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Search Results: 1 - 10 of 22218 matches for " Macedo-Costa "
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Enfermero-docente: aspectos interrelacionados con su formación
Macedo-Costa,K.N de F.; De Almeida Rebou?as,C.B.; Freitas da Silva,G.R.; Markert,W.;
Enfermería Global , 2010, DOI: 10.4321/S1695-61412010000200017
Abstract: este texto trata de algunas reflexiones que juzgamos importantes y que están juntos para la formación cultural del profesor. son presentados los conceptos de semicultura y teoría inmanente de adorno, así como crítica reflexiva a la industria cultural. también es expuesto el concepto de modernidad de habermas. focalizamos la formación del persona y los tabúes asociados al magisterio. al final, con el auxilio de las lecturas de esos pensadores, sugerimos algunas cuestiones orientadas a la formación profesional del enfermero docente.
Eficácia do extrato de Myrciaria cauliflora (Mart.) O. Berg. (jabuticabeira) sobre bactérias orais
Macedo-Costa, Maria R.;Diniz, Denise N.;Carvalho, Carine M.;Pereira, Maria do Socorro V.;Pereira, Jozinete V.;Higino, Jane S.;
Revista Brasileira de Farmacognosia , 2009, DOI: 10.1590/S0102-695X2009000400010
Abstract: the aim of this study was to evaluate in vitro antimicrobial activity of myrciaria cauliflora (mart.) o. berg., myrtaceae leaves extract on: streptococcus mitis (atcc 903), streptococcus mutans (atcc 25175), streptococcus sanguinis (atcc 15300), streptococcus oralis (atcc 10557), streptococcus salivarius (atcc 7073) and lactobacillus casei (atcc 9595). the study was done using laborious bacteriological techniques. the assays were made through dilution in agar diffusion method in order to reach the minimum inhibitory concentration (mic) determination. the results obtained were transferred for database and had the statistics parameter calculated by spss program 13.0 version. the t-student test was used with 5% of significance. in comparative study, the digluconate of chlorexidine (0,12%) was determinated. the leaf extract of myrciaria cauliflora berg. formed halos of inhibition oscillating between 10-18 mm of diameter and it showed middle performance significantly inferior in respect to digluconate of chlorexidine (0,12%), on the pure extract and in the concentrations 1:2 and 1:4. it follows that, the myrciaria cauliflora berg. extract produced a significative in vitro bactericidal activity on the former oral biofilm bacterias, that suggests the use of these substances as an economic and viable kind of alternative to the control of odontological diseases.
Comunica o terapêutica entre enfermeiros e pacientes de uma unidade hospitalar
Patrícia de Lemos Negreiros,Mayara de Oliveira Fernandes,Kátia Nêyla de Freitas Macedo-Costa,Grazielle Roberta Freitas da Silva
Revista Eletr?nica de Enfermagem , 2010,
Abstract: A comunica o é uma competência diária dos enfermeiros, sendo fator determinante na rela o de ajuda e indicador na avalia o dos cuidados prestados. Dessa forma, objetivou-se descrever a comunica o terapêutica entre enfermeiros e pacientes no ambiente hospitalar. Trata-se de estudo descritivo-exploratório, com abordagem quantitativa, realizado em um hospital do estado do Ceará em outubro/2007, com cinco enfermeiros, mediante observa o sistemática das intera es estabelecidas com os pacientes internados. Para registro dos dados utilizou-se check-list, contendo estratégias para efetiva o da comunica o, segundo cada intera o. Das 21 intera es, algumas se direcionam exclusivamente à práticacomunicativa, como as orienta es aos pacientes. Outras se referiram aos seguintes procedimentos: sondagem vesical; verifica o de sinais vitais; realiza o de curativos; acompanhamento da evolu o e trabalho de parto; pun o venosa e vacina o. Do total de intera es, o enfermeiro C foi o profissional que mais se comunicou de modo terapêutico (42,9%). Das demais 12 intera es (57,1%), realizadas pelos enfermeiros A, B, D e E, oito foram consideradas n o-terapêuticas. Dessas, o item mais utilizado foi o Uso de jarg o profissional, importante fator que pode interferir negativamente no prognóstico do paciente. Os enfermeiros precisam conhecer e implementar no seu cotidiano as estratégias de comunica o terapêutica como forma de atender as necessidades dos pacientes.
