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Search Results: 1 - 10 of 14015 matches for " MAHAVEER SINGH "
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Characterization of Driver Nodes of Anti-Stable Networks
Ram Niwash Mahia,Deepak Fulwani,Mahaveer Singh
Computer Science , 2014,
Abstract: A controllable network can be driven from any initial state to any desired state using driver nodes. A set of driver nodes to control a network is not unique. It is important to characterize these driver nodes and select the right driver nodes. The work discusses theory and algorithms to select driver node such that largest region of attraction can be obtained considering limited capacity of driver node and with unstable eigenvalues of adjacency matrix. A network which can be controllable using one driver node is considered. Nonuniqueness of driver node poses a challenge to select right driver node when multiple possibilities exist. The work addresses this issue.
PHYLOGENETIC SELECTION GUIDED SACCHAROMYCES CEREVISIAE S288C GLUCOSE FERMENTATION MODELING
ASHISH RUNTHALA,ANKITASH TULYANI,DHIRAJ SHARMA,MAHAVEER SINGH
International Journal of Bioinformatics Research , 2011,
Abstract: Fermentation products are indigenous to many civilizations, and they have been produced by industriessince a long time. Saccharomyces cerevisiae S288C (commonly known as baker's yeast) is the strain mainly usedin the Glucose based fermentation industries. We have seen the use of same yeast strain at different places withdifferent Phenotypic Constraints. The way to improve the adaptability of considered strain for desired phenotypicconditions, using smart selection of genes through cybernetic modeling is illustrated. Phylogenetic homologues forall S. cerevisiae S288c Glucose Fermentation pathway genes were screened to search evolutionarily relatedfunctional domains in other yeast strains like Saccharomyces cerevisiae YJM789, Candida glabrata CBS138,Kluyveromyces lactis NRRL Y-1140, Ashbya gossypii ATCC10895 etc., which are adapted naturally in different setof environment. We observed that Saccharomyces cerevisiae YJM789, Candida glabrata CBS138, Ashbyagossypii ATCC10895, Kluyveromyces lactis NRRL Y-1140 possess highly conserved functional domains, whichcan be carefully selected based on usage. This study aims at designing an algorithm to select and incorporateevolutionary homologues for genes of a considered strain, which mostly show sub-optimal performance in thedesired set of experimental constraints. Such a consideration of native microenvironment and evolutionarycloseness in the selection of functional homologues of the entire genetic set can thus be significantly fruitful.
EFFECT OF VARIOUS SUPER DISINTEGRANTS ON DRUG RELEASE OF ORALLY DISINTEGRATING TABLET
Mahaveer P. Khinchi
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: In present scenario Bronchial Asthma is a common respiration inflammatory disease. Salbutamol Sulphate is readily available in conventional tablet dosage form. These are not suitable for pediatric as well as geriatric patient because it is not easy to swallow during asthmatic attack. Hence it was decided to formulate orally disintegrating tablets of salbutamol sulphate by employing direct compression technique using directly compressible mannitol (pearlitol SD 200), micro crystalline cellulose (MCC), various concentration of super disintegrating agents like Ac-di-sol, Primojel, and Polyplasdone R- XL as 2%, 3%, 4%, and 5%. These formulations were evaluated for thickness, friability, weight uniformity, disintegration time, wetting time, and in-vitro dissolution study. All the Formulations has showed satisfactory the result i.e. disintegration was less than one minute and in-vitro release was within three minute thus ensure the immediate effect. The formulation A-4 and A-8 prepared by Ac-di-sol 5% and Polyplasdone R- XL 5% showed 100% drug release within two minute and three minute respectively while 100% drug release of marketed conventional tablet was found to be within twenty five minute. Which was much higher as compared to mouth dissolving tablet.
Clinical profile of psoriasis in Western Rajasthan: Study of 300 cases
Kalla G,Goyal Archana,Goyal Mahaveer
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract:
Novel molecular imaging platform for monitoring oncological kinases
Shyam Nyati, Brian D Ross, Alnawaz Rehemtulla, Mahaveer S Bhojani
Cancer Cell International , 2010, DOI: 10.1186/1475-2867-10-23
Abstract: Cell signaling is a mode of communication by which the intracellular information is conveyed from the site of instigation to the site of action. Recent advances in molecular profiling technologies such as microarrays and proteomics along with synergistic growth in the field of bio-informatics, have actuated our appreciation of signaling changes in patho-physiological conditions and led to identification of unique disease biomarkers [1-5]. For example growth factor such as EGFR or Her-2, may be considered as biomarkers in certain human cancers where they are amplified, overexpressed and/or mutated and immensely alter the downstream signaling [6-12]. Identification of such unique central regulators in the disease signaling has lead to development of targeted molecular drugs [6,12]. Although, number of these disease biomarkers have been identified and characterized, the true impact of these understandings will be felt only when applied to diagnosis, staging and treatment of patients. Currently, these innovative developments in understanding the role of biomarkers in human malignancy have minimally ameliorated clinical oncology. This is partly due to the fact that most of the efforts are focused on identifying biomarkers from cancer samples obtained by biopsy of tumors which provide a frozen snapshot of biomarkers at the time of sample retrieval and fail to provide any information on the dynamic changes within the malignancy and its milieu [13]. Therefore, concurrent innovations are needed for real time and non-invasive monitoring of biomarker and events they modulate in live cells or organisms [14].Molecular imaging is a recent area of investigation that attempt to develop suitable probes for noninvasive visual representation of biological processes at the cellular and molecular level in the whole organism and the modalities and instrumentation to support the visualization and quantification of these processes. This is an attempt to bridge the gap between discovery of
EFFECT OF MEDIA COMPOSITION AND CULTURE CONDITION ON PULLULANASE ENZYME FROM EXTREMOPHILE BACTERIAL SPECIES
Ramdas Malakar,Mahaveer Yadav,S. N. Malviya,Archna Tiwari
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i9.584
Abstract: Pullulanase is of great significant due to its wide area of potential application. Pullulanase is widely used in industries in the saccharification of starch. It converts starch into glucose and maltose which are used in the production of glucose syrup more efficiently. In this present study the enzyme was isolated by the extremophilic strains of Streptococci isolated from extreme conditions. Pullulanase enzyme 98 KDa was successfully produced and purified by the isolated strains. In this process to study enzyme activity the enzyme substrate reaction was performed based on various parameters temperature 50 °C, time 72 hours, and pH 6. As it is clearly stated after the detail analysis of all parameters that the pullulanase isolated in the present study is very stable and active at different parameters. The Pullulanase activity of Gel filtration column chromatography of precipitated protein by ammonium sulphate gave rise 130.66 IU pullulanase activity which was greater than the 0-30% (98.0 IU) and 70-90% (130.66 IU). And thus it can be used in various industrial processes where normal mesophilic enzymes cannot be applied.
