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Search Results: 1 - 10 of 400779 matches for " M. Mathrusri Annapurna "
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Validated LC Method for the Estimation of Dorzolamide HCl (Carbonic Anhydrase Inhibitor) in Ophthalmic Solutions
A. Narendra,D. Deepika,M. Mathrusri Annapurna
Journal of Chemistry , 2012, DOI: 10.1155/2012/258261
Abstract: A reverse phase HPLC method is described for the determination of Dorzolamide in eye drops. Chromatography was carried on an Inertsil ODS 3V column using Acetonitrile : (0.02M) 1,Octane Sulphonic acid buffer (pH 3.5) (36:64 v/v) on isocratic mode at a flow rate of 1 mL/min with UV detection at 254 nm. The detector response was linear in the concentration range 4-720 µg/mL. The limit of detection and limit of quantification are found to be 0.7041 and 2.3483 µg/mL respectively. The method was validated as per the ICH guidelines. The proposed method is rapid, accurate and precise and can be applied for the routine analysis of dorzolamide in ophthalimic solutions.
New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms
A. Narendra,D. Deepika,M. Mathrusri Annapurna
Journal of Chemistry , 2012, DOI: 10.1155/2012/359745
Abstract: A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Bosentan in bulk and in pharmaceutical formulations. Bosentan exhibits absorption maxima at 273 nm with apparent molar absorptivity of 1.3293×104 L/mol.cm in methanol and octane 1-sulfonic acid solvent mixture. Beer's law was found to be obeyed in the concentration range of 0.1-100 μg/mL. The method was validated as per the ICH guidelines.
Liquid Chromatographic Method for the Analysis of Brimonidine in Ophthalmic Formulations
A. Narendra,D. Deepika,M. Mathrusri Annapurna
Journal of Chemistry , 2012, DOI: 10.1155/2012/647187
Abstract: A reverse phase LC method was developed for the determination of Brimonidine in eye drops. Chromatography was carried on an Inertsil ODS 3V column (C18) using a mixture of Octane 1- sulfonic acid sodium salt (0.02M) (pH 3.5 ± 0.05) and acetonitrile (64:36 v/v) as mobile phase at a flow rate of 1 mL/min with UV detection at 254 nm. The drug was eluted at 4.636 min. The detector response was linear in the concentration range of 0.4–72 μg/mL. The limit of detection and limit of quantification were found to be 0.0561 and 0.1848 μg/mL respectively. The proposed method was validated as per the ICH guidelines and can be applied for the routine analysis of Brimonidine in eye drops.
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR S IMULTANEOUS DETERMINATION OF DORZOLAMID E AND TIMOLOL MALEATE IN PHARMACEUTICAL DOS AGE FORMS
M Mathrusri Annapurna,A Narendra,D Deepika
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: A fast, sensitive and accurate reverse phase liquid chromatographic method was developed and validated for the simultaneous determination of Dorzolamide and Timo lo l maleate in ophthalmic preparations. Chro matographic separation was achieved on Inertsil ODS 3V C18 co lu mn (250 X 4.6 mm, 5 μm particle size) with mobile phase consisting of Acetonitrile and 1-Octane Sulphonic acid buffer (0.02M) p H adjusted to 3.5 ± 0.05 with o-phosphoric acid (36:64 V/V) at a flo w rate of 1.0 mL/min. The analytes were detected at 254 n m and 295 n m fo r Dorzo lamide and Timolol maleate respectively by PDA detector. Brimonid ine was used as internal standard (IS). The retention time of Dorzolamide, Timo lol maleate and Brimon idine were found to be at 6.020 ± 0.02, 8.254 ± 0.01 and 4.636 ± 0.01 mins respectively. The linearity of the method ranged between 4-720 and 1-180 μg/mL for Dorzolamide and Timo lol maleate respectively with correlation coefficient 0.999 for both the drugs in binary mixture. The LOD was found to be 0.6951 μg/mL and 0.2489 μg/mL for Dorzolamide and Timolol maleate respectively and LOQ was found to be 2.3214 μg/mL and 0.8317 μg/mL for Dorzolamide and Timo lo l maleate respectively.
