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Search Results: 1 - 10 of 401296 matches for " M. Pozzato "
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Fibronectin gene polymorphisms and clinical manifestations of mixed cryoglobulinemic syndrome: increased risk of lymphoma associated to MspI DD and HaeIII AA genotypes
M. Fabris,L. Quartuccio,V. De Re,G. Pozzato
Reumatismo , 2011, DOI: 10.4081/reumatismo.2008.28
Abstract: Objective: To analyse FN gene polymorphisms in type II mixed cryoglobulinemic syndrome (MCsn), an immune-complex mediated systemic vasculitis linked to hepatitis C virus (HCV) infection and characterized by rheumatoid factor (RF) positive B-cell proliferation at high risk for the progression into non Hodgkin’s lymphoma (NHL). Methods: Samples from eighty-one patients, with MCsn (type II serum cryoglobulins and clinical signs of vasculitis) were studied. Sixthy-five (65/81, 80.3%) patients were HCV-positive. Twenty-one (25.9%) patients had developed a B-cell NHL during the course of MCsn. Seventy-two patients with HCV-negative and MC-unrelated NHL and 110 healthy blood donors (HBDs) were taken as controls. HaeIIIb and MspI FN gene polymorphisms were analysed by PCR and specific restriction enzyme digestions, following reported procedures. Plasma FN levels were analysed by ELISA, whenever possible. Results: HaeIIIb and MspI allele and genotype frequencies did not differ between MCsn patients and HBDs. Of note, the DD-MspI (OR=5.56; CI=1.67-18.51, p=0.0046) and the AA-HaeIIIb (OR=5.54; CI=1.64-18.76, p=0.0066) homozygosis appeared significantly and independently associated with the development of B-cell NHL in MCsn patients, with the HaeIIIb A allele possibly conferring an increased risk of NHL in the general population (OR=1.72, CI=1.128- 2.635, p=0.0133). In contrast, the major vasculitic manifestations, such as peripheral neuropathy, skin ulcers and glomerulonephritis tended to be associated with the counterpart MspI C allele. No association between FN plasma levels and FN genotypes was found. Conclusion: Genotyping for MspI and HaeIIIb FN gene polymorphisms may be clinically relevant to define the predisposition to the major clinical manifestations in MCsn.
Oral Lesions and Lymphoproliferative Disorders
P. Castellarin,G. Pozzato,G. Tirelli,R. Di Lenarda,M. Biasotto
Journal of Oncology , 2010, DOI: 10.1155/2010/202305
Abstract: Lymphoproliferative disorders are heterogeneous malignancy characterized by the expansion of a lymphoid clone more or less differentiated. At the level of the oral cavity, the lymphoproliferative disorder can occur in various ways, most commonly as lymphoid lesions with extranodal externalization, but sometimes, oral lesions may represent a localization of a disease spread. With regard to the primary localizations of lymphoproliferative disorders, a careful examination of the head and neck, oral, and oropharyngeal area is necessary in order to identify suspicious lesions, and their early detection results in a better prognosis for the patient. Numerous complications have been described and frequently found at oral level, due to pathology or different therapeutic strategies. These complications require precise diagnosis and measures to oral health care. In all this, oral pathologists, as well as dental practitioners, have a central role in the treatment and long-term monitoring of these patients. 1. Introduction Under the name of lymphoproliferative disorders various disease patterns are included which are characterized by the expansion of a lymphoid clone more or less differentiated. The application in recent times, of immunological methods for determining the phenotype of many cell components, together with the acquisitions of cytogenetic and molecular biology, as well as clinical behavior, have helped to relatively define a wide range of diseases that may present a heterogeneous clinical and morphological picture. In fact, the last classification of lymphoproliferative disorders lists 40 types of lymphoproliferative syndromes to immunophenotype B and 23 to immunophenotype T [1]. At the level of the oral cavity, the lymphoproliferative disorder can occur in various ways, most commonly as lymphoid lesions with extranodal externalization, but sometimes, oral lesions may represent a localization of a disease spread [2]. Under the key research that sees lymphoproliferative disorders associated with injury or events at the oral cavity, the present paper proposes a comprehensive classification as listed in Table 1 and deeply described below. Table 1: Classification of the oral pathologies associated with lymphoproliferative disorders (see text for details). 2. Classification and Related Aspects of the Oral Pathologies Associated with Lymphoproliferative Disorders 2.1. Group 1: Primary Oral Lymphoproliferative Disorders Limited to the Oral Cavity that Will not Invade Other Body Districts Primary extranodal involvement can be seen in 10% to 35% of cases of
