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Search Results: 1 - 10 of 10935 matches for " Mabel Elena; Montealegre Lynett "
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Detección de Helicobacter pylori y caracterización del la región -31 del gen de la Interleucina 1- humana en pacientes de una población colombiana con enfermedades gastroduodenales Helicobacter pylori detection and human Interleukin 1- genotyping in Colombian patients affected by gastroduodenal diseases
María Camila Montealegre Ortiz,Carlos Jaramillo Henao,Mabel Elena Bohórquez Lozano,Gustavo Montealegre Lynett
Revista Colombiana de Gastroenterologia , 2008,
Abstract: El propósito de este estudio fue investigar la presencia de Helicobacter pylori, realizar la caracterización del polimorfismo -31 del gen de la interleucina 1-β humana y establecer si existe asociación entre la presentación de alguno de los genotipos y la severidad de las manifestaciones clínicas en una población colombiana. Se analizaron biopsias gástricas provenientes de 71 pacientes, mediante histopatología y métodos moleculares (PCR y PCR-RFLP). Los resultados mostraron que el 97,2% de los pacientes presentaba alteraciones de la mucosa gástrica. La presencia de H. pylori se demostró en 44 pacientes y la frecuencia de los genotipos de IL-1B: TT, CT y CC fue de 12,7%, 60,6% y 26,8% respectivamente. No se encontró asociación entre los genotipos de la región polimórfica -31 del gen IL-1B y el grado de alteración de la mucosa gástrica en la población estudiada. The aim of this study was to investigate the presence of Helicobacter pylori and interleukin 1-β genotyping (IL-1B -31), to determine the relationship between one polymorphism in the -31 region of interleukin 1-β gene and the severity of the clinical manifestations. Gastric biopsies from 71 patients were submitted to histopathological examination and genotyped by molecular methods (PCR y PCR-RFLP). The results indicated that 97.2% of the patients have alterations in the gastric mucosa, the presence of H. pylori was demonstrated in 44 patients and TT, CT and CC genotypes were detected in 12.7%, 60.6% and 26.8%, respectively. IL-1B genotypes were not associated with the severity of gastric mucosal damage in the studied population.
Detección de Helicobacter pylori y caracterización del la región -31 del gen de la Interleucina 1-? humana en pacientes de una población colombiana con enfermedades gastroduodenales
Montealegre Ortiz,María Camila; Jaramillo Henao,Carlos; Bohórquez Lozano,Mabel Elena; Montealegre Lynett,Gustavo; Delgado,María del Pilar;
Revista Colombiana de Gastroenterologia , 2008,
Abstract: the aim of this study was to investigate the presence of helicobacter pylori and interleukin 1-β genotyping (il-1b -31), to determine the relationship between one polymorphism in the -31 region of interleukin 1-β gene and the severity of the clinical manifestations. gastric biopsies from 71 patients were submitted to histopathological examination and genotyped by molecular methods (pcr y pcr-rflp). the results indicated that 97.2% of the patients have alterations in the gastric mucosa, the presence of h. pylori was demonstrated in 44 patients and tt, ct and cc genotypes were detected in 12.7%, 60.6% and 26.8%, respectively. il-1b genotypes were not associated with the severity of gastric mucosal damage in the studied population.
?Tienen aprendizajes de calidad los estudiantes de medicina?
Montealegre Lynett,Gustavo; Nú?ez Rodríguez,Martha Lucia;
Acta Medica Colombiana , 2009,
Abstract: the purpose of this investigation is to identify the approaches to learning used by a group of medical students from the university of tolima who participated in the integral health i teaching project during semester a of 2008. the methodology used was that of a quantitative, descriptive, cross-sectional study. 39 students from the fifth level of medical school were selected. the instrument employed was biggs? r-spq-2f questionnaire.
Tienen aprendizajes de calidad los estudiantes de medicina? Do medical students get high-quality learning?
