Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 19 )

2018 ( 361 )

2017 ( 358 )

2016 ( 318 )

Custom range...

Search Results: 1 - 10 of 27879 matches for " Ma Dongying "
All listed articles are free for downloading (OA Articles)
Page 1 /27879
Display every page Item
Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics
Xia Yan,Ma Dongying,Hu Jian,Tang Chunling
Behavioral and Brain Functions , 2012, DOI: 10.1186/1744-9081-8-42
Abstract: Background We studied the effects of single nucleotide polymorphisms (SNPs) in the metabotropic glutamate receptor 3 (GRM3) gene on brain N-acetylaspartate (NAA) concentrations and executive function (EF) skills in non-smoking, active alcoholics, and evaluated associations between these variables. Methods SNPs (rs6465084, rs1468412, and rs2299225) in GRM3 were genotyped in 49 male, non-smoking, alcohol-dependent patients and 45 healthy control subjects using ligase detection reactions. NAA/creatine (Cr) ratios in left prefrontal gray matter (GM) and white matter (WM), left parietal GM, left parietal WM, and cerebellar vermis regions were measured by Proton 1 H Magnetic resonance spectroscopy (MRS). EF was measured by the Wisconsin Card Sorting Test (WCST). Results Compared to controls, alcoholics had lower NAA/Cr ratios in prefrontal GM and WM regions and performed more poorly on all EF tests (P < 0.001). Alcoholics with the A/A genotype for SNP rs6465084 had lower NAA/Cr ratios in prefrontal GM and WM regions and had poorer EF skills than alcoholics who were G-carriers for this SNP (P < 0.01). Non-alcoholics with the A/A genotype for rs6465084 also had lower NAA/Cr levels in prefrontal GM and made more random errors in the WCST than G-carriers (P < 0.01). The A/A genotype group for SNP rs6465084 was significantly different from the G carriers for the variables of NAA/Cr ratios and WCST scores in both alcoholics and controls (P < 0.05). Alcoholics who were T-carriers for rs1468412 had lower NAA/Cr ratios in prefrontal GM and showed poorer EF skills (P < 0.05). No effects of rs2299225 genotype on NAA/Cr or executive skills were observed. NAA/Cr in left prefrontal regions correlated with certain parameters of EF testing in both alcoholics and controls (P < 0.05), but the significance of this correlation among alcoholics disappeared after adjustment for the effects of genotype. Conclusions Our results provide evidence that glutamate system dysfunction may play a role in the prefrontal functional abnormalities seen in alcohol dependence. It is possible that certain GRM3 SNP genotypes (the A/A genotype of rs6465084 and the T allele of rs1468412) may further lower NAA/Cr levels and EF skills in addition to the effect of alcohol.
Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population
Jun Ma, Dongying Zhang, Kerstin Brismar, Suad Efendic, Harvest F Gu
BMC Medical Genetics , 2008, DOI: 10.1186/1471-2350-9-47
Abstract: Two common non-synonymous SNPs, including rs5498(E469K) and rs1799969(R241G), in the ICAM-1 gene were genotyped in 662 (312 female/350 male) T1D patients with DN and 620 (369/251) without DN. All patients were selected from the GoKinD study.Genotype distributions of both SNPs were in Hardy-Weinberg equilibrium but SNP rs5498(E469K) had high heterozygous index. In this SNP, the heterozygosity and positivity for the allele G were found to be significantly associated with DN in female T1D patients (P = 0.010, OR = 0.633, CI 95% 0.447–0.895 and P = 0.026, OR = 0.692, CI 95% 0.500–0.958). Furthermore, the female patients without DN carrying three genotypes A/A, A/G and G/G had different cystatin levels (0.79 ± 0.17, 0.81 ± 0.14 and 0.75 ± 0.12 mg/L, P = 0.021). No significant association of SNP rs1799969 (R241G) with DN was found.The present study provides further evidence that SNP rs5498(E469K) in the ICAM-1 gene presents a high heterozygous index and the allele G of this polymorphism may confers the decreased risk susceptibility to the development of DN in female T1D patients among the GoKinD population.Genome-wide scans and linkage analyses have predicted that the susceptibility gene(s) for type 1 diabetes (T1D) and diabetic nephropathy (DN) reside in chromosome 19p13 [1-3]. The intercellular adhesion molecule-1 (ICAM-1) gene is located in this chromosomal region. ICAM-1 is a 90-kD cell surface glycoprotein of the Ig super family involved in the firm attachment of leukocytes to endothelium [4,5]. Expression of ICAM-1 can be induced by multiple factors, including inflammatory cytokines, reactive oxygen species and shear stress [6,7]. Normally, ICAM-1 is expressed at low levels on the surface of arterial endothelial cells, but the expression at both mRNA and protein levels are significantly increased in animal models of diabetic nephropathy with T1D [7-9] and T2D [10-12]. Furthermore, clinical evidence indicates that the levels of plasma adhesion molecule are elevated i

