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Search Results: 1 - 10 of 400811 matches for " M. Cazacu "
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Why Is Hard To Patent An Invention?
D. BEIN,Wolfgang BEIN,M.P. BRUT,M. CAZACU
Informatica Economica Journal , 2007,
Abstract: When employed by a company, in almost all the cases a new employee has to sign an agreement giving the company exclusive rights to any intellectual property developed as part of their work assignments. This agreement could extend beyond a change of jobs and cause conflict of interests in new employment situations. A patent is a government-granted monopoly given to an inventor as both a reward for the intellectual and financial investment, and a stimulus to innovate. As a monopoly, the patent has legal power to exclude others from exploiting the invention in any way for a period of 20 years from the time the patent application has been filed. A trademark provides instant recognition of a product or company; a service mark provides instant recognition of a service. They both have unlimited lifetime. But the owner must renew or confirm continuous use at the end of five years, and every 10 years thereafter. A trade secret is information keep secret by the owner to give him advantage over competitors. Since it is secret, a trade secret protection has unlimited lifetime.
IMMUNOTHERAPY WITH VISCUM ALBUM EXTRACT IN THE TREATMENT OF ADVANCED COLORECTAL CANCER
T. Oniu,M. Cazacu,V. Muntean,Melania Oniu
Jurnalul de Chirurgie , 2011,
Abstract: Background: Most clinical trials using mistletoe to treat colorectal cancer are out-of-date and have major methodological weaknesses that raise doubts about their findings. Meanwhile, the arsenal of chemotherapy has much evolved over the last decade. Thus, the aim of this study was to determine the effectiveness of the total plant extract Isorel in association with modern chemotherapy in the treatment of colorectal cancer. Methods: After the surgical removal of the primary tumor, a total of 124 patients with advanced colorectal cancer (stage Dukes C and D), were randomly divided into the immunotherapy group (Isorel associated in most of the cases with chemotherapy, n=58) and the control group (most of which received chemotherapy). The chemotherapy regimens were based on 5-fluorouracil, irinotecan and oxaliplatin. Overall survival and adverse events were observed. Results: The addition of immunotherapy with Viscum album extract Isorel to 5FU-based chemotherapy significantly improved overall survival in Dukes stage C (5-year survival: 46% vs. 17%; median survival: 46 vs. 24 months, p=0.004) and D (median survival: 13,5 vs. 9,5 months, p=0.02; longest survival: 26 vs. 12 months). The addition of immunotherapy to oxaliplatin- and irinotecan-based chemotherapy further improved overall survival in Dukes stage C (5-year survival: 64% vs. 38%; median survival: 57,5 vs. 34 months, p=0.04) and D (median survival: 24 vs. 18 months, p=0.02; longest survival: 36 vs. 24 months). Inflammatory local reactions at the s.c. injection site occur frequently (83% of patients) at the beginning of the treatment for 1 to 8 weeks. Conclusions: Immunotherapy with Viscum album extract Isorel, added to chemotherapy, improves the survival of the patients operated for advanced colorectal cancer compared with chemotherapy alone, whatever its type.
Fish farms as nesting sites for Chlidonias hybridus (Aves, Charadriiformes, Sternidae)
Mariana CAZACU
North-Western Journal of Zoology , 2006,
Abstract: Since 1948 the Prut River basin has been subject to high levels of hydrotechnical and hydrological works. As a result of these many aquaculture ponds for rearing fish have appeared. These aquatic basins represent concentration areas of some important populations of bird species, both during migration and reproduction. The avifauna of the lower basin of River Prut was relatively un-studied until 1992. Since then numerous studies were conducted on the dynamics of the bird populations (including Chlidonias hybridus) in the Romanian basin of River Prut. In this study I detail the size of the breeding populations of Chlidonias hybridus species in the fish-ponds of the lower basin of River Prut and their change beteen 2002 and 2005. The study was conducted between May and July (2003-2005). C. hybridus colonies were surveyed within the Carja-Ma a-R deanu ponds, Vl de ti ponds and Brate fishponds complex, located in the Prut river lower basin. The results observed are discussed with respect to the weather conditions that determine the nesting of this species in the fish-ponds, the influence of the fishery works on the C. hybridus colonies and the importance of the ponds as nesting places for this species.
THE FISH-BREEDING FARMS AS NESTING PLACES FOR CHLIDONIAS HYBRIDUS (AVES, ORD. CHARADRIIFORMES, FAM. STERNIDAE)
Mariana Cazacu
Annals of West University of Timi?oara : Series of Biology , 2005,
Abstract: Starting with 1948, the Prut River basin has suffered a lot of hydrotechnical and hydrological works. As a result of these works many ponds with fish rearing destination have appeared. These aquatic basins represent concentration areas of same important populations of the bird species both in the passage period and in the reproduction one. The avifauna of the inferior basin of River Prut was less studied until 1992. Starting with this year many studies were constantly made on the dynamics of the bird populations in the Romanian basin of River Prut (the studies also included Chlidonias hybridus species).In this study we presents the size of the breeding populations of Chlidonias hybridus species in the fish-ponds of the inferior basin of River Prut and their evolution after 2002, the weather conditions that determine the nesting of this species in the fish-ponds, the influence of the fishery works on the Chlidonias hybridus colonies and the importance of the ponds as nesting places for this species. The study period was in May-July, 2003-2005. The Chlidonias hybridus colonies were reviewed within the Carja-Ma a-R deanu ponds, Vl de ti ponds and Brate fishponds complex, all with a fish rearing destination in the Prut River inferior basin.