Gustavo Montealegre Lynett,Martha Lucia Nú?ez Rodríguez
Acta Medica Colombiana , 2009,
Abstract: La presente investigación tiene como propósito identificar los enfoques de aprendizaje utilizados por un grupo de estudiantes de medicina de la Universidad del Tolima, que cursaron el proyecto pedagógico SALUD INTEGRAL I, en el semestre A 2008. Corresponde a un estudio de modalidad cuantitativa, de tipo descriptivo de corte transversal. Para el logro de este propósito fueron seleccionados los 39 estudiantes matriculados en el V nivel del programa de medicina, quienes contestaron el instrumento denominado R-SPQ-2F propuesto por Biggs. Dicho instrumento permite medir los componentes: motivos y estrategias que caracterizan a cada uno de los enfoques de aprendizaje (superficial y profundo), y determinar en cada participante a cuál de ellos corresponde. Los datos obtenidos fueron procesados mediante la utilización del paquete estadístico SPSS versión 10 de Windows, encontrando que 61,5% de la población objeto de estudio utilizaba un enfoque de aprendizaje profundo (de calidad), el 33% aprendizaje superficial y 5,5% tiene un enfoque indeterminado. De las mujeres 62% utilizaba un enfoque de aprendizaje profundo. Los resultados son consistentes con los resultados de investigaciones previas realizadas en latinoamericanos. The purpose of this investigation is to identify the approaches to learning used by a group of medical students from the University of Tolima who participated in the INTEGRAL HEALTH I Teaching Project during semester A of 2008. The methodology used was that of a quantitative, descriptive, cross-sectional study. 39 students from the fifth level of medical school were selected. The instrument employed was Biggs’ R-SPQ-2F questionnaire.
Genotipificación de los polimorfismos -511, -31 y +3954 del gen de la interleucina-1β humana en una población colombiana con cuadro de dispepsia Genetic characterization of the interleukin 1 β polymorphisms -511, -31 y +3954 in a Colombian population with dyspepsia
María Teresa Arango,Carlos Jaramillo,María Camila Montealegre,Mabel Helena Bohórquez
Biomédica , 2010,
Abstract: Introducción. Varios estudios sugieren que algunos polimorfismos del gen de la interleucina-1β humana (IL-1β), como -511, -31 y +3954, están asociados al cáncer gástrico, debido al efecto inhibidor que esta citocina tiene sobre la secreción ácida del estómago, lo cual facilita la colonización e infección por agentes como Helicobacter pylori, así como la génesis de estados preneoplásicos que pueden conducir al desarrollo de cáncer. Objetivo. Genotipificar los polimorfismos +3954,-511 y -31 de la IL-1β y establecer sus frecuencias en una población de pacientes con diferente sintomatología gástrica. Materiales y métodos. Se analizaron 111 biopsias del antro gástrico obtenidas de pacientes con sintomatología de alguna alteración gástrica. La detección de H. pylori en las muestras se realizó mediante PCR empleando iniciadores específicos para cada región y la genotipificación de las regiones polimórficas de la IL-1β se realizó por RFLP empleando las enzimas Aval, Alul y Taql para -511, -31 y +3954, respectivamente. Resultados. Se detectó H. pylori en 59,5% de las biopsias gástricas, mientras que el estudio histopatológico reveló que 82,9% de los pacientes padecía alguna enfermedad. La caracterización de las regiones polimórficas del gen de la IL-1β, seguida de la tipificación por RFLP, permitió evidenciar los tres posibles genotipos de cada uno de los polimorfismos en la población. En los pacientes infectados por H. pylori se encontró con mayor frecuencia (28,6%) el genotipo CC en la región polimórfica -31. Conclusión. No se encontraron diferencias significativas en los genotipos de los individuos infectados y los no infectados por H. pylori, a excepción del genotipo CC en la región polimórfica -31, el cual se encontró con mayor frecuencia en los pacientes con enfermedades benignas. Introduction. The human interleukin-1β gen (IL-1 β) polymorphisms such as -511, -31 and +3954 have been associated with the presence of gastric cancer, due to the inhibitor effect that this protein has on acid secretion in the stomach. Thisfacility can enhance the colonization and infection by agents like Helicobactor. pylori and the genesis of preneoplastic states that can lead to cancer development. Objective. Three polymorphisms of IL-1β (+3954, -511 and -31) will be genetically characterized and their frequencies established in a population of patients with gastric symptoms. Materials and methods. Gastric antrum biopsies were obtained from 111 patients that showed signs of gastric disorder. A PCR was done to detect the H. pylori presence; a PCR using designed primers for speci
Factores salivales asociados a prevalencia e incremento de caries dental en escolares rurales
Cornejo,Lila Susana; Brunotto,Mabel; Hilas,Elena;
Revista de Saúde Pública , 2008, DOI: 10.1590/S0034-89102008000100003
