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Search Results: 1 - 10 of 1708 matches for " Madhura Kulkarni "
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Acute toxicity of Cypermethrin, a synthetic pyrethroid to estuarine clam Katelysia opima (Gmelin) and its effect on oxygen consumption  [PDF]
Madhura Mukadam, Arvind Kulkarni
Journal of Agricultural Chemistry and Environment (JACEN) , 2014, DOI: 10.4236/jacen.2014.34016
Abstract: The impact of acute exposure of Cypermethrin on the rate of oxygen consumption of the estuarine clam, Katelysia opima was studied. After 12, 24, 36, 48, 60, 72 84 and 96 h of exposure to acute concentration, the average oxygen consumption in LC0 group was 0.215, 0.305, 0364, 0.355, 0.362, 0.376, 0.313, 0.305, 0.297 (ml/L/hr/gm) and in LC50 group it was 0.210, 0.299, 0.356, 0.247, 0.217, 0.244, 0.203, 0.186, 0.174 (ml/L/hr/gm). It was observed that the rate of oxygen consumption fluctuated with an increase in the exposure period. The decrease was maximum in LC50 group as compared to LC0 group.
E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development
Madhura Kulkarni,Harold E. Smith
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000131
Abstract: Poly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination cascade, and its activity is necessary for all subsequent steps in the reaction. We have isolated a temperature-sensitive mutation in the Caenorhabditis elegans uba-1 gene, which encodes the sole E1 enzyme in this organism. Manipulation of UBA-1 activity at different developmental stages reveals a variety of functions for ubiquitination, including novel roles in sperm fertility, control of body size, and sex-specific development. Levels of ubiquitin conjugates are substantially reduced in the mutant, consistent with reduced E1 activity. The uba-1 mutation causes delays in meiotic progression in the early embryo, a process that is known to be regulated by ubiquitin-mediated proteolysis. The uba-1 mutation also demonstrates synthetic lethal interactions with alleles of the anaphase-promoting complex, an E3 ubiquitin ligase. The uba-1 mutation provides a sensitized genetic background for identifying new in vivo functions for downstream components of the ubiquitin enzyme cascade, and it is one of the first conditional mutations reported for the essential E1 enzyme in a metazoan animal model.
Toxic Effect of Imidacloprid on Protein Content in Estuarine Clam, Katelysia opima (Gmelin)  [PDF]
Madhura D. Mukadam, Arvind S. Kulkarni
Open Access Library Journal (OALib Journal) , 2014, DOI: 10.4236/oalib.1100407
Abstract: The indiscriminate use of insecticide has caused serious pollution problems of aquatic ecosystems. Imidacloprid is mainly used to control sucking insects such as rice hoppers, aphids, thrips and some species of beetles. Further it is known to cause apathy, myatonia, tremor and myospasms in humans. Toxic effects of imidacloprid were estimated by selecting Katelysia opima as an animal model. Effect of imidacloprid on total protein content of gill, mantle, hepatopancreas, foot, male gonad and female gonad of estuarine clam, Katelysia opima was studied. The clams were exposed to 86.6 ppm of imidacloprid or acute treatment; it was found that there was decrease in protein content in various tissues in LC50 as compared to control. In LC50 group protein content was decreased in mantle hepatopancreas, foot male and female gonad as compared to the control. This decrease was more in foot, male gonad and female gonad in LC50 group as compared to LC0 group. Gill, mantle and hepatopancreas showed increase in protein content in LC50 group as compared to LC0 group. Decrease in protein content was more in foot, male gonad and female gonad in LC50 group due to the higher concentrations of imidacloprid.
GPGPU PROCESSING IN CUDA ARCHITECTURE
Jayshree Ghorpade,Jitendra Parande,Madhura Kulkarni,Amit Bawaskar
Advanced Computing : an International Journal , 2012,
Abstract: The future of computation is the Graphical Processing Unit, i.e. the GPU. The promise that the graphicscards have shown in the field of image processing and accelerated rendering of 3D scenes, and thecomputational capability that these GPUs possess, they are developing into great parallel computingunits. It is quite simple to program a graphics processor to perform general parallel tasks. But afterunderstanding the various architectural aspects of the graphics processor, it can be used to performother taxing tasks as well. In this paper, we will show how CUDA can fully utilize the tremendous powerof these GPUs. CUDA is NVIDIA’s parallel computing architecture. It enables dramatic increases incomputing performance, by harnessing the power of the GPU. This paper talks about CUDA and itsarchitecture. It takes us through a comparison of CUDA C/C++ with other parallel programminglanguages like OpenCL and DirectCompute. The paper also lists out the common myths about CUDAand how the future seems to be promising for CUDA.
GPGPU Processing in CUDA Architecture
Jayshree Ghorpade,Jitendra Parande,Madhura Kulkarni,Amit Bawaskar
Computer Science , 2012, DOI: 10.5121/acij.2012.3109
Abstract: The future of computation is the Graphical Processing Unit, i.e. the GPU. The promise that the graphics cards have shown in the field of image processing and accelerated rendering of 3D scenes, and the computational capability that these GPUs possess, they are developing into great parallel computing units. It is quite simple to program a graphics processor to perform general parallel tasks. But after understanding the various architectural aspects of the graphics processor, it can be used to perform other taxing tasks as well. In this paper, we will show how CUDA can fully utilize the tremendous power of these GPUs. CUDA is NVIDIA's parallel computing architecture. It enables dramatic increases in computing performance, by harnessing the power of the GPU. This paper talks about CUDA and its architecture. It takes us through a comparison of CUDA C/C++ with other parallel programming languages like OpenCL and DirectCompute. The paper also lists out the common myths about CUDA and how the future seems to be promising for CUDA.
