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Search Results: 1 - 10 of 9321 matches for " Magda Carolina; "
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Platón y el consentimiento informado contemporáneo
Chuaire,Lilian; Sánchez,Magda Carolina;
Colombia Médica , 2007,
Abstract: informed consent is an ethical concept inherent to contemporary medical practice and research. in recognition of its importance, some plato’s ideas are examined, on the basis of the influence upon its definition and reaches, especially what refers to the connection between the quality of a free person and his right to make decisions about his health.
Platón y el consentimiento informado contemporáneo
Lilian Chuaire,Magda Carolina Sánchez
Colombia Médica , 2007,
Abstract: El consentimiento informado es un concepto ético consustancial a la práctica y la investigación médica contemporáneas. En reconocimiento de su importancia, se examina la influencia de las ideas de Platón, tanto sobre su planteamiento como sobre sus alcances, en especial en lo que se refiere a la asociación entre el carácter del hombre libre y su derecho a tomar decisiones acerca de su salud.
Revisiting the X-Chromosome Inactivation and Its Impact on Female Longevity  [PDF]
Lilian Chuaire-Noack, Magda Carolina Sánchez-Corredor, María Martínez-Agüero
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.56067

X-chromosome inactivation is the genetic mechanism by which X-linked gene expression is equalized between the male and female genders of all placental mammal species. Given that the probability of mutant X-linked allele expression decreases as a result of the inactivation, it has been proposed that females have biological advantages relative to males. These advantages have grabbed the attention of the scientific community in recent years and have focused it on this topic and its clinical implications. To shed some new light on this intriguing phenomenon, this article reviews the most relevant molecular events involved in this process. These events include the role of Xist, the selection mechanism for future X-chromosome inactivation, the age-related inactivation skewing, and the relationship between inactivation and the emergence of X-linked diseases, possible treatments, and longevity.

Distúrbios da aquisi??o da linguagem e da aprendizagem
Schirmer, Carolina R.;Fontoura, Denise R.;Nunes, Magda L.;
Jornal de Pediatria , 2004, DOI: 10.1590/S0021-75572004000300012
Abstract: objective: to aid health professionals, especially pediatricians, in the diagnosis and prevention of language and learning disorders. sources of data: review of the relevant literature published in the past 5 years (medline and textbooks). summary of the findings: multiple variables, among them neurological diseases, may be related to the etiology of language and learning disorders. conclusion: an adequate diagnostic investigation may guide the choice of treatment.
Avalia??o da arquitetura do sono em crian?as com epilepsia refratária
Pereira, Alessandra M.;Kaemmerer, Carolina;Palmini, Andre;Nunes, Magda L.;
Journal of Epilepsy and Clinical Neurophysiology , 2011, DOI: 10.1590/S1676-26492011000100004
Abstract: abstract introduction: there has been a growing interest in the relations between sleep and epilepsy, kindled by the realization that there are many potentially relevant two-way interactions. even though the hyper-synchronizing role of sleep and its attending increase in the probability of seizure generation are well known, the degree to which sleep may facilitate or induce epileptogenic phenomena in lesional epilepsies remains unclear. the lesional epilepsies seems to have intrinsic epileptogenic properties and the knowledge about sleep macro and microarchiteture could help clinician to anticipate and monitor sleep-related epileptic phenomena according to the etiology of the epilepsy objective: discuss the relationship between sleep and epilepsy in childhood and adolescence. methods: literature review in journals indexed through medline, from the last 15 years. conclusion: refractory epilepsy during childhood influences sleep organization mainly in patients with lesional etiology. the definition of the type of epilepsy is important to anticipate sleep disorders in this population.
