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Aspectos relacionais, familiares e sociais da rela??o pai-filho com deficiência física
Chacon, Miguel Cláudio Moriel;
Revista Brasileira de Educa??o Especial , 2011, DOI: 10.1590/S1413-65382011000300007
Abstract: the survey sought information from the relationship between father and child with disability regarding space, responsibilities and feelings in the parental relationship. ten fathers, aged 31 to 66 years, with varied educational and professional backgrounds, answered a questionnaire with 19 semi-structured questions grouped into 16 categories of analysis. the conclusion showed that fathers perceive disability differently over time. the information usually comes from a doctor, but when the disability is not very evident, and doesn't cause significant impairment, realization comes over time. the shock of the discovery and behaviors of rejection are major feelings for fathers. most fathers report differences in roles played by women and men in raising children; they believe that their responsibility is to provide for the family, while the mother's duty is to accompany the child. they feel that they share with the mothers the responsibility for caring for the child and, in general they don't feel they have been accused of being distant. they try to follow the child's treatment. the children are as attached to them as to other family members. to live with a minimum of quality of life they agreed unanimously about the need for greater income and benefits from social welfare. most recognize that they are afraid of having other children with disabilities. they express low expectations for the total independence of the children, and among the fathers who have more than one child, the majority acknowledged the existence of differential treatment. they attributed the causes to medical errors. fathers feel much the same as mothers, but they have different ways of demonstrating what they feel.
Reflex es sobre precoces, prodígios, gênios e as altas habilidades, com base na neurociência cognitiva
Miguel Cláudio Moriel Chacon,Carlos Eduardo Paulino
Revista Educa??o Especial , 2011,
Abstract: Em Educa o Especial, altas habilidades designam pessoas que demonstram capacidades, potenciais ou desempenho, em atividades humanas, bem acima da média. Objetivamos, utilizando-se da neurociência, entender os precoces, prodígios, gênios e altas habilidades como resultantes de um processo único das forma es da memória. Trata-se de uma pesquisa bibliográfica, em que as obras foram identificadas, localizadas, compiladas, fichadas e analisadas. O material foi localizado a partir de palavras-chave em bases de dados. Para a compila o, foram utilizados, como critério de inclus o, a intersec o dos unitermos adotados, bem como os trabalhos de pesquisadores da educa o, psicologia e neurociência, publicados entre 1966 e 2009. Analisamos qualitativamente 40 referências, sendo 18 artigos e 22 outros textos. A trajetória de análise foi desenvolvida tendo a quest o norteadora: há necessidade de se explicar diferentemente os precoces, prodígios, gênios e as AH? Chegamos a três proposi es lógicas. Procuramos demonstrar, por meio desse exercício lógico, que n o haveria necessidade de se explicar diferentemente os precoces, prodígios, gênios e as AH, mas concluímos que há necessidade de tais diferencia es, mesmo dentro da área da neurociência, no entanto, a demonstra o acima aponta para a teoria de Renzulli como válida para gênios e AH, com ressalvas para precoces e prodígios, que merecem um olhar mais aprofundado. Palavras-chave: Altas habilidades. Memória. Neurociência cognitiva. Neurotransmissores.
Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension
Moriel P.,Sevanian A.,Ajzen S.,Zanella M.T.
Brazilian Journal of Medical and Biological Research , 2002,
Abstract: The objective of the present study was to identify disturbances of nitric oxide radical (·NO) metabolism and the formation of cholesterol oxidation products in human essential hypertension. The concentrations of·NO derivatives (nitrite, nitrate, S-nitrosothiols and nitrotyrosine), water and lipid-soluble antioxidants and cholesterol oxides were measured in plasma of 11 patients with mild essential hypertension (H: 57.8 ± 9.7 years; blood pressure, 148.3 ± 24.8/90.8 ± 10.2 mmHg) and in 11 healthy subjects (N: 48.4 ± 7.0 years; blood pressure, 119.4 ± 9.4/75.0 ± 8.0 mmHg).Nitrite, nitrate and S-nitrosothiols were measured by chemiluminescence and nitrotyrosine was determined by ELISA. Antioxidants were determined by reverse-phase HPLC and cholesterol oxides by gas chromatography. Hypertensive patients had reduced endothelium-dependent vasodilation in response to reactive hyperemia (H: 9.3 and N: 15.1% increase of diameter 90 s after hyperemia), and lower levels of ascorbate (H: 29.2 ± 26.0, N: 54.2 ± 24.9 μM), urate (H: 108.5 ± 18.9, N: 156.4 ± 26.3 μM), -carotene (H: 1.1 ± 0.8, N: 2.5 ± 1.2 nmol/mg cholesterol), and lycopene (H: 0.4 ± 0.2, N: 0.7 ± 0.2 nmol/mg cholesterol), in plasma, compared to normotensive subjects. The content of 7-ketocholesterol, 5alpha-cholestane-3 ,5,6 -triol and 5,6alpha-epoxy-5alpha-cholestan-3alpha-ol in LDL, and the concentration of endothelin-1 (H: 0.9 ± 0.2, N: 0.7 ± 0.1 ng/ml) in plasma were increased in hypertensive patients. No differences were found for ·NO derivatives between groups. These data suggest that an increase in cholesterol oxidation is associated with endothelium dysfunction in essential hypertension and oxidative stress, although ·NO metabolite levels in plasma are not modified in the presence of elevated cholesterol oxides.
