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Search Results: 1 - 10 of 401304 matches for " M. Mayle "
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Exploiting the composite character of Rydberg atoms for cold atom trapping
M. Mayle,I. Lesanovsky,P. Schmelcher
Physics , 2009, DOI: 10.1103/PhysRevA.79.041403
Abstract: By investigating the quantum properties of magnetically trapped nS Rydberg atoms, it is demonstrated that the composite nature of Rydberg atoms significantly alters their trapping properties opposed to point-like particles with the same magnetic moment. We show how the specific signatures of the Rydberg trapping potential can be probed by means of ground state atoms that are off-resonantly coupled to the Rydberg state via a two photon laser transition. In addition, it is demonstrated how this approach provides new possibilities for generating traps for ground state atoms. Simulated time-of-flight pictures mirroring the experimental situation are provided.
Constraints on Dirac Neutrinos from SN 1987A
R. Mayle,D. N. Schramm,M. S. Turner,J. Wilson
Physics , 1993, DOI: 10.1016/0370-2693(93)91580-G
Abstract: The Livermore Supernova Explosion Code was used to calculate the effect of a massive Dirac neutrino on neutrino emission from SN 1987A in a fully self-consistent manner. Spin-flip interactions lead to the copious emission of sterile, right-handed neutrinos and cool the core faster than the observed neutrino emission time for Dirac masses exceeding about 3$\,$keV. This limit is relaxed to $7\,$keV if pion emission processes in the core are neglected. These limits are compared with the previous less stringent limits of Burrows et al.
Creating versatile atom traps by applying near resonant laser light in magnetic traps
S. Middelkamp,M. Mayle,I. Lesanovsky,P. Schmelcher
Physics , 2010, DOI: 10.1103/PhysRevA.81.053414
Abstract: We utilize the combination of two standard trapping techniques, a magnetic trap and an optical trap in a Raman setup, to propose a versatile and tunable trap for cold atoms. The created potential provides several advantages over conventional trapping potentials. One can easily convert the type of the trap, e.g., from a single well to a double well trap. Atoms in different internal states can be trapped in different trap types, thereby enabling the realization of experiments with multi-component Bose-Einstein condensates. Moreover, one can achieve variations of the trapping potential on small length scales without the need of microstructures. We present the potential surfaces for different setups, demonstrate their tunability, give a semi-analytical expression for the potential, and propose experiments which can be realized within such a trap.
Electric field control in ultralong-range triatomic polar Rydberg molecules
M. Mayle,S. T. Rittenhouse,P. Schmelcher,H. R. Sadeghpour
Physics , 2012,
Abstract: We explore the external electric field control of a species of ultralong-range molecules that emerge from the interaction of a ground state polar molecule with a Rydberg atom. The external field mixes the Rydberg electronic states and therefore strongly alters the electric field seen by the polar diatomic molecule due to the Rydberg electron. As a consequence, the adiabatic potential energy curves responsible for the molecular binding can be tuned in such a way that an intersection with neighboring curves occurs. The latter leads to admixture of s-wave character in the Rydberg wave function and will substantially facilitate the experimental preparation and realization of this particular class of Rydberg molecule species.
Ultralong-range polyatomic Rydberg molecules formed by a polar perturber
Seth T. Rittenhouse,M. Mayle,P. Schmelcher,H. R. Sadeghpour
Physics , 2011, DOI: 10.1088/0953-4075/44/18/184005
Abstract: The internal electric field of a Rydberg atom electron can bind a polar molecule to form a giant ultralong-range stable polyatomic molecule. Such molecules not only share their properties with Rydberg atoms, they possess huge permanent electric dipole moments and in addition allow for coherent control of the polar molecule orientation. In this work, we include additional Rydberg manifolds which couple to the nearly degenerate set of Rydberg states employed in [S. T. Rittenhouse and H. R. Sadeghpour, Phys. Rev. Lett. 104, 243002 (2010)]. The coupling of a set of $(n+3)s$ Rydberg states with the $n(l>2)$ nearly degenerate Rydberg manifolds in alkali metal atoms leads to pronounced avoided crossings in the Born-Oppenheimer potentials. Ultimately, these avoided crossings enable the formation of the giant polyatomic Rydberg molecules with standard two-photon laser photoassociation techniques.
Comparative study of the rovibrational properties of heteronuclear alkali dimers in electric fields
R. Gonzalez-Ferez,M. Mayle,P. Sanchez-Moreno,P. Schmelcher
Physics , 2008, DOI: 10.1209/0295-5075/83/43001
Abstract: A comparative study of the effect of a static homogeneous electric field on the rovibrational spectra of several polar dimers in their $\textrm{X}^1\Sigma^+$ electronic ground state is performed. Focusing upon the rotational ground state within each vibrational band, results for energies and various expectation values are presented. For moderate field strengths the electric field-induced energy shifts, orientation, alignment, and angular motion hybridization are analyzed up to high vibrational excitations close to the dissociation threshold.
