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Search Results: 1 - 10 of 401423 matches for " M. Ragul "
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Design of Transportation Robot and Ultrasonic Obstacle Detection with Wireless Monitoring
C. Sasikumar,P. Rakeshmalhotra,M. Ragul,D. Manivannan
Journal of Artificial Intelligence , 2013,
Abstract: Robot is an economical pilotless transportation in forest and industries for detecting obstacles and for monitoring to prevent damages of robot. Avoidance of obstacle is based on PIC microcontroller, Sensor and wireless techniques. The whole system can be made functional and deployed. It stops the robot when there is an obstacle and passes the information to the client about the barrier. The system is monitored through Groupe Special Mobile (GSM) and Radio frequency identification and detection (RFID). Vehicle navigation is carried out using RFID technology and ultrasonic sensor is used to detect the obstacle. If any obstacle is detected, the information is sent to the user through GSM. Battery power and overload is monitored to indicate the worker as well as to send information to main user through GSM. Embedded system helps to minimize human power, decreases power consumption and provides greater performance.
Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases
Anshuman Dixit,Lin Yi,Ragul Gowthaman,Ali Torkamani,Nicholas J. Schork,Gennady M. Verkhivker
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007485
Abstract: Protein kinases are the most common protein domains implicated in cancer, where somatically acquired mutations are known to be functionally linked to a variety of cancers. Resequencing studies of protein kinase coding regions have emphasized the importance of sequence and structure determinants of cancer-causing kinase mutations in understanding of the mutation-dependent activation process. We have developed an integrated bioinformatics resource, which consolidated and mapped all currently available information on genetic modifications in protein kinase genes with sequence, structure and functional data. The integration of diverse data types provided a convenient framework for kinome-wide study of sequence-based and structure-based signatures of cancer mutations. The database-driven analysis has revealed a differential enrichment of SNPs categories in functional regions of the kinase domain, demonstrating that a significant number of cancer mutations could fall at structurally equivalent positions (mutational hotspots) within the catalytic core. We have also found that structurally conserved mutational hotspots can be shared by multiple kinase genes and are often enriched by cancer driver mutations with high oncogenic activity. Structural modeling and energetic analysis of the mutational hotspots have suggested a common molecular mechanism of kinase activation by cancer mutations, and have allowed to reconcile the experimental data. According to a proposed mechanism, structural effect of kinase mutations with a high oncogenic potential may manifest in a significant destabilization of the autoinhibited kinase form, which is likely to drive tumorigenesis at some level. Structure-based functional annotation and prediction of cancer mutation effects in protein kinases can facilitate an understanding of the mutation-dependent activation process and inform experimental studies exploring molecular pathology of tumorigenesis.
Computational screening of inhibitors for HIV-1 integrase using a receptor based pharmacophore model
Janani Jaganatharaja,Ragul Gowthaman
Bioinformation , 2006,
Abstract: The HIV (human immuno-deficiency virus) integrase has a crucial role in viral replication. Moreover, it has no cellular homologue in humans. Hence, it is considered as an attractive drug target. Many inhibitors against the integrase protein has been designed and discussed. The Y-3 inhibitor (4-acetyl amino-5-hydroxy naphthalene - 2, 7- disulfonic acid) is already known to inhibit HIV-1 integrase. However, it is not suitable as a drug like candidate due to its high cyto-toxicity. In this report, a pharmacophore model for HIV integrase is described using the already known Y-3 inhibitor binding site. Fourteen compounds chemically related to the Y-3 inhibitor were generated using the described pharmacophore model and reported. Subsequent computational analysis showed that these compounds have interactions with the Y3 binding site and their possible utility as an integrase inhibitor is discussed.
Database of cell signaling enzymes
Ragul Gowthaman,Ramya Venugopal,Dhiviya Dayanandam
Bioinformation , 2006,
Abstract: This paper describes a database for cell signaling enzymes. Our web database offers methods to study, interpret and compare cell-signaling enzymes. Searching and retrieving data from this database has been made easy and user friendly and it is well integrated with other related databases. We believe the end user will be benefited from this database.
TeCK Database: A comprehensive collection of telomeric and centromeric sequences with their associated proteins
Ragul Gowthaman,Saranya Krishnamoorthy,Renuka Devi Nandakumar,Vishalini Ayyarappan
Bioinformation , 2007,
Abstract: Telomeres and centromere are two essential features of all eukaryotic chromosomes. Each provides unique function that is absolutely necessary for the stability of chromosomes. We developed a comprehensive database named TeCK, which covers a gamut of sequence and other related information about telomeric patterns, telomere repeat sequences, centromere sequences and centromeric patterns present in chromosomes. It also contains information about telomerase ribo-nucleoprotein complexes, centromere binding protein and centromere DNA-binding protein complexes. The database also includes a collection of all kinetochore-associated proteins including inner, outer and central kinetochore proteins. The database can be searched using a user-friendly web interface.
