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Search and Rescue Organizations and National Medical Rescue Teams (NMRT)
Mücahit Günaydn, ?zgür Tatl?, Esra Ers?z Gen?
Dogal Afetler ve Cevre Dergisi , 2017, DOI: 10.21324/dacd.267345
Abstract: Disaster is a generic name given to an event causing physical, economic and social losses for people and it stops or interrupts the normal life and actions of the people. When looking at the outcomes of disasters, it can be seen that they mostly cause loss of life and property. While some of these losses emerged immediately with the disaster, some may occur after a certain time. Rapid intervention in during and after disaster is extremely important to recovery of people’s life. Many search and rescue organizations were founded in the World in order to intervene to disasters and emergency situations. After the 1999 earthquake that caused a lot of casualties, National Medical Rescue Teams (NMRT), one of the search and rescue organizations of Turkey, was founded in 2004 for the purpose of reducing number of dead and wounded to an acceptable rate by doing accurate and quick intervention for people exposed to disasters. NMRT are teams made up of volunteer health personnel working according to the regulations created by Ministry of Health to provide medical rescue services to victims of disasters and emergencies of all kinds, both domestic and international.
Co-Expression of Anti-Rotavirus Proteins (Llama VHH Antibody Fragments) in Lactobacillus: Development and Functionality of Vectors Containing Two Expression Cassettes in Tandem
G?k?e Günaydn, Beatriz álvarez, Yin Lin, Lennart Hammarstr?m, Harold Marcotte
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096409
Abstract: Rotavirus is an important pediatric pathogen, causing severe diarrhea and being associated with a high mortality rate causing approximately 500 000 deaths annually worldwide. Even though some vaccines are currently available, their efficacy is lower in the developing world, as compared to developed countries. Therefore, alternative or complementary treatment options are needed in the developing countries where the disease burden is the largest. The effect of Lactobacillus in promoting health and its use as a vehicle for delivery of protein and antibody fragments was previously shown. In this study, we have developed co-expression vectors enabling Lactobacillus paracasei BL23 to produce two VHH fragments against rotavirus (referred to as anti-rotavirus proteins 1 and 3, ARP1 and ARP3) as secreted and/or surface displayed products. ARP1 and ARP3 fragments were successfully co-expressed as shown by Western blot and flow cytometry. In addition, engineered Lactobacillus produced VHH antibody fragments were shown to bind to a broad range of rotavirus serotypes (including the human rotavirus strains 69M, Va70, F45, DS1, Wa and ST3 and simian rotavirus strains including RRV and SA11), by flow cytometry and ELISA. Hereby, we have demonstrated for the first time that when RRV was captured by one VHH displayed on the surface of co-expressor Lactobacillus, targeting other epitope was possible with another VHH secreted from the same bacterium. Therefore, Lactobacillus producing two VHH antibody fragments may potentially serve as treatment against rotavirus with a reduced risk of development of escape mutants. This co-expression and delivery platform can also be used for delivery of VHH fragments against a variety of mucosal pathogens or production of other therapeutic molecules.
Prognostic value of carbonic anhydrase IX and HIF-1α in renal cell carcinoma
Bilal Günaydn,As?f Y?ld?r?m,Ebru Zemheri,?eyma ?zkanl?
