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Search Results: 1 - 10 of 402558 matches for " Maciel Ana Maria T. R. "
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First isolation of enterovirus 71 (EV-71) from Northern Brazil
Lamar?o, Leticia Martins;Maciel, Ana Maria T. R.;Gomes, Maria de Lourdes Contente;
Brazilian Journal of Infectious Diseases , 2003, DOI: 10.1590/S1413-86702003000400009
Abstract: enterovirus 71 (ev-71) has been associated to cases of neurological disease in many countries including brazil. this virus has now been reported from three of the five brazilian regions. our study relates the findings concerning to the first isolate of this virus in northern region of brazil. a 15-month old female patient, from the rural zone of the municipality of santana do araguaia in southern pará state was admitted at the hospital with acute, flaccid, asymmetric and ascending motor deficiency, located in the right lower limb. stools samples from this child were inoculated in rd cells and was isolated an ev-71. we plan to sequence our strain and compare it to other isolates in brazil. differences at the molecular level can explain why ev-71 strains circulating in other continents, such as asia, appear to be more virulent.
First isolation of enterovirus 71 (EV-71) from Northern Brazil
Lamar?o Leticia Martins,Maciel Ana Maria T. R.,Gomes Maria de Lourdes Contente
Brazilian Journal of Infectious Diseases , 2003,
Abstract: Enterovirus 71 (EV-71) has been associated to cases of neurological disease in many countries including Brazil. This virus has now been reported from three of the five Brazilian regions. Our study relates the findings concerning to the first isolate of this virus in Northern region of Brazil. A 15-month old female patient, from the rural zone of the municipality of Santana do Araguaia in southern Pará state was admitted at the hospital with acute, flaccid, asymmetric and ascending motor deficiency, located in the right lower limb. Stools samples from this child were inoculated in RD cells and was isolated an EV-71. We plan to sequence our strain and compare it to other isolates in Brazil. Differences at the molecular level can explain why EV-71 strains circulating in other continents, such as Asia, appear to be more virulent.
Prevalência de anormalidades genitais em recém-nascidos
Monlleó, Isabella L.;Zanotti, Susane V.;Araújo, Bárbara Priscila B. de;Cavalcante Júnior, Erisvaldo F.;Pereira, Paula D.;Barros, Paulo M. de;Araújo, Maria Deysiane P.;Mendon?a, Ana Thaysa V. S. de;Santos, Catarina R. S.;Santos, Ylana R. dos;Michelatto, Débora de Paula;Mello, Maricilda P. de;Maciel-Guerra, Andrea T.;Guerra-Júnior, Gil;
Jornal de Pediatria , 2012, DOI: 10.1590/S0021-75572012000600008
Abstract: objectives: to assess the prevalence of genital abnormalities among neonates in two public maternity-schools. methods: case-control, cross-sectional descriptive study. genital morphology of 2,916 neonates was assessed using a clinical protocol between 04/19/2010 and 04/18/2011. control group included neonates without birth defects, born at the same maternity unit and in the same day in which a case was identified. fisher and kruskal-wallis tests were used for statistics. results: the study identified 29 (1:100) neonates with genital abnormalities. most of them were examined within 3 days of life and presented only one genital defect. morphological abnormalities comprised: genital ambiguity (1/29), fusion of labia majora (1/29), micropenis (2/29), enlarged clitoris (6/29), hypospadia (9/29), and combined defects (4/29). only one case reported the genital abnormality in the statement of live birth correctly. prematurity occurred in 13/29 cases and was the only variable statistically associated with genital defects. eight cases agreed on the complementary investigation of the genital defect, among which three were diagnosed with disorder of sex development. conclusions: there is a high prevalence of genital abnormalities in the maternity units included in the present study and most cases are under-diagnosed and under-reported. our results reinforce the importance of a careful examination of genital morphology in neonatal period towards the recognition of minor defects that can be clinical features of a disorder of sex development.
