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Search Results: 1 - 10 of 401612 matches for " M. Franke "
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Los usos del sexo
Franke,Katherine M;
Revista de Estudios Sociales , 2007,
Abstract: this article analyzes how the social and legal classification of certain injuries as "sexual" or "sexbased" risks telling us too much and not enough about the kind of harm these injuries inflict. this classification both overdetermines the conduct and the injury as sexual and underdetermines other aspects of the conduct and the injury that get crowded out once the "sexual" label is applied - aspects such as racial, nationalistic or religious. using three examples - the interpretations by some anthropologists of the seminal practices of the sambia in new guinea as a kind of "ritualized homosexuality," the attack against haitian immigrant abner louima by new york city police officers, and the rapes and other assaults against men and women by soldiers in the former yugoslavia - the article shows how the notion of "sexual practices" or "sexual crime" can hide gender, racial, and religious discrimination. with this in mind, it proposes a move from the discretionary legal use of the "sexual" towards a revision of violence from the perspective of international human rights law. we cannot, the article concludes, lose sight of "the uses of sex in the construction of men, masculinity and nations and in the destruction of women, men and the people."
Los Usos del Sexo
Katherine M. Franke
Revista de Estudios Sociales , 2007,
Abstract: This article analyze show the social and legal classification of certain injuries as "sexual" or "sexbased" risks telling ustoomuchand notenough about the kind of harm these injuries inflict. This classification both overdetermines the conduct and the injury as sexual and underdetermines other aspects of the conduct and the injury that get crowded out once the "sexual" label is applied aspects such as racial, nationalistic or religious. Using three examplesthe interpretations bysome anthropologists of the seminal practices of the Sambia in New Guinea as a kind of "ritualized homosexuality," the attack against Haitian immigrant Abner Louima by New York City police officers, and the rapes and other assaults against men and women by soldiers in the former Yugoslavia the article shows how the notion of "sexual practices" or "sexual crime" can hide gender, racial, and religious discrimination. With this in mind, it proposes a move from the discretionary legal use of the "sexual" towards a revision of violence from the perspective of international human rights law. We cannot, the article concludes, lose sight of "the uses of sex in the construction of men, masculinity and nations and in the destruction of women, men and the people."
Role of primary surgery in advanced ovarian cancer
Karsten Münstedt, Folker E Franke
World Journal of Surgical Oncology , 2004, DOI: 10.1186/1477-7819-2-32
Abstract: We reviewed published reports on primary surgical treatment, surgical expertise, inadequate primary surgery/quality assurance, neoadjuvant chemotherapy, interval debulking, and surgical prognostic factors in advanced ovarian cancer to help resolve outstanding issues.The aim of primary surgery is a well-planned and complete intervention with optimal staging and surgery. Surgical debulking is worthwhile as there are further effective treatments available to control unresectable residual disease. Patients of gynecologic oncology specialist surgeons have better survival rates. This may reflect a working 'culture' rather than better technical skills. One major problem though, is that despite pleas to restrict surgery to experienced surgeons, specialist centers are often left to cope with the results of inadequate primary surgical resections. Patients with primary chemotherapy or those who have had suboptimal debulking may benefit from interval debulking. A proposal for a better classification of residual tumor is given.Optimal surgical interventions have definite role to play in advanced ovarian cancers. Improvements in surgical treatment in the general population will probably improve patients' survival when coupled with improvements in current chemotherapeutic approaches.The Fédération Internationale de Gynécologie et d'Obstétrigue (FIGO) classifies ovarian carcinoma in stage I to IV [1,2]. Stage I has been defined as growth limited to the ovaries; stage II as growth involving one or both ovaries with pelvic extension; stage III as tumor involving one or both ovaries with peritoneal implants, and outside the pelvis and/or positive retroperitoneal or inguinal nodes and stage IV as having distant metastasis [1,2].Tumors in stages I and II are generally considered to represent early disease, while stages III and IV evince late or advanced disease [3,4]. The strong prognostic value of the FIGO classification system has been proved in number of studies [5].Unfortunately, mo
Institutional change and political decision-making in the creation of the Brazilian National Health Surveillance Agency
Piovesan, Márcia Franke;Labra, Maria Eliana;
Cadernos de Saúde Pública , 2007, DOI: 10.1590/S0102-311X2007000600012
Abstract: this article examines the decision-making process that led to the creation of the brazilian national health surveillance agency (anvisa) in 1999. the authors begin by discussing the history of the agency's predecessor, the health surveillance secretariat, and the need for its modernization to adjust the quality of the products under its control to domestic and international demands. from the theoretical perspective of neo-institutionalism, the article goes on to analyze the social and political context surrounding the debate on the proposed alternatives to adjust health surveillance to new rules in line with such requirements, focusing especially on the formulation of the new policy, the decision-making arena, and the actors with specific interests in the sector. the research drew on extensive documentary and media material, plus interviews with key actors. the article concludes that a determinant factor for the creation of anvisa was the favorable domestic political context, fostering a positive correlation of forces that (in an extremely short timeframe, 1998-1999) allowed the creation of the first regulatory agency in the social policies area in brazil.
