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Search Results: 1 - 10 of 401187 matches for " M. Goeger-Nef "
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Solar neutrino physics with Borexino I
L. Ludhova,G. Bellini,J. Benziger,D. Bick,G. Bonfini,D. Bravo,M. Buizza Avanzini,B. Caccianiga,L. Cadonati,F. Calaprice,C. Carraro,P. Cavalcante,A. Chavarria,D. D'Angelo,S. Davini,A. Derbin,A. Etenko,K. Fomenko,D. Franco,C. Galbiati,S. Gazzana,C. Ghiano,M. Giammarchi,M. Goeger-Nef,A. Goretti,L. Grandi,E. Guardincerri,S. Hardy,Aldo Ianni,Andrea Ianni,A. Kayunov,V. Kobychev,D. Korablev,G. Korga,Y. Koshio,D. Kryn,M. Laubenstein,T. Lewke,E. Litvinovich,B. Loer,F. Lombardi,P. Lombardi,I. Machulin,S. Manecki,W. Maneschg,G. Manuzio,Q. Meindl,E. Meroni,L. Miramonti,M. Misiaszek,D. Montanari,P. Mosteiro,V. Muratova,L. Oberauer,M. Obolenksy,F. Ortica,K. Otis,M. Pallavicini,L. Papp,L. Perasso,S. Perasso,A. Pocar,R. S. Raghavan,G. Ranucci,A. Razeto,A. Re,P. A. Romani,A. Sabelnikov,R. Saldanha,C. Salvo,S. Schoenert,H. Simgen,M. Skorokhvatov,O. Smirnov,A. Sotnikov,S. Sukhotin,Y. Suvorov,R. Tartaglia,G. Testera,D. Vignaud,R. B. Vogelaar,F. Von Feilitzsch,J. Winter,M. Wojcik,A. Wright,M. Wurm,J. Xu,O. Zaimidoroga,S. Zavatarelli,G. Zuzel
Physics , 2012,
Abstract: Borexino is a large-volume liquid scintillator detector installed in the underground halls of the Laboratori Nazionali del Gran Sasso in Italy. After several years of construction, data taking started in May 2007. The Borexino phase I ended after about three years of data taking. Borexino provided the first real time measurement of the $^{7}$Be solar neutrino interaction rate with accuracy better than 5% and confirmed the absence of its day-night asymmetry with 1.4% precision. This latter Borexino results alone rejects the LOW region of solar neutrino oscillation parameters at more than 8.5 $\sigma$ C.L. Combined with the other solar neutrino data, Borexino measurements isolate the MSW-LMA solution of neutrino oscillations without assuming CPT invariance in the neutrino sector. Borexino has also directly observed solar neutrinos in the 1.0-1.5 MeV energy range, leading to the first direct evidence of the $pep$ solar neutrino signal and the strongest constraint of the CNO solar neutrino flux up to date. Borexino provided the measurement of the solar $^{8}$B neutrino rate with 3 MeV energy threshold.