Clinical assessment of language development in children at age 3 years that were born preterm
Schirmer, Carolina Rizzotto;Portuguez, Mirna Wetters;Nunes, Magda Lahorgue;
Arquivos de Neuro-Psiquiatria , 2006, DOI: 10.1590/S0004-282X2006000600007
Abstract: objective: to evaluate the influence of gestational age and birth weight on language development and neurodevelopmental outcome at age 3 years in children born preterm. method: cross sectional study including 69 children followed in our developmental outpatient clinic. patients were consecutively included at the time of the 3 years of age appointment and stratified for birth weight (<1500 grams and between 1500-2500 grams). all patients were assessed for receptive and expressive language , denver ii and bayley ii tests and clinical neurological examination. for analysis patients were divided in two groups normal language acquisition (nla) and delay in language acquisition (dla). results: nla children had higher scores on mental and psychomotor (p=<0.01, p=0.012) indexes of bayley ii. newborns with less than 1500 grams had lower scores on all bayley scale at age 36 months (p=0.002, p=0.007 and p<0.001). multivariate analysis suggests an association between gestational age (p=0.032), abnormal behavior (p<0.001) and delay in language acquisition. denver test at 12 and 24 months of age was a good predictor of delayed receptive and expressive language at three years of age (p=<0.01 and p=<0.01). conclusion: children born prematurely with low birth weight had an increased risk of language acquisition delay, and those had also lower cognitive and behavior scores when compared to nla.
Glucosa-6-fosfato deshidrogenasa (G6PD): Respuesta de los hematíes y otras células humanas a la disminución en su actividad
Bonilla,Javier Fernando; Sánchez,Magda Carolina; Chuaire,Lilian;
Colombia Médica , 2007,
Abstract: glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (nadph), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis. g6pdh deficiency is the most common x-chromosome-linked enzymopathy in human beings. although it is present in any type cell, its absolute deficiency is incompatible with life. according to who, 400 million people are affected by g6pd deficiency in the world but in colombia, the severe form prevalence is about 3% to 7%. there are no data related to slight and moderate alterations, that also have clinical effects. this paper reviews some g6pd biomolecular aspects, its classification according to activity and electrophoretic mobility, as well assome main clinical aspects related to its activity alteration.
Deficiencia de glucosa 6 fosfato deshidrogenasa: análisis enzimático y molecular en una población de Bogotá
Sánchez,Magda Carolina; Villegas,Victoria Eugenia; Fonseca,Dora;
Colombia Médica , 2008,
Abstract: objective: to determine the frequency of g-6pd and molecular analysis for identification of a+, a- and mediterranean in healthy persons in bogotá. methods: quantitative spectrophotometric assays for enzyme activity of g-6pd were carried out on the red cells of 348 asymptomatic and healthy adult males and females. through molecular analysis of dna from g-6pd deficients the relevant exons were amplified for pcr and then analysed with the restriction enzymes nlaiii, fok i and mboii, for the detection of a+, a- and mediterranean variants. results and conclusions: among 348 samples, 1.4% exhibited total deficiency and 1.7% had intermediate deficiency while 96.3% were normal. the combined prevalence was 3.7%. in enzymatic activity no statistically significance was seen between males and females. no variant was found among these patients and any of the subjects studied displayed any sign of hemolysis and other clinical manifestations. although it is not yet clearly understood other mechanisms must exist to offer protection from the oxidative stresses. the finding of severe enzyme deficiency in some heterozygote females is due to extreme degree of x inactivation of the normal chromosome.
Reacción en cadena de la polimerasa y diagnóstico molecular
Villegas,Victoria Eugenia; Sánchez,Magda Carolina; Chuaire,Lilian;
Colombia Médica , 2009,
Abstract: pcr, acronym of polymerase chain reaction, has revolutionized the field of molecular diagnostics to the point that it currently represents the fastest-growing segment in clinical laboratories worldwide, where it has become an invaluable tool. this paper describes the fundamentals of pcr and its developments in some of its many applications in the diagnosis, from its beginnings to the present.
Reacción en cadena de la polimerasa y diagnóstico molecular
Victoria Eugenia Villegas,Magda Carolina Sánchez,Lilian Chuaire
Colombia Médica , 2009,
Abstract: La PCR, acrónimo de la reacción en cadena de la polimerasa, revolucionó el campo del diagnóstico molecular, hasta el punto de que en la actualidad representa el segmento de mayor crecimiento en los laboratorios clínicos del mundo entero, en los que se ha convertido en herramienta de invaluable utilidad. El presente escrito describe los fundamentos de la metodología, así como algunas de sus múltiples aplicaciones en la diagnosis, desde sus albores hasta el presente.
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