Guo Liangqian,Ma Qing,Du Xuesong,Sun Dongying,

大地测量与地球动力学 , 2008,
Abstract: 用线性拟合方法计算了华北地区1985—2006年断层背景活动速率,并对跨断层形变测量资料逐项扫描识别异常,分区带统计计算异常数量和异常频率。结果显示,在6级及以上地震发生前一年左右,异常频率开始增大,地震发生在异常高频延续过程中或者结束后。异常频率对5级地震也有一定的反映。
Genetic Variant rs7758229 in 6q26–q27 Is Not Associated with Colorectal Cancer Risk in a Chinese Population
Lingjun Zhu, Mulong Du, Dongying Gu, Lan Ma, Haiyan Chu, Na Tong, Jinfei Chen, Zhengdong Zhang, Meilin Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059256
Abstract: Background A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the Chinese population. Methods We examined the associations between rs7758229 and colorectal cancer risk among 1,147 cases and 1,203 controls matched by age and sex. Logistic regression model was used to assess the associations. Results No significant association was found between rs7758229 and colorectal cancer risk (OR = 0.95, 95%CI = 0.84–1.09, P = 0.463). Similar results were observed in the stratification of tumor location (OR = 0.94, 95%CI = 0.80–1.11, P = 0.481 for colon cancer, and OR = 0.96, 95%CI = 0.82–1.13, P = 0.621 for rectum cancer). Conclusions Our findings did not support an association between rs7758229 in 6q26-q27 and the risk of colorectal cancer in a Chinese population.
Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis
Daniella M. Mizurini?,Jorgeane S. Aslan?,Tainá Gomes?,Dongying Ma,Ivo M. B. Francischetti?,Robson Q. Monteiro
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003869
Abstract: Background The saliva of blood-feeding arthropods contains a notable diversity of molecules that target the hemostatic and immune systems of the host. Dipetalodipin and triplatin are triatomine salivary proteins that exhibit high affinity binding to prostanoids, such as TXA2, thus resulting in potent inhibitory effect on platelet aggregation in vitro. It was recently demonstrated that platelet-derived TXA2 mediates the formation of neutrophil extracellular traps (NETs), a newly recognized link between inflammation and thrombosis that promote thrombus growth and stability. Methodology/Principal Findings This study evaluated the ability of dipetalodipin and triplatin to block NETs formation in vitro. We also investigated the in vivo antithrombotic activity of TXA2 binding proteins by employing two murine models of experimental thrombosis. Remarkably, we observed that both inhibitors abolished the platelet-mediated formation of NETs in vitro. Dipetalodipin and triplatin significantly increased carotid artery occlusion time in a FeCl3-induced injury model. Treatment with TXA2-binding proteins also protected mice from lethal pulmonary thromboembolism evoked by the intravenous injection of collagen and epinephrine. Effective antithrombotic doses of dipetalodipin and triplatin did not increase blood loss, which was estimated using the tail transection method. Conclusions/Significance Salivary TXA2-binding proteins, dipetalodipin and triplatin, are capable to prevent platelet-mediated NETs formation in vitro. This ability may contribute to the antithrombotic effects in vivo. Notably, both molecules inhibit arterial thrombosis without promoting excessive bleeding. Our results provide new insight into the antihemostatic effects of TXA2-binding proteins and may have important significance in elucidating the mechanisms of saliva to avoid host’s hemostatic responses and innate immune system.
Modular Decomposition Method Based on Design Structure Matrix and Application
Mengqi Li,Dongying Li
TELKOMNIKA : Indonesian Journal of Electrical Engineering , 2012, DOI: 10.11591/telkomnika.v10i8.1656