La nisba tribale entre identification individuelle et catégorisation. Variations dans la Sicile des xe-xiie siècles Individualizing and categorizing: the tribal nisba and its variants in Sicilian sources of the Xth-XIIth centuries
Annliese Nef
Revue des Mondes Musulmans et de la Méditerranée , 2012, DOI: 10.4000/remmm.6586
Abstract: Il s’agit ici de cerner le r le de la nisba tribale dans le cadre de l’identification par l’anthroponymie en Sicile entre le xe et le xiie siècle. Les sources considérées permettent, pour une part (chroniques, ouvrages de abaqat), de retracer le contexte dans lequel s’insèrent les documents locaux analysés, tous fruits de la pratique administrative ou notariale. Le foisonnement du nom islamique permet de décliner des dénominations sélectives en fonction du contexte et la nisba tribale n’est pas un élément décisif de l’identification par la dénomination individuelle dans la Sicile des xie-xiie siècles. Arborée par les savants et, surtout, quasiment obligatoire pour les témoins énumérés dans les actes notariés, elle qualifie les élites urbaines et est un signe d’appartenance à une aristocratie, à une notabilité. En revanche, dans les zones rurales, documentées partiellement par des listes fiscales, elle appara t très effacée. La nisba tribale véhicule d’autres éléments (honorabilité, appartenance aux élites, etc.) que ceux strictement nécessaires à l’identification personnelle. Elle n’individualise pas mais identifie en renvoyant à un groupe, ici la tribu et sa célébrité. Il s’agit donc plus d’un élément de catégorisation que d’individuation. This article aims to elucidate the role played by tribal nisba-s in people’s names in Sicily between the tenth and the twelfth century. The sources considered (narratives and abaqat) allow us to describe the context in which local administrative as well as notarial documents should be read.Islamic personal names, consisting of various elements, allow selective variations according to context, and tribal nisba-s are not necessarily central to individual identification. Sanctioned by the learned and an almost necessary requirement for witnesses of notarial acts, the tribal nisba indicates urban élite-status and aristocrayic birth, whereas it remains very rare in rural areas as can be documented through fiscal rolls. Thus, tribal nisba-sconvey social attributes (such as honour or class), rather than merely indicating a person’s individual identity. Individuals are defined in relation to groups i.e. the tribe and its fame. Therefore, tribal nisba-scategorize rather than individualize.
High Sensitivity CRP Predicts Long-Term Mortality in Patients with Atrial Fibrillation and Evident Acute Coronary Syndrome  [PDF]
Christoph Liebetrau Liebetrau, Luise Gaede, Sebastian Szardien, Johannes Rixe, Oliver Doerr, Matthias Willmer, Michael Weber, Andreas Rolf, Helge M?llmann, Albrecht Els?sser, Christian Hamm, Holger Nef
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.43025

Background: Atrial fibrillation (AF) is a frequent arrhythmia associated with an adverse prognostic value in patients with ACS. Risk stratification as well as diagnosis of ACS is strongly supported by biomarkers. High sensitivity CRP (hs-CRP) is known to be elevated in patients presenting with ACS as well as with AF.Methods: In total, 2034 consecutive patients with an ACS were analysed. The incidence of AF in the setting of ACS, the prognostic value of hs-CRP and the clinical outcome within 6 months were subject of the study. Death after 6 months was considered as primary endpoint. Results: The frequency of AF among patients admitted with suspected ACS was 124 (6.1%). During 6-month follow-up the mortality rate among patients with AF was significantly higher (20 [16.1%] vs 133 [6.9%]; log-rank 13.72; p < 0.001) compared to patients without AF. Cox regression analysis revealed an increased risk for ACS patients with AF with an adjusted HR of 2.63 (95% CI 1.48 - 3.78; p < 0.001). Patients with AF showed significant higher levels of hs-CRP than patients without AF (6.01mg/dl IQR [1.7 - 17.8] vs 3.3mg/dl IQR [1.37 - 9.83];

La mystique a-t-elle une valeur philosophique ? William James et Bertrand Russell
Frédéric Nef
ThéoRèmes : Enjeux des Approches Empiriques des Religions , 2010, DOI: 10.4000/theoremes.73
Abstract: L’article se propose d’examiner les points de convergence et de divergence entre deux conceptions des rapports entre science, philosophie et mystique, celles de William James et de Bertrand Russell.
