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Search Results: 1 - 10 of 39 matches for " MEGA SAFITHRI "
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Potency of Piper crocatum Decoction as an Antihiperglycemia in Rat Strain Sprague dawley
MEGA SAFITHRI,FARAH FAHMA
HAYATI Journal of Biosciences , 2008,
Abstract: Current researches for appropriate hypoglycemic agents focused on plants for traditional medicine. Traditionally in diabetic treatment, people used decoctions of Piper crocatum (Piperaceae). However, there is no phytochemical data of decoctions extract of P. crocatum. Hence, the aims of this study were to explore the phytochemical of P. crocatum decoctions and its antihyperglicemic activity. Fresh leaves of P. crocatum were boiled in water to obtain decoction and were examined phytochemical compounds by using Harbone assay. Antihyperglicemic activity of P. crocatum decoction extract was orally fed to alloxan induced diabetic rats. Results showed that P. crocatum decoction extract contained flavonoids, tanins, and alkaloids. Ten days of daily treatment of various doses decoction extract of P. crocatum led to reduce blood sugar level by 10-38% and prevent fall in body weight level by 5-52%. This result showed the same activity as Daonil treatment, which was the diabetic drug. Hence, this extract showed antihyperglicemic activity in alloxan-induced diabetic rats and increasing of their body weight.
The Comparative Ability of Antioxidant Activity of Piper crocatum in Inhibiting Fatty Acid Oxidation and Free Radical Scavenging
MUHAMMAD ALFARABI,MARIA BINTANG,SURYANI,MEGA SAFITHRI
HAYATI Journal of Biosciences , 2010,
Abstract: The excessive number of free radicals in human body could increase lipid peroxides and causes a variety of degenerative diseases. Piper crocatum is a plant containing natural chemicals that may have an antioxidant ability to inhibit fatty acid oxidation and reduce free radicals, however, there is no published scientific reports up to now. Therefore, the objective of this research is to study the ability of ethanol extract of P. crocatum as an antioxidant. The leaves of P. crocatum (25 g) were extracted with 100 ml of 70% ethanol. Antioxidant activity was measured by thiobarbituric acid method and compared with 2,2-diphenil-1-picryl hydrazyl method with α-tocopherol as the standard antioxidant. The results showed that the extract of 200 ppm inhibited fatty acids oxidation by 80.40% and IC50 for free radical scavenging was 85.82 ppm. There was no significant different (α = 0.05) inhibition of unsaturated fatty acids oxidation between the sample and α-tocopherol at 200 ppm. This study suggested that the leaves extract of P. crocatum has a potential natural antioxidant.
Toxicity Study of Antidiabetics Functional Drink of Piper crocatum and Cinnamomum burmannii
MEGA SAFITHRI,SEDARNAWATI YASNI,MARIA BINTANG,ANNA SETIADI RANTI
HAYATI Journal of Biosciences , 2012,
Abstract: Piper crocatum and Cinnamomum burmannii formulations is known to be a new diabetes functional drink. Thus, its toxicological profile needs to be studied. At present, the formulation was evaluated for the repeated dose toxicity study. The Sprague dawley albino rats were treated with P. crocatum and C. burmannii formulations (0, 630, 1260, and 1890 mg/kg) and administered orally for a period of 28 days in albino rats. The effects on body weight, food and water consumption, organ weight, hematology, clinical biochemistry as well as histology were studied. There were no significant differences in the body weight, organ weights and feeding habits between control and treated animals. Hematological analysis showed no marked differences in any of the parameters examined in either the control or treated groups. There were no significant changes that occurred in the blood chemistry analysis including glucose, cholesterol, triglycerides, creatinine, SGPT, and SGOT in experimental animals. Pathologically, neither gross abnormalities nor histopathological changes were observed. The formulation of P. crocatum and C. burmannii was found safe in repeated dose toxicity studies.
