oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

匹配条件: “Madgulkar Ashwini” ,找到相关结果约211条。
列表显示的所有文章,均可免费获取
第1页/共211条
每页显示
Development of trilayered mucoadhesive tablet of itraconazole with zero-order release
Madgulkar Ashwini,Kadam Shivajirao,Pokharkar Varsha
Asian Journal of Pharmaceutics , 2008,
Abstract: Itraconazole is practically insoluble in water; large interindividual and intraindividual variations of its oral bioavailability are reported. A mucoadhesive drug delivery system is useful to prolong the retention time of a dosage form in the stomach, thereby improving the oral bioavailability of the drug. Solid dispersion of itraconazole with Eudragit E100 was prepared by spray-drying method to improve dissolution. Trilayered mucoadhesive tablet was prepared, with inner core containing solid dispersion of the drug and with carbopol and HPMC sandwiched between two layers of hydrophilic mucoadhesive polymer mixture of carbopol and Hydroxypropyl methyl cellulose (HPMC). Amounts of Carbopol 934P (CP) and Methocel K4M (HPMC) were varied in the outer coat around the solid dispersion. The drug-release pattern for all the formulation combinations was found to be nonfickian, approaching zero-order kinetics. Suitable combination of two polymers provided adequate bioadhesive strength and sustained-release profile with zero-order kinetics.
Eservative Efficacy Testing for Pharmaceutical Products During Stability Studies
Shivani Rao,Mangesh Bhalekar,Ashwini Madgulkar,Saloni Vora
Pharmaceutical Reviews , 2006,
Abstract: Stability studies are performed on all pharmaceutical products before theyare marketed. These include the exposure of the products to stress conditionsfor short time period.Preservatives or antimicrobials are added in some ofthe products in view of protecting it against contaminants during the usageor storage by the consumer.This renders the testing of the efficacy of the preservative as a necessityduring stability studies. Preservative efficacy testing can be done by analyticalor microbiological methods. The article highlights importance of preservativeefficacy testing during stability studies, the regulatory status and needfor harmonization.The rapidmethods for testing preservative testing are also described.
TRIPS: India - Patent Protection for Pharmaceuticals
Ashwini R. Madgulkar,Mangesh Bhalekar,Vinay Kolhe,Shivani Rao
Pharmaceutical Reviews , 2007,
Abstract: The first round of trade negotiations took place while the Preparatory Committee was still working on drafting the Charter because the participants were anxious to begin the process of trade liberalization as soon as possible. Their results were incorporated into the General Agreement (GATT), which was signed in 1947. Having agreed that in implementing their commitments on market access, developed country Members would take fully into account the particular needs and conditions of developing country Members by providing for a greater improvement of opportunities and terms of access for agricultural products of particular interest to these Members, including the fullest liberalization of trade in tropical agricultural products as agreed at the Mid-Term Review, and products of particular importance to the diversification of production from the growing of illicit narcotic crops;
Formulation and optimization of sustained release tablets of venlafaxine resinates using response surface methodology
Madgulkar Ashwini,Bhalekar M,Kolhe V,Kenjale Y
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: The aim of the current study was to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer combinations. Venlafaxine HCl was loaded onto Indion 244 by batch method and then resinate were wet granulated with ethyl cellulose and blended with hydroxypropylmethylcellulose and compressed. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile at 2 h and at 18 h. Hydroxypropylmethylcellulose and ethylcellulose were taken as the independent variables. Response surface plots and contour plots were drawn, and optimum formulations were selected by feasibility and grid searches. Resinate shows inadequate sustained release profile. Compressed matrices exhibited the anomalous release mechanism, as the value of release rate exponent (n) varied between 08109 and 08719, resulting in regulated and complete release until 20 h. Validation of optimization study, performed using five confirmatory runs, indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as 1.152±1.88%. Regulated drug release study indicates that the hydrophilic and hydrophobic matrix tablets of venlafaxine resinate prepared using hydroxypropylmethylcellulose and ethylcellulose, can successfully be employed as a once-a-day oral controlled release drug delivery system.
