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匹配条件： “M. Kaleemullah Khan” ，找到相关结果约406066条。
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ACE I/D gene polymorphism in diabetic nephropathy: Clinical implications
M. Kaleemullah Khan,N. Parimala,Mohammed Ishaq,Mohammed Siraj
Journal of Medical and Allied Sciences , 2011,

Abstract: Diabetic nephropathy (DN) is a major microvascular complication accounting for about 30% of End-Stage Renal Disease (ESRD) cases. An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-I converting enzyme (ACE) is reported to be a candidate gene predisposing to diabetic nephropathy. Accordingly, we investigated the ACE I/D gene polymorphism in 52 Type 2 diabetes mellitus (T2DM) cases suffering from nephropathy as assessed by 24 hrs urinary protein levels. 50 age and sex matched healthy subjects served as controls. ACE I/D genotyping was carried out by polymerase chain reaction (PCR) amplification using allele specific primers. The frequencies of ACE DD, ID and II genotypes in the diabetic nephropathy patients were 38.5% , 50% and 11.5% and in the control subjects, 22%, 38% and 40% respectively. There was an increase of 16.5% in the frequency of DD genotype in the patients compared to controls. The frequency of D allele in the patients was 63% which was found to be statistically significant (p< 0.05, Odds ratio=2.6) compared to 41% in the controls. These results indicate that Type 2 diabetic patients with D allele (those with DD & ID genotypes) have more than two fold risk of developing nephropathy. Clinical implications of ACE genotyping in planning for patient’s management have been discussed.

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A simple and sensitive RP-UPLC method for the determination of 2-(4',4'-Dibromomethylphenyl)benzonitrile impurity content in Irbesartan drug substance
T Kaleemullah
Asian Journal of Biomedical and Pharmaceutical Sciences , 2012,

Abstract: This paper describes the development and validation of a simple reverse phase ultra performance liquid chromatography (RP-UPLC) method for the quantitative determination of 2-(4',4'-Dibromomethylphenyl)benzonitrile impurity content at low level in Irbesartan drug substance. Separation was achieved with 100mm x 2.1mm, 1.7μm particle size, ODS column. The mobile was a gradient prepared by simple phosphoric acid buffer, and Acetonitirle at a flow rate of 0.1 mL min-1, UV detection was performed at 205nm. The method was validated to confirm selectivity, precision, linearity and accuracy parameters as per ICH guideline. Because of its speed and accuracy the detection limit and quantification limit are found to be 0.41 μg ml-1 and 1.46 μg ml-1 respectively. Repeatability is good, with a relative standard deviation of 2.1% to 3.2%. The drug substance was subjected to stability studies as well as stress condition of hydrolysis, oxidation, photolytic, thermal and humidity degradation using optimized method condition to enhance low level of detection within the minimum acquisition time indicating the accuracy of the optimized RP-UPLC method. This simple, efficient methodology can be used for quality control bulk manufacturing as well as routine analysis.

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Structural and Electrical Characterization of Sintered Silicon Nitride Ceramic [PDF]
Imran Khan, M. Zulfequar
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.27102

Abstract: The electrical conduction phenomena, dielectric response and microstructure have been discussed in sintered silicon nitride ceramics at different temperature and frequencies. Microstructure and phase of the sintered samples was investigated by Scanning Electron Microscope (SEM) and X-ray diffractometer (XRD). The electrical conductivity, dielectric constant and dielectric loss increases exponentially with temperature greater than 600 K. The dielectric constant and loss have been measured in the frequency range 100 Hz to 1 MHz. The a.c. conduction studies in the audio frequency range 500 Hz to 1 MHz indicates that the conduction may be due to the electronic hopping mechanism. Silicon Nitride ceramics became dense after sintering. The effect of grain size and role of phase on electrical and dielectric properties have been discussed. These types of samples can be used as a high temperature semi conducting materials for device packaging.

