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Search Results: 1 - 10 of 489353 matches for " M. F. Seeds "
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The Young Solar Analogs Project: I. Spectroscopic and Photometric Methods and Multi-year Timescale Spectroscopic Results
R. O. Gray,J. M. Saken,C. J. Corbally,M. M. Briley,R. A. Lambert,V. A. Fuller,I. M. Newsome,M. F. Seeds,Y. Kahvaz
Physics , 2015,
Abstract: This is the first in a series of papers presenting methods and results from the Young Solar Analogs Project, which began in 2007. This project monitors both spectroscopically and photometrically a set of 31 young (300 - 1500 Myr) solar-type stars with the goal of gaining insight into the space environment of the Earth during the period when life first appeared. From our spectroscopic observations we derive the Mount Wilson $S$ chromospheric activity index ($S_{\rm MW}$), and describe the method we use to transform our instrumental indices to $S_{\rm MW}$ without the need for a color term. We introduce three photospheric indices based on strong absorption features in the blue-violet spectrum -- the G-band, the Ca I resonance line, and the Hydrogen-$\gamma$ line -- with the expectation that these indices might prove to be useful in detecting variations in the surface temperatures of active solar-type stars. We also describe our photometric program, and in particular our "Superstar technique" for differential photometry which, instead of relying on a handful of comparison stars, uses the photon flux in the entire star field in the CCD image to derive the program star magnitude. We present time series plots of our spectroscopic data for all four indices, and carry out extensive statistical tests on those time series demonstrating the reality of variations on timescales of years in all four indices. We also statistically test for and discover correlations and anti-correlations between the four indices. We discuss the physical basis of those correlations. As it turns out, the "photospheric" indices appear to be most strongly affected by continuum emission. We thus anticipate that these indices may prove to be useful proxies for monitoring continuum emission in the near ultraviolet.
Adolescent Exposure of JWH-018 “Spice” Produces Subtle Effects on Learning and Memory Performance in Adulthood  [PDF]
David M. Compton, Megan Seeds, Grant Pottash, Brian Gradwohl, Chris Welton, Ross Davids
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.22017
Abstract: The active components associated with the bio-designer drugs known variously as “Spice” or “K2” have rapidly gained in popularity among recreational users, forcing the United States Drug Enforcement Administration to classify these compounds as Schedule I drugs in the Spring of 2011. However, although there is some information about many of the synthetic cannabinoids used in Spice products, little is known about the consequences of the main constituent, (1-pentyl-3-(1-naphthoyl)indole; JWH-018), on neuropsychological development or behavior. In the present experiment, adolescent rats were given repeated injections of either saline or 100 μg/kg of JWH-018. Once the animals were 75 days of age, they were trained using tasks with spatial components of various levels of difficulty and a spatial learning set task. On early trials with water maze tasks of varying difficulty, the JWH-018 treated rats were impaired relative to controls. However, by the end of each phase of testing, drug and control animals were comparable, although on probe trials the drug-treated animals spent significantly less time in the target quadrant. In addition, the performance of the drug-treated rats was inferior to that of the control animals on a learning set task, suggesting some difficulty in adapting their responses to changing task demands. The results suggest that chronic exposure to this potent cannabinoid CB1 receptor agonist during adolescence is capable of producing a variety of subtle changes affecting spatial learning and memory performance in adulthood, well after the drug exposure period.
DNA Methylation in an Enhancer Region of the FADS Cluster Is Associated with FADS Activity in Human Liver
Timothy D. Howard, Rasika A. Mathias, Michael C. Seeds, David M. Herrington, James E. Hixson, Lawrence C. Shimmin, Greg A. Hawkins, Matthew Sellers, Hannah C. Ainsworth, Susan Sergeant, Leslie R. Miller, Floyd H. Chilton
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097510
Abstract: Levels of omega-6 (n-6) and omega-3 (n-3), long chain polyunsaturated fatty acids (LcPUFAs) such as arachidonic acid (AA; 20:4, n-6), eicosapentaenoic acid (EPA; 20:5, n-3) and docosahexaenoic acid (DHA; 22:6, n-3) impact a wide range of biological activities, including immune signaling, inflammation, and brain development and function. Two desaturase steps (Δ6, encoded by FADS2 and Δ5, encoded by FADS1) are rate limiting in the conversion of dietary essential 18 carbon PUFAs (18C-PUFAs) such as LA (18:2, n-6) to AA and α-linolenic acid (ALA, 18:3, n-3) to EPA and DHA. GWAS and candidate gene studies have consistently identified genetic variants within FADS1 and FADS2 as determinants of desaturase efficiencies and levels of LcPUFAs in circulating, cellular and breast milk lipids. Importantly, these same variants are documented determinants of important cardiovascular disease risk factors (total, LDL, and HDL cholesterol, triglycerides, CRP and proinflammatory eicosanoids). FADS1 and FADS2 lie head-to-head (5′ to 5′) in a cluster configuration on chromosome 11 (11q12.2). There is considerable linkage disequilibrium (LD) in this region, where multiple SNPs display association with LcPUFA levels. For instance, rs174537, located ~15 kb downstream of FADS1, is associated with both FADS1 desaturase activity and with circulating AA levels (p-value for AA levels = 5.95×10?46) in humans. To determine if DNA methylation variation impacts FADS activities, we performed genome-wide allele-specific methylation (ASM) with rs174537 in 144 human liver samples. This approach identified highly significant ASM with CpG sites between FADS1 and FADS2 in a putative enhancer signature region, leading to the hypothesis that the phenotypic associations of rs174537 are likely due to methylation differences. In support of this hypothesis, methylation levels of the most significant probe were strongly associated with FADS1 and, to a lesser degree, FADS2 activities.