Formulation development of domperidone buccal bioadhesive hydrophilic matrix tablets
Madgulkar Ashwini,Bhalekar Mangesh,Ner Amruta,Wable Nitin
Asian Journal of Pharmaceutics , 2011,
Abstract: Buccoadhesives have long been employed to improve the bioavailability of drugs undergoing significant hepatic first pass metabolism. Domperidone is also reported to have low oral bioavailability due to an extensive hepatic first-pass effect. Buccoadhesive hydrophilic matrices containing Domperidone were prepared using a 32 factorial design. The amounts of Carbopol 934P (CP) and Methocel K100LV (HPMC) were taken as the formulation variables (factors) for optimizing bioadhesion and kinetics of dissolution. A mathematical model was generated for each response parameter. Bioadhesive strength tended to vary quite linearly in an increasing order with an increasing amount of each polymer. The drug release pattern for all the formulation combinations was found to be non Fickian, approaching zero-order kinetics. A suitable combination of two polymers provided adequate bioadhesive strength and fairly regulated the release profile up to 4 hr. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results. The optimum formulations were chosen and their predicted results were found to be in close agreement with the experimental findings.
DETERMINATION OF CEFDITOREN PIVOXIL IN HUMAN PLASMA BY HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD
Dhoka Madhura Vishal,Sonawane Prajakta Anurath,Madgulkar Ashwini,Nimbalkar Umesh
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: A simple, rapid, sensitive high performance thin layer chromatography method for cefditoren pivoxil in human plasma using cephalexin as an internal standard has been developed and validated. The method enables to determine cefditoren pivoxil with minimum quantification limit 0.1μg ml-1 to 0.6 μg ml-1 having retention factor of 0.74±0.03. The sample preparation involves the simple protein precipitation technique using methanol as a precipitating agent. The determination was carried out on silica gel 60 F245 TLC plate with a mobile phase consisted of toluene: methanol: triethylamine (5:3.5:0.09 v/v/v). The wavelength selected was 250nm.
Novel ion exchange resin-based combination drug-delivery system for treatment of gastro esophageal reflux diseases
Bhalekar, Mangesh Ramesh;Kadam, Nitin Madhukar;Patil, Nilam Hindurao;Gawale, Nitin Somnath;Madgulkar, Ashwini;
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/S1984-82502010000200021
Abstract: the present study involves preparation and characterization of a combination tablet of ranitidine in immediate release form and domperidone in sustained release form, using ion exchange resins. ranitidine lowers acid secretion, while domperidone release over a prolonged period improves gastric motility thus justifying this combination in gastro esophageal reflux diseases (gerd) and ensuring patient compliance. drug loading was carried out by batch method & resinates were characterized using ftir, xrpd. resinates were formulated as a combination tablet and evaluated for tablet properties & in vitro drug release. resinates provided sustained release of domperidone and immediate release of ranitidine. ir and x-ray studies indicate complexation of drug and resin along with monomolecular distribution of drugs in amorphous form in the resin matrix. the tablets of resinate combination showed good tablet properties. in-vitro drug release gave desired release profiles and ex-vivo drug absorption studies carried out by placing everted rat intestine in dissolution medium indicated statistically significant similarity in absorption from test and marketed formulation. the novelty of this study is that the retardation in release of domperidone from resinates is achieved by presence of weak resin in the formulation.
