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Search Results: 1 - 10 of 401151 matches for " M. Wi?cek "
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The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women
M. Holecki,J. Chudek,A. Wicek,M. Titz-Bober,J. Du?awa
International Journal of Endocrinology , 2011, DOI: 10.1155/2011/707126
Abstract: Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls. Serum parathyroid hormone, 25-hydroxyvitamin D3, CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were assessed. DXA of lumbar spine and femoral neck was performed to determine bone mineral density (BMD). Plasma iFGF-23 concentration was significantly higher in obese patients (by 42%) and correlated with age and BMD of proximal femur ( ; , resp.) but not with markers of bone turnover. However, serum phosphorus level in obese subjects was significantly lower. iFGF-23 concentration correlated significantly with body mass index ( ) and fat content ( ) in all study subjects. Moreover, a significant correlation between iFGF-23 and iPTH ( ) was found. No correlation between serum phosphorus or eGFR and plasma iFGF-23 and between eGFR and serum phosphorus was found. Elevated serum iFGF-23 concentration may partially explain lower phosphorus levels in the obese and seems not to reflect bone turnover. 1. Introduction Epidemiological studies have suggested a protective effect of obesity on postmenopausal bone loss [1]. In general, obesity in women is associated with lower risk of osteoporosis, which may be due to the beneficial effect of hyperestrogenemia [2]. The obese are characterized by calciotropic hormones disturbances, including lower 25-hydroxyvitamin-D3 (25-OH-D3) and higher parathyroid hormone (PTH) serum concentrations [3, 4], which increases along with the degree of obesity [5, 6]. Lower 25-OH-D3 levels in obese may be explained by decreased exposure to sunlight (limited mobility of some obese) [7], inhibited vitamin D hydroxylation in the liver [8], and probably excessive storage of vitamin D in adipose tissue [6]. The regulation of bone metabolism is complex including hormones and a long list of cytokines and growth factors. Recently, a new hormone involved in calcium-phosphate homeostasis was found—fibroblast growth factor-23 (FGF-23). FGF-23 is a 251-aminoacid residues protein that belongs to FGF family [9]. Fibroblast growth factors regulate the development of subcutaneous white adipose tissue (scWAT); however only five of them (FGF-1, 2, 7, 9 and 18) and not FGF-23 were identified in scWAT [10]. Osteocytes and osteoblast turned out to be the major physiological sources of FGF-23 [11–13]. FGF-23 regulates serum phosphate and 1,25(OH)2D3 levels by acting on the kidney and intestines. FGF-23 reduces serum phosphorus level by suppressing
Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1
Grzegorz Piecha,Jerzy Chudek,Andrzej Wicek
International Journal of Endocrinology , 2010, DOI: 10.1155/2010/928383
Abstract: Primary hyperparathyroidism may occur as a part of an inherited syndrome in a combination with pancreatic endocrine tumours and/or pituitary adenoma, which is classified as Multiple Endocrine Neoplasia type 1 (MEN-1). This syndrome is caused by a germline mutation in MEN-1 gene encoding a tumour-suppressor protein, menin. Primary hyperparathyroidism is the most frequent clinical presentation of MEN-1, which usually appears in the second decade of life as an asymptomatic hypercalcemia and progresses through the next decades. The most frequent clinical presentation of MEN-1-associated primary hyperparathyroidism is bone demineralisation and recurrent kidney stones rarely followed by chronic kidney disease. The aim of this paper is to present the pathomechanism, screening procedures, diagnosis, and management of primary hyperparathyroidism in the MEN-1 syndrome. It also summarises the recent advances in the pharmacological therapy with a new group of drugs—calcimimetics. 