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Search Results: 1 - 10 of 401174 matches for " M. Montuschi "
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Role of Leukotrienes and Leukotriene Modifiers in Asthma
Paolo Montuschi
Pharmaceuticals , 2010, DOI: 10.3390/ph3061792
Abstract: Leukotrienes (LTs), including cysteinyl LTs (CysLTs) and LTB 4, are potent lipid mediators that are pivotal in the pathophysiology of asthma phenotypes. At least two receptor subtypes for CysLTs – CysLT 1 and CysLT 2 – have been identified. Most of the pathophysiological effects of CysLTs in asthma, including increased airway smooth muscle activity, microvascular permeability and airway mucus secretion, are mediated by the activation of the CysLT 1 receptor. LTB 4 may have a role in the development of airway hyperresponsiveness, severe asthma and asthma exacerbations. Although generally less effective than inhaled glucocorticoids, CysLT 1 receptor antagonists can be given orally as monotherapy in patients with persistent mild asthma. In patients with more severe asthma, CysLT 1 receptor antagonists can be combined with inhaled glucocorticoids. This therapeutic strategy improves asthma control and enables the dose of inhaled glucocorticoids to be reduced, while maintaining similar efficacy. The identification of subgroups of patients with asthma who respond to CysLT 1 receptor antagonists is relevant for asthma management, as the response to these drugs is variable. The potential anti-remodeling effect of CysLT 1 receptor antagonists might be important for preventing or reversing airway structural changes in patients with asthma. This review discusses the role of LTs in asthma and the therapeutic implications of the pharmacological modulation of the LT pathway for asthma.
Toward a Personalized Pharmacotherapy of Respiratory Diseases
Paolo Montuschi
Frontiers in Pharmacology , 2010, DOI: 10.3389/fphar.2010.00131
Abstract:
Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children
Paolo Montuschi, Simona Martello, Marialinda Felli, Chiara Mondino, Peter J Barnes, Marcello Chiarotti
Respiratory Research , 2005, DOI: 10.1186/1465-9921-6-119
Abstract: Fifteen healthy children, 20 atopic nonasthmatic children, 25 steroid-na?ve atopic asthmatic children, and 22 atopic asthmatic children receiving inhaled corticosteroids were studied. The study design was of cross-sectional type. Exhaled LTB4 concentrations were measured using liquid chromatography/mass spectrometry-mass spectrometry (LC/MS/MS) with a triple quadrupole mass spectrometer. Exhaled NO was measured by chemiluminescence with a single breath on-line method. LTB4 values were expressed as the total amount (in pg) of eicosanoid expired in the 15-minute breath test. Kruskal-Wallis test was used to compare groups.Compared with healthy children [87.5 (82.5–102.5) pg, median and interquartile range], exhaled LTB4 was increased in steroid-na?ve atopic asthmatic [255.1 (175.0–314.7) pg, p < 0.001], but not in atopic nonasthmatic children [96.5 (87.3–102.5) pg, p = 0.59)]. Asthmatic children who were receiving inhaled corticosteroids had lower concentrations of exhaled LTB4 than steroid-na?ve asthmatics [125.0 (25.0–245.0) pg vs 255.1 (175.0–314.7) pg, p < 0.01, respectively]. Exhaled NO was higher in atopic nonasthmatic children [16.2 (13.5–22.4) ppb, p < 0.05] and, to a greater extent, in atopic steroid-na?ve asthmatic children [37.0 (31.7–57.6) ppb, p < 0.001] than in healthy children [8.3 (6.1–9.9) ppb]. Compared with steroid-na?ve asthmatic children, exhaled NO levels were reduced in asthmatic children who were receiving inhaled corticosteroids [15.9 (11.5–31.7) ppb, p < 0.01].In contrast to exhaled NO concentrations, exhaled LTB4 values are selectively elevated in steroid-na?ve atopic asthmatic children, but not in atopic nonasthmatic children. Although placebo control studies are warranted, inhaled corticosteroids seem to reduce exhaled LTB4 in asthmatic children. LC/MS/MS analysis of exhaled LTB4 might provide a non-invasive, sensitive, and quantitative method for airway inflammation assessment in asthmatic children.Chronic airway inflammation, the primary
