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Computer-Aided Vaccine Design: A Brief Report
R Ghasemi Khorasgani,M Sanaei,M Mohammad Beigi
Tehran University Medical Journal , 2012,
Abstract: Background: Although the conventional vaccines have been instrumented in the incidence of many infectious diseases, the advances in genetic engineering and bioinformatics have provided the opportunity for developing improved and new vaccines.Methods: Reverse vaccinology was pioneered by a group of researchers investigating development of a vaccine against serogroup B Neisseria meningitidis. Reverse vaccinology analyzes the entire genome of a pathogen with the aid of computational programs to identify potentially antigenic extracellular proteins.Results: Using this method for Neisseria meningitidis genome analysis, 600 secretory or surface-exposed proteins were identified and, subsequently, 350 proteins were expressed and purified. Finally, seven proteins capable of activating the immune system against a range of strains were identified.Conclusion: Improved computational techniques are now able to provide researchers with high-confidence predictions for complex biological characteristics. This will herald a move to computer-aided biotechnology in which time-consuming and expensive large-scale experimental approaches are progressively replaced by functional bioinformatic investigations.
General Physicians’ Knowledge about Nutrition in Shiraz, Iran
A. Ahmadi,M. Ershad,H. Givzadeh,A. Mohammad-Beigi
Pakistan Journal of Biological Sciences , 2009,
Abstract: Several studies have indicated a poor nutritional knowledge among physicians, thus a survey was carried out to determine the nutritional knowledge of physicians working in general and private practice (governmental and non-governmental centers, respectively) in Iran. Data were collected by means of a questionnaire including multiple-choice questions. The study was conducted among randomly selected 200 physicians (male: 140, female: 60) working in clinics related to the Ministry of Health and Medical Education (MOHME). The responses of the physicians to the questions about nutrition (particularly hypertension, diabetes and obesity) were evaluated by scoring them. The average scores of the nutrition knowledge level of the male and female physicians were 9.61±2.63 and 9.61±2.85, respectively. It was found that the nutrition knowledge level of just 13.1% of the physicians was mediocre and 86.9% was poor. The results indicate that physicians don’t have enough knowledge about important topics in nutrition such as diet therapy in topics mentioned; therefore they need more education in nutrition.
A Comparison of the Labor Progression Pattern with Friedman's Labor Curve in Nulliparous Women, Fasa, Iran
N Mohammad Salehi (MSc.),HR Tabatabaee (Ph.D),M Raoofi (Ph.D),A Mohammad Beigi (MSc.).
Hayat Journal of Faculty of Nursing & Midwifery , 2009,
Abstract: Background & Aim: Labor refers to a chain of physiologic events that allows a fetus to undertake its journey from the uterus to the outside. Friedman (1954) described a sigmoid pattern for labor. This study was carried out to compare the pattern of labor progression in nullipara women of Fasa with the Friedman's labor curve. Methods & Materials: This cross-sectional study was conducted among 619 nulliparous women aged 18-35 who had term delivery and had no serious disease. In order to data analysis, we used one way ANOVA for comparing the means, and fixed effect of regression models in reverse method for curves drawings. Results: In all of the subgroups, effacement rate increased by increasing the cervical dilatation. Mean of dilatation rate was significantly higher in induced group than the other groups. Duration of the active phase was longer in the group that had sedation than the other two groups. Means of the duration of active phase and second stage were significantly lower in our study than the durations in the Freidman's study (P<0.001) (3.87 hours vs. 4.9 hours; and 52 minutes vs. 57 minutes, respectively). We did not observe the deceleration phase in our study. Conclusion: The pattern of labor progression differed from the Freidman's curve and had not sigmoid shape. The most important factor in latent phase was the time of admission to the labor ward. Key words: Iran, labor, multi level analysis
Prediction of Peptides Binding to Major Histocompatibility Class II Molecules Using Machine Learning Methods  [PDF]
Fateme Kazemi Faramarzi, Majid Mohammad Beigi, Yasamin Botorabi, Najme Mousavi
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B105
Abstract:

In daily life,we are frequently attacked by infection organisms such as bacteria and viruses. Major Histocompatibility (MHC) molecules have an essential role in T-cell activation and initiating an adaptive immune response. Development of methods for prediction of MHC-Peptide binding is important in vaccine design and immunotherapy. In this study, we try to predict the binding between peptides and MHC class II. Support vector machine (SVM) and Multi-Layer Percep-tron (MLP) are used for classification. These classifiers based on pseudo amino acid compositions of data that we ex-tracted from PseAAC server, classify the data. Since, the dataset, used in this work, is imbalanced, we apply a pre-processing step to over-sample the minority class and come over this problem. The results show that using the concept of pseudo amino acid composition and applying over-sampling method, increases the performance of predictor. Fur-thermore, the results demonstrate that using the concept of PseAAC and SVM is a successful method for the prediction of MHC class II molecules.