Database of neurodegenerative disorders
Ragul Gowthaman,Nithiyadevi Gowthaman,Madhan Kumar Rajangam,Kalyanaraman Srinivasan
Bioinformation , 2007,
Abstract: A neurological disorder is a disorder caused by the deterioration of certain nerve cells called neurons. Changes in these cells cause them to function abnormally, eventually bringing about their death. In this paper we present a comprehensive database for neurodegenerative diseases, a first-of-its kind covering all known or suspected genes, proteins, pathways related to neurodegenerative diseases. This dynamically compiled database allows researchers to link neurological disorders to the candidate genes & proteins. It serves as a tool to navigate potential gene-protein-pathway relationships in the context of neurodegenerative diseases. The neurodegenerative disorder database covers more then 100 disease concepts including synonyms and research topics. The current version of the database provides links to 728 abstracts and over 203 unique genes/proteins with 137 drugs. Also it is integrated well with other related databases. The aim of this database is to provide the researcher with a quick overview of potential links between genes and proteins with related neurodegenerative diseases. Thus DND providing a user-friendly interface is designed as a source to enhance research on neurodegenerative disorders.
Modeling of the Potential coiled-coil structure of Snapin protein and its interaction with SNARE complex
Ragul Gowthaman,A Johnwin Silvester,Saranya K.,Rathna Kanya K.S.
Bioinformation , 2006,
Abstract: Autism is a developmental disability causing learning and memory disorder. The heart of the search for a cure for this syndrome is the need to understand dendrite branch patterning, a process crucial for proper synaptic transmission. Due to the association of snapin with the SNARE complex and its role in synaptic transmission it is reported as a potential drug target for autism therapies. We wish to impart the noesis of the 3D structure of the snapin protein, and in this chase we predict the native structure from its sequence of amino acid residues using the classical Comparative protein structure modeling methods. The predicted protein model can be of great assistance in understanding the structural insights, which is necessary to understand the protein function. Understanding the interactions between snapin and SNARE complex is crucial in studying its role in the neurotransmitter release process. We also presented a computational model that shows the interaction between the snapin and SNAP-25 protein, a part of the larger SNARE complex.
Application of Wavelet Transform for the Detection and Minimization of Harmonics using Shunt Active Filter
Priyadharshini. A,Hans John D,Naresh. B Ragul.J,Swathy. S
International Journal of Advanced Electrical and Electronics Engineering , 2013,
Abstract: In the recent days the use of non linear loads have increased thereby creating distortions in voltage and current waveforms. These disturbances cause Harmonic distortions which cause reduction in power quality. Hence harmonic reduction becomes a necessary
Study of Duct Characteristics Deduced from Low Latitude Ground Observations of Day-Time Whistler at Jammu  [PDF]
M. Altaf, M. M. Ahmad
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.33032

Propagation characteristics of low latitude whistler duct characteristics have been investigated based on day-time measurements at Jammu. The morphogical characteristics of low latitude whistlers are discussed and compared with characteristics of middle and high latitude whistlers. The Max. electron density (Nm) at the height of the ionosphere obtained from whistler dispersion comes out to be higher than that of the background which is in accordance with the characteristics of whistler duct. The equivalent width is found to be close to the satellite observations and the characteristics of whistler duct in low latitude ionosphere are similar to those in middle and high latitude ionosphere. The width of ducts estimated from the diffuseness of the whistler track observed during magnetic storm is found to lie in the range of 50 - 200 Km.

Review Article: Immobilized Molecules Using Biomaterials and Nanobiotechnology  [PDF]
Magdy M. M. Elnashar
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2010, DOI: 10.4236/jbnb.2010.11008
Abstract: Immobilized molecules using biomaterials and nanobiotechnology is a very interesting topic that touching almost all aspects of our life. It uses the sciences of biology, chemistry, physics, materials engineering and computer science to develop instruments and products that are at the cutting edge of some of today’s most promising scientific frontiers. In this review article, the author based on his experience in this arena has tried to focus on some of the supports for im-mobilization; the most important molecules to be immobilized such as DNA, cells, enzymes, metals, polysaccharides, etc and their applications in medicine, food, drug, water treatment, energy and even in aerospace. He specified a special section on what is new in the arena of supports and technologies used in enzyme immobilization and finally a recommendation by the author for future work with a special attention to up-to-date references.
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