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Search Results: 1 - 10 of 432 matches for " Magaly Arrais "
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Transcatheter aortic valve replacement in elderly patients

Dimytri Siqueir,Alexandre Abizai,Magaly Arrais,J Eduardo Sousa,

老年心脏病学杂志(英文版) , 2012,
Abstract: Aortic stenosis is the most common native valve disease, affecting up to 5% of the elderly population. Surgical aortic valve replacement reduces symptoms and improves survival, and is the definitive therapy in patients with symptomatic severe aortic stenosis. However, despite the good results of classic surgery, risk is markedly increased in elderly patients with co-morbidities. Transcatheter aortic valve replacement (TAVR) allows implantation of a prosthetic heart valve within the diseased native aortic valve without the need for open heart surgery and cardiopulmonary bypass, offering a new therapeutic option to elderly patients considered at high surgical risk or with contraindications to surgery. To date, several multicenter registries and a randomized trial have confirmed the safety and efficacy of TAVR in those patients. In this chapter, we review the background and clinical applications of TAVR in elderly patients.
Transcatheter aortic valve replacement in elderly patients
Dimytri Siqueira,Alexandre Abizaid,Magaly Arrais,J. Eduardo Sousa
老年心脏病学杂志(英文版) , 2012,
Abstract: Aortic stenosis is the most common native valve disease, affecting up to 5% of the elderly population. Surgical aortic valve replacement reduces symptoms and improves survival, and is the definitive therapy in patients with symptomatic severe aortic stenosis. However, despite the good results of classic surgery, risk is markedly increased in elderly patients with co-morbidities. Transcatheter aortic valve replacement (TAVR) allows implantation of a prosthetic heart valve within the diseased native aortic valve without the need for open heart surgery and cardiopulmonary bypass, offering a new therapeutic option to elderly patients considered at high surgical risk or with contraindications to surgery. To date, several multicenter registries and a randomized trial have confirmed the safety and efficacy of TAVR in those patients. In this chapter, we review the background and clinical applications of TAVR in elderly patients.
Cardiac muscle apoptosis: a comparison of myocardium revascularization with and without cardiopulmonary bypass
Gaia, Diego Felipe;Moreira, Rafael Saviolo;Arrais, Magaly;Vinhola, Nivia Cristina Tot;Buffolo, Enio;Smith, Ricardo Luiz;
Revista Brasileira de Cirurgia Cardiovascular , 2003, DOI: 10.1590/S0102-76382003000300006
Abstract: objective: inflammatory response and metabolic disturbances in coronary artery bypass grafting (cabg) with cardiopulmonary bypass (cpb) and without (off-pump) have been researched. apoptosis in ischemic reperfusion and chronic disease models has been shown in recent studies. the objective of this study is to compare the apoptosis intensity detected in cardiac myocytes before and after cabg with and without cardiopulmonary bypass. method: eighteen patients undergoing elective cabg were divided in two groups: the first group underwent cardiopulmonary bypasses and the second group did not. auricle myocardial samples were obtained at the beginning and at the end of the surgery. specimens were examined for apoptosis using the tunel method. results: there was no significant difference between the two groups in the surgical, demographic and postoperative data. the number of grafts was statistically different. there was no significant difference between the numbers of cells undergoing apoptosis in the two groups at the beginning of the procedure. there was no significant difference in the number of cells undergoing apoptosis from the beginning to the end of cabg in the off-pump group. there was a significant difference between the number of cells undergoing apoptosis at the beginning and the end of the cabg in the cpb group (p<0.01). conclusion: the smaller number of cells undergoing apoptosis in the off-pump group is in accordance with published data that suggest cpb is capable of promoting cell lesion. having shown that, another favorable argument can be added to the indication of the cabg without cpb.
Revasculariza??o do miocárdio com emprego de ambas artérias mamárias internas em pacientes com diabetes mellitus
Martins, Stevan Krieger;Santos, Magaly Arrais dos;Tirado, Freddy H. Ponce;Martins Jr, Francisco C. E.;Malat, Hassan F.;Jatene, Adib Domingos;Souza, Luiz Carlos Bento de;
Revista Brasileira de Cirurgia Cardiovascular , 2007, DOI: 10.1590/S0102-76382007000300004
Abstract: objective: we sought to describe the use of both internal mammary arteries (ima) in patients with diabetes mellitus (dm) submitted to coronary artery bypass grafting (cabg). method: between january of 1995 to august of 2005, 4.569 patients received isolated cabg in our institution, of these, 1.298 had dm. mean sample age was 62 years, and total mortality was 2.18% (100 patients). we have used both ima's in 700 patients, that here are split in two groups, with dm (group i, 148 patients), and without dm (group ii, 552 patients). patient selection for double ima grafting was based on coronary artery anatomy and sternal bone quality, the later was evaluated during sternal transsection. when these two factors were considered favorable, we harvested both ima's, not mattering if the patient had or had not dm. during ima's harvest, care was taken not to open the pleural spaces. results: there was small difference between the two groups in terms of morbidity and mortality. conclusion: our data suggest that patients with dm can benefit of double ima's grafting, with little increase in risk for complications if its application is carefully indicated.