A test of electric charge conservation with Borexino
Borexino Collaboration,M. Agostini,S. Appel,G. Bellini,J. Benziger,D. Bick,G. Bonfini,D. Bravo,B. Caccianiga,F. Calaprice,A. Caminata,P. Cavalcante,A. Chepurnov,D. D'Angelo,S. Davini,A. Derbin,L. Di Noto,I. Drachnev,A. Empl,A. Etenko,K. Fomenko,D. Franco,F. Gabriele,C. Galbiati,C. Ghiano,M. Giammarchi,M. Goeger-Neff,A. Goretti,M. Gromov,C. Hagner,E. Hungerford,Aldo Ianni,Andrea Ianni,K. Jedrzejczak,M. Kaiser,V. Kobychev,D. Korablev,G. Korga,D. Kryn,M. Laubenstein,B. Lehnert,E. Litvinovich,F. Lombardi,P. Lombardi,L. Ludhova,G. Lukyanchenko,I. Machulin,S. Manecki,W. Maneschg,S. Marcocci,E. Meroni,M. Meyer,L. Miramonti,M. Misiaszek,M. Montuschi,P. Mosteiro,V. Muratova,B. Neumair,L. Oberauer,M. Obolensky,F. Ortica,K. Otis,M. Pallavicini,L. Papp,L. Perasso,A. Pocar,G. Ranucci,A. Razeto,A. Re,A. Romani,R. Roncin,N. Rossi,S. Schoenert,D. Semenov,H. Simgen,M. Skorokhvatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,G. Testera,J. Thurn,M. Toropova,E. Unzhakov,A. Vishneva,R. B. Vogelaar,F. von Feilitzsch,H. Wang,S. Weinz,J. Winter,M. Wojcik,M. Wurm,Z. Yokley,O. Zaimidoroga,S. Zavatarelli,K. Zuber,G. Zuzel
Physics , 2015, DOI: 10.1103/PhysRevLett.115.231802
Abstract: Borexino is a liquid scintillation detector located deep underground at the Laboratori Nazionali del Gran Sasso (LNGS, Italy). Thanks to the unmatched radio-purity of the scintillator, and to the well understood detector response at low energy, a new limit on the stability of the electron for decay into a neutrino and a single mono-energetic photon was obtained. This new bound, tau > 6.6 10**28 yr at 90 % C.L., is two orders of magnitude better than the previous limit.
Spectroscopy of geo-neutrinos from 2056 days of Borexino data
Borexino collaboration,M. Agostini,S. Appel,G. Bellini,J. Benziger,D. Bick,G. Bonfini,D. Bravo,B. Caccianiga,F. Calaprice,A. Caminata,P. Cavalcante,A. Chepurnov,K. Choi,D. DAngelo,S. Davini,A. Derbin,L. Di Noto,I. Drachnev,A. Empl,A. Etenko,G. Fiorentini,K. Fomenko,D. Franco,F. Gabriele,C. Galbiati,C. Ghiano,M. Giammarchi,M. Goger-Neff,A. Goretti,M. Gromov,C. Hagner,E. Hungerford,Aldo Ianni,Andrea Ianni,K. Jedrzejczak,M. Kaiser,V. Kobychev,D. Korablev,G. Korga,D. Kryn,M. Laubenstein,B. Lehnert,E. Litvinovich,F. Lombardi,P. Lombardi,L. Ludhova,G. Lukyanchenko,I. Machulin,S. Manecki,W. Maneschg,F. Mantovani,S. Marcocci,E. Meroni,M. Meyer,L. Miramonti,M. Misiaszek,M. Montuschi,P. Mosteiro,V. Muratova,L. Oberauer,M. Obolensky,F. Ortica,K. Otis,L. Pagani,M. Pallavicini,L. Papp,L. Perasso,S. Perasso,A. Pocar,G. Ranucci,A. Razeto,A. Re,B. Ricci,A. Romani,R. Roncin,N. Rossi,S. Schoenert,D. Semenov,H. Simgen,M. Skorokhavatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,G. Testera,J. Thurn,M. Toropova,E. Unzhakov,R. B. Vogelaar,F. von Feilitzsch,H. Wang,S. Weinz,J. Winter,M. Woicik,M. Wurm,Z. Yokley,O. Zaimidoroga,S. Zavatarelli,K. Zuber,G. Zuzel
Statistics , 2015, DOI: 10.1103/PhysRevD.92.031101
Abstract: We report an improved geo-neutrino measurement with Borexino from 2056 days of data taking. The present exposure is $(5.5\pm0.3)\times10^{31}$ proton$\times$yr. Assuming a chondritic Th/U mass ratio of 3.9, we obtain $23.7 ^{+6.5}_{-5.7} (stat) ^{+0.9}_{-0.6} (sys)$ geo-neutrino events. The null observation of geo-neutrinos with Borexino alone has a probability of $3.6 \times 10^{-9}$ (5.9$\sigma$). A geo-neutrino signal from the mantle is obtained at 98\% C.L. The radiogenic heat production for U and Th from the present best-fit result is restricted to the range 23-36 TW, taking into account the uncertainty on the distribution of heat producing elements inside the Earth.
Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun
P. Mosteiro,G. Bellini,J. Benziger,D. Bick,G. Bonfini,D. Bravo,B. Caccianiga,L. Cadonati,F. Calaprice,A. Caminata,P. Cavalcante,A. Chavarria,A. Chepurnov,D. D'Angelo,S. Davini,A. Derbin,A. Empl,A. Etenko,K. Fomenko,D. Franco,F. Gabriele,C. Galbiati,S. Gazzana,C. Ghiano,M. Giammarchi,M. Goeger-Neff,A. Goretti,M. Gromov,C. Hagner,E. Hungerford,Al. Ianni,An. Ianni,V. Kobychev,D. Korablev,G. Korga,D. Kryn,M. Laubenstein,B. Lehnert,T. Lewke,E. Litvinovich,F. Lombardi,P. Lombardi,L. Ludhova,G. Lukyanchenko,I. Machulin,S. Manecki,W. Maneschg,S. Marcocci,Q. Meindl,E. Meroni,M. Meyer,L. Miramonti,M. Misiaszek,M. Montuschi,V. Muratova,L. Oberauer,M. Obolensky,F. Ortica,K. Otis,M. Pallavicini,L. Papp,L. Perasso,A. Pocar,G. Ranucci,A. Razeto,A. Re,A. Romani,N. Rossi,R. Saldanha,C. Salvo,S. Schoenert,H. Simgen,M. Skorokhvatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,G. Testera,D. Vignaud,R. B. Vogelaar,F. von Feilitzsch,H. Wang,J. Winter,M. Wojcik,A. Wright,M. Wurm,O. Zaimidoroga,S. Zavatarelli,K. Zuber,G. Zuzel
Physics , 2015, DOI: 10.1016/j.nuclphysbps.2015.06.023
Abstract: The Sun is fueled by a series of nuclear reactions that produce the energy that makes it shine. The primary reaction is the fusion of two protons into a deuteron, a positron and a neutrino. These neutrinos constitute the vast majority of neutrinos reaching Earth, providing us with key information about what goes on at the core of our star. Several experiments have now confirmed the observation of neutrino oscillations by detecting neutrinos from secondary nuclear processes in the Sun; this is the first direct spectral measurement of the neutrinos from the keystone proton-proton fusion. This observation is a crucial step towards the completion of the spectroscopy of pp-chain neutrinos, as well as further validation of the LMA-MSW model of neutrino oscillations.
