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Search Results: 1 - 10 of 401464 matches for " M. Goger-Neff "
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Large underground, liquid based detectors for astro-particle physics in Europe: scientific case and prospects
Autiero, D.;Aysto, J.;Badertscher, A.;Bezrukov, L.;Bouchez, J.;Bueno, A.;Busto, J.;Campagne, J. -E.;Cavata, Ch.;Chaussard, L.;de Bellefon, A.;Declais, Y.;Dumarchez, J.;Ebert, J.;Enqvist, T.;Ereditato, A.;von Feilitzsch, F.;Perez, P. Fileviez;Goger-Neff, M.;Gninenko, S.;Gruber, W.;Hagner, C.;Hess, M.;Hochmuth, K. A.;Kisiel, J.;Knecht, L.;Kreslo, I.;Kudryavtsev, V. A.;Kuusiniemi, P.;Lachenmaier, T.;Laffranchi, M.;Lefievre, B.;Lightfoot, P. K.;Lindner, M.;Maalampi, J.;Maltoni, M.;Marchionni, A.;Undagoitia, T. Marrodan;Marteau, J.;Meregaglia, A.;Messina, M.;Mezzetto, M.;Mirizzi, A.;Mosca, L.;Moser, U.;Muller, A.;Natterer, G.;Oberauer, L.;Otiougova, P.;Patzak, T.;Peltoniemi, J.;Potzel, W.;Pistillo, C .;Raffelt, G. G.;Rondio, E.;Roos, M.;Rossi, B.;Rubbia, A.;Savvinov, N.;Schwetz, T.;Sobczyk, J.;Spooner, N. J. C.;Stefan, D.;Tonazzo, A.;Trzaska, W.;Ulbricht, J.;Volpe, C.;Winter, J.;Wurm, M.;Zalewska, A.;Zimmermann, R.
High Energy Physics - Phenomenology , 2007, DOI: 10.1088/1475-7516/2007/11/011
Abstract: This document reports on a series of experimental and theoretical studies conducted to assess the astro-particle physics potential of three future large-scale particle detectors proposed in Europe as next generation underground observatories. The proposed apparatus employ three different and, to some extent, complementary detection techniques: GLACIER (liquid Argon TPC), LENA (liquid scintillator) and MEMPHYS (\WC), based on the use of large mass of liquids as active detection media. The results of these studies are presented along with a critical discussion of the performance attainable by the three proposed approaches coupled to existing or planned underground laboratories, in relation to open and outstanding physics issues such as the search for matter instability, the detection of astrophysical- and geo-neutrinos and to the possible use of these detectors in future high-intensity neutrino beams.
Spectroscopy of geo-neutrinos from 2056 days of Borexino data
Borexino collaboration,M. Agostini,S. Appel,G. Bellini,J. Benziger,D. Bick,G. Bonfini,D. Bravo,B. Caccianiga,F. Calaprice,A. Caminata,P. Cavalcante,A. Chepurnov,K. Choi,D. DAngelo,S. Davini,A. Derbin,L. Di Noto,I. Drachnev,A. Empl,A. Etenko,G. Fiorentini,K. Fomenko,D. Franco,F. Gabriele,C. Galbiati,C. Ghiano,M. Giammarchi,M. Goger-Neff,A. Goretti,M. Gromov,C. Hagner,E. Hungerford,Aldo Ianni,Andrea Ianni,K. Jedrzejczak,M. Kaiser,V. Kobychev,D. Korablev,G. Korga,D. Kryn,M. Laubenstein,B. Lehnert,E. Litvinovich,F. Lombardi,P. Lombardi,L. Ludhova,G. Lukyanchenko,I. Machulin,S. Manecki,W. Maneschg,F. Mantovani,S. Marcocci,E. Meroni,M. Meyer,L. Miramonti,M. Misiaszek,M. Montuschi,P. Mosteiro,V. Muratova,L. Oberauer,M. Obolensky,F. Ortica,K. Otis,L. Pagani,M. Pallavicini,L. Papp,L. Perasso,S. Perasso,A. Pocar,G. Ranucci,A. Razeto,A. Re,B. Ricci,A. Romani,R. Roncin,N. Rossi,S. Schoenert,D. Semenov,H. Simgen,M. Skorokhavatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,G. Testera,J. Thurn,M. Toropova,E. Unzhakov,R. B. Vogelaar,F. von Feilitzsch,H. Wang,S. Weinz,J. Winter,M. Woicik,M. Wurm,Z. Yokley,O. Zaimidoroga,S. Zavatarelli,K. Zuber,G. Zuzel
Statistics , 2015, DOI: 10.1103/PhysRevD.92.031101
Abstract: We report an improved geo-neutrino measurement with Borexino from 2056 days of data taking. The present exposure is $(5.5\pm0.3)\times10^{31}$ proton$\times$yr. Assuming a chondritic Th/U mass ratio of 3.9, we obtain $23.7 ^{+6.5}_{-5.7} (stat) ^{+0.9}_{-0.6} (sys)$ geo-neutrino events. The null observation of geo-neutrinos with Borexino alone has a probability of $3.6 \times 10^{-9}$ (5.9$\sigma$). A geo-neutrino signal from the mantle is obtained at 98\% C.L. The radiogenic heat production for U and Th from the present best-fit result is restricted to the range 23-36 TW, taking into account the uncertainty on the distribution of heat producing elements inside the Earth.