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Small Angle Neutron Scattering and X-Ray Diffraction Studies of Nanocrystalline Titanium Dioxide [PDF]
M. Nasir Khan, J. Bashir
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.29115

Abstract: Nanocrystalline titanium dioxide powder is characterized for phase analysis as well as particle size and its distribution by x-ray diffraction and small angle neutron scattering measurements. Analysis of the SANS data in the momentum transfer range q = 0.1 - 1.8 nm^–1 reveals an average particle size of 24.82 nm in good agreement with the particle size determined earlier by transmission electron microscopy. XRD measurement proves co-existence of rutile and anatase phases in this commercial TiO₂ nanocrystalline powder.

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A Simple and Sensitive RP-UPLC Method for the Simultaneous Determination of N-Hydroxybenzotriazole, Cinchonidine and 1,3-Dicyclohexyl Urea Contents in Fosinopril Sodium Drug Substance
M. Narendra Kumar,V. Krishna Reddy,Hemant Kumar Sharma,T. Kaleemullah,T. Chandra Sekhar Reddy,G. Thirupathi Reddy,N. Sreenivas,Goutam Sen
Journal of Chemistry , 2012, DOI: 10.1155/2012/780247

Abstract: A simple and sensitive reverse phase ultra performance liquid chromatography (RP-UPLC) method has been developed, optimized and validated for the simultaneous determination of N-Hydroxybenzotriazole (HOBt), Cinchonidine and 1,3-Dicyclohexyl urea (DCU) contents at low levels in fosinopril sodium drug substance. Efficient chromatographic separation was achieved on Acquity UPLC HSS C18 column, 100 mm long with 2.1 mm i.d., 1.8 µm particle diameter, thermo stated at 30°C. Gradient elution involving binary mixture of potassium dihydrogen orthophosphate (0.01M, pH:3.0±0.05 with ortho-phosphoric acid) and acetonitrile at a flow rate of 0.10 mL min-1 has been used. The analytes were monitored by photodiode array (PDA) detector set at 205 nm. The drug substance was subjected to stress conditions of hydrolysis, oxidation, photolysis, thermal and humidity degradation. The method was validated for specificity, sensitivity, linearity, precision, accuracy and solution stability. The limit of detection (LOD) and limit of quantification (LOQ) for HOBt, Cinchonidine and DCU were in the range of 0.85-3.52 ppm and 2.57-10.67 ppm, respectively. The average recoveries for HOBt, Cinchonidine and DCU are in the range of 98.1% to 102.6%. The method can be used for the routine quality control analysis of fosinopril sodium drug substance.

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Abstract: A simple and sensitive reverse phase ultra performance liquid chromatography (RP-UPLC) method has been developed, optimized and validated for the simultaneous determination of N-Hydroxybenzotriazole (HOBt), Cinchonidine and 1,3-Dicyclohexyl urea (DCU) contents at low levels in fosinopril sodium drug substance. Efficient chromatographic separation was achieved on Acquity UPLC HSS C18 column, 100 mm long with 2.1 mm i.d., 1.8 μm particle diameter, thermo stated at 30°C. Gradient elution involving binary mixture of potassium dihydrogen orthophosphate (0.01M, pH:3.0±0.05 with ortho-phosphoric acid) and acetonitrile at a flow rate of 0.10 mL min-1 has been used. The analytes were monitored by photodiode array (PDA) detector set at 205 nm. The drug substance was subjected to stress conditions of hydrolysis, oxidation, photolysis, thermal and humidity degradation. The method was validated for specificity, sensitivity, linearity, precision, accuracy and solution stability. The limit of detection (LOD) and limit of quantification (LOQ) for HOBt, Cinchonidine and DCU were in the range of 0.85-3.52 ppm and 2.57-10.67 ppm, respectively. The average recoveries for HOBt, Cinchonidine and DCU are in the range of 98.1% to 102.6%. The method can be used for the routine quality control analysis of fosinopril sodium drug substance.