Antibacterial Activity of Garlic Extract Against some Pathogenic Animal Bacteria
M. Safithri,M. Bintang,M. Poeloengan
Media Peternakan , 2011,
Abstract: The antimicrobial activity of garlic extract against Gram-positive and Gram-negative bacterial isolates was well studied. However, reports on antibacterial activity of garlic extract against some pathogenic bacteria in animals in Indonesia, are still limited. Therefore, the aim of this study was to evaluate the antibacterial activity of water and ethanol extracts of garlic against Salmonella typhimurium in chickens, and Streptococcus agalactie, Escherichia coli, and Staphylococcus aureus causing mastitis in dairy cows in Indonesia. A filtrate of fresh garlic was used to determine the antibacterial activity against S. typhimurium at concentrations of 5%, 10%, 20%, 30%, and 40% w/v, whereas, the antibacterial activity of water and ethanol extracts was determined against S. agalactie, E. coli, and S. aureus at concentrations of 5%, 10%, 15%, 20%, and 25% w/v. Results showed that antibacterial activity of 30% garlic filtrate was equivalent to 10% tetracycline. Meanwhile, antibacterial activity of garlic aqueous extract on mastitis bacteria was better than that of the garlic ethanol extract. Aqueous extract of garlic at 20% had the same antibacterial activity as 0.01% ampicillin on mastitis bacteria. Filtrates of fresh garlic can be used to inhibit growth of S. typhimurium and mastitis bacteria.
Prática do espa?o, experiência do corpo: sennett e a cidade
Andrade, Marta Mega de;
Anais do Museu Paulista: História e Cultura Material , 1996, DOI: 10.1590/S0101-47141996000100020
Abstract: this essay focuses on richard sennett's flesh and stone. the body and the cify in western dvilization. it stresses some of lhe central questions in sennett's baok: the relationship between a global history and a local perspective; .uses" or .ways of doing" as ways of producing. although not sennett's main concern, implications of these questions in lhe field of material culture studies are investigated, especially the possibility of a discursive paradigm in the analysis of spatial practices and bodily experiences.
O espa?o funerário: comemora??es privadas e exposi??o pública das mulheres em Atenas (séculos VI-IV a.C.)
Andrade, Marta Mega de;
Revista Brasileira de História , 2011, DOI: 10.1590/S0102-01882011000100010
Abstract: this paper analyses the funerary celebrations of women in athens, focusing particularly on attic epigrams. it explores the thesis that funerary contexts, viewed as 'publicizing' and exposing spaces, highlight a positive relation of the polis community towards its women, by means of the valorization of question such as philia relationships and the recurring epic traditional eulogies, which formerly applied only to men. i seek to discuss this positivity, drawing on vernant's thesis of a strong connection between the public space and political identity, arguing that female presentation in funerary spaces can be conceived as one of the ways by which polis society represents its identity, moving beyond the restrictive frame of citizen values.
Including Extra Virgin Olive Oil May More Improve Glycemic Control despite Similar Weight Loss Compared to the Diet Recommended by the Prostate Cancer Foundation: A Randomized, Pilot Study  [PDF]
Mary M. Flynn, Jennifer Cunningham, Joseph Renzulli, Anthony Mega
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.810077
Abstract: Recommendations for prostate cancer treatment include weight loss, but the most efficacious diet has not been determined. Men on active surveillance or with untreated biochemical relapse consumed both the diet recommended by the Prostate Cancer Foundation (PCF) and a plant-based that included three tablespoons of extra virgin olive oil per day for 8 weeks of weight loss and improvement in some laboratory biomarkers with random assignment to the diet order. They then selected one of the diets for six months of follow-up. Thirty men started the protocol and 18 completed the 44 week study. Mean age: 66.6 ± 5.9 years; baseline body mass index: 30.9 ± 2.7 kg/m2. Weight loss was comparable between the diets after 8 weeks (PCF: 2.5% ± 3.1% v olive oil: 2.8% ± 3.7%; p = 0.86), but the diet that included olive oil resulted in lower insulin (PCF: 13.7 ± 7.0 mU/L v olive oil: 11.5 ± 4.4 mU/L; p = 0.02), glucose (PCF: 104.9 ± 9.9 mg/dl v 99.1 ± 9.6 mg/dl; p = 0.01), and HOMA-IR (PCF: 3.6 ± 2.1 v olive oil: 2.9 ± 1.2; p = 0.02). Thirteen of the 18 men choose the olive oil diet for six months of follow-up and weight loss and lab improvements were maintained. This pilot study indicates that both the PCF diet and the plant-based diet that included extra virgin olive oil can produce similar weight loss short-term. However, a plant-based diet that includes extra virgin olive may be more acceptable for long-term use, and produce better glycemic control.