Fetal Programming of Adult Glucose Homeostasis in Mice
Christopher R. Cederroth, Serge Nef
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0007281
Abstract: Background Emerging evidence suggests that dietary soy and phytoestrogens can have beneficial effects on lipid and glucose metabolism. We have previously shown that male mice fed from conception to adulthood with a high soy-containing diet had reduced body weight, adiposity and a decrease in glucose intolerance, an early marker of insulin resistance and diabetes. Objectives The purpose of this study was to identify the precise periods of exposure during which phytoestrogens and dietary soy improve lipid and glucose metabolism. Since intrauterine position (IUP) has been shown to alter sensitivity to endocrine disruptors, we also investigated whether the combination of IUP and fetal exposure to dietary phytoestrogens could potentially affect adult metabolic parameters. Methods Male outbred mice (CD-1) were allowed ad libitum access to either a high soy-containing diet or a soy-free diet either during gestation, lactation or after weaning. Adiposity and bone mass density was assessed by dual x-ray absorptiometry. Glucose tolerance was assessed by a glucose tolerance test. Blood pressure was examined by the tail-cuff system. Results Here we show that metabolic improvements are dependent on precise windows of exposure during life. The beneficial effects of dietary soy and phytoestrogens on adiposity were apparent only in animals fed post-natally, while the improvements in glucose tolerance are restricted to animals with fetal exposure to soy. Interestingly, we observed that IUP influenced adult glucose tolerance, but not adiposity. Similar IUP trends were observed for other estrogen-related metabolic parameters such as blood pressure and bone mass density. Conclusion Our results suggest that IUP and fetal exposure to estrogenic environmental disrupting compounds, such as dietary phytoestrogens, could alter metabolic and cardiovascular parameters in adult individuals independently of adipose gain.
Short-Term Treatment with Bisphenol-A Leads to Metabolic Abnormalities in Adult Male Mice
Thiago M. Batista, Paloma Alonso-Magdalena, Elaine Vieira, Maria Esmeria C. Amaral, Christopher R. Cederroth, Serge Nef, Ivan Quesada, Everardo M. Carneiro, Angel Nadal
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033814
Abstract: Bisphenol-A (BPA) is one of the most widespread endocrine disrupting chemicals (EDC) used as the base compound in the manufacture of polycarbonate plastics. Although evidence points to consider exposure to BPA as a risk factor for insulin resistance, its actions on whole body metabolism and on insulin-sensitive tissues are still unclear. The aim of the present work was to study the effects of low doses of BPA in insulin-sensitive peripheral tissues and whole body metabolism in adult mice. Adult mice were treated with subcutaneous injection of 100 μg/kg BPA or vehicle for 8 days. Whole body energy homeostasis was assessed with in vivo indirect calorimetry. Insulin signaling assays were conducted by western blot analysis. Mice treated with BPA were insulin resistant and had increased glucose-stimulated insulin release. BPA-treated mice had decreased food intake, lower body temperature and locomotor activity compared to control. In skeletal muscle, insulin-stimulated tyrosine phosphorylation of the insulin receptor β subunit was impaired in BPA-treated mice. This impairment was associated with a reduced insulin-stimulated Akt phosphorylation in the Thr308 residue. Both skeletal muscle and liver displayed an upregulation of IRS-1 protein by BPA. The mitogen-activated protein kinase (MAPK) signaling pathway was also impaired in the skeletal muscle from BPA-treated mice. In the liver, BPA effects were of lesser intensity with decreased insulin-stimulated tyrosine phosphorylation of the insulin receptor β subunit. In conclusion, short-term treatment with low doses of BPA slows down whole body energy metabolism and disrupts insulin signaling in peripheral tissues. Thus, our findings support the notion that BPA can be considered a risk factor for the development of type 2 diabetes.
Effects of age and eccentricity on visual target detection
Nicole Gruber,René M. Müri,Urs P. Mosimann,Rahel Bieri,Andrea Aeschimann,Giuseppe A. Zito,Prabitha Urwyler,Thomas Nyffeler,Tobias Nef
Frontiers in Aging Neuroscience , 2013, DOI: 10.3389/fnagi.2013.00101
Abstract: The aim of this study was to examine the effects of aging and target eccentricity on a visual search task comprising 30 images of everyday life projected into a hemisphere, realizing a ± 90° visual field. The task performed binocularly allowed participants to freely move their eyes to scan images for an appearing target or distractor stimulus (presented at 10°; 30°, and 50° eccentricity). The distractor stimulus required no response, while the target stimulus required acknowledgment by pressing the response button. 117 healthy subjects (mean age=49.63 years, SD=17.40 years, age range 20-78 years) were studied. The results show that target detection performance decreases with age as well as with increasing eccentricity, especially for older subjects. Reaction time also increases with age and eccentricity, but in contrast to target detection, there is no interaction between age and eccentricity. Eye movement analysis showed that younger subjects exhibited a passive search strategy while older subjects exhibited an active search strategy probably as a compensation for their reduced peripheral detection performance.
