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Search Results: 1 - 10 of 408297 matches for " M. Ahmed Mesaik "
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Identification of anti-inflammatory and other biological activities of 3-carboxamide, 3-carbohydrazide and ester derivatives of gatifloxacin
Najma Sultana, M Saeed Arayne, Asia Naz, M Ahmed Mesaik
Chemistry Central Journal , 2013, DOI: 10.1186/1752-153x-7-6
Abstract: The analog N-(3-aminophenyl)-1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxamide has been identified as a potentially excellent anti-inflammatory agent, which exhibited highly potent effects on the oxidative burst activity of whole blood phagocytes (IC50 <12.5 mug mL-1), neutrophils (IC50 <0.1 mug mL-1) and macrophages phagocytes (IC50 <3.1 mug mL-1) as well as potent T-cell proliferation inhibitory effect (IC50 3.7 mug mL-1) while having comparable antibacterial activity to gatifloxacin. Another analog, 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carbohydrazide has tremendous T-cell proliferation inhibitory effect IC50 <3.1 mug mL-1 as compared to prednisolone, whereas, 3,5-dihydroxyphenyl1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate and 2-hydroxyphenyl-1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate envision good inhibitory activity on T-cells proliferation (IC50 6.8 & 8.8 mug mL-1 respectively).The structural modification at carboxylic group has resulted in improved anti-inflammatory activities with comparable antibacterial activity to gatifloxacin. We believe that C3 structural modifications of gatifloxacin are definitely important in bringing major immunomodulatory changes in these compounds.
Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes
Saeed Arayne,Najma Sultana,Urooj Haroon,M. Ahmed Mesaik
Bioinorganic Chemistry and Applications , 2009, DOI: 10.1155/2009/914105
Abstract: The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)2(H2O)2]3H2O(M=CuII,NiIIorMnII) and [M(eno)(H2O)2]Cl?4H2O(M=FeIII) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by MnII and CuII complexes exhibited potential to mediate anti-inflammatory response.
Synthesis, characterization and biological activities of cetirizine analogues
Najma Sultana,M. Saeed Arayne,Hina Shamshad,Agha Zeeshan Mirza,Malik Asia Naz,Beenish Fatima,M. Asif,M. Ahmed Mesaik
Spectroscopy: An International Journal , 2011, DOI: 10.3233/spe-2011-0537
Abstract: Cetirizine second generation H1-receptor antagonist is an acid metabolite of hydroxyzine. Present work was based on six new analogues of cetirizine having nucleophilic substitution reaction synthetic pathway. The reactions were proceeded by replacing the scaffold on the cetirizine moiety using nucleophilic substitution reaction. The structures of analogues were confirmed using UV, IR, 1H NMR and mass spectroscopic techniques. The analogues were tested for the anti-inflammatory activities on cellular immune response. Oxidative burst response of phagocytes after exposure to the analogues was found to exhibit moderate to significant inhibitory activity (23 to <3.1). However, the compounds as MPC and PPC also showed remarkable inhibitory effect on PHA activated T-cells response and may prove to be lead compounds in therapeutic world.
New Vistas in the Therapeutic Uses of Stem Cells
Sheikh Arshad Saeed,Muhammad Ahmed Mesaik
Journal of Medical Sciences , 2005,
Abstract: Stem cell technology has emerged in the face of extraordinary advances for prevention, diagnosis and treatment of human diseases such as heart disease, diabetes, cancer and diseases of the nervous system, such as Parkinson’s disease and Alzheimer’s Disease (AD). It offers great promise for tissue regeneration, cell replacement and gene therapy, but clinical applications remain limited. Despite considerable ethical and practical barriers to their acceptance in the society, their potential in medicine is tantalising. There is a balance between the search for ways to regenerate bodies ravaged by age and disease on the one hand, with the need to ground these ideas in scientific fact and medical caution on the other. Stem cells are certainly exciting both as models of developmental biology and potential in human disease. Brain can be turned into blood, blood can be turned into brain, muscle, myocardium or liver and in some hands, bone marrow and neural stem cells can be turned into almost any type of cell. Such remarkable properties render it now feasible to contemplate isolating living healthy stem cells from the body, expanding them under cell culture conditions, combining them with biocompatible carrier molecules, directing their proliferation with growth factors and then transplanting them or their progeny into patients for clinical gain. In this way stem cells may, in future, be used to alleviate degenerative disorders, replace diseased or failing tissues with engineered substitutes and correct genetic disease. These living tissue substitutes may indeed overcome the drawbacks of classic transplantation and the limitations of standard treatments for degenerative disease, but their origins and potential are increasingly challenged by developments in science and medicine, politics and ethics.
Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone
Naik Tameen Khan, Marium Bibi, Sammer Yousuf, Izhar Husain Qureshi, Atta-ur-Rahman, Abdullah Mohammad Al-Majid, Muhammad Ahmed Mesaik, Ahmed Shukralla Khalid, Samina A Sattar, Atia-tul-Wahab, M Iqbal Choudhary
Chemistry Central Journal , 2012, DOI: 10.1186/1752-153x-6-153
Abstract: Incubation of oxymetholone (1) with Macrophomina phaseolina, Aspergillus niger, Rhizopus stolonifer, and Fusarium lini produced 17beta-hydroxy-2-(hydroxy-methyl)-17alpha-methyl-5alpha-androstan-1-en-3-one (2), 2alpha,17alpha-di(hydroxyl-methyl)-5alpha-androstan-3beta,17beta-diol (3), 17alpha-methyl-5alpha-androstan-2alpha,3beta,17beta-triol (4), 17beta-hydroxy-2-(hydroxymethyl)-17alpha-methyl-androst-1,4-dien-3-one (5), 17beta-hydroxy-2alpha-(hydroxy-methyl)-17alpha-methyl-5alpha-androstan-3-one (6), and 2alpha-(hydroxymethyl)-17alpha-methyl-5alpha-androstan-3beta-17beta-diol (7). Their structures were deduced by spectral analyses, as well as single-crystal X-ray diffraction studies. Compounds 2--5 were identified as the new metabolites of 1. The immunomodulatory, and anti-inflammatory activities and cytotoxicity of compounds 1--7 were evaluated by observing their effects on T-cell proliferation, reactive oxygen species (ROS) production, and normal cell growth in MTT assays, respectively. These compounds showed immunosuppressant effect in the T-cell proliferation assay with IC50 values between 31.2 to 2.7 mug/mL, while the IC50 values for ROS inhibition, representing anti-inflammatory effect, were in the range of 25.6 to 2.0 mug/mL. All the compounds were found to be non-toxic in a cell-based cytotoxicity assay.Microbial transformation of oxymetholone (1) provides an efficient method for structural transformation of 1. The transformed products were obtained as a result of de novo stereoselective reduction of the enone system, isomerization of double bond, insertion of double bond and hydroxylation. The transformed products, which showed significant immunosuppressant and anti-inflammatory activities, can be further studied for their potential as novel drugs.
Cheiradone: a vascular endothelial cell growth factor receptor antagonist
Sajjad Hussain, Mark Slevin, Mohammad A Mesaik, Mohammad I Choudhary, Abdul H Elosta, Sabine Matou, Nessar Ahmed, David West, John Gaffney
BMC Cell Biology , 2008, DOI: 10.1186/1471-2121-9-7
Abstract: Cheiradone inhibited all stages of VEGF-induced angiogenesis with IC50 values in the range 5.20–7.50 μM but did not inhibit FGF-2 or EGF-induced angiogenesis. It also inhibited VEGF binding to VEGF receptor-1 and 2 with IC50 values of 2.9 and 0.61 μM respectively.Cheiradone inhibited VEGF-induced angiogenesis by binding to VEGF receptors -1 and -2 and may be a useful investigative tool to study the specific contribution of VEGF to angiogenesis and may have therapeutic potential.Angiogenesis, the growth of new blood vessels from the existing vasculature is associated with physiological (wound healing, endometrial cycle and embryonic development) and pathological processes (tumour growth, rheumatoid arthritis, diabetic retinopathy, and brain and cardiac infarctions) [1,2]. Angiogenesis is mediated by pro-angiogenic factors including vascular endothelial cell growth factor (VEGF), fibroblast growth factor-2 (FGF-2), angiopoietin, and epidermal growth factor (EGF) [3-6].VEGF comprises a family of multifunctional cytokines which include the variants VEGF-A, -B, -C, -D and-E and placental growth factor (PlGF) [7,8]. VEGF-A is mitogenic in vitro and angiogenic in vivo [9,10] and its role in angiogenesis and vasculogenesis has been elucidated [11-13]. At least nine different isoforms of human VEGF-A have been identified with 121, 145, 148, 162, 165, 183, 189 and 206 amino acid residues [14,8]. Of these, VEGF165 is most clearly associated with pathological angiogenesis [8] and exerts its biological action upon binding with two high affinity receptor tyrosine kinases; VEGFR-1 (flt-1) and VEGFR-2 (kinase domain receptor; flk-1) [8,15]. The role of these receptors, especially flk-1 in angiogenesis has been confirmed through gene knockout studies and flk-1-/- embryos are unable to form blood islands and to generate haematopoietic precursors [reviewed in [16]]. VEGFR-1 has a 50 times higher binding affinity for VEGFR-1 than VEGFR-2 [17] however, VEGFR-2 has a stronger receptor ty
Kinetics and Modeling of H2S Removal in a Novel Biofilter  [PDF]
Zarook M. Shareefdeen, Wasim Ahmed, Ahmed Aidan
Advances in Chemical Engineering and Science (ACES) , 2011, DOI: 10.4236/aces.2011.12012
Abstract: Biofiltration has become a widely accepted technology for the removal of hydrogen sulfide (H2S) which is one of the major odor causing gases present in the air streams of municipal wastewater treatment facilities. In addition to odorous nature, H2S is toxic and corrosive. In this study, a biofilter which uses a novel media was employed in a pumping station which is closely located at the University City, Sharjah, UAE. The H2S removal performance data were collected and subsequently used in the determination of kinetics and modeling of H2S. The data were best represented by a first order biofilter model. Based on the first order kinetic constant, a correlation is developed to predict concentrations at the biofilter outlet. Based on the predicted outlet concentrations and dispersion (gaussian and US-EPA AERMOD) models, a study on H2S dispersion is conducted. The dispersion study confirmed a biofilter installation at the pumping station site would significantly reduce H2S levels in the University community and would provide cleaner air.