1. Introduction Primary hyperparathyroidism is rarely a part of multiple endocrine neoplasia type 1 (MEN-1) syndrome with familial occurrence. The genetic background of this syndrome offers a unique opportunity to review a pathomechanism of tumourigenesis that may be also operative in some sporadic tumours. The classic clinical manifestation of MEN-1 is a composition of parathyroid hyperplasia, pancreatic endocrine tumour, and pituitary adenoma [1]. All three tumours, however, do not develop in all affected patients during their life span. Therefore, the contemporary definition of MEN-1 is the coincidence of at least two of the above-mentioned tumours [1]. A diagnosis of familial MEN-1 requires, besides that, a first-degree relative with at least one of the three tumours [1]. In an autopsy series, prevalence of the MEN-1 syndrome was estimated at 2.2 per 1000 in the general population [2], but biochemical surveys suggested lower figures—0.01–0.175 per 1000 [3, 4]. In patients with primary hyperparathyroidism (HPT) approximately 1–5% is associated with the MEN-1 syndrome [3, 5]. Combining this data with HPT incidence, the prevalence of MEN-1 can be estimated to be 10–30 per 100,000 in the general population. In about 60% of MEN-1 patients enteropancreatic tumours are found. Most of them are small and nonsecreting. The most common hormonally active ones are insulinomas and gastrinomas. Opposite to parathyroid tumours MEN-1-associated gastrinomas are typically multiple, often malignant [6]. Moreover, it is important to stress that other enteropancreatic tumours usually accompany gastrinoma in
Analysis of the Relationship Between Fatness of Late Pregnant and Lactating Sows and Selected Lipid Parameters of Blood, Colostrum and Milk
Anna Rekiel , Justyna Wi cek , Karolina Beyga
Annals of Animal Science , 2011, DOI: 10.2478/v10220-011-0001-3
Abstract: This study determined the relationships between backfat thickness in sows on day 104 (±2) of pregnancy, changes in fatness between high pregnancy and lactation (day 21), the body weight of late pregnant sows, the level of selected lipid parameters in blood serum, and basic components and fatty acid profile of colostrum and milk. Backfat measurements were taken using an ultrasound device at the P1, P2, P3 and P4 sites and loin eye height was measured at the P4M site. In late pregnant sows, fatness measured at P1, P2, P3 and P4 and the mean of measurements taken at P2 and P4 were correlated with HDL (+0.491**, +0.537**, +0.439*, +0.483** and 0.529**, respectively). Measurements taken at P4 and the mean of P2 and P4 were correlated with cholesterol (CHOL, +0.367* and +0.372*, respectively). Correlations were also found between the level of fatness of pregnant sows (P2, P3, P4, (P2 + P4)/2) and the level of HDL at the end of lactation (+0.534**, +0.440*, +0.412* and +0.487**, respectively). The body weight of late pregnant sows was significantly correlated with the energy and fat levels in colostrum (-0.467** and -0.429*, respectively). In addition, it was correlated with the proportion of fatty acids in the profile (C18:2 +0.417*, C18:3 +0.493*). Correlations were observed between P1 backfat thickness and the proportion of colostrum fatty acids (C18:1 +0.483*, CLA +0.475*), and between P2 backfat thickness and the C20:4 content of milk (-0.421*). A relationship between backfat thickness measured at farrowing and the levels of selected fatty acids in colostrum was found for P2 and C18:3 (+0.471*), P3 and C18:0 (-0.608**), C18:2 (+0.463*) and C18:3 (+0.517*), and P4M and C16:1 (-0.513*). The greater the difference in P1 backfat thickness between late pregnancy and weaning, the higher the content of fat (+0.549**), energy (+0.510*), C18:0 (+0.493*) and CLA (+0.488*), and the lower the content of C14:0 (-0.512*) and C16:0 (-0.457*) in milk. The strong correlations of fatness in late pregnant sows and of changes in fatness during late pregnancy and weaning with some blood, colostrum and milk parameters suggest that sows should be evaluated for fatness during their productive life.
Uszkodzenie w troby w przebiegu mukowiscydozy
Sabina Wicek,Halina Wo?,Urszula Grzybowska-Chlebowczyk
Pediatria Wspó?czesna , 2012,
Abstract: Zmiany w trobowe w przebiegu mukowiscydozy to zespó z o onych interakcji procesów w óknienia, zapalenia, remodelingu, apoptozy oraz cholestazy. Nie uda o si dotychczas w pe ni wyja ni z o ono ci procesów maj cych miejsce w w trobie i drogach ó ciowych w przebiegu tej choroby. Pomimo e dotycz jedynie 5-20% pacjentów z rozpoznan mukowiscydoz , jednak e zwi kszaj miertelno , skracaj czas prze ycia i pogarszaj jako ycia. Celem pracy by a ocena czynników ryzyka, objawów klinicznych, metod diagnostycznych oraz stosowanego leczenia zmian w trobowych w przebiegu mukowiscydozy.