New limits on heavy sterile neutrino mixing in ${^{8}\rm{B}}$-decay obtained with the Borexino detector
Borexino collaboration,G. Bellini,J. Benziger,D. Bick,G. Bonfini,D. Bravo,M. Buizza Avanzini,B. Caccianiga,L. Cadonati,F. Calaprice,P. Cavalcante,A. Chavarria,A. Chepurnov,D. DAngelo,S. Davini,A. Derbin,I. Drachnev,A. Empl,A. Etenko,K. Fomenko,D. Franco,C. Galbiati,S. Gazzana,C. Ghiano,M. Giammarchi,M. Goger-Neff,A. Goretti,L. Grandi,C. Hagner,E. Hungerford,Aldo Ianni,Andrea Ianni,V. Kobychev,D. Korablev,G. Korga,D. Kryn,M. Laubenstein,T. Lewke,E. Litvinovich,B. Loer,F. Lombardi,P. Lombardi,L. Ludhova,G. Lukyanchenko,I. Machulin,S. Manecki,W. Maneschg,G. Manuzio,Q. Meindl,E. Meroni,L. Miramonti,M. Misiaszek,P. Mosteiro,V. Muratova,L. Oberauer,M. Obolensky,F. Ortica,K. Otis,M. Pallavicini,L. Papp,L. Perasso,S. Perasso,A. Pocar,G. Ranucci,A. Razeto,A. Re,A. Romani,N. Rossi,R. Saldanha,C. Salvo,S. Schonert,H. Simgen,M. Skorokhvatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,G. Testera,D. Vignaud,R. B. Vogelaar,F. von Feilitzsch,J. Winter,M. Wojcik,A. Wright,M. Wurm,J. Xu,O. Zaimidoroga,S. Zavatarelli,G. Zuzel
Physics , 2013, DOI: 10.1103/PhysRevD.88.072010
Abstract: If heavy neutrinos with mass $m_{\nu_{H}}\geq$2$ m_e $ are produced in the Sun via the decay ${^8\rm{B}} \rightarrow {^8\rm{Be}} + e^+ + \nu_H$ in a side branch of pp-chain, they would undergo the observable decay into an electron, a positron and a light neutrino $\nu_{H}\rightarrow\nu_{L}+e^++e^-$. In the present work Borexino data are used to set a bound on the existence of such decays. We constrain the mixing of a heavy neutrino with mass 1.5 MeV $\leq m_{\nu_{H}} \le$ 14 MeV to be $|U_{eH}|^2\leq (10^{-3}-4\times10^{-6})$ respectively. These are tighter limits on the mixing parameters than obtained in previous experiments at nuclear reactors and accelerators.
