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Search Results: 1 - 10 of 542367 matches for " M. Araya Pérez "
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Alimentación y diabetes Food and diabetes
S. Durán Agüero,E. Carrasco Pi?a,M. Araya Pérez
Nutrición Hospitalaria , 2012, DOI: 10.3305/nh.2012.27.4.5859
Abstract: Una dieta con bajo índice glicémico puede mejorar el control metabólico en la diabetes tipo 2, pero el debate aún continúa. Las frutas a pesar de la fructosa que contienen, también puede bajar el índice glicérico, además su consumo se ha asociado con una reducción de los niveles de A1c y pueden influir positivamente en el colesterol HDL, presión arterial y riesgo de enfermedad coronaria en general. Con respecto a la ingesta de grasa no se observa una relación entre ella y la A1c. Con respecto al consumo de alcohol se ha reportado que el consumo moderado de alcohol se asocia con una menor prevalencia de síndrome metabólico, aunque no hay información que lo relacione con el A1c. En este artículo se revisa la evidencia publicada sobre el efecto del consumo de frutas, grasas y alcohol sobre el control metabólico en diabéticos. A low glycemic diet may improve metabolic control in type 2 diabetes, but the debate continues. Fruits, despite the fructose they contain, may also lower the glycemic index, as well as its consumption has been associated with a reduction in A1c levels and can positively influence HDL cholesterol, blood pressure and risk of coronary heart disease in general. There is no relationship between fat intake and A1c. On the consumption of alcohol has been reported that moderate alcohol consumption is associated with a lower prevalence of metabolic syndrome, although there is information that relates to the A1c. This article reviews the published evidence on the effect of consumption of fruits, fats and alcohol on metabolic control in diabetics.
Fast and reliable calibration of solid substrate fermentation kinetic models using advanced non-linear programming techniques
Araya,M. Macarena; Arrieta,Juan J; Pérez-Correa,J. Ricardo; Biegler,Lorenz T; Jorquera,Héctor;
Electronic Journal of Biotechnology , 2007,
Abstract: calibration of mechanistic kinetic models describing microorganism growth and secondary metabolite production on solid substrates is difficult due to model complexity given the sheer number of parameters needing to be estimated and violation of standard conditions of numerical regularity. we show how advanced non-linear programming techniques can be applied to achieve fast and reliable calibration of a complex kinetic model describing growth of gibberella fujikuroi and production of gibberellic acid on an inert solid support in glass columns. experimental culture data was obtained under different temperature and water activity conditions. model differential equations were discretized using orthogonal collocations on finite elements while model calibration was formulated as a simultaneous solution/optimization problem. a special purpose optimization code (ipopt) was used to solve the resulting large-scale non-linear program. convergence proved much faster and a better fitting model was achieved in comparison with the standard sequential solution/optimization approach. furthermore, statistical analysis showed that most parameter estimates were reliable and accurate
La innovación en los sistemas de información financiera gubernamental en la región centroamericana: evidencias desde Costa Rica
Araya-Leandro,Carlos E; Caba-Pérez,Carmen; López-Hernández,Antonio M;
Innovar , 2011,
Abstract: the purpose of this article is to analyze the process being followed to adopt international public sector accounting standards (ipsas) as innovation in the governmental accounting systems of the central american countries, while placing particular attention on the case of costa rica. that country is the focus because it is the first in the region that has decided on its adoption, which is why the actions that have been carried out in the implementation process could serve as a basis for neighboring countries that in the future decide to carry out similar processes. thus, the results show that the central american countries, to a greater or lesser extent, are implementing actions aimed at aligning their accounting systems to the ifac standards for the public sector. specifically in the case of costa rica, where it has been necessary to address numerous contextual and instrumental factors as well as behavioral ones in order to ensure successful adoption.
