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Search Results: 1 - 10 of 401585 matches for " M. Rosenthal "
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Pediatric Ethics Guidelines for Hereditary Medullary Thyroid Cancer
M Rosenthal, Douglas S Diekema
International Journal of Pediatric Endocrinology , 2011, DOI: 10.1155/2011/847603
Abstract: Medullary thyroid cancer (MTC) is an uncommon type of aggressive thyroid cancer that does not respond to systemic radioactive iodine, an effective treatment for most other types of thyroid cancer. This cancer's aggressive biological behavior also diminishes the effectiveness of surgical therapy, and there is currently no standard effective chemotherapy for this cancer.The etiology of MTC is well documented in the literature; it may occur sporadically or present as part of an autosomal dominant inherited disorder. If inherited, MTC is 100% penetrant [1], although the age of onset is variable [1–5]. In 1993, germline mutations in the RET proto-oncogene were found to be responsible for hereditary MTC [3], allowing genetic testing to be used as the primary tool for detecting its presence in at-risk family members. We use the term hereditary medullary thyroid cancer to discuss both familial medullary thyroid cancer (FMTC) and medullary thyroid cancer arising from MEN 2 syndromes (MEN 2A and MEN 2B). In the general population, MTC accounts for 5%–8% percent of all thyroid cancers [6–8] and about 15% of all thyroid cancer-related deaths [6]. However, the published statistics on this type of cancer are based on narrow studies and a small literature; the true incidence and prevalence of MTC is likely much higher than what has been reported. According to 2009 SEER data available from the National Cancer Institute, we estimate the national incidence rate of MTC to be approximately 3000 new index cases per year, with a national prevalence of roughly 35,000. Since MTC can be either inherited (familial or hereditary) or not inherited (sporadic), it is also standard of care to offer all index patients genetic testing to rule out the genetic mutation for the inherited form. If an index patient decides not to get tested, he or she may unknowingly represent a large kindred comprising dozens, or hundreds, of at-risk individuals who may eventually die from this cancer because the oppor
Creating a Library Database Search using Drupal
Danielle M. Rosenthal,Mario Bernardo
Code4Lib Journal , 2010,
Abstract: When Florida Gulf Coast University Library was faced with having to replace its database locator, they needed to find a low-cost, non-staff intensive replacement for their 350 plus databases search tool. This article details the development of a library database locator, based on the methods described in Leo Klein’s “Creating a Library Database Page using Drupal” online presentation. The article describes how the library used Drupal along with several modules, such as CCK, Views, and FCKeditor. It also discusses various Drupal search modules that were evaluated during the process.
Modification to the Luminosity Distance Redshift Relation in Modified Gravity Theories
éanna é. Flanagan,Eran Rosenthal,Ira M. Wasserman
Physics , 2008, DOI: 10.1103/PhysRevD.79.044032
Abstract: We derive an expression for the luminosity distance as a function of redshift for a flat Robertson-Walker spacetime perturbed by arbitrary scalar perturbations possibly produced by a modified gravity theory with two different scalar perturbation potentials. Measurements of the luminosity distance as function of redshift provide a constraint on a combination of the scalar potentials and so they can complement weak lensing and other measurements in trying to distinguish among the various alternative theories of gravity.
Degree of the generalized Plücker embedding of a Quot scheme and Quantum cohomology
M. S. Ravi,J. Rosenthal,X. Wang
Physics , 1994,
Abstract: We compute the degree of the generalized Pl\"ucker embedding $\kappa$ of a Quot scheme $X$ over $\PP^1$. The space $X$ can also be considered as a compactification of the space of algebraic maps of a fixed degree from $\PP^1$ to the Grassmanian $\rm{Grass}(m,n)$. Then the degree of the embedded variety $\kappa (X)$ can be interpreted as an intersection product of pullbacks of cohomology classes from $\rm{Grass}(m,n)$ through the map $\psi$ that evaluates a map from $\PP^1$ at a point $x\in \PP^1$. We show that our formula for the degree verifies the formula for these intersection products predicted by physicists through Quantum cohomology~\cite{va92}~\cite{in91}~\cite{wi94}. We arrive at the degree by proving a version of the classical Pieri's formula on the variety $X$, using a cell decomposition of a space that lies in between $X$ and $\kappa (X)$.
Output Feedback Invariants
M. S. Ravi,Joachim Rosenthal,Uwe Helmke
Mathematics , 2000,
Abstract: The paper is concerned with the problem of determining a complete set of invariants for output feedback. Using tools from geometric invariant theory it is shown that there exists a quasi-projective variety whose points parameterize the output feedback orbits in a unique way. If the McMillan degree $n\geq mp$, the product of number of inputs and number of outputs, then it is shown that in the closure of every feedback orbit there is exactly one nondegenerate system.