Efeito antimicrobiano in vitro do extrato de jabuticaba [Myrciaria cauliflora (Mart.)O.Berg.] sobre Streptococcus da cavidade oral
Carvalho, C.M.;Macedo-Costa, M.R.;Pereira, M.S.V.;Higino, J.S.;Carvalho, L.F.P.C.;Costa, L.J.;
Revista Brasileira de Plantas Medicinais , 2009, DOI: 10.1590/S1516-05722009000100013
Abstract: this study evaluated the action of ethanolic extract of myrciaria cauliflora (mart.)o.berg leaves on three streptococcus cultures from dental plaque. antimicrobial activity was assessed by agar-well diffusion method. the obtained data were satisfactory for all assayed species (streptococcus mutans atcc 25175, streptococcus sobrinus atcc 27609 and streptococcus sanguis atcc 10557) yielding inhibition halos when the pure extract and 1:2 and 1:4 dilutions were used. these results encourage new studies for the production of therapeutic compounds to be used in clinical dentistry.
Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment
Teresa Maria Santos Amaral,Daniela Macedo,Isabel Fernandes,Luis Costa
Prostate Cancer , 2012, DOI: 10.1155/2012/327253
Abstract: Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy. This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC. 1. Introduction Prostate cancer is the most common malignancy in males in Western countries, representing the second leading cause of cancer death [1]. Advances in screening and diagnosis have allowed detection of the disease in early stages (approximately 85% of cases diagnosed), stages at which the therapeutic options are curative and include surgery, radiation and, in some cases, active surveillance only [2–4]. However, for late-stage disseminated disease, current therapies are merely palliative. In 1941, a study of Huggins and Hodges showed the close relationship of androgens with prostate tumor growth and androgen-deprivation therapy (castration) became the key treatment for these stages in monotherapy or in combination with other methods [2, 4, 5]. Initial responses to castration therapy are quite favorable, with a significant clinical regression and rapid biochemical responses, as assessed by decline in levels of serum marker, prostate-specific antigen (PSA) in 80–90% of patients with metastatic disease [2, 4, 6]. Despite a good initial response, remissions last on average 2-3 years, with eventual progression occurring despite castration [4, 5, 7]. In these cases prostate cancer will progress to a castration-insensitive phase of disease (Castration-Resistant Prostate Cancer—CRPC) which carries a worse prognosis and translates into a survival time of 16–18 months in average from the beginning of progression [2, 4–6]. Systemic therapies have also been an option in the management to these patients. However, chemotherapy is not well tolerated by all CRPC patients, who were often elderly men with limited bone marrow reserve and concurrent medical conditions [8]. In 2004 the result of two major phase 3 clinical trials established docetaxel as the first-line
Addition of Bevacizumab to Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
André Bacellar Costa Lima, Ligia T. Macedo, André Deeke Sasse
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022681
Abstract: Introduction Recently, studies have demonstrated that the addition of bevacizumab to chemotherapy could be associated with better outcomes in patients with advanced non-small cell lung cancer (NSCLC). However, the benefit seems to be dependent on the drugs used in the chemotherapy regimens. This systematic review evaluated the strength of data on efficacy of the addition of bevacizumab to chemotherapy in advanced NSCLC. Methods PubMed, EMBASE, and Cochrane databases were searched. Eligible studies were randomized clinical trials (RCTs) that evaluated chemotherapy with or without bevacizumab in patients with advanced NSCLC. The outcomes included overall survival (OS), progression-free survival (PFS), response rate (RR), toxicities and treatment related mortality. Hazard ratios (HR) and odds ratios (OR) were used for the meta-analysis and were expressed with 95% confidence intervals (CI). Results We included results reported from five RCTs, with a total of 2,252 patients included in the primary analysis, all of them using platinum-based chemotherapy regimens. Compared to chemotherapy alone, the addition of bevacizumab to chemotherapy resulted in a significant longer OS (HR 0.89; 95% CI 0.79 to 0.99; p = 0.04), longer PFS (HR 0.73; 95% CI 0.66 to 0.82; p<0.00001) and higher response rates (OR 2.34; 95% CI 1.89 to 2.89; p<0.00001). We found no heterogeneity between trials, in all comparisons. There was a slight increase in toxicities in bevacizumab group, as well as an increased rate of treatment-related mortality. Conclusions The addition of bevacizumab to chemotherapy in patients with advanced NSCLC prolongs OS, PFS and RR. Considering the toxicities added, and the small absolute benefits found, bevacizumab plus platinum-based chemotherapy can be considered an option in selected patients with advanced NSCLC. However, risks and benefits should be discussed with patients before decision making.
Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: a systematic review and meta-analysis, with emphasis on chemotherapy subgroups
Ligia Macedo, Andre da Costa Lima, Andre Sasse
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-89
Abstract: A wide search of randomized clinical trials using bevacizumab in first-line metastatic colorectal cancer was performed in Embase, MEDLINE, LILACS and Cochrane databases. Meeting presentations and abstracts were also investigated. The resulting data were examined and included in the meta-analysis according to the type of regimen.Six trials, totaling 3060 patients, were analyzed. There was an advantage to using bevacizumab for overall survival (OS) and progression-free survival (PFS) (HR = 0.84; CI: 0.77-0.91; P < 0.00001 and HR = 0.72; CI: 0.66-0.78; P < 0.00001, respectively). However, heterogeneity of results was very high for both outcomes, and subgroup analyses supported the OS advantage with bevacizumab restricted to irinotecan-based regimens. Infusional fluorouracil subsets involved a minor proportion, and did not demonstrate statistical benefit in PFS or OS. Regarding toxicity, higher rates of grades 3-4 hypertension, bleeding, thromboembolic events and proteinuria were uniformly observed with bevacizumab, leading to increased treatment interruptions (HR = 1.47; P = 0.0004).Bevacizumab has efficacy in first-line treatment of advanced colorectal cancer, but the current data are insufficient to support efficacy in all regimens, especially infusional fluorouracil regimens, like FOLFIRI and FOLFOX.Colorectal cancer is currently the third most diagnosed cancer in men and the second in women worldwide, with an estimate of over 1.2 million new cases and 608,700 deaths in 2008 [1]. In the attempt of disease control, target therapy has been a matter of extensive research. Anti-angiogenesis is one of the pivotal theories involved in this approach, ever since the discovery of increased vascularity as a probable key for tumour progression [2,3]. One of the main pathways associated with the anti-angiogenic process is the vascular endothelial growth factor (VEGF) family, with high expression of its receptors observed not only in colorectal neoplasms, but in a wide variety o
Enteroparasitoses em gestantes e puérperas no Rio de Janeiro
Macedo, Lêda Maria da Costa;Rey, Luis;
Cadernos de Saúde Pública , 1996, DOI: 10.1590/S0102-311X1996000300011
Abstract: from november 1989 to may 1991, in rio de janeiro, brazil, the prevalence of intestinal parasitosis was investigated in 795 women coming from the public health services, who were divided into three groups: 490 pregnant women in pre-natal care period, 104 after-delivery women and 201 non-pregnant women (control). coproparasitologic tests were run using the sedimentation through centrifugation, faust, kato-katz and baermann-moraes methods. positivities were found ranging from 37.6% to 53.6% for pregnant women, 38.3% for non-pregnant women and 69.2% for after-delivery women, with statistically significant differences between the rates of pregnant women and after-delivery women, and with no statistic difference between the groups of pregnant and non-pregnant women. the most frequent parasites found were a. lumbricoides and t. trichiura. the conclusion was that the control of intestinal parasitosis is not a priority in the pregnant population studied because, in spite of the regular assistance provided during the pre-natal care period, they keep on infected .
Prenhez em rebanhos ovinos do Rio Grande do Sul-Brasil
Ribeiro, Luiz Alberto Oliveira;Gregory, Ricardo Macedo;Mattos, Rodrigo Costa;
Ciência Rural , 2002, DOI: 10.1590/S0103-84782002000400015
Abstract: in this paper, data from real-time ultrasound pregnancy diagnosis carried out in 45 sheep flock during six reproductive seasons are presented. a total of 27089 ewes from commercial flocks, mated during autumn, were scanned. the mean pregnancy percentage(pp) found was 81.6% showing a variation from 77.3 to 89.9%. mutton breed flocks (hampshire down, suffolk and texel) showed the highest pp of 85.6%, followed by cross breeds, with a pp of 82.9%. the pp of wool breeds flocks (australian merino, corriedale and polwarth) was 80.8%. the causes of low pp founded on some flocks is presented and discussed.
Estrela que vem do Norte: os baianos na umbanda de S?o Paulo
Macedo, Alice Costa;Bairr?o, José Francisco Miguel Henriques;
Paidéia (Ribeir?o Preto) , 2011, DOI: 10.1590/S0103-863X2011000200008
Abstract: the baianos of the umbanda comprise a category of spirits associated with characters typical from the brazilian northeast. this study characterizes the spiritual category baiano in the practice of umbanda in the southeast and uncovers how the pantheon incorporates human experiences and social types. literature was consulted and data were collected through participative observation and interviews with medians in trances. terreiros (places where the rituals occur) from the state of s?o paulo, brazil collaborated. the narratives revealed aspects that overlap those from the culture of the people of the northeast, suggesting there is a transmutation of regional scenes in metonymies and metaphors that are recombined so that one does not immediately reflect upon types that are socially determined. these meanings are materialized in rituals and in narratives rich in oxymorons, as well, enabling one to express contradictions and provide religious symbols in which the human, paradoxical and conflictive elements can be recognized.
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