PHARMACEUTICAL WASTE MANAGEMENT: A CHALLENGE TO MAKE ENVIRONMENT ECOFRIENDLY
Sharma Natasha,Agarwal Dilip,Khinchi Mahaveer,Gupta M.K.
International Journal of Research in Ayurveda and Pharmacy , 2010,
Abstract: The pharmaceutical industry has made progress over the past several years to minimizing use of reagents that are hazardous to the environment and by designing alternate synthesis pathways. It is anticipated that they will extend these principles to product design, through such measures as increasing therapeutic efficacy by enhancing delivery to the target site, thus minimizing dosage required. The industry should be encouraged to investigate expiration dates to establish a maximum shelf life for a drug product, to minimize wastage.Pharmaceutical pollution, all sectors involved in health care pharmaceutical developers and manufacturers, hospitals, individual physicians and all those involved in the health care system, law enforcement agencies, pharmacies, waste management agencies, consumers, environmental protection organizations, and governmental agency to participate in preventing pharmaceutical pollution. This powerful approach provides a comprehensive solution to an issue that has the potential to affect much of life on earth to make the environment eco friendly.
EVALUATION OF ANTIULCER ACTIVITY OF CASTOR OIL IN RATS
Rachhadiya Rakesh M.,Kabra Mahaveer Prasad,Shete Rajkumar V
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: To study the antiulcer activity of oil of Ricinus communis seed using different models of gastric ulceration in rats. Antiulcer activity of castor oil was studied in rats by administration of ethanol or aspirin or by pyloric ligation. Castor oil was administered in the dose of 500 mg/kg and 1000 mg/kg orally 30 min prior to ulcer induction. The antiulcer activity was assessed by determining and comparing the ulcer index in the test drug group with that of the ulcerated control group. Gastric total acid output and pepsin activity were estimated in the pylorus ligated rats. Ranitidine and Sucralfate were used as a reference drug. The ulcer index in the castor oil treated animals was found to be significantly less in all the models compared to ulcerated control animals. This antiulcer property was more prominent in animals in whom ulcers were induced by ethanol, aspirin and pyloric ligation. Ranitidine (30 mg/kg) produced a significant gastric ulcer protection when compared with the control group. The anti-ulcer activity of castor oil was however, less than that of ranitidine. Our results suggest that castor oil possesses significant antiulcer property which could be either due to cytoprotective action of the drug or by strengthening of gastric mucosa and thus enhancing mucosal defence.
Lesion Location in Depression Post Traumatic Brain Injury Using Magnetic Resonance Spectroscopy: Preliminary Results from a Pilot Study
Vani Rao,Jennifer Spiro,Mahaveer Degoankar,Alena Horská
The European Journal of Psychiatry , 2006,
Abstract: OBJECTIVE: To determine the metabolic status of the brain in post traumatic brain injury(TBI) depression using proton magnetic resonance spectroscopy (MRS). DESIGN: Case-control study including 5 TBI depressed subjects and 5 age matched non-TBI non-depressed controls. METHODS: Metabolic status was assessed using proton MRS. Ratios of N-acetylaspartate (NAA), choline (Cho) and total creatine (Cr) were calculated in frontal cortex, basal ganglia and thalamus. RESULTS: NAA/Cho or NAA/Cr ratios were significantly reduced in the TBI depressed group compared to controls in frontal cortex, basal ganglia and thalamus. CONCLUSION: Reduced levels of NAA in frontal regions, basal ganglia and thalamus in TBI depression suggest neuronal damage or dysfunction which may be a associated with the primary brain injury or with depressed mood.
Analysis of Vortex Motion in Porous Media  [PDF]
Beant Singh, Chanpreet Singh
Journal of Electronics Cooling and Thermal Control (JECTC) , 2012, DOI: 10.4236/jectc.2012.22003
Abstract: In vortex motion fluid moves in curve path and the stream lines are curved. When the fluid flows between curved stream line, the centrifugal forces are setup which is counter balanced by pressure forces acting in the radial direction. The vortex motion has two types of curved motion. The first type called free vortex type, the fluid moves due to its own natural effect but energy is not added to fluid when moving in curved path. The second type called forced vortex, in which energy is added to fluid. A two dimensional steady laminar free convective flow of viscous incompressible flow in porous media voids is considered. In this paper the motion of fluid is studied while moving in the porous media. It is studied that the motion of the fluid in the porous media is vortex motion at the low Reynolds’s number, where the motion is laminar motion and the fluid obeys the laws of vortex motion.
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