oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 6 )

2019 ( 805 )

2018 ( 1141 )

2017 ( 1121 )

Custom range...

Search Results: 1 - 10 of 510873 matches for " M. H. Alai et al. "
All listed articles are free for downloading (OA Articles)
Page 1 /510873
Display every page Item
CARBON NANOTUBES: AN APPROACH TO NOVEL DRUG DELIVERY SYSTEM
M. H. Alai et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Carbon nanotubes are cylindrical carbon molecules have novel properties, making them potentially useful in many applications in nanotechnology, electronics, optics, and other fields of material science as well as potential uses in architectural fields. They have unique electronic, mechanical, optical and chemical properties that make them good candidates for a wide variety of applications, including drug transporters, new therapeutics, delivery systems and diagnostics. Their unique surface area, stiffness, strength and resilience have led to much excitement in the field of pharmacy. Nanotubes are categorized as single-walled nanotubes, multiple walled nanotubes. Various techniques have been developed to produce nanotubes in sizeable quantities, including arc discharge, laser ablation, chemical vapor deposition. They can pass through membranes, carrying therapeutic drugs, vaccines and nucleic acids deep into the cell to targets previously unreachable. Purification of the tubes can be divided into a couple of main techniques: oxidation, acid treatment, annealing, sonication, filtering and functionalization techniques. The main problem of insolubility in aqueous media has been solved by developing a synthetic protocol that allows highly water-soluble carbon NTs to be obtained. The modifications are done to improve efficiency of carbon nanotubes by formulating luminescent carbon nanotubes, ultrathin carbon nanoneedles, magnetically guided nanotubes. The application of carbon nanotube in tissue engineering, drug carrier release system, wound healing, in cancer treatment and as biosensor. Researchers have recently developed a new approach to Boron Neutron Capture Therapy in the treatment of cancer using substituted Carborane-Appended Water-Soluble single-wall carbon nanotubes.
EFFECT OF ADMINISTRATION OF ETIZOLAM ON THE DEVELOPMENT OF THE CHICK EMBRYO
Shweta P. Alai et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: There are various drugs used in daily life. Some of them show hazardous effect on various organs and some of them shows even lethal effect. Such drugs are required to banned. One of them is Etizolam (marketed under the brand name Sedekopan, Pasaden or Depas) is a drug which is a thiebenzothiodiazepines analog. The aim of this work is done to compare the effect of administration of the etizolam drug at (Zero-day) before incubation and at the (5-day) first week of incubation, to get an idea about the extent of the teratogenic effect of this drug on the development of chick embryo. So that morphological and biochemical studies were done on the chick embryo of 8- and 16-days old chick embryos treated with (0.5mg/ml egg) of etizolam on the (zero and 5-th days) of incubation. Etizolam caused abnormality in concentration dependent manner. Enlarged remains of primitive streak was seen at 0.1mg/ml and o.3mg/ml concentration of Etizolam embryo dies. Etizolam inhibit development of somites of the development of 5-day at of incubation also it does not allow the development of notochord. The toxic effects of the drug was seen also more at 16-days treated chick embryos and the drug induced death of chick embryo at both 8- and 16-days treated with 0.1mg/ml and o.3mg/ml. The conclusion from this study was the etizolam drug has dangerous effects on tissues and with powerful toxicity on the cells, because the drug absorbed rapidly with peak plasma levels achieved between 30 minutes and 2 hours and has a mean elimination half life of about 3 and a half hours.
Synchronous bilateral breast cancer in a patient with Klinefelter’s syndrome
H M R Hoque, A Kothari, H Hamed, et al
International Journal of General Medicine , 2010, DOI: http://dx.doi.org/10.2147/IJGM.S7821
Abstract: chronous bilateral breast cancer in a patient with Klinefelter’s syndrome Case report (4601) Total Article Views Authors: H M R Hoque, A Kothari, H Hamed, et al Published Date December 2009 Volume 2010:3 Pages 19 - 21 DOI: http://dx.doi.org/10.2147/IJGM.S7821 H M R Hoque, A Kothari, H Hamed, I S Fentiman Hedley Atkins Breast Unit, Guys’ Hospital, London, UK Abstract: Synchronous bilateral male breast cancer (MBC) is rare and only a few cases have been reported in the literature. The majority of MBC patients have no definable risk factors. We describe a case with Klinefelter’s syndrome, prior thymic irradiation, testicular surgery, and first degree family history in a 61-year-old male.
Combined Analysis of the Binary-Lens Caustic-Crossing Event MACHO 98-SMC-1
C. Afonso,C. Alcock,S. H. Rhie,A. Udalski et al.,M. Albrow et al.
Physics , 1999, DOI: 10.1086/308561