SPE-44 Implements Sperm Cell Fate
Madhura Kulkarni equal contributor,Diane C. Shakes equal contributor,Katie Guevel,Harold E. Smith
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002678
Abstract: The sperm/oocyte decision in the hermaphrodite germline of Caenorhabditis elegans provides a powerful model for the characterization of stem cell fate specification and differentiation. The germline sex determination program that governs gamete fate has been well studied, but direct mediators of cell-type-specific transcription are largely unknown. We report the identification of spe-44 as a critical regulator of sperm gene expression. Deletion of spe-44 causes sperm-specific defects in cytokinesis, cell cycle progression, and organelle assembly resulting in sterility. Expression of spe-44 correlates precisely with spermatogenesis and is regulated by the germline sex determination pathway. spe-44 is required for the appropriate expression of several hundred sperm-enriched genes. The SPE-44 protein is restricted to the sperm-producing germline, where it localizes to the autosomes (which contain sperm genes) but is excluded from the transcriptionally silent X chromosome (which does not). The orthologous gene in other Caenorhabditis species is similarly expressed in a sex-biased manner, and the protein likewise exhibits autosome-specific localization in developing sperm, strongly suggestive of an evolutionarily conserved role in sperm gene expression. Our analysis represents the first identification of a transcriptional regulator whose primary function is the control of gamete-type-specific transcription in this system.
An Area Efficient, High Speed Novel VHDL Implementation of Linear Convolution of Two Finite Length Sequences Using Vedic Mathematics
Madhura Tilak
International Journal of Innovative Technology and Exploring Engineering , 2012,
Abstract: This paper presents a novel method of implementing linear convolution of two finite length sequences (N×N) in hardware using hardware description language (VHDL). The proposed method uses modified design approach by replacing the conventional multiplier by Vedic multiplier internally in the implementations. The proposed method is efficient in terms of computational speed, hardware resources and area significantly. The efficiency of the proposed algorithm is tested by simulations and comparisons with different design approaches using XILLINX software. The presented circuit consumes less power and has a delay of 17ns from input to output. The proposed circuit is also modular, expandable and regular which provides flexibility to form different number of bits.
Electrocaloric effect in BaTiO$_3$: a first-principles-based study on the effect of misfit strain
Madhura Marathe,Claude Ederer
Physics , 2014, DOI: 10.1063/1.4879840
Abstract: We address the question of how the electrocaloric effect in epitaxial thin films of the prototypical ferroelectric BaTiO$_3$ is affected by the clamping to the substrate and by substrate-induced misfit strain. We use molecular dynamics simulations and a first-principles-based effective Hamiltonian to calculate the adiabatic temperature change $\Delta T$ under different epitaxial constraints. Our results demonstrate that, consistent with phenomenological theory, clamping by the substrate reduces the maximum $\Delta T$ compared to bulk BaTiO$_3$. On the other hand, compressive misfit-strain leads to a strong increase of $\Delta T$ and shifts the maximum of the electrocaloric effect to higher temperatures. A rather small compressive strain of $-0.75$% is sufficient to obtain a $\Delta T$ that is larger than the corresponding bulk value.
A Dynamical Model to Analyze the Influence of Sliding Friction on Motion on a Curve—An Analytical Method  [PDF]
Prahlad Kulkarni
Open Journal of Applied Sciences (OJAppS) , 2015, DOI: 10.4236/ojapps.2015.58043
Abstract: To demonstrate the influence of sliding friction of motion on a curve, a circular path is considered for simplicity on which a person slides from the highest point to the lowest point. A slide which represents a quadrant of radius 5 m and a person of mass 60 kg are considered for comparison in this paper. A Differential equation for motion considering the fact that the normal force depends both on the sin component of weight and also on the tangential velocity, is established and is solved using integrating factor method, and the motion is analysed for different surface roughness of the slide and is compared using superimposed graphs, also the limiting value of friction coefficient at which the person just exits the slide is determined. The correction factor for exit velocity with friction as compared with the exit velocity for zero friction is determined. The fraction of energy lost to friction at the exit is evaluated. The Variation of normal force with the position of the person on the slide is plotted for different surface roughness of the slide, and the position on the slide where the normal force or the force experienced by the person is maximum, is determined and hence its maximum value is evaluated for different surface roughness. For simplicity, a point contact between the body and the slide is considered.
Lyman alpha absorbers in motion: consequences of gravitational lensing for the cosmological redshift drift experiment
Madhura Killedar,Geraint F. Lewis
Physics , 2009, DOI: 10.1111/j.1365-2966.2009.15913.x
Abstract: The evolution of the expansion rate of the Universe results in a drift in the redshift of distant sources over time. A measurement of this drift would provide us with a direct probe of expansion history. The Lyman alpha forest has been recognized as the best candidate for this experiment, but the signal would be weak and it will take next generation large telescopes coupled with ultra-stable high resolution spectrographs to reach the cm/s resolution required. One source of noise that has not yet been assessed is the transverse motion of Lyman alpha absorbers, which varies the gravitational potential in the line of sight and subsequently shifts the positions of background absorption lines. We examine the relationship between the pure cosmic signal and the observed redshift drift in the presence of moving Lyman alpha clouds, particularly the collapsed structures associated with Lyman limit systems (LLSs) and damped Lyman alpha systems (DLAs). Surprisingly, the peculiar velocities and peculiar accelerations both enter the expression, although the acceleration term stands alone as an absolute error, whilst the velocity term appears as a fractional noise component. An estimate of the magnitude of the noise reassures us that the motion of the Lyman alpha absorbers will not pose a threat to the detection of the signal.
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