Analysis of Nabumetone in Bulk and Tablet Formulation by a New and Validated Reverse Phase High Performance Liquid Chromatography
Prafulla Kumar Sahu,M. Mathrusri Annapurna
Journal of Chemistry , 2009, DOI: 10.1155/2009/795896
Abstract:
Validated Spectrophotometric Methods for the Determination of Mycophenolate: An Anti-Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms
A. Narendra,D. Deepika,M. Mathrusri Annapurna
Journal of Chemistry , 2013, DOI: 10.1155/2013/523193
Abstract:
Estimation of acetorphan in pharmaceutical dosage forms by derivative spectrophotometry and liquid chromatographic methods
Sasmita Kumari Acharjya,M. Mathrusri Annapurna
Journal of Pharmaceutical Education and Research , 2010,
Abstract: Two simple and accurate methods of analysis to determine Acetorphan (ACT) in pharmaceutical dosage forms were developed using first-derivative spectrophotometry and reversed-phase liquid chromatography (LC). ACT was quantified using the first-derivative response at 241.0 nm in spectra of its solution in methanol. The calibrationcurve was linear [correlation coefficient (r) = 0.999] in the concentration range of 10.0–100.0 μg/ml. In the LC method, analysis was performed on a Hypersil ODS-C18 column with 5 μm particle size using the mobile phase methanol-water (80 + 20; v/v), at a flow rate of 1.0 ml/min. Measurement was made at a wavelength of 232 nmand the retention time was 5.358 min. The calibration curve was linear (r = 0.999) in the concentration range of 10.0–500.0 μg/ml. Both methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. The developed methods were successfully applied to the estimation of ACT in pharmaceutical dosage forms.
Computer augmented modeling studies of Cu2+, Ni2+ and Co2+ complexes of ethambutol
G. Nageswara Rao,M. Mathrusri Annapurna
Journal of Pharmaceutical Education and Research , 2010,
Abstract: The protonation and complexation equilibria of Ethambutol dihydrochloride have been studied pH-metrically in aqueous medium at an ionic strength of 0.1 mol dm-3 and 303K temperature. Its protonation constants as well as the binary stability constants of Cu2+, Ni2+ and Co2+complexes were evaluated and the best-fit models were chosenbased on the statistical parameters using MINIQUAD75 computer program. The species distribution diagrams of the binary metal complexes are reported.
Validated RP-HPLC Method for the Assay of Etoricoxib (A Non-Steroidal Anti-Inflammatory Drug) in Pharmaceutical Dosage Forms
Srinivasu Topalli,T. G. Chandrashekhar,M. Mathrusri Annapurna
Journal of Chemistry , 2012, DOI: 10.1155/2012/264567
Abstract: A simple, accurate, sensitive and reproducible reverse phase high performance liquid chromatographic method has been developed for the quantitative determination of Etoricoxib in pharmaceutical dosage forms. The assay was performed on Hypersil ODS C-18 (250 x 4.6 mm., 5µm particle size) column using acetonitrile and potassium dihydrogen phosphate buffer (pH 4.2) (46:54 % v/v) as mobile phase with UV detection at 280 nm (flow rate 1.2 ml/min). Bromhexine was used as an internal standard. Quantization was achieved by measurement of the peak area ratio of the drug to the internal standard. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.0704 µg ml-1 and 0.2134 µg ml-1 respectively. Each analysis required no longer than 10 minutes. The calibration curve was linear over the concentration range from 0.5-85.0 µg ml-1. The retention times of Etoricoxib and Bromhexine were found to be 3.083 and 7.631 minutes respectively. The proposed method was validated according to the ICH guidelines and can be used successfully to analyse marketed formulations.
LIQUID CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS QUANTITATIVE DETERMINATION OF CANDESARTAN CILEXETIL AND HYDROCHLORTHIAZIDE IN PHARMACEUTICAL DOSAGE FORMS
M. Mathrusri Annapurna,A. Narendra,K. Ravi Kumar
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: A simple and sensitive RP-HPLC method was developed and validated for the determination of Candesartan cilexetil and Hydrochlorthiazide in pharmaceutical dosage forms. The separation of components was achieved on a SHIMADZU Hypersil ODS-C18 column (250 × 4.6 mm, 5 μm) with UV detection at 270 nm. Isocratic elution with a mobile phase consisting of 10 mM (pH 3.37) Tetra butyl ammonium hydrogen sulphate: methanol (15:85, V/V), at a flow rate 1.0 mL min-1was employed. Linearity was observed in the concentration range 0.625-62.5 μg/mL for Hydrochlorthiazide and 0.8-80 μg/mL for Candesartan cilexetil respectively. The linear regression equation was found to be Y=64002X-1412.6 for Hydrochlorthiazide and Y=24649X-6701.8 for Candesartan cilexetil respectively with correlation coefficients greater than 0.999. The LOD was found to be 0.1385 and 0.1892 μg/mL for Hydrochlorthiazide and Candesartan cilexetil respectively where as the LOQ was found to be 0.4394 and 0.6187μg/mL for Hydrochlorthiazide and Candesartan cilexetil respectively. The mean analytical recovery in determination of Candesartan cilexetil and Hydrochlorthiazide tablets was 99.31-100.08% Hydrochlorthiazide and 99.58-100.39% for Candesartan cilexetil respectively. Thus, the proposed method is applicable for routine determination of Candesartan cilexetil and Hydrochlorthiazide in pharmaceutical formulations.
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