Modeling variations of marine reservoir ages during the last 45 000 years
J. Franke, A. Paul,M. Schulz
Climate of the Past (CP) & Discussions (CPD) , 2008,
Abstract: When dating marine samples with 14C, the reservoir-age effect is usually assumed to be constant, although atmospheric 14C production rate and ocean circulation changes cause temporal and spatial reservoir-age variations. These lead to dating errors, which can limit the interpretation of cause and effect in paleoclimate data. We used a global ocean circulation model forced by transient atmospheric Δ14C variations to calculate reservoir ages for the last 45 000 years for a present day-like and a last glacial maximum-like ocean circulation. A ~30% reduced Atlantic meridonal overturning circulation leads to increased reservoir ages by up to ~500 years in high latitudes. Temporal variations are proportional to the absolute value of the reservoir age; regions with large reservoir age also show large variation. Temporal variations range between ~300 years in parts of the subtropics and ~1000 years in the Southern Ocean. For tropical regions, which are generally assumed to have nearly stable reservoir ages, the model suggests variations of several hundred years.
Modeling variations of marine reservoir ages during the last 45 000 years
J. Franke,A. Paul,M. Schulz
Climate of the Past Discussions , 2008,
Abstract: When dating marine samples with 14C, the reservoir-age effect is usually assumed to be constant, although atmospheric 14C production rate and ocean circulation changes cause temporal and spatial reservoir-age variations. These lead to dating errors, which can limit the interpretation of cause and effect in paleoclimate data. We used a global ocean circulation model forced by transient atmospheric Δ14C variations to calculate reservoir ages for the last 45 000 years for a present day-like and a last glacial maximum-like ocean circulation. A ~30% reduced Atlantic meridonal overturning circulation leads to increased reservoir ages by up to ~500 years in high latitudes. Temporal variations are proportional to the absolute value of the reservoir age; regions with large reservoir age also show large variation. Temporal variations range between ~300 years in parts of the subtropics and ~1000 years in the Southern Ocean. For tropical regions, which are generally assumed to have nearly stable reservoir ages, the model suggests variations of several hundred years.
OVALOCYTOSIS AND MALARIA IN NAPU VALLEY, CENTRAL SULAWESI, INDONESIA
Purnomo Purnomo,M. Sudomo,Edward M. Lane,Eileen D. Franke
Bulletin of Health Research , 2012,
Abstract: Pada Penelitian di 3 desa, Tamadue, Maholo dan Winowanga di Lembah Napu, Sulawesi Tengah, didapatkan pre-valensi ovalositosis pada penduduk masing-masing sebesar 26%, 25% dan 14%. Dari jumlah penduduk 371 yang diperik-sa darahnya dari ketiga desa tersebut 22% menderita ovalositosis dengan 7% di antaranya menderita malaria. Sedang-kan dari sisanya 78% penduduk yang mempunyai sel darah merah normal, 20% di antaranya menderita malaria. Per-bedaan ini ternyata bermakna, sehingga ada korelasi antara ovalositosis dengan infeksi malaria. Ada kecenderungan golongan anak umur 2-9 tahun yang mempunyai ovalositosis dalam darahnya akan lebih resisten terhadap infeksi mala-ria dibanding golongan umur yang lain. Selain P. falciparum, juga P. vivax dan P. malariae lebih banyak dijumpai pada penderita yang mempunyai sel darah merah normal daripada penderita yang mempunyai sel darah oval.
Substitui??o parcial do farelo de soja por proteína texturizada de soja na dieta de leit?es desmamados
Bertol, Teresinha Marisa;Mores, Nelson;Franke, Márcia Regina;
Revista Brasileira de Zootecnia , 2001, DOI: 10.1590/S1516-35982001000100021
Abstract: two experiments were carried out to evaluate partial substitution of soybean meal (sm) by texturized soybean protein (tsp) in the pre-starter diet, for piglets weaned at 21 days of age. four levels (0, 25, 50 and 75% and 0, 20, 40 and 60%, respectively) of replacement of sm by tsp were compared in each experiment. in the first experiment, the replacement of sm by tst showed a feed: gain (fg) linear decrease in the fed period of the diets and reduction the incidence of diarrhea and in the average height of the intestinal mucous (him) with the increase of tsp levels. in the second experiment, there was a cubic effect on the daily weight gain (dgw) and on the body weight at the end of the nursery phase (bw35) as the result of partial replacement of sm by tsp. it was impracticable to estimate the best level of replacement of sm by tsp. it was concluded that, partial replacement of sm by tsp in the diets for piglets weaned at 21 days of age improved the performance of piglets at the initial post-weaning period, however, this effect may not to be extended until the end of the nursery phase. the partial substitution of sm by tsp leaded to a decrease in the incidence and length of diarrhea after the weaning, and leaded to a reduction in the intestinal mucous morphology alterations.