Clinical Outcome of Early Enteral Feeding on Patients Post Esophagectomy  [PDF]
Badawy M. Ahmed, Ahmed A. S. Salem
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.84029
Abstract: Objectives: Aim of our work is to study the effect of early enteral feeding through either nasoentral or feeding jejunostomy tube post esophagectomy on patients recovery and hospital stay. Background: Postoperative nutrition is a well known aspect of care in recent years and has been shown to decrease the incidence of complications and hospital stay. Enteral nutrition has been shown to be superior to parenteral nutrition as it is more physiological, safer, cheaper and early enteral nutrition has been clearly confirmed to reduce postoperative morbidity. Methods: This is randomized combined retrospective and prospective study that is conducted in surgical oncology department, South Egypt cancer institute, Assiut University; from October 2012 to October 2016. Patients in this study were divided into two groups: group 1 includes patients with feeding jejunostomy and group 2 is patients with nasoenteral tube. Results: 25 Patients included in this study (19 males & 6 females). All cases were primarily diagnosed as esophageal cancer, middle and lower 1/3 esophagus or proximal gastric carcinoma infiltrating cardia by clinical data associated with abdominal sonar and/or C.T scan and upper endoscopy with biopsy. There was no significant difference in catheter related complications (P value 0.238). There was no operative mortality. Conclusion: Early postoperative enteral nutrition was feasible and safe for patients undergoing esophagectomy. There is no significant difference between NE and FJ. Enteral nutrition either through nasoenteral or feeding jejunostomy is an effective method for postoperative nutritional support in this type of major surgery.
A Long-term Follow-up: Suture versus Mesh Repair for Adult Umbilical Hernia in Saudi Patients. A Single Center Prospective Study  [PDF]
Ahmed M. Kensarah
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.23033
Abstract: Objective: To report results of mesh repair vs. the modified Mayo’s suture overlap in the surgical treatment of adult umbilical and paraumbilcal hernias in our medical center. Patients & Methods: The study is a Saudi single center single surgeon trial composed of sixty two patients. It was performed in the Surgical Department of King Abdul-Aziz University Hospital at Jeddah. The patients were randomly assigned into 2 groups. Group A patients underwent onlay mesh repair while modified Mayo’s repair was used in group B patients. Median follow-up was 28 months, and data were collected regarding size of hernia, type of the operation, complications, length of follow-up and the recurrence rate. Chi square test was used to compare results at 0.05 levels. Results: Complication was reported in 17% in group A and 8% in group B .There was no difference in scar pain, cosmetic result, and overall patient satisfaction between both groups. The recurrence rate was 10% for mesh repair and 18.8% for suture repair. Conclusions: Despite higher complication rate, mesh repair is superior to suture repair due to lower recurrence rate. Suture repair still has a place under certain circumstances, also it is simple less costly and has insignificant infection rate.
Taxonomic Study on the Feather Stars (Crinoidea: Echinodermata) from Egyptian Red Sea Coasts and Suez Canal, Egypt  [PDF]
Ahmed M. Hellal
Open Journal of Marine Science (OJMS) , 2012, DOI: 10.4236/ojms.2012.22007
Abstract: A taxonomic study on the crinoids (feather stars) collected from 34 sites from the Red Sea coasts and islands as well as the Suez Canal was done during the period from 1992 to 2003. A total of 15 species are now known from the Red Sea belonging to eleven genera under six families. Among them four species are endemic to the Red Sea and the two spe- cies, Decametra chadwicki and Lamprometra klunzingeri, are recorded from the Suez Canal for the first time. Also, the two species, Oligometra serripinna and Dorometra aegyptica, are new record from Gulf of Suez, and Decametra mollis from Gulf of Aqaba and Northern Red Sea. This study represents the first proper documentation of crinoid species in the study area. Summaries are provided of the specific habitats and geographical distribution.
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