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Search Results: 1 - 10 of 436692 matches for " M. Y. Guan "
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Enhanced oral bioavailability of cyclosporine A by liposomes containing a bile salt
Guan P,Lu Y,Qi J,Niu M
International Journal of Nanomedicine , 2011,
Abstract: Peipei Guan1, Yi Lu1, Jianping Qi1, Mengmeng Niu1, Ruyue Lian1, Fuqiang Hu2, Wei Wu11School of Pharmacy, Fudan University, Shanghai, People's Republic of China; 2School of Pharmacy, Zhejiang University, Hangzhou, People's Republic of ChinaAbstract: The main purpose of this study was to evaluate liposomes containing a bile salt, sodium deoxycholate (SDC), as oral drug delivery systems to enhance the oral bioavailability of the poorly water-soluble and poorly permeable drug, cyclosporine A (CyA). Liposomes composed of soybean phosphatidylcholine (SPC) and SDC were prepared by a thin-film dispersion method followed by homogenization. Several properties of the liposomes including particle size, polydispersity index, and entrapment efficiency were characterized. The in vitro release of CyA from these liposomes was less than 5% at 12 hours as measured by a dynamic dialysis method. The pharmacokinetic results in rats showed improved absorption of CyA in SPC/SDC liposomes, compared with CyA-loaded conventional SPC/cholesterol (Chol) liposomes and microemulsion-based Sandimmune Neoral . The relative oral bioavailability of CyA-loaded SPC/SDC and SPC/Chol liposomes was 120.3% and 98.6%, respectively, with Sandimmun Neoral as the reference. The enhanced bioavailability of CyA was probably due to facilitated absorption by the liposomes containing SDC rather than improved release rate.Keywords: liposomes, bile salt, sodium deoxycholate, cyclosporine A, oral bioavailability
Magnetic ordering and quantum statistical effects in strongly repulsive Fermi-Fermi and Bose-Fermi mixtures
X. -W. Guan,M. T. Batchelor,J. -Y. Lee
Physics , 2008, DOI: 10.1103/PhysRevA.78.023621
Abstract: We investigate magnetic properties and statistical effects in 1D strongly repulsive two-component fermions and in a 1D mixture of strongly repulsive polarized fermions and bosons. Universality in the characteristics of phase transitions, magnetization and susceptibility in the presence of an external magnetic field $H$ are analyzed from the exact thermodynamic Bethe ansatz solution. We show explicitly that polarized fermions with a repulsive interaction have antiferromagnetic behavior at zero temperature. A universality class of linear field-dependent magnetization persists for weak and finite strong interaction. The system is fully polarized when the external field exceeds the critical value $H^F_c\approx \frac{8}{\gamma}E_F$, where $E_F$ is the Fermi energy and $\gamma$ is the dimensionless interaction strength. In contrast, the mixture of polarized fermions and bosons in an external field exhibits square-root field-dependent magnetization in the vicinities of H=0 and the critical value $H=H^M_c\approx \frac{16}{\gamma}E_F$. We find that a pure boson phase occurs in the absence of the external field, fully-polarized fermions and bosons coexist for $0
Yang-Yang method for the thermodynamics of one-dimensional multi-component interacting fermions
J. Y. Lee,X. W. Guan,M. T. Batchelor
Physics , 2010, DOI: 10.1088/1751-8113/44/16/165002
Abstract: Using Yang and Yang's particle-hole description, we present a thorough derivation of the thermodynamic Bethe ansatz equations for a general $SU(\kappa)$ fermionic system in one-dimension for both the repulsive and attractive regimes under the presence of an external magnetic field. These equations are derived from Sutherland's Bethe ansatz equations by using the spin-string hypothesis. The Bethe ansatz root patterns for the attractive case are discussed in detail. The relationship between the various phases of the magnetic phase diagrams and the external magnetic fields is given for the attractive case. We also give a quantitative description of the ground state energies for both strongly repulsive and strongly attractive regimes.
Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers
Guan M, Zhu QL, Liu Y, Bei YY, Gu ZL, Zhang XN, Zhang Q
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S30034
Abstract: ake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers Original Research (4421) Total Article Views Authors: Guan M, Zhu QL, Liu Y, Bei YY, Gu ZL, Zhang XN, Zhang Q Published Date April 2012 Volume 2012:7 Pages 1921 - 1930 DOI: http://dx.doi.org/10.2147/IJN.S30034 Received: 18 January 2012 Accepted: 11 February 2012 Published: 11 April 2012 Min Guan1, Qiao-Ling Zhu1, Yang Liu1, Yong-Yan Bei1, Zong-Lin Gu1, Xue-Nong Zhang1, Qiang Zhang2 1Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou, People's Republic of China; 2Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing, People's Republic of China Abstract: In this paper, novel liver-targeting nanoparticles (NPs), lactosyl-norcantharidin (Lac-NCTD)-associated N-trimethyl chitosan (TMC) NPs (Lac-NCTD-TMC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, and encapsulation efficiency of the nanoparticles were then investigated. The continuous line of heterogeneous human epithelial colorectal adenocarcinoma cells (Caco-2) cell monolayer model was used to study the transport mechanism of Lac-NCTD, and the effects of factors such as time, temperature, pH level, drug concentration, enhancers, and inhibitors. This model was also used to indicate the differences among Lac-NCTD, Lac-NCTD-associated chitosan NPs (Lac-NCTD-CS-NPs), and Lac-NCTD-TMC-NPs in the absorption and transportation of membranes. Drug concentration levels were measured using high-performance liquid chromatography. Active transport and paracellular transport were suggested to be both the primary and secondary mechanisms for Lac-NCTD absorption, respectively. Lac-NCTD uptake and absorption were not controlled by pH levels, but were positively correlated to uptake time, and negatively correlated to temperature. The basolateral to apical apparent permeability coefficients (Papps) were higher than those of the apical to basolateral values. The inhibitor of P-glycoprotein and the multidrug resistance-associated protein 2 significantly enhanced the uptake amount of Lac-NCTD. Compared with Lac-NCTD, Lac-NCTD-CS-NPs and Lac-NCTD-TMC-NPs significantly enhanced drug absorption. Additionally, the latter exhibited stronger action. Lac-NCTD-NPs could penetrate the plasma membrane of Caco-2 cells and translocate into the cytoplasm and even into the nucleus. Nanoparticles were uptaken into Caco-2 cells through the endocytosis pathway.
Enhanced oral bioavailability of cyclosporine A by liposomes containing a bile salt
Guan P, Lu Y, Qi J, Niu M, Lian R, Hu F, Wu W
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S19259
Abstract: hanced oral bioavailability of cyclosporine A by liposomes containing a bile salt Original Research (5349) Total Article Views Authors: Guan P, Lu Y, Qi J, Niu M, Lian R, Hu F, Wu W Published Date May 2011 Volume 2011:6 Pages 965 - 974 DOI: http://dx.doi.org/10.2147/IJN.S19259 Peipei Guan1, Yi Lu1, Jianping Qi1, Mengmeng Niu1, Ruyue Lian1, Fuqiang Hu2, Wei Wu1 1School of Pharmacy, Fudan University, Shanghai, People's Republic of China; 2School of Pharmacy, Zhejiang University, Hangzhou, People's Republic of China Abstract: The main purpose of this study was to evaluate liposomes containing a bile salt, sodium deoxycholate (SDC), as oral drug delivery systems to enhance the oral bioavailability of the poorly water-soluble and poorly permeable drug, cyclosporine A (CyA). Liposomes composed of soybean phosphatidylcholine (SPC) and SDC were prepared by a thin-film dispersion method followed by homogenization. Several properties of the liposomes including particle size, polydispersity index, and entrapment efficiency were characterized. The in vitro release of CyA from these liposomes was less than 5% at 12 hours as measured by a dynamic dialysis method. The pharmacokinetic results in rats showed improved absorption of CyA in SPC/SDC liposomes, compared with CyA-loaded conventional SPC/cholesterol (Chol) liposomes and microemulsion-based Sandimmune Neoral . The relative oral bioavailability of CyA-loaded SPC/SDC and SPC/Chol liposomes was 120.3% and 98.6%, respectively, with Sandimmun Neoral as the reference. The enhanced bioavailability of CyA was probably due to facilitated absorption by the liposomes containing SDC rather than improved release rate.
