. Women and members of minority groups and lower socioeconomic classes were barred or hindered from attaining the dignified and prestigious medical degree (MD). In the nineteenth century, new medical schools were developed to accommodate women and minorities, particularly African Americans, and dubious private schools emerged lacking university affiliation, called "proprietary schools". The Carnegie Foundation in conjunction with the American Medical Association (AMA) Council on Medical Education hired former schoolmaster Abraham Flexner to report the proper and actual basis of American and Canadian medical instruction for immediate action. In 1910, the Carnegie Foundation published Flexner's accounts titled Medical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of Training popularly called the Flexner Report [2]. In it, Flexner summarized in a prominent and sharp approach the 168 medical schools he visited. He called for the closure of all three medical schools that catered entirely to women. He subsequently
Infantile Colic: The Mysterious Crying
Shaheen Akter
Journal of Enam Medical College , 2012, DOI: http://dx.doi.org/10.3329/jemc.v2i1.11927
Abstract: Infantile colic is a distressing condition in infants, pathogenesis of which is still not clear. Several treatment strategies have been attempted before, but only some of them proven successful. The aim of this paper is to review studies on treatment options for infantile colic. For this, a systematic literature review was done on studies regarding pathophysiology, medical and conventional interventions for infantile colic from 1954 to March 2011. Forty nine articles included in Cochrane database were reviewed. Fourteen studies on pathophysiology and risk factors, 7 studies on effect of infantlie colic on parents and family,19 studies on management, 5 studies on other related factors and 4 literature reviews were included for review. Pathophysiology has been described in various ways in different studies and yet not conclusive. Regarding studies on management, simethicone could not significantly control colic, dicyclomine hydrochloride had serious side effects and cimetropium bromide results were favourable, but milder side effects were noted. Some nutritional studies reported low-allergen maternal diets in breastfed infants but suitability of these methods are questionable in Bangladesh. Behavioural studies on the use of decreased stimulation and contingent music were favourable in some studies. Mixed herbal tea and probiotic like Lactobacillus reuteri studies showed encouraging results. There are some scientific evidences to support a low-allergen maternal diet in breastfed infants with infantile colic. Some encouraging results exist for mixed herbal tea, cimetropium bromide and probiotics.
Pakistan cardiac drugs issue: Carelessness of pharmaceutical companies
Shaheen H
theHealth , 2012,
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