Ion Exchange Resins in Formulation : An Update
Mrs. Ashwini R. Madgulkar,Dr. Mangesh R. Bhalekar,Mr. Vinay J. Kolhe,Ms. Krishna G. Patel
Pharmaceutical Reviews , 2007,
Abstract: The ion exchange resins in drug delivery system are used to optimize presentation and bioavailability of established therapeutic agents. Formulations based on ion exchange resins are available in the market. Ion Exchange resins have found application not only as drug carriers, but also in a number of areas in formulations and drug delivery. Various applications of resin in drug delivery formulations, recent developments and future scope are discussed in this review. In the continuing search for novel drug delivery system to optimize presentation and bioavailability of established therapeutic agents, Ion exchange resins should be considered as polymers with unique advantageous properties. Ion exchange resins (IER) may be defined as high molecular weight water insoluble polymers containing fixed positively or negatively charged functional groups in their matrix, which have an affinity for oppositely charged counterions 1 . Since the majority of drugs possess an ionic site in their molecule, the charge of the resins provides a means to loosely attach such drugs to insoluble polymers. Various studies has revealed that ion exchange resins are equally suitable for drug delivery technology 2 , including controlled release, transdermal, site specific, fast dissolving, iontophoretically assisted transdermal, nasal, topical and taste masked system.
Research: SIMULTANEOUS ESTIMATION OF PERINDOPRIL ERBUMINE AND INDAPAMIDE IN BULK DRUG AND TABLET DOSAGE FORM BY HPTLC
Mohit G Dewani,Kailash G Bothara,Ashwini R Madgulkar,Mrinalini C Damle*
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Perindopril erbumine is one of the newly used non-peptide Angiotensin II receptor antagonist, and is used for the treatment of patients with hypertension and symptomatic heart failure. Indapamide is a diuretic of the class of Benzothiadiazines. The combined oral administration of perindopril erbumine with indapamide has been foundto be more effective than either drug alone in the treatment of hypertension. A new sensitive, simple, rapid and precise high performance thin layer chromatographic (HPTLC) method has been developed for simultaneous determination of both the drugs in Pharmaceutical dosage form. The method was based on the separation of two drugs on plates precoated with silica gel 60 F254. The mobile phase used was Dichloromethane : Methanol : Glacial acetic acid in the ratio of 9.5:0.5:0.1 v/v/v. Both the drugs showed considerable absorbance at 215 nm. Linearity was obtained in the concentration range of 1-5 μg/band and 100-500 ng/band for perindopril and indapamide respectively. The method has been successfully applied to tablets and was validated according to ICH Harmonized Tripartite guidelines.
COMPARISON OF IN VITRO DISSOLUTION PROFILES OF CEFPODOXIME PROXETIL - PEG SOLID DISPERSIONS WITH CEPODOXIME PROXETIL
Madgulkar Ashwini R,Nimbalkar Umesh A,Dhoka Madhura V,Mirajkar Reshma N
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The aims of this study were (1) to compare the in vitro dissolution profiles of Solid dispersion of Cefpodoxime Proxetil with PEG 6000, with those of pure drug and physical mixture of Cefpodoxime proxetil and PEG 6000. (2) to apply statistical models to evaluate each ratio of Cefpodoxime proxetil and PEG 6000 in solid dispersion in terms of easy application and usefulness, and (3) to identify the most suitable ratio of Cefpodoxime Proxetil and PEG 6000 as solid dispersion.Solid dispersions of Cefpodoxime Proxetil were prepared with PEG 6000 in different ratios by using kneading method. Dissolution profile of all these solid dispersions were compared with dissolution profile of Cefpodoxime proxetil and physical mixture of Cefpodoxime proxetil and PEG 6000. The results showed that the Solid dispersions containing PEG in different proportions exhibit faster release (about 2.2 – 3 fold faster) than Cefpodoxime proxetil and physical mixture of Cefpodoxime proxetil and PEG. Among the solid dispersions containing different ratios batch A containing Cefpodoxime proxetil and PEG 6000 in 1:1 ratio exhibited about 3 fold improvement in release profile. The release kinetics of Solid dispersions was investigated using several mathematical equations. In Model-independent method similarity factor, f2, was used for the comparison of in vitro dissolution profiles. The results showed that model-dependent methods were more discriminative than model-independent methods. Model independent methods seemed to be easier to apply and interpret; only one value is obtained to describe the closeness of the two dissolution profiles. The application and evaluation of model-dependent methods were more complicated; these methods present an acceptable model approach to the true relationship between percent dissolved and time variables, including statistical assumptions that could be checked.
第1页/共211条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.