Endocardite em prótese biológica por candida parapsilosis
Severo, Luiz Carlos;Alves, Ana Maria Maciel;Bassanesi, Maria Cristina;Prates, Paulo Roberto;Falleiro, Roque P. T.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1987, DOI: 10.1590/S0036-46651987000100007
Abstract: endocarditis caused by candida parapsilosis in a biological prosthetic valve is reported. a brief review of the brazilian literature in the subject was done.
Viver e trabalhar em território ocupado: a Palestina e seu povo
Montenegro, Ana Maria Maciel;
Caderno CRH , 2007, DOI: 10.1590/S0103-49792007000100011
Abstract: this paper analyzes, from a historical perspective, the different juridical and administrative means as well as the resolutions of international organs in the regulation of a disputed area among jews and palestinians the gaza strip. beginning from reading the press and specialized academic magazines the author reveals the difficulties lived by the palestinians in their organization of life and work, for the restrictions of movement within the gaza strip territory, that transform them in refugees in their own land. she concludes that those land regulatory devices ended up fundamenting the inequality of those people before the law, denying the palestinians the application of the international law according to which people are the owners of their own destinies.
Transferência de blastocisto após descongelamento de embri?es em mórula resultando em gesta??o gemelar: relato de caso
Albuquerque, Luiz Eduardo T.;Maciel, Maria Cecília R.;Matheus, Paulo C.;Catafesta, Edir;Pereira, Dirceu Henrique Mendes;
Revista Brasileira de Ginecologia e Obstetrícia , 1999, DOI: 10.1590/S0100-72031999001000007
Abstract: the cryopreservation of embryos in late developing stages seems to present satisfactory results. with the purpose of better testing the embryos' survival, they were cryopreserved in the morula or blastocyst stage, thawed and left in culture for 24 hours so that their natural evolution could be observed. amongst the frozen 2 blastocysts and 5 morulas, 4 morulas survived the thawing process, being transferred as blastocysts 24 hours later. the transfer was performed in a young patient, second marriage of a ten-year vasectomized man and resulted in twin pregnancy. thawing morula embryos and the in vitro observation of their development resumption until the blastocyst stage give us an additional parameter in the quality evaluation of the embryo and probably an improvement in pregnancy rates.
Universality class of quantum criticality in the two-dimensional Hubbard model at intermediate temperatures ($t^2/U\ll T\ll t$)
Kaden R. A. Hazzard,Ana Maria Rey,Richard T. Scalettar
Physics , 2011, DOI: 10.1103/PhysRevB.87.035110
Abstract: We show that the dilute Fermi gas quantum critical universality class quantitatively describes the Mott/metal crossover of the two-dimensional Hubbard model for temperatures somewhat less than (roughly half) the tunneling but much greater than (roughly twice) the superexchange energy. We calculate the observables expected to be universal near the transition --- density and compressibility --- with numerically exact determinantal quantum Monte Carlo. We find they are universal functions of the chemical potential. Despite arising from the strongly correlated regime of the Hubbard model, these functions are given by the weakly interacting, dilute Fermi gas model. These observables and their derivatives are the only expected universal static observables of this universality class, which we also confirm by verifying there is no scaling collapse of the kinetic energy, fraction of doubly occupied sites, and nearest neighbor spin correlations. Our work resolves the universality class of the intermediate temperature Mott/metal crossover, which had alternatively been proposed to be described by more exotic theories. However, in the presence of a Zeeman magnetic field, we find that interplay of spin with itinerant charge can lead to physics beyond the dilute Fermi gas universality class.