EmploymentWoaftgeerormesaotuicrscetescohfntohloegUiepspfoerTtehme pisque River evaluation of risks ofWfloaotedrshaesdc,oCnosestqauReniccae(oTef ctnhiecal Note) climatic change and the affectations to phytodiversity Empleo de tecnologías de geomática para la evaluación de riesgos de inundaciones como consecuencia del cambio climático y las afectaciones a la fitodiversidad
Raimundo Márquez Gurri,Nicolás Quintana Bernabe,Marta Margarita Pérez Rojas,Freddy Araya Rodríguez
Tecnología en Marcha , 2012,
Abstract: The global climatic change that takes place in the current times has diverse origins, not causing few polemics and declarations from different areas of knowledge.The floods are part of the consequences of the phenomena that take place when crisis are accentuated and the environment deteriorates. This research presents some experiences in the employment of the geomatics tools for the minimi- zation of risks when there is the possibility of the occurrence of extraordinary events: strong rains in short periods of time and floods, as a consequence of the climatic change, particularizing in the com- munication roads, as antropics elements and the interruption of the natural course of the waters on the topographical relief and the impacts on phito- diversity. El cambio climático global que tiene lugar en los tiempos actuales tiene diversos orígenes, provo- cando no pocas polémicas y declaraciones prove- nientes de diferentes áreas del conocimiento. Las inundaciones son parte de las consecuencias de los fenómenos que ocurren en momentos en que las crisis se acentúan y el medio ambiente se deteriora. En este trabajo se presentan algunas experiencias en el empleo de las herramientas geomáticas para la minimización de riesgos, ante la posibilidad de la ocurrencia de eventos extraordinarios: fuertes llu- vias en cortos periodos de tiempo e inundaciones, como consecuencia del cambio climático, particula- rizando en las vías de comunicación como elemen- tos antrópicos, la interrupción del curso natural de las aguas sobre el relieve topográfico y los impactos sobre la fitodiversidad que acontecen como resulta- do de las mismas.
Construction of a novel Pichia pastoris strain for production of xanthophylls
José Miguel Araya-Garay, José M Ageitos, Juan A Vallejo, Patricia Veiga-Crespo, Angeles Sánchez-Pérez, Tomás G Villa
AMB Express , 2012, DOI: 10.1186/2191-0855-2-24
Abstract:
Calidad de las espirometrías en un estudio epidemiológico de terreno: Factores determinantes de la necesidad de repetir el examen en el estudio Platino-Chile
Araya B.,Marcela; Pertuzé R.,Julio; Valdivia C.,Gonzalo; Batista M.,Ana María; Pérez P.,Rogelio; Fuentes Y.,Hilda; Jara V.,Alejandro; Márquez,María N.; Cifuentes S.,Mónica; Lisboa B.,Carmen;
Revista chilena de enfermedades respiratorias , 2005, DOI: 10.4067/S0717-73482005000300002
Abstract: spirometry, the most used test to evaluate pulmonary function, is only occasionally measured in field epidemiological studies. our aim was to determine which of the following factors in the platino study can be associated low quality spirometries in the first session: sex, age, socioeconomic level, educational level, body mass index, cold chill, smoking, operating technician, date and subject's previous spirometric experience. 1.168 individuals were evaluated with spirometry. fifteen nurses and 1 midwife were trained according to niosch standards. easy one ndd spirometers were used. 1.037 subjects (88.8%) performed a satisfactory spirometry in the first session, and 131 (11.2%) failed to do so. only two significant predictors of this failure were identified: age and educational level. causes for test repetition were 1) non satisfactory acceptability (77.1%); 2) lack of reproducibility (67.9%); 3) decline of post bronchodilator cvf without concomitant change in vef1 (36.6%). eighty nine of the 131 subjects accepted to repeat the test. a satisfactory spirometry was obtained in 79 subjects. hence, at the end of the study 95.5 % of the subjects attained a satisfactory test. we conclude that personnel without experience, with appropriate training, can perform high quality field spirometries. acceptability and repoducibility were the most sensitive factors associated with a bad performance of spirometry. age and schooling were the main factors related with a low quality spirometry. no association was detected regarding technician as a predictor of low quality spirometries carried out in a population setting