The Second Corps of Romanian volunteers in Russia
Ioana Cazacu
Revista Romana de Studii Baltice si Nordice , 2010,
Abstract: The situation of Romanian POWs has aggravated with the Bolshevik assuming of power. Following the Kiew occupation by Bolsheviks, the First Romanian Volunteers Corps has been disbanded and a great number of POWs remained on Russian territory with little possibilities to return to their native land. In these circumstances, the Romanians volunteers decided to depart for Moscow from where they hoped to leave for their country with the Romanian consul’s support. However, the German authorities refused to allow their crossing through Ukraine and the volunteers had to cope with their staying in Russia. They set up a body of all officers in order to represent the Romanian cause both in Russia and in France: the Second Corps of Romanian Volunteers in Russia. This occasioned them to encounter other political-military forces acting in the Russian chaotic situation, a Lithuanian army corps included. The Romanians will continue their odyssey in their attempt to be evacuated through Vladivostok, they successfully fighting the Bolsheviks and finally returning to Romania. This paper elaborates over the fate of the Second Corps of Romanian Volunteers in Russia and their encounters with their Lithuanian, other Baltic and Czechoslovak fellows.
D.A. Sturdza et ses preocupations numismatiques
Ana Cazacu
Codrul Cosminului , 2008,
Abstract:
Hardy inequalities with boundary singularities
Cristian Cazacu
Mathematics , 2010,
Abstract: In this work we prove some Hardy-Poincar\'{e} inequalities with quadratic singular potentials localized on the boundary of a smooth domain. Then, we consider conical domains with vertex on the singularity and we show upper and lower bounds for the corresponding optimal constants in the Hardy inequality. In particular, we prove the asymptotic behavior of the optimal constant when the slot of the cone tends to zero.
Hardy inequality and Pohozaev identity for operators with boundary singularities: some applications
Cristian Cazacu
Mathematics , 2011,
Abstract: We consider the Schr\"{o}dinger operator $A_\l:=-\D -\l/|x|^2$, $\l\in \rr$, when the singularity is located on the boundary of a smooth domain $\Omega\subset \rr^N$, $N\geq 1$ The aim of this Note is two folded. Firstly, we justify the extension of the classical Pohozaev identity for the Laplacian to this case. The problem we address is very much related to Hardy-Poincar\'{e} inequalities with boundary singularities. Secondly, the new Pohozaev identity allows to develop the multiplier method for the wave and the Schr\"{o}dinger equations. In this way we extend to the case of boundary singularities well known observability and control properties for the classical wave and Schr\"{o}dinger equations when the singularity is placed in the interior of the domain (Vanconstenoble and Zuazua \cite{judith}).
Schr?dinger operators with boundary singularities: Hardy inequality, Pohozaev identity and controllability results
Cristian Cazacu
Mathematics , 2011,
Abstract: The aim of this paper is two folded. Firstly, we study the validity of the Pohozaev-type identity for the Schr\"{o}dinger operator $$A_\la:=-\D -\frac{\la}{|x|^2}, \q \la\in \rr,$$ in the situation where the origin is located on the boundary of a smooth domain $\Omega\subset \rr^N$, $N\geq 1$. The problem we address is very much related to optimal Hardy-Poincar\'{e} inequality with boundary singularities which has been investigated in the recent past in various papers. In view of that, the proper functional framework is described and explained. Secondly, we apply the Pohozaev identity not only to study semi-linear elliptic equations but also to derive the method of multipliers in order to study the exact boundary controllability of the wave and Schr\"{o}dinger equations corresponding to the singular operator $A_\la$. In particular, this complements and extends well known results by Vanconstenoble and Zuazua [34], who discussed the same issue in the case of interior singularity.
New estimates for the Hardy constants of multipolar Schr?dinger operators
Cristian Cazacu
Mathematics , 2014, DOI: 10.1142/S0219199715500935
Abstract: In this paper we study the optimization problem $$\mu^\star(\Omega):=\inf_{u\in \semi}\frac{\into |\n u|^2 \dx}{\into V u^2 \dx}$$ in a suitable functional space $\semi$. Here, $V$ is the multi-singular potential given by $$V:=\sum_{1\leq i\mu^\star(\rr^N)$ when $n\geq 3$ and $\mu^\star(\Omega)=\mu^\star(\rr^N)$ when $n=2$ (It is known from \cite{cristi1} that $\mu^\star(\rr^N)=(N-2)^2/n^2)$. In the situation when all the poles are located on the boundary we show that $\mu^\star(\Omega)=N^2/n^2$ if $\Omega$ is either a ball, the exterior of a ball or a half-space. Our results do not depend on the distances between the poles. In addition, in the case of boundary singularities we obtain that $\mu^\star(\Omega)$ is attained in $\hoi$ when $\Omega$ is a ball and $n\geq 3$. Besides, $\mu^\star(\Omega)$ is attained in $\semi$ when $\Omega$ is the exterior of a ball with $N\geq 3$ and $n\geq 3$ whereas in the case of a half-space $\mu^\star(\Omega)$ is attained in $\semi$ when $n\geq 3$. We also analyze the critical constants in the so-called \textit{weak} Hardy inequality which characterizes the range of $\mu's$ ensuring the existence of a lower bound for the spectrum of the Schr\"{o}dinger operator $-\Delta -\mu V$. In the context of both interior and boundary singularities we show that the critical constants in the weak Hardy inequality are $(N-2)^2/(4n-4)$ and $N^2/(4n-4)$, respectively.
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