Abstract: We fit the data for the binary-lens microlensing event MACHO 98-SMC-1 from 5 different microlensing collaborations and find two distinct solutions characterized by binary separation d and mass ratio q: (d,q)=(0.54,0.50) and (d,q)=(3.65,0.36), where d is in units of the Einstein radius. However, the relative proper motion of the lens is very similar in the two solutions, 1.30 km/s/kpc and 1.48 km/s/kpc, thus confirming that the lens is in the Small Magellanic Cloud. The close binary can be either rotating or approximately static but the wide binary must be rotating at close its maximum allowed rate to be consistent with all the data. We measure limb-darkening coefficients for five bands ranging from I to V. As expected, these progressively decrease with rising wavelength. This is the first measurement of limb darkening for a metal-poor A star.
Antihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers
Elisabet Ekman, Staffan H gg, Anders Sundstr m, et al
Drug, Healthcare and Patient Safety , 2010, DOI: http://dx.doi.org/10.2147/DHPS.S8432
Abstract: ntihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers Original Research (5418) Total Article Views Authors: Elisabet Ekman, Staffan H gg, Anders Sundstr m, et al Published Date March 2010 Volume 2010:2 Pages 21 - 25 DOI: http://dx.doi.org/10.2147/DHPS.S8432 Elisabet Ekman1, Staffan H gg2, Anders Sundstr m3, Viktoria Werkstr m1 1Regional Pharmacovigilance Unit, Clinical Pharmacology, Lund University Hospital, Lund, Sweden; 2Division of Clinical Pharmacology, Link ping University, Link ping, Sweden; 3Centre for Pharmacoepidemiology, Karolinska Institute, Stockholm, Sweden Aim: To describe spontaneously reported cases of erectile dysfunction (ED) in association with angiotensin II type I blockers (ARB) and other antihypertensive drugs. Subjects and methods: All spontaneously reported cases of ED submitted to the Swedish Medical Products Agency (MPA) between 1990 and 2006, where at least one antihypertensive drug was the suspected agent, were scrutinized. Patient demographics, drug treatment and adverse reactions were recorded. Using the Bayesian Confidence Propagation Neural Network (BCPNN) method, the information component (IC) was calculated. Results: Among a total of 225 reports of ED, 59 involved antihypertensive drugs including ARB (9 cases) as suspected agents. A positive IC value was found indicating that ED was reported more often in association with antihypertensive drugs classes, except for angiotensin-converting enzyme inhibitors, compared with all other drugs in the database. Positive dechallenge was reported in 43 cases (72%). Discussion: All classes of major antihypertensive drugs including ARB were implicated as suspected agents in cases of ED. Few risk factors were identified. The relatively high reporting of ED in association with ARB is in contrast with previous studies, suggesting that ARB have neither a positive nor any effect on ED. This discrepancy suggests that further studies are warrnted on this potential adverse reaction to ARB.
Economic burden of chronic bronchitis in the United States: a retrospective case-control study
Christopher M Blanchette, Melissa H Roberts, Hans Petersen, et al
International Journal of Chronic Obstructive Pulmonary Disease , 2011, DOI: http://dx.doi.org/10.2147/COPD.S15882
Abstract: onomic burden of chronic bronchitis in the United States: a retrospective case-control study Original Research (3984) Total Article Views Authors: Christopher M Blanchette, Melissa H Roberts, Hans Petersen, et al Published Date January 2011 Volume 2011:6 Pages 73 - 81 DOI: http://dx.doi.org/10.2147/COPD.S15882 Christopher M Blanchette1, Melissa H Roberts1, Hans Petersen1, Anand A Dalal2, Douglas W Mapel3 1Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, NC, USA; 2US Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC, USA; 3Lovelace Clinic Foundation, Albuquerque, NM, USA Background: Chronic bronchitis (CB) is often misdiagnosed or diagnosed at a later stage of chronic obstructive pulmonary disease (COPD). We examined how this later diagnosis may impact health care costs and utilization during the 12 months prior to and 24 months post initial CB diagnosis. Methods: This retrospective case-control analysis used claims data from a large US database from July 1, 2003 through June 30, 2007. Patients with CB aged 40 years and older were propensity matched (N = 11,674) to patients without evidence of COPD or asthma by demographics, CB diagnosis quarter/year, and comorbidities. Group differences were assessed using Student's t-test and Pearson chi-square test statistics. Results: Six months prediagnosis, CB patients had higher frequencies of any hospitalization (9.6%, 6.7%; P < 0.05), emergency department/urgent care visits (13.3%, 6.7%; P < 0.05), and prescriptions (97.3%, 94.1%; P < 0.05). Six months postdiagnosis, CB patients had 5.6 times more hospitalizations (P < 0.05) and 3.1 times more emergency department/urgent care visits (P < 0.05) compared with controls. Mean total costs (US$) for CB patients 12 months prediagnosis were significantly higher than controls (months 12–7: $4212, $3826; P < 0.05; months 6–1: $5289, $4285; P < 0.05). CB patients had higher mean total costs ($8919; P < 0.05) 6 months postdiagnosis. Costs remained $2429 higher for CB patients 19–24 months postdiagnosis (P < 0.05). Conclusion: Health care costs and utilization among CB patients are increased both prior to diagnosis and during the 2 years postdiagnosis. This study suggests that not accurately diagnosing CB early has a substantial impact on health care costs, and that the economic burden for CB patients remains elevated even after adjustment for comorbidities associated with COPD.