Using biomedical networks to prioritize gene–disease associations
Arrais JP, Oliveira JL
Open Access Bioinformatics , 2011, DOI: http://dx.doi.org/10.2147/OAB.S21325
Abstract: ing biomedical networks to prioritize gene–disease associations Original Research (3452) Total Article Views Authors: Arrais JP, Oliveira JL Published Date August 2011 Volume 2011:3 Pages 123 - 130 DOI: http://dx.doi.org/10.2147/OAB.S21325 Joel P Arrais, José Luís Oliveira Department of Electronics, Telecommunications and Informatics (DETI), Institute of Electronics and Telematics Engineering of Aveiro (IEETA), University of Aveiro, Portugal Abstract: Understanding the genetic foundations of genetic diseases, such as cancer, Alzheimer disease, or Huntington’s disease, is critical to the development of new diagnostics and treatments. Several computational methods have been used to speed up the discovery process, eg, by selecting the molecular targets for a given disease. However, despite the achievements obtained over recent years, better solutions are still required. This paper presents an innovative computational method that addresses the problem of using disperse biomedical knowledge to select the best candidate genes associated with a disease. The method uses a network representation of current biomedical knowledge that includes biomolecular concepts such as genes, diseases, pathways, and biological process. It also applies information extraction techniques to enrich the network with more dynamic and updated data. A biologically inspired algorithm is applied to this network in order to identify association levels between genes and diseases. The solution proposed here surpasses many limitations of previous methods such as the need for training data. The validation applied demonstrates that the proposed method has best overall results compared with state-of-the-art methods as it also performs especially well for the critical top-rank positions. We believe this method represents a major advance over previous work and that it will be a key tool for future gene–disease association studies.
Estrutura profunda e padr es de representa o semantica
Telmo Correia Arrais
Trans/Form/A??o , 1975, DOI: 10.1590/s0101-31731975000100006
Abstract:
Estruturas frásicas com predica o recessiva em português
Telmo Correia Arrais
Alfa : Revista de Linguística , 2001,
Abstract: A recessividade é entendida como um tra o que leva a frase a perde um argumento. é proposta uma divis o das constru es recessivas, diversa da de Tesnière, além de se considerar uma maior variedade de processos, quais sejam: a recessividade por intrasitiva o, a recessividade pronominaliza o e a recessividade por lexicaliza o.
Apontamentos para o estudo da estrutura da frase
Telmo Correia Arrais
Alfa : Revista de Linguística , 2001,
Abstract: Neste trabalho se esbo a uma critica às concep es correntes nos estudos da frase, apontando-se as dificuldades de delimita o dos componentes, as inadequa es dos níveis estruturais e as controvérsias de quest es como criatividade, primazia da sintaxe e universalidade. Descarta-se a identifica o das estruturas conceptuais com as representa es semanticas, ressaltando-se o papel da codifica o na determina o da forma em que as estruturas conceptuais devem ser moldadas na manifesta o lingüística. Enfim, destaca-se a relevancia da "perspectiva" na estrutura o da frase e a semantica como componente básico da gramática.
Rela es reversivas na predica o em português
Telmo Correia Arrais
Alfa : Revista de Linguística , 2001,
Abstract: A no o de oonversividade lógica é transposta para um tratamento lingüístico, a f im de estudarmos as estruturas sintático-semanticas das frases de predica o reversiva em português. Após a caracteriza o formal da reversividade, analisamos seu mecanismo transformacional, para nos determos enfim nos problemas de sua estrutura semantica profunda e de suas propriedades lógicas.
Aspectos da significa o da frase: categoriza o do verbo, rela es e fun es semanticas
Telmo Correia Arrais
Alfa : Revista de Linguística , 2001,
Abstract: Na análise da significa o da frase, há necessidade de distinguir dois níveis: o elocucional e o proposicional. Ambos devem ser considerados na representa o semantica da frase, projetada como um conjunto de predica es dispostas em níveis estratificados. O estrato existencial e o do conteúdo objetivo têm rela o estrutural mútua, constituindo o cerne da proposi o. Nesta, os verbos apresentam certas categorias semanticas que propiciam rela es apropriadas com os nomes a eles associados, determinando suas fun es semanticas. Para a análise desse problema, busca-se integrar os sistemas de Fillmore, Chafe e Jackendoff num modelo único. A partir de tra os básicos, analisa-se sua combina o com outros mais especificadores, que levam a rela es abstratas com os argumentos; três fun es s o depreendidas em cada tipo de rela o. Ressalta-se, por fim, o alcance explicativo de um sistema que considera rela es e fun es semanticas na descri o dos fatos da língua.
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