Abstract: objective: to evaluate the association between saliva and prevalence of dental caries. methods: two-year longitudinal study in rural schoolchildren at cruz del eje, argentina between 2000 and 2002. the study population comprised all schoolchildren (n=196) aged 5 to 14 years of both sexes attending eight rural schools. they were assessed at three different time points (n=46): baseline, 12 and 24 months. salivary components and dmft and dmft indexes were used. nominal variables, "decay" and "new decay", were created to assess risk of decay at baseline, 12, and 24 months, respectively. principal component analysis was applied to select salivary factors associated to decay and then they were categorized according to the median as a cutoff value. results: high prevalence of decay (50%-90%) was found at the three time points of study. there was significantly increase in caries at 12 months (p=0.000) compared to that seen at 24 months. at baseline there were homogeneous low levels of calcium and phosphate and a significant association (p<0.050) between calcium and phosphorus and calcium/phosphorus molar ratio and decay. conclusions: phosphorus levels and calcium/phosphorus molar ratio can be considered risk factors for the development of caries in populations with characteristics similar to those studied.
Genotipificación de los polimorfismos -511, -31 y +3954 del gen de la interleucina-1 β humana en una población colombiana con cuadro de dispepsia
Arango,María Teresa; Jaramillo,Carlos; Montealegre,María Camila; Bohórquez,Mabel Helena; Delgado,María del Pilar;
Biomédica , 2010,
Abstract: introduction. the human interleukin-1b gen (il-1 b) polymorphisms such as -511, -31 and +3954 have been associated with the presence of gastric cancer, due to the inhibitor effect that this protein has on acid secretion in the stomach. thisfacility can enhance the colonization and infection by agents like helicobactor. pylori and the genesis of preneoplastic states that can lead to cancer development. objective. three polymorphisms of il-1β (+3954, -511 and -31) will be genetically characterized and their frequencies established in a population of patients with gastric symptoms. materials and methods. gastric antrum biopsies were obtained from 111 patients that showed signs of gastric disorder. a pcr was done to detect the h. pylori presence; a pcr using designed primers for specific regions was done to define the three polymorphic regions of il-1β, and a rflp was carried out using aval, alul and taqi for the position -511, -231 and +3954 for each case. results.helicobacter pylori was detected in 59.5% of the evaluated gastric while the histopathology study revealed that 82.9% of patients had some pathology. characterization of polymorphic regions of il-1β gen were joined to rflp typing evidenced that all descfribed genotypes were present in the study population. however, patients with benign pathologies infected with h. pylori had a high frequency of the cc genotype (28.6%) in the -31 polymorphic regions. conclusion. no significant differences were found between the genotype frequenciess of the h. pylori-infected and the non-infected populations with one exception. the cc genotype in the -31 polymorphic region was associated with benign pathologies.
Distribución parcial de Paragonimus (Digenea: Troglotrematidae) en Antioquia, por presenciade metacercarias en cangrejos dulciacuícolas
Uruburu,Mónica; Granada,Mabel; Velásquez,Luz Elena;
Biomédica , 2008,
Abstract: introduction. paragonimosis or lung fluke disease courses with signs similar to those seen in tuberculosis. the causative agent is a parasite of the genus paragonimus (digenea: troglotrematidae). people become infected by ingesting raw or partially cooked crabs containing metacercariae. the first focus of human paragonimosis in colombia was recorded in the county of urrao, where two species of crabs infected with paragonimus were found. in 2005, crabs with paragonimus? metacercariae were captured near medellín, western colombia. this prompted a search for the parasite in other locations through its presence in the crabs. objective. to establish the distribution of paragonimus in antioquia, we evaluated the presence of metacercaria in freshwater brachyuran crabs. materials and methods. from 2005 to 2007, crabs were captured in 13 counties of antioquia. the crabs were relaxed and dissected to determine presence of trematodes and then to make the taxonomic identifications. results. from 52 crabs captured in 9 counties, 42 (80.8%) were found with paragonimus metacercariae. the crabs were identified as pseudothelphusidae in 2 genera-hypolobocera and strengeriana- and were assigned to four species. three of the species were recorded for the first time as hosts of paragonimus. conclusions. a paragonimus? distribution map was constructed for antioquia; for the first time urban zones were included. because of the high rate of infection, the handling and consumption of raw and poorly cooked crabs pose risk factors for human infection. because crabs are affordable and provide means of easy diagnosis, crabs are targeted as primary agents of and diagnostic tools for paragonmosis.