Light Yield in DarkSide-10: a Prototype Two-phase Liquid Argon TPC for Dark Matter Searches
T. Alexander,D. Alton,K. Arisaka,H. O. Back,P. Beltrame,J. Benziger,G. Bonfini,A. Brigatti,J. Brodsky,L. Cadonati,F. Calaprice,A. Candela,H. Cao,P. Cavalcante,A. Chavarria,A. Chepurnov,D. Cline,A. G. Cocco,C. Condon,D. D'Angelo,S. Davini,E. De Haas,A. Derbin,G. Di Pietro,I. Dratchnev,D. Durben,A. Empl,A. Etenko,A. Fan,G. Fiorillo,K. Fomenko,F. Gabriele,C. Galbiati,S. Gazzana,C. Ghag,C. Ghiano,A. Goretti,L. Grandi,M. Gromov,M. Guan,C. Guo,G. Guray,E. V. Hungerford,Al. Ianni,An. Ianni,A. Kayunov,K. Keeter,C. Kendziora,S. Kidner,V. Kobychev,G. Koh,D. Korablev,G. Korga,E. Shields,P. Li,B. Loer,P. Lombardi,C. Love,L. Ludhova,L. Lukyanchenko,A. Lund,K. Lung,Y. Ma,I. Machulin,J. Maricic,C. J. Martoff,Y. Meng,E. Meroni,P. D. Meyers,T. Mohayai,D. Montanari,M. Montuschi,P. Mosteiro,B. Mount,V. Muratova,A. Nelson,A. Nemtzow,N. Nurakhov,M. Orsini,F. Ortica,M. Pallavicini,E. Pantic,S. Parmeggiano,R. Parsells,N. Pelliccia,L. Perasso,F. Perfetto,L. Pinsky,A. Pocar,S. Pordes,G. Ranucci,A. Razeto,A. Romani,N. Rossi,P. Saggese,R. Saldanha,C. Salvo,W. Sands,M. Seigar,D. Semenov,M. Skorokhvatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,J. Tatarowicz,G. Testera,A. Teymourian,J. Thompson,E. Unzhakov,R. B. Vogelaar,H. Wang,S. Westerdale,M. Wojcik,A. Wright,J. Xu,C. Yang,S. Zavatarelli,M. Zehfus,W. Zhong,G. Zuzel
Physics , 2012, DOI: 10.1016/j.astropartphys.2013.08.004
Abstract: As part of the DarkSide program of direct dark matter searches using liquid argon TPCs, a prototype detector with an active volume containing 10 kg of liquid argon, DarkSide-10, was built and operated underground in the Gran Sasso National Laboratory in Italy. A critically important parameter for such devices is the scintillation light yield, as photon statistics limits the rejection of electron-recoil backgrounds by pulse shape discrimination. We have measured the light yield of DarkSide-10 using the readily-identifiable full-absorption peaks from gamma ray sources combined with single-photoelectron calibrations using low-occupancy laser pulses. For gamma lines of energies in the range 122-1275 keV, we get consistent light yields averaging 8.887+-0.003(stat)+-0.444(sys) p.e./keVee. With additional purification, the light yield measured at 511 keV increased to 9.142+-0.006(stat) p.e./keVee.
The veto system of the DarkSide-50 experiment
The DarkSide Collaboration,P. Agnes,L. Agostino,I. F. M. Albuquerque,T. Alexander,A. K. Alton,K. Arisaka,H. O. Back,B. Baldin,K. Biery,G. Bonfini,M. Bossa,B. Bottino,A. Brigatti,J. Brodsky,F. Budano,S. Bussino,M. Cadeddu,L. Cadonati,M. Cadoni,F. Calaprice,N. Canci,A. Candela,H. Cao,M. Cariello,M. Carlini,S. Catalanotti,P. Cavalcante,A. Chepurnov,A. G. Cocco,G. Covone,L. Crippa,D. D'Angelo,M. D'Incecco,S. Davini,S. De Cecco,M. De Deo,M. De Vincenzi,A. Derbin,A. Devoto,F. Di Eusanio,G. Di Pietro,E. Edkins,A. Empl,A. Fan,G. Fiorillo,K. Fomenko,G. Foster,D. Franco,F. Gabriele,C. Galbiati,C. Giganti,A. M. Goretti,F. Granato,L. Grandi,M. Gromov,M. Guan,Y. Guardincerri,B. R. Hackett,K. R. Herner,E. V. Hungerford,Aldo Ianni,Andrea Ianni,I. James,T. Johnson,C. Jollet,K. Keeter,C. L. Kendziora,V. Kobychev,G. Koh,D. Korablev,G. Korga,A. Kubankin,X. Li,M. Lissia,P. Lombardi,S. Luitz,Y. Ma,I. N. Machulin,A. Mandarano,S. M. Mari,J. Maricic,L. Marini,C. J. Martoff,A. Meregaglia,P. D. Meyers,T. Miletic,R. Milincic,D. Montanari,A. Monte,M. Montuschi,M. E. Monzani,P. Mosteiro,B. J. Mount,V. N. Muratova,P. Musico,J. Napolitano,A. Nelson,S. Odrowski,M. Orsini,F. Ortica,L. Pagani,M. Pallavicini,E. Pantic,S. Parmeggiano,K. Pelczar,N. Pelliccia,S. Perasso,A. Pocar,S. Pordes,D. A. Pugachev,H. Qian,K. Randle,G. Ranucci,A. Razeto,B. Reinhold,A. L. Renshaw,A. Romani,B. Rossi,N. Rossi,S. D. Rountree,D. Sablone,P. Saggese,R. Saldanha,W. Sands,S. Sangiorgio,C. Savarese,E. Segreto,D. A. Semenov,E. Shields
