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Search Results: 1 - 10 of 400749 matches for " M Sigdel "
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Spatial and Temporal Analysis of Drought in Nepal using Standardized Precipitation Index and its Relationship with Climate Indices
M Sigdel,M Ikeda
Journal of Hydrology and Meteorology , 2010, DOI: 10.3126/jhm.v7i1.5617
Abstract: Drought over Nepal is studied on the basis of precipitation as a key parameter. Using monthly mean precipitation data for a period of 33 years, Standardized Precipitation Index (SPI) is produced for the drought analysis with the time scale of 3 months (SPI-3) and 12 months (SPI-12) as they are applicable for agriculture and hydrological aspects, respectively. Time-space variability is explored based on Principal Component Analysis (PCA) along with Rotated PCA (RPCA). Four rotated components were explored for both SPI-3 and SPI-12 representing climatic variability with cores over eastern, central and western Nepal separately. Droughts associated with SPI-3 occurred almost evenly over these regions. Droughts associated with SPI-12 were consistent with SPI-3 for summer, since summer precipitation dominates annual precipitation. Connection between SPI and the climate indices such as Southern Oscillation Index (SOI) and Indian Ocean Dipole Mode Index (DMI) was studied, suggesting that one of the causes for summer droughts is El Nino, while the winter droughts could be related with positive DMI. Keywords: Standardized Precipitation Index; Nepal; Principal component analysis; Drought DOI: http://dx.doi.org/10.3126/jhm.v7i1.5617 JHM 2010; 7(1): 59-74
Eosinophilic Fascitis: A Rare Fibrosing Disorder
Buddhi Paudyal,M Gyawalee,K Sigdel
Kathmandu University Medical Journal , 2012, DOI: 10.3126/kumj.v10i3.8025
Abstract: Eosinophilic fasciitis is a rare systemic disease characterized by inflammatory thickening of the skin and underlying fascia, peripheral eosinophilia, elevated inflammatory markers and typical biopsy findings. Internal organ involvement is rare unlike in other fibrosing disorders. Though this is usually a benign disease, it is often difficult to diagnose and the course may also be variable. Glucocorticoids are the mainstay of therapy, but in many cases steroid sparing immunosuppressive drugs are required particularly if the diseases has protracted course. The author reports a typical case of this rare disorder which could well be a first report from Nepal. Kathmandu University Medical Journal | VOL.10 | NO. 3 | ISSUE 39 | JUL- SEP 2012 | Page 73-75 DOI: http://dx.doi.org/10.3126/kumj.v10i3.8025
Utilization of plant resources in Dang district, West Nepal
S. R. Sigdel,M. B. Rokaya
Banko Janakari , 2011, DOI: 10.3126/banko.v21i2.9143
Abstract: This paper aims to highlight the uses of forest resources in Purandhara, Panchakule and Goltakuri Village Development Committees (VDCs) of Dang district, western Nepal. The ethnobotanical data was collected through Participatory Rural Appraisal (PRA) that involved discussion with local people and key informants, through semi-structured questions and informal conversations. Vulnerability of plants used in the study area was assessed by adapting the Rapid Vulnerability Approach (RVA). Altogether 85 plant species belonging to 79 genera and 56 families were recorded in the study areas. Twelve plant species were found to be used for various purposes other than medicinal. They were used as food, fodder, in construction, in religious purposes and even in yielding dyes. Seventy three plant species were found to be medicinal in properties for treating 144 different ailments. Remedies for 27 ailments were reported as new uses. The most common way of admission of medicine was oral (76.71 %) followed by external or topical (35.6 %) and nasal (1.27 %). The RVA test showed Dalbergia sissoo (with 15 scores) and Terminalia alata (with 14 scores) as most vulnerable ones.
