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Search Results: 1 - 10 of 401290 matches for " M Stoltenberg "
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Bismuth ions are metabolized into autometallographic traceable bismuth-sulphur quantum dots
M Stoltenberg,S Juhl,G Danscher
European Journal of Histochemistry , 2007, DOI: 10.4081/1012
Abstract: Bismuth – sulphur quantum dots can be silver enhanced by autometallography (AMG). In the present study, autometallographic silver enhanced bismuth-sulphur nanocrystals were isolated from unfixed cryo-sections of kidneys and livers of rats exposed to bismuth (Bi207) subnitrate. After being subjected to AMG all the organic material was removed by sonication and enzymatic digestion and the silver enhanced Bi- S quantum dots spun down by an ultracentrifuge and analyzed by scintillation. The analysis showed that the autometallographic technique traces approximately 94% of the total bismuth. This implies that the injected bismuth is ultimately captured in bismuthsulphur quantum dots, i.e., that Bi-S nanocrystals are the end product of bismuth metabolism
Effects of AS-cast and wrought cobalt-chrome-molybdenum and titanium-aluminium-vanadium alloys on cytokine gene expression and protein secretion in J774A.1 macrophages
S S Jakobsen,A Larsen,M Stoltenberg,J M Bruun
European Cells and Materials (ECM) , 2007,
Abstract: Insertion of metal implants is associated with a possible change in the delicate balance between pro- and anti-inflammatory proteins, probably leading to an unfavourable predominantly pro-inflammatory milieu. The most likely cause is an inappropriate activation of macrophages in close relation to the metal implant and wear-products. The aim of the present study was to compare surfaces of as-cast and wrought Cobalt-Chrome-Molybdenum (CoCrMo) alloys and Titanium-Aluminium-Vanadium (TiAlV) alloy when incubated with mouse macrophage J774A.1 cell cultures. Changes in pro- and anti-inflammatory cytokines [TNF-alpha, IL-6, IL-alpha, IL-1beta, IL-10] and proteins known to induce proliferation [M-CSF], chemotaxis [MCP-1] and osteogenesis [TGF-beta, OPG] were determined by ELISA and Real Time reverse transcriptase - PCR (Real Time rt-PCR). Lactate dehydrogenase (LDH) was measured in the medium to asses the cell viability. Surface properties of the discs were characterised with a profilometer and with energy dispersive X-ray spectroscopy. We here report, for the first time, that the prosthetic material surface (non-phagocytable) of as-cast high carbon CoCrMo reduces the pro-inflammatory cytokine IL-6 transcription, the chemokine MCP-1 secretion, and M-CSF secretion by 77 %, 36 %, and 62 %, respectively. Furthermore, we found that reducing surface roughness did not affect this reduction. The results suggest that as-cast CoCrMo alloy is more inert than wrought CoCrMo and wrought TiAlV alloys and could prove to be a superior implant material generating less inflammation which might result in less osteolysis.
Det nye pasientregisteret kan redde liv
Camilla Stoltenberg
Norsk Epidemiologi , 2007,
Abstract: F rste juli 2007 ble Helseregisterloven endret og Norsk pasientregister (NPR) blir personidentifiserbart uten samtykke. Dette er en milep l i den lange historien om fors kene p etablere et sykdoms- og skaderegister i Norge.
Vi trenger sterkere samarbeid. Om behovet for koordinering av genetisk epidemiologisk forskning i Norge
Camilla Stoltenberg
Norsk Epidemiologi , 2009,
Abstract: -
Folat og medf dte misdannelser – Skal vi berike matvarer eller teste gener?
Camilla Stoltenberg
Norsk Epidemiologi , 2009,
Abstract: --
Det nye pasientregisteret kan redde liv
Camilla Stoltenberg
Norsk Epidemiologi , 2009,
Abstract: F rste juli 2007 ble Helseregisterloven endret og Norsk pasientregister (NPR) blir personidentifiserbart uten samtykke. Dette er en milep l i den lange historien om fors kene p etablere et sykdoms- og skaderegister i Norge.
Eternal Inflation with Arrival Terminals
Henry Stoltenberg,Andreas Albrecht
Physics , 2014, DOI: 10.1103/PhysRevD.91.023503
Abstract: We analyze the cosmological role of terminal vacua in the string theory landscape, and point out that existing work on this topic makes very strong assumptions about the properties of the terminal vacua. We explore the implications of relaxing these assumptions (by including "arrival" as well as "departure" terminals) and demonstrate that the results in earlier work are highly sensitive to their assumption of no arrival terminals. We use our discussion to make some general points about tuning and initial conditions in cosmology.
Global health and service learning: lessons learned at US medical schools
Mark Stoltenberg,Natalia Rumas,Kayhan Parsi
Medical Education Online , 2012, DOI: 10.3402/meo.v17i0.18848
Abstract: Background: Interest in global health is rapidly increasing amongst US medical students. Many students aspire to incorporate global health into their future careers, while others seek international opportunities to better prepare themselves for domestic practice. US medical schools have begun responding to this burgeoning interest with varying intensity and through a number of different strategies. Conclusions: Three important themes involved include: increasing the academic rigor of programming, fostering sustainable site partnerships, and encouraging mentorship and reflection for the students involved. Finally, the growing practice of service learning might also play a helpful role in integrating these themes into expanding global health programs.
Serotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making
Scott F. Stoltenberg,Melissa K. Lehmann
Frontiers in Genetics , 2011, DOI: 10.3389/fgene.2011.00033
Abstract: The factors that influence individual differences in decision making are not yet fully characterized, but convergent evidence is accumulating that implicates serotonin (5-HT) system function. Therefore, both genes and environments that influence serotonin function are good candidates for association with risky decision making. In the present study we examined associations between common polymorphisms in the serotonin transporter gene (SLC6A4; 5-HTTLPR and rs25531), the experience of childhood trauma and decision making on the Iowa gambling task (IGT) in 391 (64.5% female) healthy Caucasian adults. Homozygosity for the 5-HTTLPR L allele was associated with riskier decision making in the first block of 20 trials (i.e., decision making under ambiguity, p = 0.004). In addition, mean IGT performance was significantly worse in blocks 3–5 (i.e., decision making under risk, p ≤ 0.05) for those participants who reported experiencing higher levels of childhood trauma. Our findings add to the growing evidence that genetic variation in the 5-HT system is associated with individual differences in decision making under ambiguity; and we report that the experience of childhood trauma is associated with relatively poor decision making under risk.
Chemical Blocking of Zinc Ions in CNS Increases Neuronal Damage Following Traumatic Brain Injury (TBI) in Mice
Peter Doering,Meredin Stoltenberg,Milena Penkowa,J?rgen Rungby,Agnete Larsen,Gorm Danscher
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010131
Abstract: Traumatic brain injury (TBI) is one of the leading causes of disability and death among young people. Although much is already known about secondary brain damage the full range of brain tissue responses to TBI remains to be elucidated. A population of neurons located in cerebral areas associated with higher cognitive functions harbours a vesicular zinc pool co-localized with glutamate. This zinc enriched pool of synaptic vesicles has been hypothesized to take part in the injurious signalling cascade that follows pathological conditions such as seizures, ischemia and traumatic brain injury. Pathological release of excess zinc ions from pre-synaptic vesicles has been suggested to mediate cell damage/death to postsynaptic neurons.
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