Global Functional Performance and Caregiver Assistance in Autism and Asperger Syndrome  [PDF]
Michele Gea Guimar?es Pozzato, Thais Soares Cianciarullo Minett, Marcelo Rodrigues Masruha, Luiz Celso Pereira Vilanova
Neuroscience & Medicine (NM) , 2014, DOI: 10.4236/nm.2014.51007
Abstract:

Autism and Asperger’s syndrome belong to a family of neuro-developmental disorders called Pervasive Development Disorders. The aims of this study were to 1) quantify the overall functional performance and need for caregiver assistance in autism (A) and Asperger’s syndrome (AS), 2) compare the findings between groups and to normative data from Brazilian children. Methods: A cross-sectional study was carried out involving 52 children between three and eight years of age diagnosed with either A (n = 26) or SA (n = 26). The Brazilian version of the Pediatric Evaluation of Disability Inventory was administered. Results: The children with A and AS achieved significantly lower scores than that expected for normality. The children with AS had a significantly better social function than that the children with A had. However, those with A achieved significantly better scores than those with AS on activities related to self-care and mobility, requiring less assistance. Conclusion: While patients with AS are better at social interaction than typical autistic children, they exhibit greater deficits with regard to basic tasks, such as self-care and mobility, requiring greater assistance than children with A.

A Sequent Calculus and a Theorem Prover for Standard Conditional Logics
Nicola Olivetti,Gian Luca Pozzato,Camilla Schwind
Computer Science , 2004,
Abstract: In this paper we present a cut-free sequent calculus, called SeqS, for some standard conditional logics, namely CK, CK+ID, CK+MP and CK+MP+ID. The calculus uses labels and transition formulas and can be used to prove decidability and space complexity bounds for the respective logics. We also present CondLean, a theorem prover for these logics implementing SeqS calculi written in SICStus Prolog.
A non-conventional neutrino beamline for the measurement of the electron neutrino cross section
A. Berra,S. Cecchini,F. Cindolo,C. Jollet,A. Longhin,L. Ludovici,G. Mandrioli,N. Mauri,A. Meregaglia,A. Paoloni,L. Pasqualini,L. Patrizii,F. Pupilli,M. Pozzato,M. Prest,G. Sirri,F. Terranova,E. Vallazza,L. Votano
Physics , 2015,
Abstract: Absolute neutrino cross section measurements at the GeV scale are ultimately limited by the knowledge of the initial $\nu$ flux. In order to evade such limitation and reach the accuracy that is needed for precision oscillation physics ($\sim 1$%), substantial advances in flux measurement techniques are requested. We discuss here the possibility of instrumenting the decay tunnel to identify large-angle positrons and monitor $\nu_e$ production from $K^+ \rightarrow e^+ \nu_e \pi^0$ decays. This non conventional technique opens up opportunities to measure the $\nu_e$ CC cross section at the per cent level in the energy range of interest for DUNE/HK. We discuss the progress in the simulation of the facility (beamline and instrumentation) and the ongoing R&D.
Hepatitis C virus and non-Hodgkin’s lymphoma: biology, epidemiology and therapy
Gabriele Pozzato,Francesca Zorat,Stefania Bonetto,Cesare Mazzaro
Oncology Reviews , 2011, DOI: 10.4081/40
Abstract: Although the association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin’s lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.
Analytic Tableaux Calculi for KLM Logics of Nonmonotonic Reasoning
Laura Giordano,Valentina Gliozzi,Nicola Olivetti,Gian Luca Pozzato
Computer Science , 2006,
Abstract: We present tableau calculi for some logics of nonmonotonic reasoning, as defined by Kraus, Lehmann and Magidor. We give a tableau proof procedure for all KLM logics, namely preferential, loop-cumulative, cumulative and rational logics. Our calculi are obtained by introducing suitable modalities to interpret conditional assertions. We provide a decision procedure for the logics considered, and we study their complexity.