Toward a dynamical model for prime numbers
Claudio Bonanno,Mirko S. Mega
Physics , 2003, DOI: 10.1016/S0960-0779(03)00433-8
Abstract: We show one possible dynamical approach to the study of the distribution of prime numbers. Our approach is based on two complexity methods, the Computable Information Content and the Entropy Information Gain, looking for analogies between the prime numbers and intermittency.
A Feirinha do Largo da Ordem como espa o público A Feirinha do Largo da Ordem como espa o comercial e lúdico em Curitiba
Virgilia Maria Serra,Alan Jose' Mega
Revista Espa?o Acadêmico , 2011,
Abstract: A Feirinha do Largo da Ordem, que se iniciou no centro histórico de Curitiba nos anos 70 como uma simples feira hippie, cresceu e se diversificou nos últimos quarenta anos. Atualmente, a Feirinha se transformou num centro de artesanatos ao ar livre, assim como também ponto de encontro para muitas pessoas que vêm comprar artesanatos, comer das comidas típicas, ouvir música ao vivo, ver mímicos, capoeira e outras dan as. A Feirinha do Largo da Ordem, que se iniciou no centro histórico de Curitiba nos anos 70 como uma simples feira hippie, cresceu e se diversificou nos últimos quarenta anos. Atualmente, a Feirinha se transformou num centro de artesanatos ao ar livre, assim como também ponto de encontro para muitas pessoas que vêm comprar artesanatos, comer das comidas típicas, ouvir música ao vivo, ver mímicos, capoeira e outras dan as.
The Impact of Multidisciplinary Care in a Large Volume Robot-Assisted Radical Prostatectomy Program: A Paradoxical Stage Migration toward More Aggressive Disease  [PDF]
Jospeh F. Renzulli II, Michael M. Maddox, Omar Nadeem, Simone Thavaseelan, Gyan Pareek, Anthony E. Mega
Open Journal of Internal Medicine (OJIM) , 2014, DOI: 10.4236/ojim.2014.44017
Abstract: Introduction: With the widespread use of robot-assisted radical prostatectomy (RARP), a stage migration to less aggressive prostate cancer (CaP) may be expected in pathological specimens due to over-treatment of low risk disease. It is unclear whether implementation of a multidisciplinary clinic (MDC) model would offset this phenomenon. We sought to analyze our database for possible stage migration in prostatectomy specimens in the setting of MDC. Methods: A total of 262 patients who underwent open prostatectomy (OP) from 2004 to 2006 and 757 patients who underwent RARP from 2007 to 2011 were identified from our prospective database. The implementation of MDC occurred concurrently at the time of RARP initiation. Demographic data, pathology, positive margin rates along with standard CaP reporting data were recorded. The two groups were compared with regards to percentage of cases stratified by Gleason grade. Results: The number of CaP cases managed at our institution increased considerably after the introduction of robotics and MDC. There was a significant decrease in the patients with Gleason 6 CaP undergoing RARP as compared with OP (p = 0.001). Additionally, RARP was performed on a significantly greater percentage of Gleason 7 disease (p < 0.001). When comparing pathological stage, there was a significant increase in the incidence of pT3 disease following RARP (p < 0.0001). Conclusions: The introduction of a MDC and minimally invasive radical prostatectomy did not result in an increased application of surgery for the treatment of low risk prostate cancer. This highlights the importance of MDC in a large volume RARP program.
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