Turkish Journal of Urology , 2012,
Abstract: Objective: In this study, we evaluated the prognostic value of carbonic anhydrase IX (CA9) and HIF-1α and their relations with anatomic, histopathologic and clinic prognostic factors.Materials and Methods: Immunohistochemical analysis was performed on paraffin-embedded specimens from 39 patients treated with a nephrectomy for renal cell carcinoma. The immunoreactivity levels of CA9 and HIF-1α were classified into four groups: 0%, 1-25%, 26-50%, >50% for CA9; and ≤1-10%, 11-50%, 51-80%, >80% for HIF-1α. The CA9 and HIF-1α stains were compared with the patient’s age, sex, tumor volume, recurrence status, T stage and Fuhrman grade. Results: The age distribution of all patients with clear cell renal cell carcinoma (RCC) was as follows: 23 (59%) were older than 50, and 16 (41%) were younger. Twenty-eight patients (71.8%) were male, and 11 (28.2%) were female. Among these patients, 34 (87.2%) survived, and 5 (12.8%) died because of RCC. Seven (17.9%) patients had a recurrence after undergoing a nephrectomy. Twenty-four (61.5%) patients were classified as stage T1 and 15 (38.2%) as stage T2. Thirty-three (84.6%) patients were classified as Fuhrman grade 2 and six (15.4%) patients as Fuhrman grade 3. Although there were different degrees of staining, immunohistochemical staining was positive in all pathological samples for either CA9 or HIF-1α (7 1-25%, 15 26-50%, 17 >%50 for CA9; 11 <10%, 10 10-50%, 14 50-80%, 4 >80% for HIF-1α). Among the CA9 immunoreactive-positive patients, the number of male patients was statistically higher in the 1-25% group than the 26-50% and >50% groups (p=0.019). Among HIF-1α immunoreactive-positive patients, the ≤%10 group had a statistically lower number of tumors sized >4 cm than the other groups (p=0.01). Conclusions: We noted that there was no relationship between CA9 and HIF-1α expression with other prognostic clinicopathologic features.
General Physical Therapy Applications for Elderly People
Rezzan Günaydn
Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi , 2009,
Abstract: Physical agents are modalities that are used to produce a therapeutic response in tissues. The most common modalities used in clinical practice are heat, cryotherapy, and electrotherapy. Pharmacologic treatment of the pain and dysfunciton has some disadvantages particularly in the elderly. For this reason, nonpharmacologic approaches, including physical therapy modalities, should also take part in the treatment protocol of geriatric patients. The purpose of this review is to discuss the evidence related with the use of physical agents in older people and to provide suggestions for application of these modalities in older adults. Turk J Phys Med Rehab 2009; 55 Suppl 2: 85-7.
The Comparison of Vena Cava Inferior Diameter Measurement and Hemoglobin Level Follow-Up for the Assessment of Traumatic Patient in Emergency Service
Mücahit Avcil,N. G?kben ?etin,?nder Tomruk,H. Hakan Arma?an
Journal of Academic Emergency Medicine , 2011,
Abstract: Objective: In trauma patients determining and excluding occult bleeding is a difficult and error-prone work in emergency services. Material and Methods: The vena cava inferior diameters were measured by ultrasound at reference time, first hour and third hour, in sixty patients who were admitted to our university hospital and suffered multiple trauma. Their hemoglobin levels and vital signs were observed simultaneously. Follow-up results were compared to each other. Results: No serious bleeding was found in our patient population. The reference time vena cava inferior diameter mean value of our study group was 16.84±3.93 mms. This value was 16.79±3.74 mms for the first hour and 16.49±3.23 mms for the third hour. In the statistical evaluation of data there was no significant difference between the measurements (Pillai analyse p=0.29). In contrast, there was a decrease-mean of 0.68±0.91 mg/dl in hemoglobin values particularly between the reference and the third time and it was statistically significant (p=0.000). During this time a decrease in hemoglobin level was observed at gretaer than1 mg/dl and in 30% of patients. These changes in measuring hemoglobin levels were not correlated with fluid given to the patients. During all time intervals vena cava inferior measurement’s specivity was determined as approximately 95% and was 70% for hemoglobin level follow-up. Conclusion: Vena cava inferior serial measurements with ultrasound may be more beneficial to hemogram follow up for excluding occult bleeding in trauma patients.