Frequency of MYO9B polymorphisms in celiac patients and controls Frecuencia de polimorfismos del gen MYO9B en pacientes celiacos y en sujetos controles
Tamara Loeff,Magdalena Araya,Francisco Pérez-Bravo
Revista Espa?ola de Enfermedades Digestivas , 2012,
Abstract: Introduction: the MYO9B gene contributes to the maintenance of the intestinal barrier and it has been postulated as a risk factor of celiac disease (CD). The objective of this study was to compare the frequency and association rs2305764, rs2305767and rs1457092 MYO09B polymorphisms in pediatric CD patients from Chile and Argentina. Patients and methods: the study was made in 104 CD pediatric patients (Chilean and Argentineans) and 104 controls subjects. MYO9B gene polymorphisms were analyzed by Taqman allelic probes. We evaluated the Hardy-Weinberg equilibrium by means of Chi-square and compared the haplotypes distribution using Fisher test. Results: SNPs rs2305767 and rs1457092 were associated with celiac disease (CD); TT genotype in rs2305767 would be a protective factor (p < 0.000, OR = 0.19 CI 0.1-0.4) and the CT genotype would be a risk factor (p < 0.0001, OR = 4.9 CI 2.2 to 11.3). CC genotype in rs1457092 also showed a protective effect for celiac (p < 0.000, OR = 0.07 CI 0.0 to 0.3). Conclusion: our findings suggest that genetic variation MYO9B gene is associated with CD, as a protective or a risk factor depending on the polymorphism studied. Introducción: el gen miosina IX B (MYO9B) participa en el mantenimiento de la barrera intestinal y se postula que puede aportar riesgo para desarrollar enfermedad celiaca (EC). El objetivo de este estudio fue comparar la frecuencia y la asociación de los polimorfismos rs 2305764, rs 2305767 y rs 1457092 del gen MYO9B en pacientes pediátricos con EC procedentes de Chile y Argentina. Pacientes y métodos: el estudio se realizó en 104 pacientes pediátricos con EC (chilenos y argentinos) y en 104 sujetos controles. El análisis de los polimorfismos del gen MYO9B se realizó mediante ensayos Taqman de discriminación alélica. Se evalúo equilibrio de Hardy-Weinberg mediante Chi-cuadrado y comparación de haplotipos según prueba de Fisher. Resultados: los polimorfismos de un solo nucleótido (SNPs) rs2305767 y rs1457092 mostraron asociación con la EC. El genotipo TT del rs2305767 sería un factor protector (p < 0,0001, OR = 0,19 IC 0,1-0,4) mientras que el genotipo CT sería un factor de riesgo (p < 0,0001, OR = 4,9 IC 2,2-11,3). En el rs1457092, el genotipo CC resultó también un factor protector frente a esta enfermedad (p < 0,0001, OR = 0,07 IC 0,0-0,3). Conclusión: nuestros hallazgos sugieren que la variación genética del gen MYO9B estaría asociada a la EC en este grupo de pacientes, constituyendo un factor tanto de protección como a susceptibilidad dependiendo del polimorfismo en cuestión.
Diagnóstico de la infección por Treponema pallidum en pacientes con sífilis temprana y neurosífilis mediante reacción de la polimerasa en cadena
García C,Patricia; Grassi C,Bruno; Fich S,Félix; Salvo L,Aurelio; Araya C,Luis; Abarzúa C,Fernando; Soto M,Julia; Poggi M,Helena; Lagos L,Marcela; Vásquez T,Patricia; León C,Eugenia P; Pérez C,Carlos; Wozniak B,Aniela;
Revista chilena de infectología , 2011, DOI: 10.4067/S0716-10182011000500002
Abstract: syphilis is a sexually transmitted disease caused by treponema pallidum. the diagnosis is based mainly in clinical presentation and non-specific assays. pcr-based diagnosis has been suggested as an attractive alternative method. the aim of this study was the validation of a pcr-based test for the diagnosis of early syphilis (es) and neurosyphilis (ns). clinical samples of mucocutaneous lesions and cerebrospinal fluid (csf) specimens from patients previously diagnosed for es and ns respectively using an enlarged gold standard, were tested by pcr. the reaction was done using primers targeting the tpn47gene. twenty out of 21 mucocutaneous samples from patients diagnosed with es were positive by pcr, with a clinical sensitivity of 95%. four out of 8 csf samples from patients previously diagnosed with ns were positive by pcr, with a clinical sensitivity of 50%. the clinical specificity for both es and ns was 100%. the pcr sensitivity and specificity for mucocutaneous samples allowed us to implement this assay in our laboratory for routine diagnosis. although the sensitivity of the pcr in csf was low, it may be useful to support clinical diagnosis.
