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Search Results: 1 - 10 of 527534 matches for " M. Serdar Kü?üko?lu "
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The odyssey of pulmonary hypertension
Cihangir Kaymaz,M. Serdar Kü?ükolu
Anadolu Kardiyoloji Dergisi , 2010,
Pulmonary hypertension: Great expectations
Cihangir Kaymaz,M. Serdar Kü?ükolu
Anadolu Kardiyoloji Dergisi , 2010,
Phosphodiesterase type 5 inhibitors in the treatment of pulmonary arterial hypertension
Kadriye K?l??kesmez,M. Serdar Kü?ükolu
Anadolu Kardiyoloji Dergisi , 2010,
Abstract: The pathology of pulmonary arterial hypertension (PAH) is characterized by vascular vasoconstriction, smooth muscle cell proliferation, and thrombosis. Experimental studies have shown the beneficial effect of phosphodiesterase type 5 (PDE-5) inhibitors on pulmonary vascular remodeling and vasodilatation. Randomized clinical trials in monotherapy or combination therapy have been conducted in PAH with sildenafil and tadalafil which significantly improve clinical status, exercise capacity and hemodynamics of PAH patients. Combination therapy of PDE-5 inhibitors with prostacyclin analogs and endothelin receptor antagonists may be helpful in management of PAH. The third PDE-5 inhibitor, vardenafil, is currently being investigated in PAH. Side effects are usually mild and transient and include headache, flushing, nasal congestion, digestive disorders, and myalgia.
Pulmonary hypertension: diagnosis and clinical classification
M. Serdar Kü?ükolu,Murat Ba?kurt
Anadolu Kardiyoloji Dergisi , 2010,
Abstract: Pulmonary hypertension (PH) is a complex disease with limiting the physical activity, life expectancy significantly and requires multidisciplinary approach. In recent years, a dramatic increase was observed in the understanding and management of the disease. The first clinical classification of PH was made in Evian (France) in 1973 and the last clinical classification of PH was made in Dana Point (USA) in 2008. Diagnosis and clinical classification of PH is discussed in this review.
Prostanoids in the treatment of pulmonary arterial hypertension
Murat Ba?kurt,M. Serdar Kü?ükolu
Anadolu Kardiyoloji Dergisi , 2010,
Abstract: Prostacyclin, endothelin-1, and nitric oxide pathways are involved in the pathogenesis of pulmonary arterial hypertension. This devastating disease of the pulmonary vasculature is associated with vasoconstriction, thrombosis and proliferation, and this may be partly due to lack of endogenous prostacyclin secondary to prostacyclin synthase downregulation. Prostanoids (prostacycin analogues) are potent vasodilators and possess antiaggregant, antiinflammatory and antiproliferative properties. The first agent to be approved for the treatment of pulmonary arterial hypertension was epoprostenol. In the last decade other prostanoids (treprostinil, iloprost) has been approved for the treatment of pulmonary arterial hypertension.
Expert panel on cost analysis of atrial fibrillation
Ali Serdar Fak,M. Serdar Kü?ükolu,Nazire Af?ar Fak,Mesut Demir
Anadolu Kardiyoloji Dergisi , 2013,
Abstract: Objective: To estimate total cost of atrial fibrillation (AF) management concerning acute coronary syndrome, heart failure, stroke and drug related adverse events with respect to clinical practice and available guidelines.Methods: This cost analysis study was based on identification of total costs related to management of acute coronary syndrome, heart failure, stroke and the drug related adverse events in patients with AF based on standardized questionnaire forms filled by experts according to their daily clinical practice and also to ACCF/AHA/ESC guidelines. Total cost included cost items related to treatment, healthcare resources utilization, and diagnostic test and consultations.Results: The yearly cost of acute coronary syndrome per patient was 5.478.43 TL according to expert’s view reflecting real clinical practice whereas it was 11.319.44 TL when calculation was based on recommendations in the guidelines. The average total cost of heart failure was 4.523.74 TL according to expert’s view whereas it was 2.925.86 TL based on guidelines. The average total cost of stroke was 5.719.25 TL according to expert’s view but 7.931.18 TL based on guidelines. Among drug related adverse events, only those related to cardiac adverse events were estimated to be higher according to expert view as compared to guideline recommendations (288.65 vs. 150.99 TL). Conclusions: Reflecting the treatment algorithms in the management of AF and related adverse events, our findings seem to emphasize the extra burden on health economics posed by patients suffering from the uncontrolled disease.