Abstract: Modular decomposition is an effective means to achieve a complex system, but that of current part-component-based does not meet the needs of the positive development of the production. Design Structure Matrix(DSM) can simultaneously reflect the sequence, iteration, and feedback information, and express the parallel, sequential, and coupled relationship between DSM elements. This article, a modular decomposition method, named Design Structure Matrix Clustering modularize method, is proposed, concerned procedures are define, based on sorting calculate and clustering analysis of DSM, according to the rules of rows exchanges and columns exchange with the same serial number. The purpose and effectiveness of DSM clustering modularize method are confirmed through case study of assembly and calibration system for the large equipment.
An Insight into the Sialotranscriptome of the Cat Flea, Ctenocephalides felis
José M. C. Ribeiro, Teresa C. F. Assump??o, Dongying Ma, Patricia H. Alvarenga, Van M. Pham, John F. Andersen, Ivo M. B. Francischetti, Kevin R. Macaluso
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044612
Abstract: Background Saliva of hematophagous arthropods contains a diverse mixture of compounds that counteracts host hemostasis. Immunomodulatory and antiinflammatory components are also found in these organisms' saliva. Blood feeding evolved at least ten times within arthropods, providing a scenario of convergent evolution for the solution of the salivary potion. Perhaps because of immune pressure from hosts, the salivary proteins of related organisms have considerable divergence, and new protein families are often found within different genera of the same family or even among subgenera. Fleas radiated with their vertebrate hosts, including within the mammal expansion initiated 65 million years ago. Currently, only one flea species–the rat flea Xenopsylla cheopis–has been investigated by means of salivary transcriptome analysis to reveal salivary constituents, or sialome. We present the analysis of the sialome of cat flea Ctenocephaides felis. Methodology and Critical Findings A salivary gland cDNA library from adult fleas was randomly sequenced, assembled, and annotated. Sialomes of cat and rat fleas have in common the enzyme families of phosphatases (inactive), CD-39-type apyrase, adenosine deaminases, and esterases. Antigen-5 members are also common to both sialomes, as are defensins. FS-I/Cys7 and the 8-Cys families of peptides are also shared by both fleas and are unique to these organisms. The Gly-His-rich peptide similar to holotricin was found only in the cat flea, as were the abundantly expressed Cys-less peptide and a novel short peptide family. Conclusions/Significance Fleas, in contrast to bloodsucking Nematocera (mosquitoes, sand flies, and black flies), appear to concentrate a good portion of their sialome in small polypeptides, none of which have a known function but could act as inhibitors of hemostasis or inflammation. They are also unique in expansion of a phosphatase family that appears to be deficient of enzyme activity and has an unknown function.
Purification and Characterization of Two New Allergens from the Venom of Vespa magnifica
Su An, Lingling Chen, Ji-Fu Wei, Xuening Yang, Dongying Ma, Xuemei Xu, Xueqing Xu, Shaoheng He, Jia Lu, Ren Lai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031920
Abstract: Due to poor diagnostic facilities and a lack of medical alertness, allergy to Vespa wasps may be underestimated. Few allergens have been identified from Vespa wasps. Possible native allergen proteins were purified from the wasp venoms (WV) (Vespa magnifica Smith) by gel filtration, ion exchange chromatography, respectively. Their sequences were determined by Edman degradation and cDNA cloning. Their allergenicities were assayed by enzyme-linked immunosorbent assay inhibition tests (ELISA-IT), immunoblots, and skin prick tests (SPTs). Their cross allergencities with Tab y 2 and Tab y 5 purified from the horsefly (Tabanus yao Macquart) were also determined. Two native allergens were identified from the WV, respectively. They are a 25-KDa antigen 5 protein (Ag5) (Vesp ma 5) and a 35-KDa hyaluronidase (Vesp ma 2). They represented major allergens in Vespa magnifica by immunoblots and SPTs. ELISA inhibition of pooled sera IgE reactivity to both the WV and the horsefly salivary gland extracts (HSGE) using four purified allergens (Vesp ma 2, Vesp ma 5 and previously purified Tab y 2 and Tab y 5) was significant. Their cross allergenicities were confirmed by ELISA-IT, immunoblots, and SPTs. They represented the cross reactive allergens from wasp and horsefly and proved the so called wasp-horsefly syndrome.