Ortho-positronium observation in the Double Chooz Experiment
Y. Abe,J. C. dos Anjos,J. C. Barriere,E. Baussan,I. Bekman,M. Bergevin,T. J. C. Bezerra,L. Bezrukov,E. Blucher,C. Buck,J. Busenitz,A. Cabrera,E. Caden,L. Camilleri,R. Carr,M. Cerrada,P. -J. Chang,E. Chauveau,P. Chimenti,A. P. Collin,E. Conover,J. M. Conrad,J. I. Crespo-Anadon,K. Crum,A. S. Cucoanes,E. Damon,J. V. Dawson,J. Dhooghe,D. Dietrich,Z. Djurcic,M. Dracos,M. Elnimr,A. Etenko,M. Fallot,F. von Feilitzsch,J. Felde,S. M. Fernandes,V. Fischer,D. Franco,M. Franke,H. Furuta,I. Gil-Botella,L. Giot,M. Goger-Neff,L. F. G. Gonzalez,L. Goodenough,M. C. Goodman,C. Grant,N. Haag,T. Hara,J. Haser,M. Hofmann,G. A. Horton-Smith,A. Hourlier,M. Ishitsuka,J. Jochum,C. Jollet,F. Kaether,L. N. Kalousis,Y. Kamyshkov,D. M. Kaplan,T. Kawasaki,E. Kemp,H. de Kerret,D. Kryn,M. Kuze,T. Lachenmaier,C. E. Lane,T. Lasserre,A. Letourneau,D. Lhuillier,H. P. Lima Jr,M. Lindner,J. M. Lopez-Castano,J. M. LoSecco,B. Lubsandorzhiev,S. Lucht,J. Maeda,C. Mariani,J. Maricic,J. Martino,T. Matsubara,G. Mention,A. Meregaglia,T. Miletic,R. Milincic,A. Minotti,Y. Nagasaka,Y. Nikitenko,P. Novella,L. Oberauer,M. Obolensky,A. Onillon,A. Osborn,C. Palomares,I. M. Pepe,S. Perasso,P. Pfahler,A. Porta,G. Pronost,J. Reichenbacher,B. Reinhold,M. Rohling,R. Roncin,S. Roth,B. Rybolt,Y. Sakamoto,R. Santorelli,A. C. Schilithz,S. Schonert,S. Schoppmann,M. H. Shaevitz,R. Sharankova,S. Shimojima,D. Shrestha,V. Sibille,V. Sinev,M. Skorokhvatov,E. Smith,J. Spitz,A. Stahl,I. Stancu,L. F. F. Stokes,M. Strait,A. Stuken,F. Suekane
Statistics , 2014, DOI: 10.1007/JHEP10(2014)032
Abstract: The Double Chooz experiment measures the neutrino mixing angle $\theta_{13}$ by detecting reactor $\bar{\nu}_e$ via inverse beta decay. The positron-neutron space and time coincidence allows for a sizable background rejection, nonetheless liquid scintillator detectors would profit from a positron/electron discrimination, if feasible in large detector, to suppress the remaining background. Standard particle identification, based on particle dependent time profile of photon emission in liquid scintillator, can not be used given the identical mass of the two particles. However, the positron annihilation is sometimes delayed by the ortho-positronium (o-Ps) metastable state formation, which induces a pulse shape distortion that could be used for positron identification. In this paper we report on the first observation of positronium formation in a large liquid scintillator detector based on pulse shape analysis of single events. The o-Ps formation fraction and its lifetime were measured, finding the values of 44$\%$ $\pm$ 12$\%$ (sys.) $\pm$ 5$\%$ (stat.) and $3.68$ns $\pm$ 0.17ns (sys.) $\pm$ 0.15ns (stat.) respectively, in agreement with the results obtained with a dedicated positron annihilation lifetime spectroscopy setup.