An Indirect Cue of Predation Risk Counteracts Female Preference for Conspecifics in a Naturally Hybridizing Fish Xiphophorus birchmanni
Pamela M. Willis, Gil G. Rosenthal, Michael J. Ryan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034802
Abstract: Mate choice is context dependent, but the importance of current context to interspecific mating and hybridization is largely unexplored. An important influence on mate choice is predation risk. We investigated how variation in an indirect cue of predation risk, distance to shelter, influences mate choice in the swordtail Xiphophorus birchmanni, a species which sometimes hybridizes with X. malinche in the wild. We conducted mate choice experiments to determine whether females attend to the distance to shelter and whether this cue of predation risk can counteract female preference for conspecifics. Females were sensitive to shelter distance independent of male presence. When conspecific and heterospecific X. malinche males were in equally risky habitats (i.e., equally distant from shelter), females associated primarily with conspecifics, suggesting an innate preference for conspecifics. However, when heterospecific males were in less risky habitat (i.e., closer to shelter) than conspecific males, females no longer exhibited a preference, suggesting that females calibrate their mate choices in response to predation risk. Our findings illustrate the potential for hybridization to arise, not necessarily through reproductive “mistakes”, but as one of many potential outcomes of a context-dependent mate choice strategy.
Enzimas envolvidas na organifica??o tireoideana do iodo
Vaisman, Mário;Rosenthal, Doris;Carvalho, Denise P.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2004, DOI: 10.1590/S0004-27302004000100003
Abstract: thyroid hormone biosynthesis depends on iodide uptake and its incorporation into the acceptor protein thyroglobulin (tg), a high molecular weight protein secreted into the follicular lumen. the sodium-iodide symporter (nis) is responsible for thyroid iodide uptake, the first step in thyroid hormonogenesis. iodide is subsequently transported through the cellular membrane by pendrin (pds) and then incorporated into tg. iodide oxidation and organification occur mainly in the thyrocyte apical surface and these reactions are catalyzed by thyroperoxidase (tpo) in the presence of hydrogen peroxide. thus, thyroid iodide organification depends on tpo activity, which is modulated by the concentration of substrates (thyroglobulin and iodide) and cofactor (hydrogen peroxide). hydrogen peroxide generation is catalyzed by the thyroid nadph oxidase (thox), which is present in the apical pole of thyrocytes, is stimulated by thyrotropin and is inhibited by iodide. hydrogen peroxide generation is the limiting step in thyroid hormone biosynthesis under iodine sufficiency conditions.
Diffusion and growth of metal clusters in nanocomposites: a Kinetic Monte Carlo study
L. Rosenthal,A. Filinov,M. Bonitz,V. Zaporojtchenko,F. Faupel
Physics , 2011, DOI: 10.1002/ctpp.201010125
Abstract: Nobel metals that are deposited on a polymer surface exhibit surface diffusion and diffusion into the bulk. At the same time the metal atoms tend to form clusters because their cohesive energy is about two orders of magnitude higher than the cohesive energy of polymers. To selfconsistently simulate these coupled processes, we present in this paper a Kinetic Monte Carlo approach. Using a simple model with diffusion coefficients taken as input parameters allows us to perform a systematic study of the behavior of a large ensemble of metal atoms on a polymer surface eventually leading to polymer nanocomposites. Special emphasis is placed on the cluster growth, cluster size distribution and the penetration of clusters into the substrate. We also study the influence of surface defects and analyze how the properties of the resulting material can be controlled by variation of the deposition rate.
Evaluación metodológica de la relación entre presión arterial sanguinea y pliegue cutáneo: un enfoque epidemiológico
Revista de Saúde Pública , 1989, DOI: 10.1590/S0034-89101989000400008
Abstract: the empirical evidence concerning the relationship between blood pressure and anthropometric characteristics (triceps skinfold, adiposity, and arm circumference) was assessed by means of meta-analysis. different studies were evaluated critically for strength of design, methods and associations. it was found that the association between blood pressure and triceps skinfold holds for three different demographic categories. the question as to the independence of these associations remained unsolved. the effect of arm adiposity on the measurement of blood pressure was also discussed. recommendations are give in order to standardize blood pressure measurements in clinical and research settings.
Editorial:What is it like to be a peahen?
Gil Rosenthal
Current Zoology , 2013,
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