1-BENZOYL-2-(2-NITROPHENYL)-1H-BENZIMIDAZOLE DERIVATIVES: A NOVEL APPROACH TO THE DEVELOPMENT OF NEW HIV-1 REVERSE TRANSCRIPTASE INHIBITORS
VáSQUEZ,DAVID; LAGOS,CARLOS F; MELLA-RAIPáN,JAIME; GONZáLEZ,LUIS; EBENSPERGER,ROBERTO; ALVAREZ-FIGUEROA,M. JAVIERA; SáEZ,EDMUNDO; PESSOA-MAHANA,HERNáN; ARAYA-SECCHP,RAúL; GONZáLEZ-WONG,ANGEL; PéREZ-ACLE,TOMáS; PESSOA-MAHANA,C. DAVID;
Journal of the Chilean Chemical Society , 2007, DOI: 10.4067/S0717-97072007000400002
Abstract: a novel approach to the development of a new class of hiv-1 rt inhibitors is reported. the 1-benzoyl-2-aryl-1h-benzimidazole series was designed as a combination of two previously reported active scaffolds, the benzimidazole and benzoyl moieties. the active compounds of the series effectively blocked the reverse transcription in the micromolar range in an in vitro assay containing the wild-type enzyme. we have demonstrated that the 2-nitrophenyl c-2 substituent is an important structural feature for the desired biological activity in this series. molecular docking experiments suggest that the active compounds adopt a butterflylike conformation within the binding pocket of the enzyme, with the benzoyl moiety located in an extended hydrophobic region defined mainly by tyrl 81, tyrl 88, and trp229
Comparación del crecimiento de Argopecten purpuratus entre cohortes obtenidas de captación de larvas en ambiente natural y de hatchery Comparison of growth among cohorts obtained Argopecten purpuratus larval recruitment in natural and hatchery
Eduardo P Pérez,Carlos Azócar,Andrea Araya,Orlando Astudillo
Latin american journal of aquatic research , 2012,
Abstract: En Chile los cultivos del ostión del norte Argopecten purpuratus han sido desarrollados intensivamente a partir de la captación de semillas en ambiente natural y desde principios de 1980 con semillas obtenidas en hatchery. Para aportar información sobre el desempeno de semillas de ostión del norte en este estudio se comparó, mediante ANCOVA, el crecimiento en longitud entre cohortes producidas a partir de semillas de ambiente natural y de hatchery en Tongoy, Chile. Se evaluó la consistencia de esta comparación en distintos anos y estaciones, comparándose parejas de cohortes producidas simultáneamente en los anos 2003 (primavera), 2005 (invierno) y 2006 (verano). El análisis estadístico mostró que existen diferencias estadísticas significativas entre cohortes obtenidas en ambiente natural y aquellas obtenidas en hatchery. La prueba de Tukey evidenció diferencias significativas entre CN2003 y CH2003 como también entre CN2005 y CH2005, pero no así entre CN2006 y CH2006. Estas diferencias indican que las cohortes de semillas de ambiente natural crecieron más rápido que las de hatchery. La comparación interanual evidenció diferencias estadísticas significativas. Estos resultados son discutidos a la luz de dos factores: la temperatura de cultivo y la heterocigocidad de la población de cultivo. In Chile crops of the northern scallop Argopecten purpuratus have been developed intensively from seeds obtained in natural environment, and since 1980 from hatchery's seed, when this technique could be controlled and developed. In order to provide information on the performance of seeds of northern scallops in this study growth in length between cohorts produced from seeds obtained in natural environment (CN) and hatchery (CH) in Tongoy (Chile) was compared using ANCOVA. We assessed the consistency of this comparison in different years and seasons. The compared cohorts are pairs of cohorts produced simultaneously in the years 2003 (spring), 2005 (winter) and 2006 (summer). Statistical analysis showed that there are significant statistical differences between cohorts obtained from natural environment and those obtained in hatchery. The Tukey's test showed differences between CN2003 and CH2003 and also between CN2005 and CH2005, while there were no significant differences between CN2006 and CH2006. These differences indicate that the cohorts of natural environment seeds grew faster than those of hatchery. Inter annual comparison showed significant statistical differences. These results are discussed in terms of the cultivation temperature and the heterozygosity for the g
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