Dicer Is Required for Haploid Male Germ Cell Differentiation in Mice
Hanna M. Korhonen, Oliver Meikar, Ram Prakash Yadav, Marilena D. Papaioannou, Yannick Romero, Matteo Da Ros, Pedro L. Herrera, Jorma Toppari, Serge Nef, Noora Kotaja
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024821
Abstract: Background The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The best-characterized function of miRNAs is gene repression at the post-transcriptional level through the pairing with mRNAs of protein-encoding genes. Small RNAs can also act at the transcriptional level by controlling the epigenetic status of chromatin. Dicer and other mediators of small RNA pathways are present in mouse male germ cells, and several miRNAs and endogenous siRNAs are expressed in the testis, suggesting that Dicer-dependent small RNAs are involved in the control of the precisely timed and highly organised process of spermatogenesis. Principal Findings Being interested in the Dicer-mediated functions during spermatogenesis, we have analysed here a male germ cell-specific Dicer1 knockout mouse model, in which the deletion of Dicer1 takes place during early postnatal development in spermatogonia. We found that Dicer1 knockout testes were reduced in size and spermatogenesis within the seminiferous tubules was disrupted. Dicer1 knockout epididymides contained very low number of mature sperm with pronounced morphological abnormalities. Spermatogonial differentiation appeared unaffected. However, the number of haploid cells was decreased in knockout testes, and an increased number of apoptotic spermatocytes was observed. The most prominent defects were found during late haploid differentiation, and Dicer was demonstrated to be critical for the normal organization of chromatin and nuclear shaping of elongating spermatids. Conclusions/Significance We demonstrate that Dicer and Dicer-dependent small RNAs are imperative regulators of haploid spermatid differentiation and essential for male fertility.
Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα
Paloma Alonso-Magdalena, Ana B. Ropero, M. Pilar Carrera, Christopher R. Cederroth, Mathurin Baquié, Benoit R. Gauthier, Serge Nef, Enrico Stefani, Angel Nadal
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002069
Abstract: The function of pancreatic β-cells is the synthesis and release of insulin, the main hormone involved in blood glucose homeostasis. Estrogen receptors, ERα and ERβ, are important molecules involved in glucose metabolism, yet their role in pancreatic β-cell physiology is still greatly unknown. In this report we show that both ERα and ERβ are present in pancreatic β-cells. Long term exposure to physiological concentrations of 17β-estradiol (E2) increased β-cell insulin content, insulin gene expression and insulin release, yet pancreatic β-cell mass was unaltered. The up-regulation of pancreatic β-cell insulin content was imitated by environmentally relevant doses of the widespread endocrine disruptor Bisphenol-A (BPA). The use of ERα and ERβ agonists as well as ERαKO and ERβKO mice suggests that the estrogen receptor involved is ERα. The up-regulation of pancreatic insulin content by ERα activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis.
Prof. Dr. Boris Agustín Nef Ulloa
Revista Eletr?nica Espa?o Teológico , 2009,
Abstract: No último século, os exegetas crist os, para obter uma compreens o mais profunda dos escritos neotestamentários, despertaram progressivamente para a necessidade de conhecer as fontes, práticas e características da exegese judaica (do período do Segundo Templo e do período Rabínico). Esta mudan a de perspectiva fez com que a exegese crist entrasse em diálogo com o derás, a hermenêutica própria do judaísmo. Neste artigo apresentamos a complexa quest o da defini o e da distin o dos dois termos: derás e midrás. Seguimos o caminho histórico percorrido pelos exegetas crist os quanto à compreens o e à aplica o dos dois termos. Enfocamos, de modo particular, o debate sobre a compreens o do midrás/derás enquanto gênero literário específico (Wright) ou método exegético e hermenêutico (Bloch; Díez Macho; Le Déaut; etc).
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