Management of stroke in emergency department in relation to blood pressure, blood sugar and use of anti-thrombotic agents
M Aryal,S Niraula,R Shahukhal,NR Mainali,S Sigdel,S Giri,S Pandey,YL Shakya
Journal of Institute of Medicine , 2010, DOI: 10.3126/joim.v32i1.3995
Abstract: Introduction: Since the Emergency Department (ED) of TUTH lacks uniformity in the treatment of stroke patients, it is assumed that these patients do not receive standard treatment in terms of reduction of blood pressure (BP), control of hyperglycemia and treatment with antithrombotic agents. Our hospital-based study aims to assess the mean stay of stroke patients in the ED and the level of optimal treatment they are getting. Methods: A retrospective hospital-based study among 82 patients diagnosed as CVA in the ED (who later got admitted), was carried out using medical records. History, clinical examinations, investigations and treatment given were analysed to gather relevant information. Results: Mean age of occurrence of stroke in the inpatients visiting ED was found to be 62.4 years. Average duration of stay in the ED before admission was 13 hours. Ischaemic stroke was almost four times more common than haemorrhagic stoke. All the patients with haemorrhagic stroke who had indication for reduction in BP received antihypertensive medications. However, 28% of the patients with ischaemic stroke, eventhough having indication for BP reduction, did not receive antihypertensives. Out of 11 patients who had an indication for reduction in blood sugar, only one patient (9%) received treatment with insulin. Only 52% of the patients who had ischaemic stroke received treatment with aspirin. Conclusions: There is lack of uniformity regarding the treatment of stroke in terms of blood pressure reduction, hyperglycemia and antithrombotic treatment. A standard protocol needs to be developed in order to bring uniformity and efficiency in the treatment of stroke. DOI: http://dx.doi.org/10.3126/joim.v32i1.3995 Journal of Institute of Medicine , April, 2010; 32:1 pp.11-14
Seasonal Contrast in Precipitation Mechanisms over Nepal Deduced from Relationship with the Large-Scale Climate Patterns
Madan Sigdel,Motoyoshi Ikeda
Nepal Journal of Science and Technology , 2012, DOI: 10.3126/njst.v13i1.7450
Abstract: Summer precipitation dominates over winter one for the annual total in south Asia, while the winter condition is still important for agricultural productions. Rain gauge data over Nepal were analyzed with large-scale atmospheric patterns such as El Ni?o-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD). In the period of June to September, summer monsoon rainfall over Nepal (SMRN) is generally higher in the eastern region along with a peak in the central region associated with the local orography. Its interannual variability was found to be correlated with the southern oscillation index (SOI): i.e., when La Ni?a occurs, eastward moisture flux is blocked over Bay of Bengal (BOB) by the anomalous Walker circulation extending from the Pacific. The local-scale condition for higher SMRN is implied by a main moisture route along the eastern arm of the low pressure in northeastern India, as proved by a significant correlation between SMRN and the northward moisture flux. In winter (DJFM), precipitation occurs more in the western region. The higher winter precipitation over Nepal (WPN) was correlated almost equally with positive Dipole Mode Index (DMI) over the Indian Ocean and also SOI, while the relationship with SOI is reversed from summer. A clear linkage was suggested with moisture flux from the Arabian Sea and the further western region. Thus, possible impacts of anomalous precipitation have to be predicted under the relationship with the large-scale indices depending on seasons.
Pattern of Ear Diseases among Paediatric ENT Patient: An Experience from Tertiary Care Centre, Pokhara, Nepal
B Sigdel,R Nepali
Journal of Nepal Paediatric Society , 2012, DOI: 10.3126/jnps.v32i2.5673
Abstract: Introduction : Ear diseases are common in children mainly due to altered anatomy of Eustachian tube which is straighter in children as compared to that in adults. However, the cause of hearing loss in children is more varied, including the etiologies. This study was done to find out the pattern of ear diseases in paediatric age group attending ear, nose and throat OPD in a tertiary care centre in Pokhara, Nepal. Materials and Methods: This is a prospective study done in paediatric patients attending ENT OPD over a period of one year from January 2010 to January 2011. The diagnoses were made on the basis of history and clinical examination. Results were expressed in numbers and percentages. Results: Out of 1632 Pediatric ENT patients, 944 had ear diseases, 59.2% were males and 40.8% females. Wax (33.4%) was the commonest diagnosis followed by Chronic suppurative otitis media (24.3%) and Acute ottitis media (13%). Conclusion: Ear diseases are most common condition in ENT OPD among paediatric age group. Wax, CSOM and ASOM were the three most common ear diseases. J. Nepal Paediatr. Soc. 32(2) 2012 142-145 doi: http://dx.doi.org/10.3126/jnps.v32i2.5673
Altitudinally coordinated pattern of plant community structure in the Shivapuri National Park, Nepal
Shalik Ram Sigdel
Banko Janakari , 2008, DOI: 10.3126/banko.v18i1.2161
Abstract: Study on plant community structure was undertaken in different altitudinal ranges of Shivapuri National Park. The general objective of this study is to analyse different plant community structure in Shivapuri National Park with regards to altitudinal variation. The forest was divided into three distinct altitudinal ranges on the basis of dominancy. In each altitudinal range standard quadrats method was applied for vegetation analysis. The highest number of species was found in site II. All the ecological parameters of the plant species were higher in site II except Basal Area of tree that was highest in site III. The pattern of distribution of plant species was not uniform according to altitude. At higher elevation, the forest was mature with almost closed canopy and trees were large; so the tree density was low. Species richness was highest in site II. Species diversity among tree and shrub species was higher in site I. But for herb species diversity was higher in site II for both seasons. Such type of variations may be due to nature of soil i.e. acidity, nutrient availability and other micro-climatic factors. The most noteworthy thing was that variation in flower colour of Rhododendron arboreum i.e. deep scarlet at low altitude, but it gradually changed into pinkish white as altitude increased.