Ion channelopathies in endocrinology: recent genetic findings and pathophysiological insights
Rolim, Ana Luiza R.;Lindsey, Susan C.;Kunii, Ilda S.;Fujikawa, Aline M.;Soares, Fernando A.;Chiamolera, Maria Izabel;Maciel, Rui M. B.;Silva, Magnus R. Dias da;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2010, DOI: 10.1590/S0004-27302010000800002
Abstract: ion channels serve diverse cellular functions, mainly in cell signal transduction. in endocrine cells, these channels play a major role in hormonal secretion, ca2+-mediated cell signaling, transepithelial transport, cell motility and growth, volume regulation and cellular ionic content and acidification of lysosomal compartments. ion channel dysfunction can cause endocrine disorders or endocrine-related manifestations, such as pseudohypoaldosteronism type 1, liddle syndrome, bartter syndrome, persistent hyperinsulinemic hypoglycemia of infancy, neonatal diabetes mellitus, cystic fibrosis, dent's disease, hypomagnesemia with secondary hipocalcemia, nephrogenic diabetes insipidus and, the most recently genetically identified channelopathy, thyrotoxic hypokalemic periodic paralysis. this review briefly recapitulates the membrane action potential in endocrine cells and offers a short overview of known endocrine channelopathies with focus on recent progress regarding the pathophysiological mechanisms and functional genetic defects.
Toxicity of Some Cinnamic Acid Derivatives to Common Bean (Phaseolus vulgaris)
Alexandra JIT?REANU,Gabriela TTR?NG?,Ana-Maria ZBANCIOC,Ursula ST?NESCU
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 2011,
Abstract: Cinnamic acid derivatives are an important class of biologically active compounds, playing an important role in the plants’ development, but may also present a wide range of actions: antimicrobial, antioxidant, antiinflamatory, antitumoral. The present study investigated the toxicity of ten cinnamic acid derivatives on Phaseolus vulgaris, this being the first step in evaluating their pharmacotoxicological potential (usually, plant toxicity tests are used for ecotoxicity assessment, but they can also provide some useful general information about the toxic potential of a pharmaceutical substance to living organisms). The bean seeds were exposed to three different concentrations of each substance (28.6 μg/cm2, 57.3 μg/cm2, 114.6 μg/cm2). All the tests were conducted in Petri dishes, using an artificial substrate (Whatman filter paper) impregnated with the investigated compounds. The analyzed elements were seedling length, root length, percentage of seeds that developed into seedlings, fresh seedling weight and the total polyphenols content. The tested compounds showed phytotoxic effects, inhibiting the growth of the plants and the biosynthesis of polyphenols as compared to the control. The substances with high logP values showed greater phytotoxic potential, but to establish an exact correlation between hydrophobicity and toxicity of the molecules a QSAR analysis must be further done.
P2×7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation
Adelson M. Rodrigues, Cassia T. Bergamaschi, Maria Jose S. Fernandes, Edgar J. Paredes-Gamero, Marcus V. Curi, Alice T. Ferreira, Sergio R. R. Araujo, Giovana R. Punaro, Fabiane R. Maciel, Guilherme B. Nogueira, Elisa M. S. Higa
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097452
Abstract: Previous studies in our laboratory showed that N-acetylcysteine supplementation or aerobic training reduced oxidative stress and the progression of diabetic nephropathy in rats. The P2X7 receptor is up-regulated in pathological conditions, such as diabetes mellitus. This up-regulation is related to oxidative stress and induces tissue apoptosis or necrosis. The aim of the present study is to assess the role of P2X7 receptor in the kidneys of diabetic rats submitted to aerobic training or N-acetylcysteine supplementation. Diabetes was induced in male Wistar rats by streptozotocin (60 mg/kg, i.v.) and the training was done on a treadmill; N-acetylcysteine was given in the drinking water (600 mg/L). By confocal microscopy, as compared to control, the kidneys of diabetic rats showed increased P2×7 receptor expression and a higher activation in response to 2′(3′)-O-(4-benzoylbenzoyl) adenosine5'–triphosphate (specific agonist) and adenosine triphosphate (nonspecific agonist) (all p<0.05). All these alterations were reduced in diabetic rats treated with N-acetylcysteine, exercise or both. We also observed measured proteinuria and albuminuria (early marker of diabetic nephropathy) in DM groups. Lipoperoxidation was strongly correlated with P2X7 receptor expression, which was also correlated to NO?, thus associating this receptor to oxidative stress and kidney lesion. We suggest that P2X7 receptor inhibition associated with the maintenance of redox homeostasis could be useful as coadjuvant treatment to delay the progression of diabetic nephropathy.
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