Physics , 2015,
Abstract: Nuclear recoil events produced by neutron scatters form one of the most important classes of background in WIMP direct detection experiments, as they may produce nuclear recoils that look exactly like WIMP interactions. In DarkSide-50, we both actively suppress and measure the rate of neutron-induced background events using our neutron veto, composed of a boron-loaded liquid scintillator detector within a water Cherenkov detector. This paper is devoted to the description of the neutron veto system of DarkSide-50, including the detector structure, the fundamentals of event reconstruction and data analysis, and basic performance parameters.
Low radioactivity argon dark matter search results from the DarkSide-50 experiment
The DarkSide Collaboration,P. Agnes,L. Agostino,I. F. M. Albuquerque,T. Alexander,A. K. Alton,K. Arisaka,H. O. Back,B. Baldin,K. Biery,G. Bonfini,M. Bossa,B. Bottino,A. Brigatti,J. Brodsky,F. Budano,S. Bussino,M. Cadeddu,L. Cadonati,M. Cadoni,F. Calaprice,N. Canci,A. Candela,H. Cao,M. Cariello,M. Carlini,S. Catalanotti,P. Cavalcante,A. Chepurnov,A. G. Cocco,G. Covone,L. Crippa,D. D'Angelo,M. D'Incecco,S. Davini,S. De Cecco,M. De Deo,M. De Vincenzi,A. Derbin,A. Devoto,F. Di Eusanio,G. Di Pietro,E. Edkins,A. Empl,A. Fan,G. Fiorillo,K. Fomenko,G. Forster,D. Franco,F. Gabriele,C. Galbiati,C. Giganti,A. M. Goretti,F. Granato,L. Grandi,M. Gromov,M. Guan,Y. Guardincerri,B. R. Hackett,K. Herner,E. V. Hungerford,Al. Ianni,An. Ianni,I. James,C. Jollet,K. Keeter,C. L. Kendziora,V. Kobychev,G. Koh,D. Korablev,G. Korga,A. Kubankin,X. Li,M. Lissia,P. Lombardi,S. Luitz,Y. Ma,I. N. Machulin,A. Mandarano,S. M. Mari,J. Maricic,L. Marini,C. J. Martoff,A. Meregaglia,P. D. Meyers,T. Miletic,R. Milincic,D. Montanari,A. Monte,M. Montuschi,M. Monzani,P. Mosteiro,B. J. Mount,V. N. Muratova,P. Musico,J. Napolitano,A. Nelson,S. Odrowski,M. Orsini,F. Ortica,L. Pagani,M. Pallavicini,E. Pantic,S. Parmeggiano,K. Pelczar,N. Pelliccia,S. Perasso,A. Pocar,S. Pordes,D. A. Pugachev,H. Qian,K. Randle,G. Ranucci,A. Razeto,B. Reinhold,A. L. Renshaw,A. Romani,B. Rossi,N. Rossi,D. Rountree,D. Sablone,P. Saggese,R. Saldanha,W. Sands,S. Sangiorgio,C. Savarese,E. Segreto,D. A. Semenov,E. Shields,P. N. Singh
Physics , 2015,
Abstract: The DarkSide-50 dark matter search reports the first results obtained using a target of low-radioactivity argon extracted from underground sources. The experiment is located at the Laboratori Nazionali del Gran Sasso and uses a two-phase time projection chamber as a detector. A total of 155 kg of low radioactivity argon has been obtained, and we have determined that underground argon is depleted in Ar-39 by a factor (1.4 +- 0.2) x 10^3 relative to atmospheric argon. The underground argon is also found to contain (2.05 +- 0.13) mBq/kg of Kr-85. We find no evidence for dark matter in the form of WIMPs in 70.9 live-days of data with a fiducial mass of (36.9 +- 0.6) kg. When combined with our preceding search with an atmospheric argon target, we set a 90 % C.L. upper limit on the WIMP-nucleon spin-independent cross section of 2.0 x 10^-44 cm^2 (8.6 x 10^-44 cm^2, 8.0 x 10^-43 cm^2) for a WIMP mass of 100 GeV/c^2 (1 TeV/c^2 , 10 TeV/c^2).