Reactor electron antineutrino disappearance in the Double Chooz experiment
Y. Abe,C. Aberle,J. C. dos Anjos,J. C. Barriere,M. Bergevin,A. Bernstein,T. J. C. Bezerra,L. Bezrukhov,E. Blucher,N. S. Bowden,C. Buck,J. Busenitz,A. Cabrera,E. Caden,L. Camilleri,R. Carr,M. Cerrada,P. -J. Chang,P. Chimenti,T. Classen,A. P. Collin,E. Conover,J. M. Conrad,J. I. Crespo-Anadón,K. Crum,A. Cucoanes,M. V. D'Agostino,E. Damon,J. V. Dawson,S. Dazeley,D. Dietrich,Z. Djurcic,M. Dracos,V. Durand,J. Ebert,Y. Efremenko,M. Elnimr,A. Etenko,M. Fallot,M. Fechner,F. von Feilitzsch,J. Felde,D. Franco,A. J. Franke,M. Franke,H. Furuta,R. Gama,I. Gil-Botella,L. Giot,M. Goger-Neff,L. F. G. Gonzalez,M. C. Goodman,J. TM. Goon,D. Greiner,N. Haag,C. Hagner,T. Hara,F. X. Hartmann,J. Haser,A. Hatzikoutelis,T. Hayakawa,M. Hofmann,G. A. Horton-Smith,A. Hourlier,M. Ishitsuka,J. Jochum,C. Jollet,C. L. Jones,F. Kaether,L. N. Kalousis,Y. Kamyshkov,D. M. Kaplan,T. Kawasaki,G. Keefer,E. Kemp,H. de Kerret,Y. Kibe,T. Konno,D. Kryn,M. Kuze,T. Lachenmaier,C. E. Lane,C. Langbrandtner,T. Lasserre,A. Letourneau,D. Lhuillier,H. P. Lima Jr,M. Lindner,J. M. López-Castan?,J. M. LoSecco,B. K. Lubsandorzhiev,S. Lucht,D. McKee,J. Maeda,C. N. Maesano,C. Mariani,J. Maricic,J. Martino,T. Matsubara,G. Mention,A. Meregaglia,T. Miletic,R. Milincic,H. Miyata,Th. A. Mueller,Y. Nagasaka,K. Nakajima,P. Novella,M. Obolensky,L. Oberauer,A. Onillon,A. Osborn,I. Ostrovskiy,C. Palomares,I. M. Pepe,S. Perasso,P. Perrin,P. Pfahler,A. Porta,W. Potzel,J. Reichenbacher,B. Reinhold,A. Remoto,M. Rohling,R. Roncin,S. Roth
Statistics , 2012, DOI: 10.1103/PhysRevD.86.052008
Abstract: The Double Chooz experiment has observed 8,249 candidate electron antineutrino events in 227.93 live days with 33.71 GW-ton-years (reactor power x detector mass x livetime) exposure using a 10.3 cubic meter fiducial volume detector located at 1050 m from the reactor cores of the Chooz nuclear power plant in France. The expectation in case of theta13 = 0 is 8,937 events. The deficit is interpreted as evidence of electron antineutrino disappearance. From a rate plus spectral shape analysis we find sin^2 2{\theta}13 = 0.109 \pm 0.030(stat) \pm 0.025(syst). The data exclude the no-oscillation hypothesis at 99.8% CL (2.9{\sigma}).
The LAGUNA design study- towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches
LAGUNA Collaboration,D. Angus,A. Ariga,D. Autiero,A. Apostu,A. Badertscher,T. Bennet,G. Bertola,P. F. Bertola,O. Besida,A. Bettini,C. Booth,J. L. Borne,I. Brancus,W. Bujakowsky,J. E. Campagne,G. Cata Danil,F. Chipesiu,M. Chorowski,J. Cripps,A. Curioni,S. Davidson,Y. Declais,U. Drost,O. Duliu,J. Dumarchez,T. Enqvist,A. Ereditato,F. von Feilitzsch,H. Fynbo,T. Gamble,G. Galvanin,A. Gendotti,W. Gizicki,M. Goger-Neff,U. Grasslin,D. Gurney,M. Hakala,S. Hannestad,M. Haworth,S. Horikawa,A. Jipa,F. Juget,T. Kalliokoski,S. Katsanevas,M. Keen,J. Kisiel,I. Kreslo,V. Kudryastev,P. Kuusiniemi,L. Labarga,T. Lachenmaier,J. C. Lanfranchi,I. Lazanu,T. Lewke,K. Loo,P. Lightfoot,M. Lindner,A. Longhin,J. Maalampi,M. Marafini,A. Marchionni,R. M. Margineanu,A. Markiewicz,T. Marrodan-Undagoita,J. E. Marteau,R. Matikainen,Q. Meindl,M. Messina,J. W. Mietelski,B. Mitrica,A. Mordasini,L. Mosca,U. Moser,G. Nuijten,L. Oberauer,A. Oprina,S. Paling,S. Pascoli,T. Patzak,M. Pectu,Z. Pilecki,F. Piquemal,W. Potzel,W. Pytel,M. Raczynski,G. Rafflet,G. Ristaino,M. Robinson,R. Rogers,J. Roinisto,M. Romana,E. Rondio,B. Rossi,A. Rubbia,Z. Sadecki,C. Saenz,A. Saftoiu,J. Salmelainen,O. Sima,J. Slizowski,K. Slizowski,J. Sobczyk,N. Spooner,S. Stoica,J. Suhonen,R. Sulej,M. Szarska,T. Szeglowski,M. Temussi,J. Thompson,L. Thompson,W. H. Trzaska,M. Tippmann,A. Tonazzo,K. Urbanczyk,G. Vasseur,A. Williams,J. Winter,K. Wojutszewska,M. Wurm,A. Zalewska,M. Zampaolo,M. Zito
Physics , 2009,
Abstract: The feasibility of a next generation neutrino observatory in Europe is being considered within the LAGUNA design study. To accommodate giant neutrino detectors and shield them from cosmic rays, a new very large underground infrastructure is required. Seven potential candidate sites in different parts of Europe and at several distances from CERN are being studied: Boulby (UK), Canfranc (Spain), Fr\'ejus (France/Italy), Pyh\"asalmi (Finland), Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The design study aims at the comprehensive and coordinated technical assessment of each site, at a coherent cost estimation, and at a prioritization of the sites within the summer 2010.
