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Search Results: 1 - 10 of 27853 matches for " MA Sathar "
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Laws, regulations and guidelines of developed countries, developing countries in Africa, and BRICS regions pertaining to the use of human biological material (HBM) in research
MA Sathar, A Dhai
South African Journal of Bioethics and Law , 2012,
Abstract: Human biological material (HBM) is an invaluable resource in biomedical research. Although research ethics committees (RECs) are guided by international guidelines and frameworks, some RECs might not be fully informed about local ethical and regulatory requirements regarding the use, collection, storage, ownership, transfer and benefit-sharing of HBM in collaborative research.
Clinical and Immunological Markers of Dengue Progression in a Study Cohort from a Hyperendemic Area in Malaysia
Anusyah Rathakrishnan, Benjamin Klekamp, Seok Mui Wang, Thamil Vaani Komarasamy, Santha Kumari Natkunam, Jameela Sathar, Azliyati Azizan, Aurora Sanchez-Anguiano, Rishya Manikam, Shamala Devi Sekaran
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092021
Abstract: Background With its elusive pathogenesis, dengue imposes serious healthcare, economic and social burden on endemic countries. This study describes the clinical and immunological parameters of a dengue cohort in a Malaysian city, the first according to the WHO 2009 dengue classification. Methodology and Findings This longitudinal descriptive study was conducted in two Malaysian hospitals where patients aged 14 and above with clinical symptoms suggestive of dengue were recruited with informed consent. Among the 504 participants, 9.3% were classified as non-dengue, 12.7% without warning signs, 77.0% with warning signs and 1.0% with severe dengue based on clinical diagnosis. Of these, 37% were misdiagnosed as non-dengue, highlighting the importance of both clinical diagnosis and laboratory findings. Thrombocytopenia, prolonged clotting time, liver enzymes, ALT and AST served as good markers for dengue progression but could not distinguish between patients with and without warning signs. HLA-A*24 and -B*57 were positively associated with Chinese and Indians patients with warning signs, respectively, whereas A*03 may be protective in the Malays. HLA-A*33 was also positively associated in patients with warning signs when compared to those without. Dengue NS1, NS2A, NS4A and NS4B were found to be important T cell epitopes; however with no apparent difference between with and without warning signs patients. Distinction between the 2 groups of patients was also not observed in any of the cytokines analyzed; nevertheless, 12 were significantly differentially expressed at the different phases of illness. Conclusion The new dengue classification system has allowed more specific detection of dengue patients, however, none of the clinical parameters allowed distinction of patients with and without warning signs. While the HLA-A*33 may be predictive marker for development of warning signs; larger studies will be needed to support this findings.
Haematological Reference Intervals in a Multiethnic Population
Angeli Ambayya, Anselm Ting Su, Nadila Haryani Osman, Nik Rosnita Nik-Samsudin, Khadijah Khalid, Kian Meng Chang, Jameela Sathar, Jay Suriar Rajasuriar, Subramanian Yegappan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091968
Abstract: Introduction Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals. Methods Two thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders and three principal races were recruited through voluntary participation. FBC was performed on two analysers, Sysmex XE-5000 and Unicel DxH 800, in addition to blood smears and haemoglobin analysis. Serum ferritin, soluble transferrin receptor and C-reactive protein assays were performed in selected subjects. All parameters of qualified subjects were tested for normality followed by determination of reference intervals, measures of central tendency and dispersion along with point estimates for each subgroup. Results Complete data was available in 2440 subjects of whom 56% (907 women and 469 men) were included in reference interval calculation. Compared to other populations there were significant differences for haemoglobin, red blood cell count, platelet count and haematocrit in Malaysians. There were differences between men and women, and between younger and older men; unlike in other populations, haemoglobin was similar in younger and older women. However ethnicity and smoking had little impact. 70% of anemia in premenopausal women, 24% in postmenopausal women and 20% of males is attributable to iron deficiency. There was excellent correlation between Sysmex XE-5000 and Unicel DxH 800. Conclusion Our data confirms the importance of population specific haematological parameters and supports the need for local guidelines rather than adoption of generalised reference intervals and cut-offs.
The Equitable Total Chromatic Number of Some Join graphs  [PDF]
Gang MA, Ming MA
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.24B023
Abstract: A proper total-coloring of graph G is said to be?equitable if the number of elements (vertices and edges) in any?two color classes differ by at most one, which the required?minimum number of colors is called the equitable total chromatic?number. In this paper, we prove some theorems on equitable?total coloring and derive the equitable total chromatic numbers?of Pm V?Sn, Pm V?Fn and Pm V Wn.