Peak Ground Acceleration Prediction by Artificial Neural Networks for Northwestern Turkey
Kemal Günayd n,Ayten Günayd n
Mathematical Problems in Engineering , 2008, DOI: 10.1155/2008/919420
Abstract: Three different artificial neural network (ANN) methods, namely, feed-forward back-propagation (FFBP), radial basis function (RBF), and generalized regression neural networks (GRNNs) were applied to predict peak ground acceleration (PGA). Ninety five three-component records from 15 ground motions that occurred in Northwestern Turkey between 1999 and 2001 were used during the applications. The earthquake moment magnitude, hypocentral distance, focal depth, and site conditions were used as inputs to estimate PGA for vertical (U-D), east-west (E-W), and north-south (N-S) directions. The direction of the maximum PGA of the three components was also added to the input layer to obtain the maximum PGA. Testing stage results of three ANN methods indicated that the FFBPs were superior to the GRNN and the RBF for all directions. The PGA values obtained from the FFBP were modified by linear regression analysis. The results showed that these modifications increased the prediction performances.
Outcomes, Complications and Management of the Congenital Aural Atresia Surgery  [PDF]
O?uz Ku?cu, Emel Tahir, ?nder Günaydn, ?mer Faruk ünal, Umut Akyol
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.34031
Abstract:

Congenital aural atresia is characterized by aplasia of the external auditory canal (EAC), often associated with abnormalities of the auricula (microtia), the middle ear, and, occasionally, the inner ear structures. The aim of this study is to evaluate the surgical challenges, complications and long term results of congenital aural atresia(CAA) surgery. Records of 103 patients who underwent surgery because of congenital aural atresia were reviewed between 1992 and 2012 in a tertiary referral center. Audiological and surgical events were observed.
Surgical technique, incision type, graft material and long term results were noted. Postoperative visit records and audiograms were investigated. Many types of ossicular chain abnormalities such as absence of an ossicle, deformity of an ossicle or ossicular block were observed. Facial canal dehiscence or abnormal location of the facial nerve was seen in 33.9% of patients. Closure of the air-bone gap (ABG) to 30 dB or less at short-term follow-up occurred in 63.1% of patients. Major complications were as follows: restenosis of the external ear canal, hearing loss, facial paralysis, iatrogenic cholesteatoma and perforation of the graft. The air-bone gap cannot be totally closed in all aural atresias, and there is also the chance of sensorineural type hearing loss. Success of

THE ADAPTATION OF "VOLUNTEER MOTIVATIONS SCALE FOR INTERNATIONAL SPORTING EVENTS" INTO TURKISH
Mücahit F??NE, Yal??n KARAG?Z
Spor Bilimleri Ara?t?rmalar? Dergisi , 2016, DOI: -
Abstract: Nowadays, thousands of volunteers take part in all units of mega sporting events and help make the event a success. So, volunteers defined as “unpaid workers” have big importance for the success of sports events. Determining the motivational factors of volunteers for being a volunteer in international sporting events and planning and implementing human resource strategies to attract them to the organization according to these factors is an important study field in management of international sporting events. The aim of this study is a) to adapt “Volunteer Motivations Scale for International Sporting Events” to Turkish and b) to test validity and reliability of the scale developed by Bang et al. (2009) for the purpose of determining the motivational factors of volunteers taking part in international sporting events. A total of 330 volunteers taking part in international sporting events, like FIFA U-20 World Cup (109 volunteers) and 17. Mediterranean Games (223 volunteers) which were organized in Turkey and accepting to participate to this study consisted the sample of this study. The easy sampling method was used. An online survey was conducted to the sample. As an instrument, “Volunteer Motivations Scale For International Sporting Events” (VMS-ISE) developed by Bang et al. (2009) for the purpose of determining the motivational factors of volunteers taking part in international sporting events was used. In the statistical analysis of the data, an exploratory factor analysis (EFA) was employed in order to assess the construct validity of the scale. Then a confirmatory factor analysis (CFA) was employed to test the accuracy of the structure designed as a result of EFA. The CFA results show that the chi-square/degrees of freedom was found as (χ2/df= 3.26) and the other parameters were found as IFI=0.905, the RMSEA=0.078, the CFI=0.904. The Total Cronbach’s alpha score of the scale had a mean of 0.894. Finally, the original Volunteer Motivations Scale for International Sporting Events consisting of 30 items and 7 subscales, became a new version consisting of 25 items and 6 subscales in adaptation study. These subscales are “Patriotism”, “Expression of Values”, “Love of Sport”, “Career Orientation”, “Interpersonal Contacts” and “Extrinsic Rewards”. The results show that the scale is a valid and reliable measurement tool in Turkish population.