New rotation periods in the Pleiades: Interpreting activity indicators
Anita Krishnamurthi,D. M. Terndrup,M. H. Pinsonneault,K. Sellgren,John R. Stauffer,R. Schild,D. E. Backman,K. B. Beisser,D. B. Dahari,A. Dasgupta,J. T. Hagelgans,M. A. Seeds,Rajan Anand,Bentley D. Laaksonen,Laurence A. Marschall,T. Ramseyer
Physics , 1997, DOI: 10.1086/305173
Abstract: We present results of photometric monitoring campaigns of G, K and M dwarfs in the Pleiades carried out in 1994, 1995 and 1996. We have determined rotation periods for 18 stars in this cluster. In this paper, we examine the validity of using observables such as X-ray activity and amplitude of photometric variations as indicators of angular momentum loss. We report the discovery of cool, slow rotators with high amplitudes of variation. This contradicts previous conclusions about the use of amplitudes as an alternate diagnostic of the saturation of angular momentum loss. We show that the X-ray data can be used as observational indicators of mass-dependent saturation in the angular momentum loss proposed on theoretical grounds.
Same Modulation but Different Starting Points: Performance Modulates Age Differences in Inferior Frontal Cortex Activity during Word-Retrieval
Marcus Meinzer, Tobias Flaisch, Lauren Seeds, Stacy Harnish, Daria Antonenko, Veronica Witte, Robert Lindenberg, Bruce Crosson
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033631
Abstract: The neural basis of word-retrieval deficits in normal aging has rarely been assessed and the few previous functional imaging studies found enhanced activity in right prefrontal areas in healthy older compared to younger adults. However, more pronounced right prefrontal recruitment has primarily been observed during challenging task conditions. Moreover, increased task difficulty may result in enhanced activity in the ventral inferior frontal gyrus (vIFG) bilaterally in younger participants as well. Thus, the question arises whether increased activity in older participants represents an age-related phenomenon or reflects task difficulty effects. In the present study, we manipulated task difficulty during overt semantic and phonemic word-generation and used functional magnetic resonance imaging to assess activity patterns in the vIFG in healthy younger and older adults (N = 16/group; mean age: 24 vs. 69 years). Both groups produced fewer correct responses during the more difficult task conditions. Overall, older participants produced fewer correct responses and showed more pronounced task-related activity in the right vIFG. However, increased activity during the more difficult conditions was found in both groups. Absolute degree of activity was correlated with performance across groups, tasks and difficulty levels. Activity modulation (difficult vs. easy conditions) was correlated with the respective drop in performance across groups and tasks. In conclusion, vIFG activity levels and modulation of activity were mediated by performance accuracy in a similar way in both groups. Group differences in the right vIFG activity were explained by performance accuracy which needs to be considered in future functional imaging studies of healthy and pathological aging.
Electrochemical Corrosion Behavior of Aluminum in Perchloric Acid  [PDF]
F. M. Mahgoub
Open Journal of Physical Chemistry (OJPC) , 2013, DOI: 10.4236/ojpc.2013.34022

The effects of acetate, citrate, benzoate, tetra-ethylammonium iodide (TEA) and 1,4,8,11 tetra-azacyclo-tetradecane (cyclam) on the corrosion behavior of aluminum in 1 M HClO4 at 40°C were studied by potentiodynamic polarization technique. Acetate, citrate, and benzoate inhibited the corrosion of aluminum and shifted the breakdown potential to positive direction. Cyclam was investigated as a macrocyclic organic inhibitor to the acid corrosion of aluminum. The addition of cyclam to the corroding medium showed a pronounced effect on the anodic but not on the cathodic part of the polarization curve. The addition of TEA to the medium enhanced the corrosion rate and shifted the breakdown potential to more negative value as the concentration increased. The results were discussed on the basis of the adsorption mechanism and the nature of the adsorbed species.