Influence of Soy Lecithin Administration on Hypercholesterolemia
Amouni Mohamed Mourad,Eder de Carvalho Pincinato,Priscila Gava Mazzola,Maricene Sabha,Patricia Moriel
Cholesterol , 2010, DOI: 10.1155/2010/824813
Abstract: Recent studies suggest that lecithin-rich diet can modify cholesterol homeostasis and hepatic lipoprotein metabolism. Considering the phytotherapeutic impact of lecithin, this work hypothesizes that lecithin administration in hypercholesterolemic patients may reduce cholesterol concentrations by increasing biliary secretion. Total cholesterol and LDL were evaluated after soy lecithin administration in hypercholesterolemic patients. One soy lecithin capsule (500 mg/RP-Sherer) was administrated daily. One-two months before the treatment beginning, blood samples were collected for total lipids and cholesterol fractions analysis. The results showed a reduction of 40.66% and 42.00% in total cholesterol and of 42.05% and 56.15% in LDL cholesterol after treatment for one and two months, respectively. A significant reduction in total cholesterol and LDL-cholesterol concentrations was observed during the first month of treatment, suggesting that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia.
Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
MORIEL,PATRICIA; PLAVNIK,FRIDA L; ZANELLA,MARIA T; BERTOLAMI,MARCELO C; ABDALLA,DULCINEIA SP;
Biological Research , 2000, DOI: 10.4067/S0716-97602000000200010
Abstract: lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. to clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of ldl, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (hc), hypertensive (h), hypercholesterolemic/hypertensive (hh) and normolipidemic/normotensive subjects (n). plasma ascorbate and lipid-soluble antioxidants were lower, while ldl oxidizability, ce-ooh and tl-ooh were higher in h, hc, and hh groups than in the n group. no difference was observed among groups for pl-ooh and isoprostanes. in summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the ldl susceptibility to oxidation were higher; 2) total cholesterol, ldl-cholesterol, apob and ce-ooh were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of ldl to oxidation; and 4) ce-ooh and tl-ooh were positively correlated with total cholesterol and ldl-cholesterol.
Cholesterol oxides inhibit cholesterol esterification by lecithin: cholesterol acyl transferase
Pincinato, Eder de Carvalho;Moriel, Patricia;Abdalla, Dulcinéia Saes Parra;
Brazilian Journal of Pharmaceutical Sciences , 2009, DOI: 10.1590/S1984-82502009000300007
Abstract: cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. the effect of 7β-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3β,5α,6β-triol,5,6β-epoxycholesterol, 5,6α-epoxycholesterol and 7α-hydroxycholesterol on esterification of cholesterol by lecithin:cholesterol acyl transferase (lcat, ec 2.3.1.43) and the transfer of esters of cholesterol oxides from high density lipoprotein (hdl) to low density lipoproteins (ldl) and very low density lipoproteins (vldl) by cholesteryl ester transfer protein (cetp) was investigated. hdl enriched with increasing concentrations of cholesterol oxides was incubated with fresh plasma as source of lcat. cholesterol and cholesterol oxides esterification was followed by measuring the consumption of respective free sterol and oxysterols. measurements of cholesterol and cholesterol oxides were done by gas-chromatography. 14c-cholesterol oxides were incorporated into hdl2 and hdl3 subfractions and then incubated with fresh plasma containing lcat and cetp. the transfer of cholesterol oxide esters was followed by measuring the 14c-cholesterol oxide-derived esters transferred to ldl and vldl. all the cholesterol oxides studied were esterified by lcat after incorporation into hdl particles, competing with cholesterol by lcat. cholesterol esterification by lcat was inversely related to the cholesterol oxide concentration. the esterification of 14c-cholesterol oxides was higher in hdl3 and the transfer of the derived esters was greater from hdl2 to ldl and vldl. the results suggest that cholesterol esterification by lcat is inhibited in cholesterol oxide-enriched hdl particles. moreover, the cholesterol oxides-derived esters are efficiently transferred to ldl and vldl. therefore, we suggest that cholesterol oxides may exert part of their atherogenic effect by inhibiting cholesterol esterification on the hdl surface and thereby disturbing reverse cholesterol tra
Optimization of biomass and astaxanthin production by the yeast Phaffia rhodozyma
Moriel, Danilo Gomes;Machado, Iara Maria Pereira;Fontana, José Domingos;Bonfim, Tania Maria Bordin;
Revista Brasileira de Ciências Farmacêuticas , 2004, DOI: 10.1590/S1516-93322004000300019
Abstract: the combination of fed-batch processes and low cost substrates (sugar cane juice and urea) was studied in view of the optimization of biomass and astaxanthin production by the yeast phaffia rhodozyma atcc 24202. in the optimized process, a biomass and astaxanthin productivity of 0.327 g/l/h and 0.124 mg/l/h was achieved, respectively. compared to the batch process studied, an increase of approximately 4.55-fold in the biomass productivity and 4.73-fold in the astaxanthin productivity was found.