Neutrino Physics with JUNO
Fengpeng An,Guangpeng An,Qi An,Vito Antonelli,Eric Baussan,John Beacom,Leonid Bezrukov,Simon Blyth,Riccardo Brugnera,Margherita Buizza Avanzini,Jose Busto,Anatael Cabrera,Hao Cai,Xiao Cai,Antonio Cammi,Guofu Cao,Jun Cao,Yun Chang,Shaomin Chen,Shenjian Chen,Yixue Chen,Davide Chiesa,Massimiliano Clemenza,Barbara Clerbaux,Janet Conrad,Davide D'Angelo,Herve De Kerret,Zhi Deng,Ziyan Deng,Yayun Ding,Zelimir Djurcic,Damien Dornic,Marcos Dracos,Olivier Drapier,Stefano Dusini,Stephen Dye,Timo Enqvist,Donghua Fan,Jian Fang,Laurent Favart,Richard Ford,Marianne Goger-Neff,Haonan Gan,Alberto Garfagnini,Marco Giammarchi,Maxim Gonchar,Guanghua Gong,Hui Gong,Michel Gonin,Marco Grassi,Christian Grewing,Mengyun Guan,Vic Guarino,Gang Guo,Wanlei Guo,Xin-Heng Guo,Caren Hagner,Ran Han,Miao He,Yuekun Heng,Yee Hsiung,Jun Hu,Shouyang Hu,Tao Hu,Hanxiong Huang,Xingtao Huang,Lei Huo,Ara Ioannisian,Manfred Jeitler,Xiangdong Ji,Xiaoshan Jiang,Cecile Jollet,Li Kang,Michael Karagounis,Narine Kazarian,Zinovy Krumshteyn,Andre Kruth,Pasi Kuusiniemi,Tobias Lachenmaier,Rupert Leitner,Chao Li,Jiaxing Li,Weidong Li,Weiguo Li,Xiaomei Li,Xiaonan Li,Yi Li,Yufeng Li,Zhi-Bing Li,Hao Liang,Guey-Lin Lin,Tao Lin,Yen-Hsun Lin,Jiajie Ling,Ivano Lippi,Dawei Liu,Hongbang Liu,Hu Liu,Jianglai Liu,Jianli Liu,Jinchang Liu,Qian Liu,Shubin Liu,Shulin Liu,Paolo Lombardi,Yongbing Long,Haoqi Lu,Jiashu Lu,Jingbin Lu,Junguang Lu,Bayarto Lubsandorzhiev,Livia Ludhova,Shu Luo,Vladimir Lyashuk,Randolph Mollenberg,Xubo Ma,Fabio Mantovani
Physics , 2015,
Abstract: The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multi-purpose underground liquid scintillator detector, was proposed with the determination of the neutrino mass hierarchy as a primary physics goal. It is also capable of observing neutrinos from terrestrial and extra-terrestrial sources, including supernova burst neutrinos, diffuse supernova neutrino background, geoneutrinos, atmospheric neutrinos, solar neutrinos, as well as exotic searches such as nucleon decays, dark matter, sterile neutrinos, etc. We present the physics motivations and the anticipated performance of the JUNO detector for various proposed measurements. By detecting reactor antineutrinos from two power plants at 53-km distance, JUNO will determine the neutrino mass hierarchy at a 3-4 sigma significance with six years of running. The measurement of antineutrino spectrum will also lead to the precise determination of three out of the six oscillation parameters to an accuracy of better than 1\%. Neutrino burst from a typical core-collapse supernova at 10 kpc would lead to ~5000 inverse-beta-decay events and ~2000 all-flavor neutrino-proton elastic scattering events in JUNO. Detection of DSNB would provide valuable information on the cosmic star-formation rate and the average core-collapsed neutrino energy spectrum. Geo-neutrinos can be detected in JUNO with a rate of ~400 events per year, significantly improving the statistics of existing geoneutrino samples. The JUNO detector is sensitive to several exotic searches, e.g. proton decay via the $p\to K^++\bar\nu$ decay channel. The JUNO detector will provide a unique facility to address many outstanding crucial questions in particle and astrophysics. It holds the great potential for further advancing our quest to understanding the fundamental properties of neutrinos, one of the building blocks of our Universe.