Universal Tomonaga-Luttinger liquid phases in one-dimensional strongly attractive SU(N) fermionic cold atoms
X. W. Guan,J. -Y. Lee,M. T. Batchelor,X. -G. Yin,S. Chen
Physics , 2009, DOI: 10.1103/PhysRevA.82.021606
Abstract: A simple set of algebraic equations is derived for the exact low-temperature thermodynamics of one-dimensional multi-component strongly attractive fermionic atoms with enlarged SU(N) spin symmetry and Zeeman splitting. Universal multi-component Tomonaga-Luttinger liquid (TLL) phases are thus determined. For linear Zeeman splitting, the physics of the gapless phase at low temperatures belongs to the universality class of a two-component asymmetric TLL corresponding to spin-neutral N-atom composites and spin-(N-1)/2 single atoms. The equation of states is also obtained to open up the study of multi-component TLL phases in 1D systems of N-component Fermi gases with population imbalance.
Unified description of pairing, trionic and quarteting states for one-dimensional SU(4) attractive fermions
X. W. Guan,M. T. Batchelor,C. Lee,J. Y. Lee
Physics , 2009, DOI: 10.1209/0295-5075/86/50003
Abstract: Paired states, trions and quarteting states in one-dimensional SU(4) attractive fermions are investigated via exact Bethe ansatz calculations. In particular, quantum phase transitions are identified and calculated from the quarteting phase into normal Fermi liquid, trionic states and spin-2 paired states which belong to the universality class of linear field-dependent magnetization in the vicinity of critical points. Moreover, unified exact results for the ground state energy, chemical potentials and complete phase diagrams for isospin $S=1/2, 1, 3/2$ attractive fermions with external fields are presented. Also identified are the magnetization plateaux of $m^z=M_s/3$ and $m^z=2M_s/3$, where $M_s$ is the magnetization saturation value. The universality of finite-size corrections and collective dispersion relations provides a further test ground for low energy effective field theory.
The asymptotic Bethe ansatz solution for one-dimensional SU(2) spinor bosons with finite range Gaussian interactions
J. Y. Lee,X. W. Guan,A. del Campo,M. T. Batchelor
Physics , 2011, DOI: 10.1103/PhysRevA.85.013629
Abstract: We propose a one-dimensional model of spinor bosons with SU(2) symmetry and a two-body finite range Gaussian interaction potential. We show that the model is exactly solvable when the width of the interaction potential is much smaller compared to the inter-particle separation. This model is then solved via the asymptotic Bethe ansatz technique. The ferromagnetic ground state energy and chemical potential are derived analytically. We also investigate the effects of a finite range potential on the density profiles through local density approximation. Finite range potentials are more likely to lead to quasi Bose-Einstein condensation than zero range potentials.
Magnetism of one-dimensional strongly repulsive spin-1 bosons with antiferromagnetic spin exchange interaction
J. Y. Lee,X. W. Guan,M. T. Batchelor,C. Lee
Physics , 2009, DOI: 10.1103/PhysRevA.80.063625
Abstract: We investigate magnetism and quantum phase transitions in a one-dimensional system of integrable spin-1 bosons with strongly repulsive density-density interaction and antiferromagnetic spin exchange interaction via the thermodynamic Bethe ansatz method. At zero temperature, the system exhibits three quantum phases: (i) a singlet phase of boson pairs when the external magnetic field $H$ is less than the lower critical field $H_{c1}$; (ii) a ferromagnetic phase of atoms in the hyperfine state $|F=1, m_{F}=1>$ when the external magnetic field exceeds the upper critical field $H_{c2}$; and (iii) a mixed phase of singlet pairs and unpaired atoms in the intermediate region $H_{c1}
Terahertz radiation by optical rectification in a hydrogen-bonded organic molecular ferroelectric crystal, 2-phenylmalondialdehyde
W. Guan,N. Kida,M. Sotome,Y. Kinoshita,R. Takeda,A. Inoue,S. Horiuchi,H. Okamoto
Physics , 2014, DOI: 10.7567/JJAP.53.09PD07
Abstract: Terahertz radiation by optical rectification has been observed at room temperature in a hydrogen-bonded organic molecular ferroelectric crystal, 2-phenyl malondialdehyde (PhMDA). The radiated electromagnetic wave consisted of a single-cycle terahertz pulse with a temporal width of $\sim$ 0.5 ps. The terahertz radiation amplitude divided by the sample thickness in PhMDA was nearly equivalent to that in a typical terahertz wave emitter ZnTe. This is attributable to a long coherence length in the range of 130 $\sim$ 800 $\mu$m for the terahertz radiation from PhMDA. We also discussed the possibility of PhMDA as a terahertz wave emitter in terms of the phase-matching condition.
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