A Critical Analysis of Empiricism  [PDF]
F. M. Anayet Hossain
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.43030
Abstract: Empiricism is a philosophical theory which argues that human knowledge is derived entirely from sensory experience. As a branch of epistemology, empiricism disregards the concept of instinctive ideas and focuses entirely on experience and evidence as it relates to sensory perception. Empiricism is a philosophical school holding that knowledge can only be (or is primarily) gained from sensory experience. Accordingly, it rejects any (or much) use of a priori reasoning in the gathering and analysis of knowledge. It rivals rationalism according to which reason is the ultimate source of knowledge. The philosophy of empiricism was first put forth in John Locke’s An Essay Concerning Human Understanding. Locke argued that the only way by which human acquire knowledge is through experience. Locke firmly argued that humans are incapable of formulating or possessing inherent ideas. The aim of this paper is to explain that the traditional empiricist standpoint in the fields of epistemology and then try to show that it is not adequate for explaining some things relevant to these fields. For that the traditional empiricist methods needs to be supplemented by extra-logical principles that are not strictly empirical.
Valence Stabilization of Fe(II) Ions during Extended Gamma Irradiation of Their Aqueous Acidic Solutions Containing Phenol, Acetone, 4-Ethylpyridine or Hydrazine Hydrate  [PDF]
M. F. Barakat, M. M. Abdel Hamid
World Journal of Nuclear Science and Technology (WJNST) , 2015, DOI: 10.4236/wjnst.2015.52008
Abstract: Valence stabilization of polyvalent ions in acidic solutions during gamma irradiation is an important issue in nuclear aqueous chemical technology. Radiolysis and self irradiation problems encountered during chemical reprocessing of nuclear fuel or during chemical separation of transuranium elements or fission products are extremely important. Consequently studies on valence stabilization of polyvalent ions in strong gamma irradiation fields are very useful. In our previous publications, the valence stabilization of Fe(II) ions in acidic solutions during continuous gamma irradiation was achieved by using an inorganic compound; such as sodium sulfite, or some organic additives such as aliphatic alcohols, aldehyds or acids prior to irradiation. It was found that the efficiency of valence stabilization depends on the amount and chemical structure of the added compounds. In the present work, valence stabilization of divalent iron during gamma irradiation was studied in presence of some organic additives, belonging to some other classes of organic compounds such as Phenol (aromatic alcohol), Acetone (aliphatic ketone), 4-Aminopyridine (heterocyclic amino compound) and Hydrazine hydrate (aliphatic amino compound) to complement our previous studies. The results showed that valence stabilization of Fe(II) in presence of these compounds depends also on the amount and chemical structure of the additive used. Some interaction mechanisms have been proposed.
Valence Stabilization of Polyvalent Uranium Ions in Presence of Some Organic Additives during Extended Gamma Irradiation of Their Aqueous Acidic Solutions  [PDF]
M. F. Barakat, M. M. Abdelhamid
World Journal of Nuclear Science and Technology (WJNST) , 2015, DOI: 10.4236/wjnst.2015.53016
Abstract: In gamma irradiated aqueous acidic uranium solutions, tetravalent uranium ions are easily oxidized while U(VI) ions remain unchanged. In general, valence change of polyvalent metallic ions during chemical reprocessing of spent nuclear fuel solutions can lead to undesirable effects under the influence of the existing gamma radiations. Consequently, studies on valence stabilization of Uranium ions during chemical treatment in strong gamma irradiation fields seem to be highly interesting. It has been reported before that some organic compounds proved to be effective in stabilizing the valence of Fe(II) ions during extended gamma irradiation of their acidic solutions. In the present work, valence stabilization of Uranium ions in acidic solutions in presence of different classes of organic compounds has been studied. The results showed that in case of U(IV), methanol or formic acid are capable of providing about 80% protection while ethanol or acetaldehyde can provide about 70% protection. Propanol has the least protective effect i.e. about 54%. On using U(VI) instead of U(IV) in the irradiated solutions, the uranium ions were reduced and the formed U(IV) was protected as follows: formic acid or methanol can provide 69% or 63% protection respectively while ethanol, acetaldehyde or propanol can provide 50%, 35% and 24% respectively. In any case, protection exists as long as the organic additives were not completely consumed.
Fixed Point Theorems of Hegedus Contraction Mapping in Some Types of Distance Spaces  [PDF]
M. A. Ahmed, F. M. Zeyada, G. F. Hassan
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2012, DOI: 10.4236/ijmnta.2012.13013
Abstract: In the present paper, we prove some fixed point theorems of Hegedus contraction in some types of distance spaces, dislocated metric space, left dislocated metric space, right dislocated metric space and dislocated quasi-metric metric space which are generalized metrics spaces where self-distances are not necessarily zero.
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