Using cryoprobes to decrease acquisition times of triple-resonance experiments used for protein resonance assignments
Michael J. Goger,James M. McDonnell,David Cowburn
Spectroscopy: An International Journal , 2003, DOI: 10.1155/2003/462471
Abstract: In most structural biology NMR laboratories, instrument time is a limiting factor in the number of structural projects a laboratory is able to support. In the post-genomic era we can expect the number of structural targets to markedly increase. Here we address to what degree recently introduced cryoprobes, which are 3–4 times as sensitive as conventional probes, can alleviate this problem. To evaluate this approach, a set of triple-resonance experiments for protein assignments were acquired with a cryoprobe. We show that, with the cryoprobe, high quality triple-resonance data can be obtained within as 4 hours/experiment. These results show that a full set of data for protein assignments can now be practically collected in 1–2 days.
Emerging role of GLP-1 receptor agonists in the treatment of obesity
Lisa M Neff, Robert F Kushner
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2010, DOI: http://dx.doi.org/10.2147/DMSO.S6816
Abstract: ging role of GLP-1 receptor agonists in the treatment of obesity Review (5830) Total Article Views Authors: Lisa M Neff, Robert F Kushner Published Date July 2010 Volume 2010:3 Pages 263 - 273 DOI: http://dx.doi.org/10.2147/DMSO.S6816 Lisa M Neff1, Robert F Kushner2 1Division of Endocrinology, Metabolism, and Molecular Medicine, 2Division of General Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Abstract: The prevalence of obesity has increased dramatically in recent decades, both in the US and worldwide. Pharmacotherapy can augment the weight-reducing effects of lifestyle modification and can facilitate long-term weight maintenance. However, there is a paucity of pharmacologic agents approved for the treatment of obesity, and the use of existing weight loss medications is frequently limited by contraindications, drug interactions, adverse effects, limited coverage by third-party payers, and cost. In recent years, there has been an increased understanding and appreciation of the role of gastrointestinal hormones in the control of body weight. One such hormone, GLP-1, also plays an important role in glucose homeostasis. GLP-1 receptor agonists, such as exenatide and liraglutide, have been developed and are already approved for the treatment of type 2 diabetes. There has also been interest in the use of GLP-1 receptor agonists for the treatment of obesity in nondiabetic patients. This review explores the potential utility and limitations of exenatide and liraglutide as therapeutic agents for obesity.
Emerging role of GLP-1 receptor agonists in the treatment of obesity
Lisa M Neff,Robert F Kushner
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2010,
Abstract: Lisa M Neff1, Robert F Kushner21Division of Endocrinology, Metabolism, and Molecular Medicine, 2Division of General Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: The prevalence of obesity has increased dramatically in recent decades, both in the US and worldwide. Pharmacotherapy can augment the weight-reducing effects of lifestyle modification and can facilitate long-term weight maintenance. However, there is a paucity of pharmacologic agents approved for the treatment of obesity, and the use of existing weight loss medications is frequently limited by contraindications, drug interactions, adverse effects, limited coverage by third-party payers, and cost. In recent years, there has been an increased understanding and appreciation of the role of gastrointestinal hormones in the control of body weight. One such hormone, GLP-1, also plays an important role in glucose homeostasis. GLP-1 receptor agonists, such as exenatide and liraglutide, have been developed and are already approved for the treatment of type 2 diabetes. There has also been interest in the use of GLP-1 receptor agonists for the treatment of obesity in nondiabetic patients. This review explores the potential utility and limitations of exenatide and liraglutide as therapeutic agents for obesity.Keywords: obesity, GLP-1, exenatide, liraglutide
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