Nontraumatic Massive Spontaneous Hemothorax with Concomitant Warfarin Use
Nurettin ?zgür Do?an,Gül Pamuk?u Günaydn,Mustafa Tekin,Yunsur ?evik
Case Reports in Emergency Medicine , 2013, DOI: 10.1155/2013/546024
Abstract: Hemorrhagic complications due to warfarin use are frequently seen in emergency departments. However, nontraumatic massive hemothorax is an unexpected complication. We report a 59-year-old woman with warfarin overdose, who had massive hemothorax in right lung without any history of trauma. Her main complaint was significant dyspnea, which has gradually increased in three days. On her physical examination, she was tachypneic and had decreased lung sounds on her right hemithorax. She took warfarin regularly for aortic and mitral valve replacement for 18 years. Her INR level was 12.9 (0.8–1.2). Computed tomography of thorax revealed massive hemothorax with mediastinal shift. Fresh frozen plasma infusion was started immediately. Tube thoracostomy was performed for reexpansion of right lung and 2000 cc blood was drained in 5 minutes. Although hemorrhagic complications can be expected in warfarin therapy, thoracic hemorrhage related to warfarin therapy is relatively rare (3% of all hemorrhagic complications due to warfarin therapy). To our knowledge, massive hemothorax due to warfarin use is an extremely rare condition. 1. Introduction Warfarin is a commonly used oral anticoagulant; warfarin therapy is associated with a number of adverse drug reactions including bleeding. Important risk factors for major hemorrhage due to warfarin therapy include history of gastrointestinal bleeding, concurrent use of antiplatelet or nonsteroidal anti-inflammatory drugs, genetic differences in warfarin metabolism, INR variability, comorbid illnesses, and duration of oral anticoagulant therapy [1]. Thoracic hemorrhage accounts for approximately 3% of all hemorrhagic complications associated with warfarin therapy and is usually related to trauma [2]. Hemothorax due to warfarin therapy is a relatively rare complication, and trauma is a major risk factor. We reported a 59-year-old woman with warfarin overdose, who developed massive hemothorax in her right lung without having any history of trauma. To our knowledge, massive hemothorax due to warfarin use is an extremely rare condition. 2. Case Presentation A 59-year-old woman presented to emergency department with dyspnea, which has gradually increased in three days. She did not complain of having any fever, cough, or sputum, but she had right-sided pleuritic chest pain. She has been taking warfarin for aortic and mitral valve replacement for 18 years and her INR levels were checked regularly. Additionally, she used 100?mg aspirin and an angiotensin receptor blocker daily. In her medical history, she did not have any systemic
Brucellosis presenting with pancytopenia due to hemophagocytic syndrome
Ela Erdem,Y?ld?z Y?ld?rmak,Nur?en Günaydn
Turkish Journal of Hematology , 2011,
Abstract: Reactive hemophagocytic syndrome is clinically characterized by fever, hepatosplenomegaly, pancytopenia, and coagulopathy, and is histologically characterized by excessive proliferation and activation of histiocytes or macrophages. It can occur with systemic infections, immunodeficiency, or underlying malignancy. Brucellosis is one of the rare causes of hemophagocytosis. Herein we report an 11-year-old male with pancytopenia due to hemophagocytosis during the course of brucellosis that responded favorably to therapy. Although rare, hemophagocytosis should be considered as a possible cause of pancytopenia in patients with brucellosis, especially in regions where brucellosis is frequently encountered.
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