Substitui??o parcial do farelo de soja por soja integral extrusada na dieta de leit?es desmamados
Bertol, Teresinha Marisa;Mores, Nelson;Franke, Márcia Regina;
Revista Brasileira de Zootecnia , 2001, DOI: 10.1590/S1516-35982001000300020
Abstract: a study including two experiments was carried out to evaluate partial substitution of soybean meal (sm) by full-fat extruded soybean (es) in the pre-starter diet, for piglets weaned at 21 days of age. in each experiment four levels (0, 20, 40 and 60%) of substitution of sm by es were compared. in the first experiment, daily feed intake (dfi) and feed:gain ratio linearly increased for the total nursery period, due to substitution of sm by es. daily gain (dg) was not affected. average height of the intestinal mucousa (him) in the low jejunum was linearly reduced, and in the duodenum had a quadratic effect, when es was increased. in the experiment 2, dg, dfi and body weight at the end of the nursery phase (bw35) had a quadratic response, in consequence of substitution of sm by es. it was concluded that partial substitution of sm by es in the pre-starter diet for piglets weaned at 21 days of age provide an improvement for performance of piglets in the initial period after weaning. in the experiment 1, it was not possible to determine the maximum value for substitution of sm by es, because dg showed a linear response until 60% of substitution. however, in the experiment 2, the best result for dg, estimated through the derivatization of the quadratic equation, was obtained at 26.82% of substitution, from 0 to 14 days post weaning.
The exposure of cancer cells to hyperthermia, iron oxide nanoparticles, and mitomycin C influences membrane multidrug resistance protein expression levels
Franke K, Kettering M, Lange K, Kaiser WA, Hilger I
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S37465
Abstract: sure of cancer cells to hyperthermia, iron oxide nanoparticles, and mitomycin C influences membrane multidrug resistance protein expression levels Original Research (1284) Total Article Views Authors: Franke K, Kettering M, Lange K, Kaiser WA, Hilger I Published Date January 2013 Volume 2013:8 Pages 351 - 363 DOI: http://dx.doi.org/10.2147/IJN.S37465 Received: 28 August 2012 Accepted: 27 October 2012 Published: 20 January 2013 Karolin Franke, Melanie Kettering, Kathleen Lange, Werner A Kaiser, Ingrid Hilger Institute of Diagnostic and Interventional Radiology, Department of Experimental Radiology, Institute of Diagnostic and Interventional Radiology I, University Hospital Jena, Friedrich-Schiller Universit t Jena, Jena, Germany Purpose: The presence of multidrug resistance-associated protein (MRP) in cancer cells is known to be responsible for many therapeutic failures in current oncological treatments. Here, we show that the combination of different effectors like hyperthermia, iron oxide nanoparticles, and chemotherapeutics influences expression of MRP 1 and 3 in an adenocarcinoma cell line. Methods: BT-474 cells were treated with magnetic nanoparticles (MNP; 1.5 to 150 μg Fe/cm2) or mitomycin C (up to 1.5 μg/cm2, 24 hours) in the presence or absence of hyperthermia (43°C, 15 to 120 minutes). Moreover, cells were also sequentially exposed to these effectors (MNP, hyperthermia, and mitomycin C). After cell harvesting, mRNA was extracted and analyzed via reverse transcription polymerase chain reaction. Additionally, membrane protein was isolated and analyzed via sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting. Results: When cells were exposed to the effectors alone or to combinations thereof, no effects on MRP 1 and 3 mRNA expression were observed. In contrast, membrane protein expression was influenced in a selective manner. The effects on MRP 3 expression were less pronounced compared with MRP 1. Treatment with mitomycin C decreased MRP expression at high concentrations and hyperthermia intensified these effects. In contrast, the presence of MNP only increased MRP 1 and 3 expression, and hyperthermia reversed these effects. When combining hyperthermia, magnetic nanoparticles, and mitomycin C, no further suppression of MRP expression was observed in comparison with the respective dual treatment modalities. Discussion: The different MRP 1 and 3 expression levels are not associated with de novo mRNA expression, but rather with an altered translocation of MRP 1 and 3 to the cell membrane as a result of reactive oxygen species production, and with shifting of intracellular MRP storage pools, changes in membrane fluidity, etc, at the protein level. Our results could be used to develop new treatment strategies by repressing mechanisms that actively export drugs from the target cell, thereby improving the therapeutic outcome in oncology.
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