On Rational Closure in Description Logics of Typicality
Laura Giordano,Valentina Gliozzi,Nicola Olivetti,Gian Luca Pozzato
Computer Science , 2013,
Abstract: We define the notion of rational closure in the context of Description Logics extended with a tipicality operator. We start from ALC+T, an extension of ALC with a typicality operator T: intuitively allowing to express concepts of the form T(C), meant to select the "most normal" instances of a concept C. The semantics we consider is based on rational model. But we further restrict the semantics to minimal models, that is to say, to models that minimise the rank of domain elements. We show that this semantics captures exactly a notion of rational closure which is a natural extension to Description Logics of Lehmann and Magidor's original one. We also extend the notion of rational closure to the Abox component. We provide an ExpTime algorithm for computing the rational closure of an Abox and we show that it is sound and complete with respect to the minimal model semantics.
Rational Closure in SHIQ
Laura Giordano,Valentina Gliozzi,Nicola Olivetti,Gian Luca Pozzato
Computer Science , 2014,
Abstract: We define a notion of rational closure for the logic SHIQ, which does not enjoys the finite model property, building on the notion of rational closure introduced by Lehmann and Magidor in [23]. We provide a semantic characterization of rational closure in SHIQ in terms of a preferential semantics, based on a finite rank characterization of minimal models. We show that the rational closure of a TBox can be computed in EXPTIME using entailment in SHIQ.
Apparent Prevalence of Beef Carcasses Contaminated with Mycobacterium avium subsp. paratuberculosis Sampled from Danish Slaughter Cattle
Hisako Okura,Nils Toft,Nicola Pozzato,Annalucia Tondo,S?ren Saxmose Nielsen
Veterinary Medicine International , 2011, DOI: 10.4061/2011/152687
Abstract: Presence of Mycobacterium avium subsp. paratuberculosis (MAP) in beef has been reported as a public health concern because asymptomatically infected cattle may contain MAP in tissues that are used for human consumption. Associations between MAP carcasses contamination and animal characteristics such as age, breed, production type, and carcass classification were assessed. Cheek muscles from 501 carcasses were sampled cross-sectionally at a Danish abattoir and tested for presence of viable MAP and MAP DNA by bacterial culture and IS900 realtime PCR, respectively. Cheek muscle tissues from carcasses of two dairy cows were positive by culture whereas 4% of the animals were estimated with ≥10?CFU/gram muscle based on realtime PCR. Age was found to be associated with carcass contamination with MAP. The observed viable MAP prevalence in beef carcasses was low. However, detection of MAP and MAP DNA in muscle tissues suggested that bacteremia occurred in slaughtered cattle. 1. Introduction Paratuberculosis is a chronic infection caused by Mycobacterium avium subsp. paratuberculosis (MAP) in cattle and other ruminants. MAP infection in cattle is often given attention due to its possible connection to Crohn’s disease (CD) in humans. CD is a chronic granulomatous ileocolitis, and patients with CD experience chronic weight loss, diarrhea, and chronic pain throughout their lives [1]. There is contradictory evidence that either support or dispute the association between MAP and CD [2, 3]. Human exposure to MAP from livestock could be via milk and meat products. For the latter, abattoirs are critical points to reduce MAP in meat and the risk of exposure to humans [4]. Infections in cattle occur primarily in calfhood, and may gradually progress to clinical disease after the incubation period, which ranges from a few months to the lifetime of an animal [5]. Although the exact time course is unclear, infected cattle may follow several stages corresponding to the changes that occur in histological and immune response such as establishment in intestines, cell-mediated immune responses, humoral immune reactions, and tissue destruction and bacteremia [6]. MAP in infected animals is primarily confined to the intestines and associated lymph nodes, but when the infection progresses, MAP is spread within the animal, although little is known about the timing and trigger mechanisms [7]. The infection prevalence of MAP at the slaughterhouse has been established, with previous studies reporting 16% and 1% in Danish dairy and nondairy cattle, respectively [8], 16% in culled dairy
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