A normofunctioning caged-ball aortic valve prosthesis for 31 years
Murat Ba?kurt,Fatma Nihan Turhan,Bar?? ?k?ün,Serdar Kü?ükolu
Anadolu Kardiyoloji Dergisi , 2009,
Atypical Chest X-Ray Calcification in an Idiopathic Constrictive Pericarditis Case
U?ur Co?kun,?smail Polat Canbolat,ümit Ya?ar Sinan,Cem Bostan,Kadriye K?l??kesmez,Ahmet Y?ld?z,Murat Ba?kurt,Fatma Nihan Turhan ?a?lar,Alican Hatemi,Cenk Eray Y?ld?z,Sadettin C?hcen,Aziz Tevfik Gürmen,Mehmet Serdar Kü?ükolu
Case Reports in Cardiology , 2013, DOI: 10.1155/2013/609610
Abstract: Constrictive pericarditis is an uncommon cause of heart failure. It is a clinical entity caused by thickening, fibrosis, and/or calcification of the pericardium. We present a 50-year-old female patient who was admitted to our institution with a 6-month history of progressive dyspnea on exertion, abdominal swelling, and lower extremity edema. Her chest X-ray revealed an oblique linear calcification in the cardiac silhouette. Transthoracic echocardiography revealed biatrial enlargement. Left ventricular size and systolic function were normal. Cardiac computed tomography revealed the pericardial thickening (>5?mm) and heavy calcification in left atrioventricular groove. Simultaneous right and left heart catheterization showed elevation and equalization of right-sided and left-sided diastolic filling pressures, with characteristic dip, and plateau. Pericardiectomy was performed which revealed a thick, fibrous, calcified, and densely adherent pericardium constricting the heart. The postoperative period was uneventful and was in NYHA functional class I after 3 months. 1. Introduction Constrictive pericarditis (CP) is uncommon cause of heart failure. It is a clinical entity caused by thickening, fibrosis, and/or calcification of the pericardium. This entity often leads to impairment of diastolic filling, resulting predominantly in symptoms of right heart failure [1]. Currently, idiopathic or viral pericarditis is the predominant cause in the industrialized countries, followed by cardiac surgery and mediastinal irradiation, which are as well the major and increasing causes of CP in the industrialized countries [2–4]. Tuberculosis is still a common cause of CP in developing and underdeveloped countries, as well as in the immunosuppressed patients [5]. Modern series from Saudi Arabia, Mexico, Turkey, and India document tuberculosis in 38% to 83% of all cases of CP. Pericardial disease rarely presents as the initial manifestation of tuberculosis [6–9]. Although pericardial calcification on chest X-ray suggests constriction, it is not diagnostic but may lead to more detailed investigations. A pericardial thickness less than 2?mm is normal and greater than 6?mm in size is specific for constriction [10]. Cardiac CT and MRI can detect pericardial thickening and calcification with high accuracy [11]. Echocardiography and new Doppler techniques are very useful for differential diagnosis between CP and restrictive cardiomyopathy [12, 13]. The gold standard for diagnosis is cardiac catheterization with analysis of intracavitary pressure curves, which are high in end
The Situation of Consultation Practice in Pathology in Turkey
Alp USUBüTüN,Serdar BALCI,Kutsal Y?RüKOLU
Türk Patoloji Dergisi , 2012,
Abstract: Objective: There are some suggestions regarding the methods of consultation practice in the literature including which case will be consulted, to whom, by which transport means, the payment methods as well as the ethical issues. There are no standards for consultations in Turkey. The standardization committee of the Federation of Turkish Pathology Societies has conducted a survey to detect the current situation, determine the problematic aspects, compare the situation with international methods and offer methods specific to Turkey.Material and Method: A survey has been prepared to cover all the aspects of consultation practice using the literature and referring to the current methods used in Turkey. The survey has been announced on the internet and 83 replies were collected.Results: Multiple choice questions were evaluated in terms of percentages and open ended questions were grouped according to the answer contents. It was seen that problems could be grouped as follows: absence of written procedures covering each step, means of transport, reaching the consultant, payment, reporting and ethical issues. The absence of procedures and issues regarding the payment methods were the interfering factors for each step of consultation.Conclusion: There are many problematic issues in consultation practice in pathology in Turkey. The basis of these problems is the absence of written regulations for procedural and payment methods. Regulations addressing these issues should be developed.
Eoteuthoidae - a new family of Late Cretaceous dibranchiate cephalopods (Coleoidea, Decapoda, Teuthina?)
Ko??ák M
Bulletin of Geosciences , 2003, DOI: 10.3140/bull.geosci.2003.02.157
Abstract: On the basis of a uniquely preserved gladius of the Turonian coleoid cephalopod, the new genus Eoteuthoides Kostak, 2002, and the new family Eoteuthoidae fam. nov. are established. Designation of a new higher taxomomic unit is based on marked morphological differences from all known fossil taxa. Eoteuthoides shows strong affinities to some living families.
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