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A plausible explanation for male dominance in typhoid ileal perforation
Khan M
Clinical and Experimental Gastroenterology , 2012, DOI: http://dx.doi.org/10.2147/CEG.S36569

Abstract: plausible explanation for male dominance in typhoid ileal perforation Commentary (784) Total Article Views Authors: Khan M Published Date November 2012 Volume 2012:5 Pages 213 - 217 DOI: http://dx.doi.org/10.2147/CEG.S36569 Received: 01 August 2012 Accepted: 07 October 2012 Published: 12 November 2012 Mohammad Khan Department of Microbiology, College of Medicine, Chichiri, Blantyre, Malawi Abstract: The phenomenon of consistent male dominance in typhoid ileal perforation (TIP) is not well understood. It cannot be explained on the basis of microbial virulence, Peyer's patch anatomy, ileal wall thickness, gastric acidity, host genetic factors, or sex-linked bias in hospital attendance. The cytokine response to an intestinal infection in males is predominantly proinflammatory as compared with that in females, presumably due to differences in the sex hormonal milieu. Sex hormone receptors have been detected on lymphocytes and macrophages, including on Peyer's patches, inflammation of which (probably similar to the Shwartzman reaction/Koch phenomenon) is the forerunner of TIP, and is not excluded from the regulatory effects of sex hormones. Hormonal control of host-pathogen interaction may override genetic control. Environmental exposure to Salmonella typhi may be more frequent in males, presumably due to sex-linked differences in hygiene practices and dining-out behavior. A plausible explanation of male dominance in TIP could include sex-linked differences in the degree of natural exposure of Peyer's patches to S. typhi. An alternative explanation may include sexual dimorphism in host inflammatory response patterns in Peyer's patches that have been induced by S. typhi. Both hypotheses are testable.

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A plausible explanation for male dominance in typhoid ileal perforation
Khan M
Clinical and Experimental Gastroenterology , 2012,

Abstract: Mohammad KhanDepartment of Microbiology, College of Medicine, Chichiri, Blantyre, MalawiAbstract: The phenomenon of consistent male dominance in typhoid ileal perforation (TIP) is not well understood. It cannot be explained on the basis of microbial virulence, Peyer's patch anatomy, ileal wall thickness, gastric acidity, host genetic factors, or sex-linked bias in hospital attendance. The cytokine response to an intestinal infection in males is predominantly proinflammatory as compared with that in females, presumably due to differences in the sex hormonal milieu. Sex hormone receptors have been detected on lymphocytes and macrophages, including on Peyer's patches, inflammation of which (probably similar to the Shwartzman reaction/Koch phenomenon) is the forerunner of TIP, and is not excluded from the regulatory effects of sex hormones. Hormonal control of host-pathogen interaction may override genetic control. Environmental exposure to Salmonella typhi may be more frequent in males, presumably due to sex-linked differences in hygiene practices and dining-out behavior. A plausible explanation of male dominance in TIP could include sex-linked differences in the degree of natural exposure of Peyer's patches to S. typhi. An alternative explanation may include sexual dimorphism in host inflammatory response patterns in Peyer's patches that have been induced by S. typhi. Both hypotheses are testable.Keywords: explanation, dominance, male, perforation, ileum, typhoid

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BASIC FACTS OF MASTITIS IN DAIRY ANIMALS: A REVIEW
M. Z. KHAN AND A. KHAN
Pakistan Veterinary Journal , 2006,

Abstract: No Abstract

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Open Quantum Systems in Noninertial Frames
Salman Khan,M. K. Khan
Mathematics , 2010, DOI: 10.1088/1751-8113/44/4/045305

Abstract: We study the effects of decoherence on the entanglement generated by Unruh effect in noninertial frames by using bit flip, phase damping and depolarizing channels. It is shown that decoherence strongly influences the initial state entanglement. The entanglement sudden death can happens irrespective of the acceleration of the noninertial frame under the action of phase flip and phase damping channels. It is investigated that an early sudden death happens for large acceleration under the depolarizing environment. Moreover, the entanglement increases for a highly decohered phase flip channel.

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