Biochemical Disturbances Seen in Polycystic Over Syndrome
Ak Y?ld?r?m H et al.
Konuralp Tip Dergisi , 2011,
Abstract: Polycystic Ovary Syndrome is seen 5-10% of women in reproductive period. Although many clinical, laboratory and experimental data are present, there are still doubts about the pathophysiology. Polycystic Ovary Syndrome can be considered as a multifactorial disease that is occurred with the synergistic effect of several systems as a result of the malfunction such as hypothalamic-pituitary dysfunction, disorder of steroidogenesis, intraovarian factors, insulin resistance, hyperinsulinemia, obesity, genetic factors, abnormal granulosa cells, enzymatic defects. In this review, we aimed to investigate these issues.
Ankle Brachial Pressure Index (ABPI): An update for practitioners
Mo Al-Qaisi, David M Nott, David H King, et al
Vascular Health and Risk Management , 2009, DOI: http://dx.doi.org/10.2147/VHRM.S6759
Abstract: nkle Brachial Pressure Index (ABPI): An update for practitioners Review (11918) Total Article Views Authors: Mo Al-Qaisi, David M Nott, David H King, et al Published Date September 2009 Volume 2009:5 Pages 833 - 841 DOI: http://dx.doi.org/10.2147/VHRM.S6759 Mo Al-Qaisi1, David M Nott1, David H King2, Sam Kaddoura1 1Imperial College, London, UK; 2Broomfield Hospital, Chelmsford, Essex, UK Abstract: Peripheral vascular disease affects some 12%–14% of the general population, and the majority of people with the disease are asymptomatic. The Ankle Brachial Pressure Index (ABPI) test is widely used by a diverse range of practitioners (in the community and hospital setting) in order to screen asymptomatic patients, diagnose patients with clinical symptoms, and to monitor patients who have had radiological or surgical intervention. This paper explains the theoretical basis of the ABPI test, as well as the relevance of the common modifications of the test. It explores the background to the quoted normal ranges for the ABPI test. It reviews the large body of literature that has developed on the association between ABPI and cardiovascular risk, as well as ABPI as a predictor for cardiovascular morbidity and mortality, highlighting the evidence that can inform practice. The review looks critically at the limitations of the ABPI test, providing practitioners with an evidence-based update on the importance and challenges of standardizing ABPI methodology. This paper highlights the influence of the key technical aspects of the ABPI test that all practitioners need to consider in order to be able to make more reliable and informed management decisions based on ABPI findings.
Ankle Brachial Pressure Index (ABPI): An update for practitioners
Mo Al-Qaisi,David M Nott,David H King,et al
Vascular Health and Risk Management , 2009,
Abstract: Mo Al-Qaisi1, David M Nott1, David H King2, Sam Kaddoura11Imperial College, London, UK; 2Broomfield Hospital, Chelmsford, Essex, UKAbstract: Peripheral vascular disease affects some 12%–14% of the general population, and the majority of people with the disease are asymptomatic. The Ankle Brachial Pressure Index (ABPI) test is widely used by a diverse range of practitioners (in the community and hospital setting) in order to screen asymptomatic patients, diagnose patients with clinical symptoms, and to monitor patients who have had radiological or surgical intervention. This paper explains the theoretical basis of the ABPI test, as well as the relevance of the common modifications of the test. It explores the background to the quoted normal ranges for the ABPI test. It reviews the large body of literature that has developed on the association between ABPI and cardiovascular risk, as well as ABPI as a predictor for cardiovascular morbidity and mortality, highlighting the evidence that can inform practice. The review looks critically at the limitations of the ABPI test, providing practitioners with an evidence-based update on the importance and challenges of standardizing ABPI methodology. This paper highlights the influence of the key technical aspects of the ABPI test that all practitioners need to consider in order to be able to make more reliable and informed management decisions based on ABPI findings.Keywords: ankle, brachial, pressure, index, ABPI, update
Synchronous bilateral breast cancer in a patient with Klinefelter’s syndrome
H M R Hoque,A Kothari,H Hamed,et al
International Journal of General Medicine , 2009,
Abstract: H M R Hoque, A Kothari, H Hamed, I S FentimanHedley Atkins Breast Unit, Guys’ Hospital, London, UKAbstract: Synchronous bilateral male breast cancer (MBC) is rare and only a few cases have been reported in the literature. The majority of MBC patients have no definable risk factors. We describe a case with Klinefelter’s syndrome, prior thymic irradiation, testicular surgery, and first degree family history in a 61-year-old male.Keywords: male breast cancer, Klinefelter’s syndrome, bilateral, risk factors
Page 1 /510873
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.