Influência do fumo na atividade da amilase salivar e na curva glicêmica
Moriel, Patricia;Madureira, Hermes Lima;Uwagoya, áurea Kátia Yuuko;Wlian, Luana;Pincinato, Eder de Carvalho;
Revista de Nutri??o , 2010, DOI: 10.1590/S1415-52732010000400007
Abstract: objective: the objective of this study was to determine salivary amylase activity and its relationship with glycemia before and after smokers and nonsmokers ingested carbohydrates. since cigarette smoke reduces salivary amylase activity in vitro, it may affect dietary carbohydrate absorption. methods: twenty volunteers participated in this study, 10 smokers and 10 nonsmokers. samples of saliva were collected before and after the smokers had a cigarette and glycemia was determined before and after the ingestion of 72g of carbohydrates. glycemia was measured 0, 15, 30, 60 and 120 minutes after carbohydrate intake. salivary amylase activity was determined by commercial kits. glycemia was determined by a glucometer (accu-chek-roche). the paired t-test was used for the statistical analyses, done by the software sigmastat, with p<0.05. results: glycemia 15, 30, 60 and 90 minutes after carbohydrate intake rose 3.9%, 11.9%, 34.8% and 22.7% in nonsmokers and 4.9%, 6.5%, 13.8% and 9.7% in smokers, respectively. the peak glucose absorption in nonsmokers was 21.0% greater than in smokers. salivary amylase activity before and after eating was 75.0% smaller in smokers. conclusion: these results suggest that smoking inhibits amylase and has a negative impact on the digestion/absorption of carbohydrates, consequently in blood glucose levels, thereby reducing the amount of energy absorbed.
Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
PATRICIA MORIEL,FRIDA L PLAVNIK,MARIA T ZANELLA,MARCELO C BERTOLAMI
Biological Research , 2000,
Abstract: Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 4) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.
Influence of Soy Lecithin Administration on Hypercholesterolemia
Amouni Mohamed Mourad,Eder de Carvalho Pincinato,Priscila Gava Mazzola,Maricene Sabha,Patricia Moriel
Cholesterol , 2010, DOI: 10.1155/2010/824813
Abstract: Recent studies suggest that lecithin-rich diet can modify cholesterol homeostasis and hepatic lipoprotein metabolism. Considering the phytotherapeutic impact of lecithin, this work hypothesizes that lecithin administration in hypercholesterolemic patients may reduce cholesterol concentrations by increasing biliary secretion. Total cholesterol and LDL were evaluated after soy lecithin administration in hypercholesterolemic patients. One soy lecithin capsule (500?mg/RP-Sherer) was administrated daily. One-two months before the treatment beginning, blood samples were collected for total lipids and cholesterol fractions analysis. The results showed a reduction of 40.66% and 42.00% in total cholesterol and of 42.05% and 56.15% in LDL cholesterol after treatment for one and two months, respectively. A significant reduction in total cholesterol and LDL-cholesterol concentrations was observed during the first month of treatment, suggesting that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia. 1. Introduction Lipid metabolism studies include a vision for the lipoprotein structure, function, and a description of the lipid metabolism forms, indicating that the dyslipidemias are important risk factors in the context of cardiovascular disease and that appropriate intervention can have a significant impact on clinical treatment [1]. Atherosclerosis, the most serious cardiovascular disease, may affect individuals at an early age (20–29 years). One of the disease symptoms is greasy striations, and its evolution depends on several factors, such as heredity addition to the diet, stress, and aging resulting from vascular serious imbalances. The relationship between hypercholesterolemia and coronary atherosclerosis disease has been demonstrated in many clinical trials [2, 3]. Moreover, the reduction in the number of events and mortality or coronary disease, interruption, or even the decline in atherosclerotic disease by plasma cholesterol-lowering drugs has also been reported by numerous studies [4, 5]. One of dietary risk factors for dyslipidemias and atherogenesis is the deficiency in the antioxidant intake, such as selenium [6], vitamin E [7], in addition to the low consumption of unsaturated fats [8, 9] and fiber [10]. More recently, it has been suggested that antioxidant substances are capable of reversing endothelial dysfunction caused by hypercholesterolemia [11–13] and also reduce the number of coronary events [14], although their use in medical practice still needs more conclusive information. Considering
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