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus
Teresa C. Assump??o?,Dongying Ma,Daniella M. Mizurini?,R. Manjunatha Kini?,José M. C. Ribeiro?,Michail Kotsyfakis?,Robson Q. Monteiro?,Ivo M. B. Francischetti
PLOS Neglected Tropical Diseases , 2016, DOI: 10.1371/journal.pntd.0004298
Abstract: Background Hematophagous mosquitos and ticks avoid host hemostatic system through expression of enzyme inhibitors targeting proteolytic reactions of the coagulation and complement cascades. While most inhibitors characterized to date were found in the salivary glands, relatively few others have been identified in the midgut. Among those, Boophilin is a 2-Kunitz multifunctional inhibitor targeting thrombin, elastase, and kallikrein. However, the kinetics of Boophilin interaction with these enzymes, how it modulates platelet function, and whether it inhibits thrombosis in vivo have not been determined. Methodology/Principal Findings Boophilin was expressed in HEK293 cells and purified to homogeneity. Using amidolytic assays and surface plasmon resonance experiments, we have demonstrated that Boophilin behaves as a classical, non-competitive inhibitor of thrombin with respect to small chromogenic substrates by a mechanism dependent on both exosite-1 and catalytic site. Inhibition is accompanied by blockade of platelet aggregation, fibrin formation, and clot-bound thrombin in vitro. Notably, we also identified Boophilin as a non-competitive inhibitor of FXIa, preventing FIX activation. In addition, Boophilin inhibits kallikrein activity and the reciprocal activation, indicating that it targets the contact pathway. Furthermore, Boophilin abrogates cathepsin G- and plasmin-induced platelet aggregation and partially affects elastase-mediated cleavage of Tissue Factor Pathway Inhibitor (TFPI). Finally, Boophilin inhibits carotid artery occlusion in vivo triggered by FeCl3, and promotes bleeding according to the mice tail transection method. Conclusion/Significance Through inhibition of several enzymes involved in proteolytic cascades and cell activation, Boophilin plays a major role in keeping the midgut microenvironment at low hemostatic and inflammatory tonus. This response allows ticks to successfully digest a blood meal which is critical for metabolism and egg development. Boophilin is the first tick midgut FXIa anticoagulant also found to inhibit thrombosis.
Improved Corrosion Resisting Property of Magnetism Iron Fiber by SiO2 Coating  [PDF]
Dongying Niu, Jinku Yu, Qi Qiao, Dongdong Wang, Runhai Liu
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2012, DOI: 10.4236/jsemat.2012.23026
Abstract: To improve the oxidation resistance property of iron fibers, a SiO2 coated iron fiber was prepared by sol-gel method, and its microstructure, element and phase composition, antioxidation property, and crystallization were characterized by scanning electron microscopy, thermal gravimetric analysis, X-ray diffraction and 3% CuSO4 solution dripping. It was found that the surface of the iron fiber can be fully covered with SiO2 by using Sol-Gel method. Our results also indicated that the time of iron begin to be corrupted in 3% CuSO4 solution drip increased from 30 s to 240 s, and the temperature increased from 200?C to 310?C. In addition, the oxidation and antioxidation mechanisms of the SiO2 coated iron fiber have also been discussed in this work.
Page 1 /27879
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.