Hiperbilirubinemie czynno ciowe u dzieci
Sabina Wicek,Halina Wo?,Urszula Grzybowska-Chlebowczyk
Pediatria Wspó?czesna , 2011,
Abstract: Podwy szony poziom bilirubiny w surowicy krwi jest problemem, z którym cz sto spotyka si w codziennej praktyce lekarz rodzinny, pediatra oraz gastroenterolog. Mo e on wynika ze wzmo onej produkcji bilirubiny, zmniejszonego jej wychwytu przez komórk w trobow , zaburzonego sprz gania z kwasem glukuronowym czy te upo ledzonego wydzielania do ó ci. Celem pracy by a analiza przyczyn hiperbilirubinemii czynno ciowych u dzieci, przebieg kliniczny oraz ocena wspó czesnych mo liwo ci diagnostycznych i terapeutycznych.
Changes in bone mineral density and bone turnover markers in obese women after short -term weight loss therapy during a 5-year follow-up
Micha? Holecki,Barbara Zahorska -Markiewicz,Jerzy Chudek,Andrzej Wicek
Polish Archives of Internal Medicine , 2010,
Abstract: INTRODUCTION: The protective effect of adipocity on bone metabolism has not been confirmed during long-term follow-up. It is not known whether the rate of bone turnover and changes in mineral metabolism in obese people result from endocrine properties of the adipose tissue or merely the mechanical load. OBJECTIVES: The aim of the study was to evaluate bone and calcium-phosphorus metabolism in obese women during a 5-year follow-up. PATIENTS AND METHODS: The study involved 47 obese women who underwent a 3-month weight loss therapy. We evaluated changes in the serum levels of parathormone (PTH), calcidiol (25(OH)D3), collagen type I crosslinked C-telopeptide (CTx-I), osteocalcin, total calcium, inorganic phosphates, and in bone mineral density. The control group consisted of 17 healthy women with proper body weight. RESULTS: We observed a similar decrease in bone mineral density (BMD) in the lumbar spine and femoral neck, and a comparable decrease in the serum levels of CTx-I and osteocalcin in both groups during the 5-year follow-up. Changes in serum PTH levels were not statistically significant. In obese women, a nonsignificant increase in the serum level of 25(OH)D3 was observed as early as after a 3-month weight loss therapy and during follow-up. In controls, serum 25(OH)D3 levels tended to decrease. During follow-up, the number of obese patients with disturbances in vitamin D metabolism decreased from 78.7% to 53.2% (P = 0.01). Such disturbances were observed in 35.3% of the control group. In obese patients, there was a positive correlation between the change in body mass and BMD in the proximal femur (r = 0.279, P = 0.04). In controls, there was a positive correlation between the change in body mass and BMD in the lumbar spine (r = 0.477, P = 0.05). CONCLUSIONS: In obese women who underwent weight loss therapy, the levels of bone turnover markers decreased and abnormal vitamin D metabolism was still observed during the 5-year follow-up.
Zespó wi zad a ukowatego po rodkowego jako rzadka przyczyna zaburzeń motoryki o dka
Halina Wo?,Sabina Wicek,Joanna ?cieszka,Robert Skrabski
Polish Gastroenterology , 2004,
Abstract: Zespó wi zad a ukowatego po rodkowego (median arcuate ligament syndrome – MALS) jest schorzeniem rzadkim, a klinicznie charakteryzuje si wyst powaniem wymiotów, nudno ci oraz bólów brzucha w nast pstwie ucisku pnia trzewnego przez wi zad o ukowate po rodkowe. W patofizjologii tych objawów rozwa ane s teorie neurogenna oraz naczyniowa, ale adna z nich nie jest do końca udowodniona. Przedstawiamy przypadek 14-letniego ch opca, który zosta przyj ty do Kliniki Pediatrii ?l skiej AM w Katowicach z powodu bólów zlokalizowanych w nadbrzuszu, wymiotów, nudno ci oraz spadku masy cia a. Badanie endoskopowe górnego odcinka przewodu pokarmowego wykaza o rozleg e zmiany zapalne w obr bie b ony luzowej prze yku, o dka oraz zniekszta cenie od wiernika. W badaniu radiologicznym górnego odcinka przewodu pokarmowego z kontrastem stwierdzono bardzo du y o dek – cz dolna si ga a talerza biodrowego, jednak opró nianie o dka by o prawid owe. Badania elektrogastrograficzne oraz scyntygraficzne wykaza y znaczne zaburzenia czynno ciowe w obr bie górnego odcinka przewodu pokarmowego. Na podstawie badania dopplerowskiego jamy brzusznej (ró nica widma dopplerowskiego na wdechu i wydechu w obr bie pnia trzewnego) oraz angiotomografii u ch opca rozpoznano zespó wi zad a ukowatego po rodkowego. Po w czeniu leczenia farmakologicznego oraz dietetycznego obserwowano ust pienie dolegliwo ci. Równie kontrolne badanie endoskopowe nie wykaza o patologii. W chwili obecnej pacjent pozostaje pod opiek poradni gastroenterologicznej oraz chirurgicznej w celu ewentualnej kwalifikacji do leczenia operacyjnego. W przedstawionym doniesieniu chcemy zwróci uwag na rzadk przyczyn zaburzeń motoryki przewodu pokarmowego, jak jest zespó wi zad a ukowatego po rodkowego oraz na ogromn rol diagnostyczn badania dopplerowskiego jamy brzusznej w postawieniu ostatecznego rozpoznania.