Las 'villas de emergencia' como espacios urbanos estigmatizados
Mabel Nélida Giménez,María Elena Ginóbili
Historia Actual Online , 2003,
Abstract: En la última década, la mayoría de las ciudades de Argentina se desarrollaron de acuerdo a dos patrones: extensión territorial y segmentación interna. Los sectores de altos ingresos se aíslan voluntariamente en zonas periféricas exclusivas, en barrios autosuficientes, dotados de costosas viviendas, servicios, seguridad privada, etc. Los más carenciados se ubican también en la periferia pero en áreas de menor valor, conocidas con el nombre de "villas de emergencia" o "villas miseria", caracterizadas por un alto grado de precariedad y deficiente equipamiento social. El trabajo intenta reflexionar sobre las relaciones que se establecen entre estos espacios urbanos y las identidades de sus habitantes.
Distribución parcial de Paragonimus (Digenea: Troglotrematidae) en Antioquia, por presencia de metacercarias en cangrejos dulciacuícolas Distribution of Paragonimus (Digenea: Troglotrematidae) in Antioquia Province, Colombia, based on metacercariae counts in freshwater crabs
Luz Elena Velásquez,Mónica Uruburu,Mabel Granada
Biomédica , 2008,
Abstract: Introducción. La paragonimosis, o distomatosis pulmonar, es una enfermedad con sintomatología similar a la observada en la tuberculosis. Es causada por parásitos del género Paragonimus (Digenea: Troglotrematidae). Las personas se infectan al consumir cangrejos crudos o mal cocidos, con metacercarias del parásito. El primer foco de paragonimosis humana en Colombia se registró durante 1995 en Urrao, Antioquia, donde se hallaron dos especies de cangrejos que hospedaban el parásito. En el 2005 se capturaron cangrejos con metacercarias de Paragonimus en Medellín, lo que motivó la búsqueda del parásito en otras localidades, mediante su presencia en estos crustáceos. Objetivo. Establecer la distribución de Paragonimus en Antioquia, evaluando la presencia de metacercarias en macrocrustáceos braquiuros, dulciacuícolas. Materiales y métodos. Desde 2005 hasta 2007 se capturaron cangrejos en 13 municipios antioque os. Se relajaron y sacrificaron para la búsqueda del digeneo y la identificación taxonómica. Resultados. En nueve municipios se capturaron 52 cangrejos, 42 (80,76%) con metacercarias de Paragonimus. Todos los crustáceos se determinaron como Pseudothelphusidae, de los géneros Hypolobocera y Strengeriana, y se asignaron a cuatro especies. Tres se registran por primera vez como huéspedes del parásito. Conclusión. Se inicia la construcción de un mapa con la distribución de Paragonimus en Antioquia que incluye por primera vez zonas urbanizadas. Se ratifican el consumo y la manipulación de los cangrejos crudos y mal cocidos como factores de riesgo para la infección humana. Se propone a los cangrejos como agentes focalizadores de paragonimosis por ser asequibles y de fácil diagnóstico. Introduction. Paragonimosis or lung fluke disease courses with signs similar to those seen in tuberculosis. The causative agent is a parasite of the genus Paragonimus (Digenea: Troglotrematidae). People become infected by ingesting raw or partially cooked crabs containing metacercariae. The first focus of human paragonimosis in Colombia was recorded in the county of Urrao, where two species of crabs infected with Paragonimus were found. In 2005, crabs with Paragonimus’ metacercariae were captured near Medellín, western Colombia. This prompted a search for the parasite in other locations through its presence in the crabs. Objective. To establish the distribution of Paragonimus in Antioquia, we evaluated the presence of metacercaria in freshwater brachyuran crabs. Materials and methods. From 2005 to 2007, crabs were captured in 13 counties of Antioquia. The crabs were relaxed and dis
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