The Electronics and Data Acquisition System of the DarkSide Dark Matter Search
The DarkSide Collaboration,P. Agnes,T. Alexander,A. Alton,K. Arisaka,H. O. Back,B. Baldin,K. Biery,G. Bonfini,M. Bossa,A. Brigatti,J. Brodsky,F. Budano,L. Cadonati,F. Calaprice,N. Canci,A. Candela,H. Cao,M. Cariello,P. Cavalcante,A. Chavarria,A. Chepurnov,A. G. Cocco,L. Crippa,D. D'Angelo,M. D'Incecco,S. Davini,M. De Deo,A. Derbin,A. Devoto,F. Di Eusanio,G. Di Pieto,E. Edkins,A. Empl,A. Fan,G. Fiorillo,K. Fomenko,G. Forster,D. Franco,F. Gabriele,C. Galbiati,A. Goretti,L. Grandi,M. Gromov,M. Y. Guan,Y. Guardincerri,B. Hackett,K. Herner,E. Hungerford,Al. Ianni,An. Ianni,C. Jollet,K. Keeter,C. Kendziora,S. Kidner,V. Kobychev,G. Koh,D. Korablev,G. Korga,A. Kurlej,P. X. Li,B. Loer,P. Lombardi,C. Love,L. Ludhova,S. Luitz,Y. Q. Ma,I. Machulin,A. Mandarano,S. M. Mari,J. Maricic,L. Marini,J. Martoff,A. Meregaglia,E. Meroni,P. D. Meyers,R. Milincic,D. Montanari,M. Montuschi,M. E. Monzani,P. Mosteiro,B. Mount,V. Muratova,P. Musico,A. Nelson,S. Odrowski,M. Okounkoa,M. Orsini,F. Ortica,L. Pagani,M. Pallavicini,E. Pantic,L. Papp,S. Parmeggiano,Bob Parsells,K. Pelczar,N. Pelliccia,S. Perasso,A. Pocar,S. Pordes,D. Pugachev,H. Qian,K. Randle,G. Ranucci,A. Razeto,B. Reinhold,A. Renshaw,A. Romani,B. Rossi,N. Rossi,S. D. Rountree,D. Sablone,P. Saggese,R. Saldanha,W. Sands,S. Sangiorgio,E. Segreto,D. Semenov,E. Shields,M. Skorokhvatov,O. Smirnov,A. Sotnikov,C. Stanford,Suvorov,R. Tartaglia,J. Tatarowicz,G. Testera,A. Tonazzo,E. Unzhakov,R. B. Vogelaar,M. Wada,S. E. Walker,H. Wang,Y. Wang
Physics , 2014,
Abstract: It is generally inferred from astronomical measurements that Dark Matter (DM) comprises approximately 27\% of the energy-density of the universe. If DM is a subatomic particle, a possible candidate is a Weakly Interacting Massive Particle (WIMP), and the DarkSide-50 (DS) experiment is a direct search for evidence of WIMP-nuclear collisions. DS is located underground at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, and consists of three active, embedded components; an outer water veto (CTF), a liquid scintillator veto (LSV), and a liquid argon (LAr) time projection chamber (TPC). This paper describes the data acquisition and electronic systems of the DS detectors, designed to detect the residual ionization from such collisions.
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