Study of endometrial Status of Patients with Abnormal Uterine Bleeding in Patan Hospital
Sabina Shrestha,B Sigdel
Journal of College of Medical Sciences-Nepal , 2013, DOI: 10.3126/jcmsn.v9i2.9683
Abstract: Background:? Abnormal uterine bleeding may be defined as changes in frequency of menstruation, duration of flow or amount of blood loss. Early accurate diagnosis and proper treatment is essential to prevent progress to endometrial cancer. Objective:? This study was done to evaluate the histopathology of endometrium for identifying the endometrial causes of abnormal uterine bleeding. Method:? This was a retrospective study done in department of pathology, Patan Hospital from 1 August 2011- to 31 July 2012; total 413 cases were included in this study. Results:? The age of the patients ranged from 19 to 70 years. The most common clinical presentation was menorrhagia (47.46%), followed by continuous bleeding (14.04%) and metrorrhagia (13%). The commonest histopathological diagnosis was secretory endometrium 128 cases (30.99%), followed by proliferative endometrium 91 cases (22.03 %). Secretory endometrium was most commonly (52 cases) observed in 41-50 years age group followed by 43 cases in 30-40 years age group. Similarly proliferative endometrium was also most commonly seen in 41-50 age group (44 cases) followed by 31-40 years of age group (32cases). Malignant disease was most commonly seen in 51-60 years age group. Conclusions:? Abnormal uterine bleeding is most common in 21-30 years age group.The most common clinical presentation is menorrhagia followed by continuous bleeding. Secretory endometrium is the most common histopathological findings. Malignancy is more common in postmenopausal group. Journal of College of Medical Sciences-Nepal, 2013, Vol-9, No-2, 20-24 DOI: http://dx.doi.org/10.3126/jcmsn.v9i2.9683
Systemic Lupus Erythematosus presenting with Bullous lesion, Lupus Nephritis and Seizure
Mahseh Raj Sigdel
Journal of Advances in Internal Medicine , 2013, DOI: 10.3126/jaim.v2i1.7633
Abstract: Development of bullous lesion is a rare cutaneous manifestation of systemic lupus erythematosus (SLE). Bullous eruptions in SLE are divided into three categories. Firstly, the lesions of SLE may blister. Secondly, a number of primarily blistering diseases have been associated with SLE.Thirdly, bullous SLE (BSLE), characterized bysub-epidermal blisters, IgG deposition at the dermoepidermal junction and autoantibodies against collagen VII, forms a distinct group. We report an18 years girl who met American College of Rheumatology diagnostic criteria for SLE presenting with bullous lesion and nephritis and developed seizure during the same admission. She had anti-nuclear antibody positive, anti-DsDNA antibody negative and serum complement, C3, level decreased. She was managed with steroid, hydroxychloroquine and cyclophosphamide to which her renal function improved significantly and the skin lesions remitted partially. We would also like to highlight the difficulties in establishing differential diagnoses of bullous lesion in SLE. Journal of Advances in Internal Medicine 2013;02(01):17-20 DOI: http://dx.doi.org/10.3126/jaim.v2i1.7633
Identification of Common Blood Gene Signatures for the Diagnosis of Renal and Cardiac Acute Allograft Rejection
Li Li, Kiran Khush, Szu-Chuan Hsieh, Lihua Ying, Helen Luikart, Tara Sigdel, Silke Roedder, Andrew Yang, Hannah Valantine, Minnie M. Sarwal
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082153
Abstract: To test, whether 10 genes, diagnostic of renal allograft rejection in blood, are able to diagnose and predict cardiac allograft rejection, we analyzed 250 blood samples from heart transplant recipients with and without acute rejection (AR) and with cytomegalovirus (CMV) infection by QPCR. A QPCR-based logistic regression model was built on 5 of these 10 genes (AR threshold composite score>37% = AR) and tested for AR prediction in an independent set of 109 samples, where it correctly diagnosed AR with 89% accuracy, with no misclassifications for AR ISHLT grade 1b. CMV infection did not confound the AR score. The genes correctly diagnosed AR in a blood sample within 6 months prior to biopsy diagnosis with 80% sensitivity and untreated grade 1b AR episodes had persistently elevated scores until 6 months after biopsy diagnosis. The gene score was also correlated with presence or absence of cardiac allograft vasculopathy (CAV) irrespective of rejection grade. In conclusion, there is a common transcriptional axis of immunological trafficking in peripheral blood in both renal and cardiac organ transplant rejection, across a diverse recipient age range. A common gene signature, initially identified in the setting of renal transplant rejection, can be utilized serially after cardiac transplantation, to diagnose and predict biopsy confirmed acute heart transplant rejection.
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