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Search Results: 1 - 10 of 401408 matches for " M Saadat "
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Consanguinity Associated with Child and Adult Mortality in 24 Asian and African Countries, an Ecological Study
M Saadat
Iranian Journal of Public Health , 2007,
Abstract: Background: Although numerous studies have found deleterious effects of inbreeding on childhood and pre-reproductive mortality, one question remains inadequately addressed: Dose inbreeding lead to increased childhood mortality rates in countries with high level of consanguinity? Methods: To evaluate the public health impact of inbreeding on offspring mortality, the association between mean of inbreeding coefficient (α) and sex specific child and adult mortality rates in 24 countries from Asia and Africa was analyzed. Results: Statistical analysis showed that countries with relatively higher rates of consanguineous marriages have higher mortality rates than the countries with lower consanguinity rates. Also, countries with relatively higher GDP per capita have lower mortality rates. After controlling the GDP per capita, significant positive correlations between α and child (Female: r=0.4355, df=21, P=0.038; Male: r=0.3991, df=21, P=0.059) mortality rates were observed. There was no significant correlation between α and adult (Female: r=0.2977, df=21, P=0.168; Male: r=0.2207, df=21, P=0.312) mortality rates, after controlling for GDP per capita. Conclusion: It is concluded that consanguinity influences child deaths rate independent of the GDP per capita and that a large proportion of deaths could be attributed to inbreeding in several countries due to high frequencies of consanguinity.
"Frequency of Glutathione S-transferase M1 (GSTM1) and GSTT1 Null Genotypes in Fars Population (South of Iran)"
M Saadat,DD Farhud,I Saadat
Iranian Journal of Public Health , 2001,
Abstract: The genes glutathione S-transferase M1 (GSTM1) and GSTT1 code for cytosolic enzymes GSTμ and GSTθ, respectively, which are involved in phase II metabolism. In human, both genes may be deleted. In the present study, the genetic polymorphisms of GSTM1 and GSTT1 were detected by PCR method in 236 healthy individuals from Shiraz population, Fars province, south of Iran. The frequency of GSTM1 and GSTT1-null genotypes were 37.7 and 31.8 percent, respectively. The studied population was then compared with reported frequencies for neighboring populations, as well as, with those for European and African populations.
Frequency of Genetic Polymorphism of the Gene Encoding 16kDa Clara Cell Secretory Protein (CC16) in Shiraz, Iran
M Saadat,DD Farhud
Iranian Journal of Public Health , 2005,
Abstract: The Clara cell protein (CC16) is a small and readily diffusible protein of 16 kDa secreted by bronchiolar Clara cells in the distal airspaces. Mutation detection methods identified an adenine to guanine substitution in the CC16 gene at position 38 (A38G) downstream from the transcription initiation site within the non-coding region of exon 1. In the present study, the genetic polymorphism of CC16 was detected by PCR-based method in 175 normal individuals from Shiraz population, Fars province (south of Iran). Initially the subjects were divided into two sex groups. Considering that there was no statistically significant differences between males and females (χ2 = 5.52; df = 2; P<0.05) the sex groups were pooled. The frequencies of 38A and 38G alleles were 0.24 and 0.76 percent, respectively. The study population was at Hardy-Weinberg equilibrium (χ2 = 2.61; df = 1; P<0.05). The present results indicated that this polymorphism might have a geographic distribution.
"Inbreeding and its Relevance to Early and Pre-reproductive Mortality Rates in Iran, an Ecological Study"
M Saadat,H Mohabbatkar
Iranian Journal of Public Health , 2003,
Abstract: Consanguinity has been a long-standing social habit among Iranians. The effect of consanguinity on early death (stillbirth plus infant death) and pre-reproductive mortality (death before age 15 years) was studied in an ecological study in 10 provinces of Iran (including, Boosheher, Chaharmahal-O-Bakhtiari, East Azarbaijan, Ilam, Fars, Kashan, Kerman, Kermanshah, Markazi, Semnan, and Yazd). The rates of early death and pre-reproductive mortality of the study populations were derived from the data from 20th March 2000 to 19th March 2001. Statistical analysis showed that there were significant correlation coefficients between mean of inbreeding coefficients of provinces and either early death (r=+0.611, t=2.32, df=9, P=0.046) or pre-reproductive mortality (r=+0.627, t=2.41, df=9, P=0.039) rates. When consider the frequency of consanguinity in terms of individual city of the study provinces, statistical analysis showed that early death (r=+0.324, t=3.18, df =86, P=0.002) was significantly correlated with the mean of inbreeding coefficients of populations.