Improvements and Generalizations of Stochastic Knapsack and Multi-Armed Bandit Approximation Algorithms: Full Version
Will Ma
Computer Science , 2013,
Abstract: The multi-armed bandit (MAB) problem features the classical tradeoff between exploration and exploitation. The input specifies several stochastic arms which evolve with each pull, and the goal is to maximize the expected reward after a fixed budget of pulls. The celebrated work of Gittins et al. [GGW89] presumes a condition on the arms called the martingale assumption. Recently, A. Gupta et al. obtained an LP-based 1/48-approximation for the problem with the martingale assumption removed [GKMR11]. We improve the algorithm to a 4/27-approximation, with simpler analysis. Our algorithm also generalizes to the case of MAB superprocesses with (stochastic) multi-period actions. This generalization captures the framework introduced by Guha and Munagala in [GM07a, GM07b], and yields new results for their budgeted learning problems. Also, we obtain a (1/2-eps)-approximation for the variant of MAB where preemption (playing an arm, switching to another arm, then coming back to the first arm) is not allowed. This contains the stochastic knapsack problem of Dean, Goemans, and Vondrak [DGV08] with correlated rewards, where we are given a knapsack of fixed size, a set of jobs each with a joint distribution for its size and reward, and the objective is to maximize expected reward before the knapsack size is exhausted. Our (1/2-eps)-approximation improves the 1/16 and 1/8 approximations of [GKMR11] for correlated stochastic knapsack with cancellation and no cancellation, respectively, providing the first tight algorithm for these problems that matches the integrality gap of 2. We sample probabilities from an exponential-sized dynamic programming solution, whose existence is guaranteed by an LP projection argument. We hope this technique can also be applied to other dynamic programming problems which can be projected down onto a small LP.
Liouville Type Theorems for Lichnerowicz Equations and Ginzburg-Landau Equation: Survey  [PDF]
Li Ma
Advances in Pure Mathematics (APM) , 2011, DOI: 10.4236/apm.2011.13022
Abstract: In this survey paper, we firstly review some existence aspects of Lichnerowicz equation and Ginzburg-Landau equations. We then discuss the uniform bounds for both equations in Rn. In the last part of this report, we consider the Liouville type theorems for Lichnerowicz equation and Ginzburg-Landau equations in Rn via two approaches from the use of maximum principle and the monotonicity formula
Simulation on SO2 and NOX Emission from Coal–Fired Power Plants in North-Eastern North America  [PDF]
Shuangchen Ma
Energy and Power Engineering (EPE) , 2010, DOI: 10.4236/epe.2010.23028
Abstract: MM5-SMOKE-CMAQ regional air quality modeling system was used to simulate pollutants emission from coal–fired power plants in North-Eastern North America. The effects of SO2 and NOX on air quality producing from coal-fired power plants in the summer of 2001 were analyzed. Simulations show the contributions of SO2 and NOX emission from coal-fired power plants using different scenarios, coal-fired power plants from US and Canada contribute 67.2% and 32.8% for total SO2 concentration, 17.6% and 6.0% for total NOX concentration in researched domain. Some control measures for coal-fired power plants were discussed. Further controls for the emissions of SO2 and NOX from coal-fired power plants are necessary to reduce the adverse environmental effects.
The Theory of Vector-Valued Function in Locally Convex Space  [PDF]
Lixin Ma
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.38133
Abstract: In this paper, the vector-valued regular functions are extended to the locally convex space. The residues theory of the functions in the locally convex space is achieved. Thereby the Cauchy theory and Cauchy integral formula are extended to the locally convex space.
Research of Extent of Well Control of Explored Reserves of Lithologic Deposit in Delta Front Area  [PDF]
Ma Dong
Advances in Materials Physics and Chemistry (AMPC) , 2012, DOI: 10.4236/ampc.2012.24B050
Abstract: Recently the explored reserves submitted in the oil field mainly situate at the end of deposit in delta front area. During the exploitation and production, problems mainly show on lithologic deposit, for example, reserves are low and difficulty of producing is huge. Based on results of sand body dissection of dense well network of developed oil deposit, and combined with explored reserves, this article researches a relation between extent of well control and reserves precision of explored reserves of lithologic deposit in delta front area by well diluted method. This article has significant influence on objectively understanding our unexploited reserves
Mystery of Modern Phillips Curve  [PDF]
Jinpeng Ma
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.38113
Abstract: The modern Phillips curve is about the relationship between inflation and unemployment and has been the center of a fierce debate in economics over fifty years. This paper reports empirical evidence that uncovers some of its mysteries. The rate of inflation and the unemployment rate are closely related to business cycles. What is of interest is that no two business cycles are exactly alike; however, all business cycles are essentially alike [1,2]. Each expansion is ended by a recession induced by adverse shocks. The U.S. economy suffers from adverse shocks all the time, but not every shock gives rise to a recession. Why do adverse shocks often induce a recession after an expansion that has lasted for a substantial duration? That is, why are double-dip recessions so rare? Here do we find important evidence in the Phillips curve that may help answer this question. We also discuss some issues related to the monetary policy and raise a few open questions about the relationship between unemployment and business cycles.
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