überresonant Scattering of Ultracold Molecules
Michael Mayle,Goulven Quéméner,Brandon P. Ruzic,John L. Bohn
Physics , 2012,
Abstract: Compared to purely atomic collisions, ultracold molecular collisions potentially support a much larger number of Fano-Feshbach resonances due to the enormous number of ro-vibrational states available. In fact, for alkali-metal dimers we find that the resulting density of resonances cannot be resolved at all, even on the sub-$\mu$K temperature scale of ultracold experiments. As a result, all observables become averaged over many resonances and can effectively be described by simpler, non-resonant scattering calculations. Two particular examples are discussed: non-chemically reactive RbCs and chemically reactive KRb. In the former case, the formation of a long-lived collision complex may lead to the ejection of molecules from a trap. In the latter case, chemical reactions broaden the resonances so much that they become unobservable.
A review of Holocene rainforest ecotonal dynamics at opposite ends of the Amazon – Bolivia versus Colombia
F. E. Mayle
Geographica Helvetica (GH) , 2012,
Abstract: No abstract available.
Epcam, CD44, and CD49f Distinguish Sphere-Forming Human Prostate Basal Cells from a Subpopulation with Predominant Tubule Initiation Capability
Changyong Guo, Haibo Liu, Bao-Hui Zhang, Radu M. Cadaneanu, Aqila M. Mayle, Isla P. Garraway
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034219
Abstract: Background Human prostate basal cells expressing alpha-6 integrin (CD49fHi) and/or CD44 form prostaspheres in vitro. This functional trait is often correlated with stem/progenitor (S/P) activity, including the ability to self-renew and induce differentiated tubules in vivo. Antigenic profiles that distinguish tubule-initiating prostate stem cells (SCs) from progenitor cells (PCs) and mature luminal cells (LCs) with less regenerative potential are unknown. Methodology/Principle Findings Prostasphere assays and RT-PCR analysis was performed following FACS separation of total benign prostate cells based upon combinations of Epcam, CD44, and/or CD49f expression. Epithelial cell fractions were isolated, including Epcam+CD44+ and Epcam+CD44+CD49fHi basal cells that formed abundant spheres. When non-sphere-forming Epcam+CD44? cells were fractionated based upon CD49f expression, a distinct subpopulation (Epcam+CD44?CD49fHi) was identified that possessed a basal profile similar to Epcam+CD44+CD49fHi sphere-forming cells (p63+ARLoPSA?). Evaluation of tubule induction capability of fractionated cells was performed, in vivo, via a fully humanized prostate tissue regeneration assay. Non-sphere-forming Epcam+CD44? cells induced significantly more prostate tubular structures than Epcam+CD44+ sphere-forming cells. Further fractionation based upon CD49f co-expression identified Epcam+CD44?CD49fHi (non-sphere-forming) basal cells with significantly increased tubule induction activity compared to Epcam+CD44?CD49fLo (true) luminal cells. Conclusions/Significance Our data delineates antigenic profiles that functionally distinguish human prostate epithelial subpopulations, including putative SCs that display superior tubule initiation capability and induce differentiated ductal/acini structures, sphere-forming PCs with relatively decreased tubule initiation activity, and terminally differentiated LCs that lack both sphere–forming and tubule-initiation activity. The results clearly demonstrate that sphere-forming ability is not predictive of tubule-initiation activity. The subpopulations identified are of interest because they may play distinct roles as cells of origin in the development of prostatic diseases, including cancer.
Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models
Xinmei Zhu, Fumihiko Nishimura, Kotaro Sasaki, Mitsugu Fujita, Jill E Dusak, Junichi Eguchi, Wendy Fellows-Mayle, Walter J Storkus, Paul R Walker, Andres M Salazar, Hideho Okada
Journal of Translational Medicine , 2007, DOI: 10.1186/1479-5876-5-10
Abstract: C57BL/6 mice bearing syngeneic CNS GL261 glioma or M05 melanoma received subcutaneous (s.c.) vaccinations with synthetic peptides encoding CTL epitopes- mEphA2 (671–679), hgp100 (25–33) and mTRP-2 (180–188) for GL261, or ovalbumin (OVA: 257–264) for M05. The mice also received intramuscular (i.m.) injections with poly-ICLC.The combination of subcutaneous (s.c.) peptide-based vaccination and i.m. poly-ICLC administration promoted systemic induction of antigen (Ag)-specific Type-1 CTLs expressing very late activation antigen (VLA)-4, which confers efficient CNS-tumor homing of vaccine-induced CTLs based on experiments with monoclonal antibody (mAb)-mediated blockade of VLA-4. In addition, the combination treatment allowed expression of IFN-γ by CNS tumor-infiltrating CTLs, and improved the survival of tumor bearing mice in the absence of detectable autoimmunity.These data suggest that poly-ICLC, which has been previously evaluated in clinical trials, can be effectively combined with tumor Ag-specific vaccine strategies, thereby providing a greater index of therapeutic efficacy.Our long-term goal is to develop safe and effective immunotherapeutic modalities for CNS tumors, such as gliomas. To this end, we have been directing our major focus on factors that promote the efficacy of peripheral vaccinations against CNS tumor-associated or specific Ags. Indeed, our recent study using adoptive transfer of ex vivo activated T-cells has demonstrated that a Type-1 phenotype for tumor-Ag specific CTLs is critical for efficient CNS tumor-tropism and for the resulting anti-tumor therapeutic efficacy, which can be further facilitated by genetic delivery of IFN-α into CNS tumor sites [1].While clinical development of adoptive transfer therapy using Type-1 CTLs specific for glioma-associated antigens (GAAs) and genetic delivery of IFN-α are feasible, efficient vaccine-based approaches may be developed as more logistically attractive alternatives, potentially by administration of a "n
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