Journal of Central European Agriculture , 2012, DOI: 10.5513/jcea01/12.4.980
Abstract: The aim of the study was to determine the effect of sows’ condition, being expressed as fat reserve – the mean from two measurements (P2 + P4)/2 on the 104th day of pregnancy (±2 – 3 days) on hematological indicators in blood of PLW x PL sows. Classification of sows into two groups was performed on the basis of lifetime evaluation of backfat thickness in 97 sows (primiparous: multiparous – 30%:70%); group I consisted of the sows with (P2 + P4)/2>20 mm and group II with (P2 + P4)/2≤20 mm. The condition of sows, as expressed by backfat thickness in three dates (late pregnancy, parturition, weaning) amounted to >3,5 for group I and ≤2.5 for group II on a 5-point scale. The examination of hematological indicators was performed on a representative group of 32 randomly chosen sows, 16 animals from each group. Blood for analyses was sampled from the sows on the 104th day of pregnancy and on the 21st day of lactation. Any significant differences between group I and II in respect of morphological indices, excluding significantly higher MCV in sows from group I vs. II on the 21st day of lactation (P≤0.05), were not found. In late pregnancy, significant differences were recorded for the content of ALB and TP (P≤0.05), BUN (P≤0.01), HDL (P≤0.001) and in final stage of lactation – HDL (P≤0.01) (higher in group I vs. II). The mean values of the studied blood indicators of the sows were found within the standards for the species, production group and stage of reproduction cycle, irrespectively of the condition of the females.
Morganella sp. rods – characteristics, infections, mechanisms of resistance to antibiotics
Patrycja Zalas-Wicek,Anna Michalska,Eugenia Gospodarek
Post?py Higieny i Medycyny Do?wiadczalnej , 2012,
Abstract: The Morganella genus is one member of the tribe Proteae, which also includes the genera Proteus and Providencia. These bacteria are commonly present in the environment.Morganella sp. rods are known to be a causative agent of opportunistic hospital infections, mainly urinary tract, wound and blood infections of severe and high mortality, even in cases of an appropriate antibiotic.These bacteria may produce many virulence factors, for example urease, hemolysins, LPS, adhesins and enzymes hydrolyzing and modifying antibiotics commonly used to treat infections.Understanding the diverse biological properties of these rods may be of importance in the development of effective methods of prevention and control of infections with their participation.
Accretion Events in Binary Systems: AZ Cas and VV Cep
C. Ga?an,M. Miko?ajewski,T. Tomov,M. Wicek,A. Majcher,P. Wychudzki,E. ?wierczyński,D. Kolev,T. Bro?ek,G. Maciejewski,S. Zo?a,M. Kurpińska-Winiarska,M. Winiarski,W. Og?oza,M. Dro?d?,J. Krzesiński
Physics , 2011,
Abstract: The sudden lengthening of orbital period of VV Cep eclipsing binary by about 1% was observed in the last epoch. The mass transfer and/or mass loss are most possible explanations of this event. The photometric behaviour of AZ Cas, the cousin of VV Cep, suggests that the accretion can occur and could be important in this system, too.
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