Primary analysis for enhancing the iron oxide and alteration minerals, using ETM+ data: a case study of Kuh-e-Zar gold deposit, NE Iran
S. Saadat,M. Ghoorchi
Iranian Journal of Earth Sciences , 2009,
Abstract: Different types of iron oxides deposits have been identified along the Khaf – Dorouneh volcanic and plutonic belt in north east of Iran. Kuh-e-Zar is one of these ore deposits known as Fe- oxide gold deposit. The main purpose of this paper is to detect and discriminate the iron oxide minerals in this area based on the ETM+ data. Data processing has been done by ENVI (Environment for Visualizing Images) software. Color Composites, Band Ratios, Principal Components (PC) analysis were used to delineate the associated zones of hydrothermal alteration and iron oxide minerals. Based on both field observations and the results of this satellite data processing, the area covered by secondary iron oxide (hematite, goethite and limonite mainly in soil) was enhanced very good, but the primary iron oxides (specularite) which are very fine grain and have a linear structure (mainly in mineralized veins) are not very clear in detail in these images.
Towards Restraining Cost in Healthcare Domain: A Multiagent Approach
Saadat M. Alhashmi
Communications of the IBIMA , 2008,
Abstract: The proliferating cost with-in the healthcare domain is forcing the researchers and practitioners alike to revisit healthcare logistics domain again and again in order to control the cost. However, controlling healthcare cost requires that limits be placed either on prices, quantities of services or both. As prices can be easily controlled by effectively focusing on the mechanism rather then involving and arguing about the services. The prototype developed has directed its attention towards coordination and intelligence in order to effectively manage the logistics while aiming for the improvement of mechanism. Coordination and user profiling has been demonstrated in multi agent environment. The idea here is to order medicines using human expertise in the form of fuzzy logics and effective coordination of different hospital pharmacies for an efficient use of medicines.
Revisiting the Art of Collaboration in the Age of Internet
Saadat M. Alhashmi,Jawed Siddiqi
Communications of the IBIMA , 2008,
Abstract: The paper establishes the necessity for collaboration for effective supply chain management in the age of Internet. In a networked society where everything is connected, collaboration is the word visited and revisited every now and then. How can we collaborate to optimize resources efficiently? This paper briefly explores some enablers, obstacles for supply chains and proposes some basic components of a strategy for enabling and overcoming these obstacles. A brief discussion of the benefits that go beyond the bottom line, including customer demands and personalisation are noted. Focus of this paper is on the collaboration within the context of supply chain management.
Survey on Spam Filtering Techniques  [PDF]
Saadat Nazirova
Communications and Network (CN) , 2011, DOI: 10.4236/cn.2011.33019
Abstract: In the recent years spam became as a big problem of Internet and electronic communication. There developed a lot of techniques to fight them. In this paper the overview of existing e-mail spam filtering methods is given. The classification, evaluation, and comparison of traditional and learning-based methods are provided. Some personal anti-spam products are tested and compared. The statement for new approach in spam filtering technique is considered.
Hematological Changes in Nurses Handling Antineoplastic Drugs
M Ansari-Lari,M Saadat
Iranian Journal of Public Health , 2002,
Abstract: A cross-sectional study to determine whether occupational exposure to antineoplastic drugs can cause hematologic changes was performed. Blood samples were collected from a group of 24 hematology/oncology nurses who were exposed to antineoplastic drugs during a mean preiod of 5.5 years (standard error =1.1). The control group, matched by sex, and age, consisted of 18 nurses, worked on other sections. Within the normal range we found significant differences between the exposed and the control group in the absolute mean number of the total white blood cells (t=-2.50; df=40; P<0.05) and neutrophils (t=-1.72; df=40; P<0.05; one tailed test). The findings suggested, that the hematologic changes can serve as biological markers for medical surveillance and early detection of health problems due to handling antineoplastic drugs.
HIGH LEVEL OF GST-P mRNA IN ISLAND TYPE OF RAT ASCITES HEPATOMA CELL LINES
M. Saadat,D.D. Farhud
Iranian Journal of Public Health , 1999,
Abstract: Several cell lines (18) of poorly differentiated rat ascites hepatomas which grown intraperitoneally were analyzed with respect to their mRNA levels of GST-P and albumin. The expression of albumin was dramatically decreased and became undetectable in all of the examined hepatomas compared with normal rat liver. The GST-P mRNA level in the hepatomas was correlated with their ability for formation of cellular islands in ascites. The island types, expressed GST-P at high level and the free type ones showed very low level of GST-P mRNA.
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