Comparison of Treatment Effect of Sodium Valprovate, Propranolol and Tricyclic Antidepressants in Migraine
Ghasami K.,Mohammad-Beigi A.
Pakistan Journal of Biological Sciences , 2009,
Abstract: This study was conducted to evaluate and compare the efficacy and treatment effect of sodium valprovate with propranolol and tricyclic antidepressive drugs. This piece is a rarandomized clinical trial conducted on 126 migraine patients admitted to brain and nerves clinic in Arak, Iran. Patients were divided in two groups then randomized to study treatments. Data were gathered using a checklist and a complete examination. They were analyzed by Chi square and exact test. In patients with normal and abnormal encephalogram the effectiveness rate of two treatments were 35, 61.9, 95.6 and 28.6%, respectively. This difference between two treatments was statistically significant (p<0.001). But didn't observe significant differences between two sex groups (p>0.05). For treatment and control of the migraine, in patients with normal encephalogram, propranolol with tricyclic antidepressive drugs advised and for abnormal encephalogram sodium valprovate can be the better treatment for management and reduction of headache attacks.
Calculation of population atributable burden of excess weight and obesity to non-contagious diseases in Markazi provience of Iran
Babak Eshrati,Jafar Hasanzadeh,Abolfdazl Mohammad Beigi
Koomesh , 2010,
Abstract: Introduction: Overweight and obesity are the most important factors in the development of chronicdiseases and have a great impact on the health and quality of life of individuals. World HealthOrganization (WHO) encourages the countries continually for calculation burden of diseases at nationallevel as the best guideline for take policy in health system. Therefore, this study was conducted todetermine the attributable burden of risk factors in non-contagious diseases in Markazi providence ofIran.Materials and Methods: Death registered data in Markazi providence were applied for calculationyears of life lost (YLL) based on comparison risk assessment (CRA) method of WHO. Attributableburden of obesity and overweight was calculated by multiply the impact fraction of any risk factors byYLL of any diseases in counterfactual analysis method.Results: From 7176 registered death, 252214 years lost from preterm death. The total of YLL infemale and male were 102245 years and 149969 years, respectively. In this study, the most importantcauses of YLL were attributable obesities to brain stroke, and cardiovascular diseases and attributableoverweight to cardiovascular diseases in females, respectively.Conclusion: This study showed the importance and necessity of diagnosis for obesity and over weightas one of the most important risk factors in non-contagious diseases, especially in women. Therefore, itseems there is a necessity for developing and conducting comprehensive intervention programs aboutthese risk factors and then assessing the programs.
Depression Prevalence and Related Factors in Iranian Students
Bayati A.,Mohammad Beigi A.,Mohammad Salehi N.
Pakistan Journal of Biological Sciences , 2009,
Abstract: This study designed to determine prevalence and related factors of depression in student of Arak, Iran. An analytical cross-sectional study was conducted on 304 undergraduate medical and basic students in Arak Universities, Markazi Province, Iran from May 2008 to July 2008. GHQ-28 questionnaire has been used for data gathering and analyzed by t and Chi square tests. Mean of mental health in students was 26.18±11.02 and 52.3% of students scored above the threshold of the GHQ- 28, indicating psychiatric disorder. Female sex, uninteresting of major, an uncertain future and positive family history were the most important risk factors of depression. In results didn’t observe any significant relationship between age, education major and year. The prevalence of depression was higher than as compared to all population and in female exceed to male students. But there wasn’t any difference between medical and non medical students. So attention to financial and occupational future graduated and under graduated students is essential.
Estimation of natural age of menopause in Iranian women: A meta-analysis study
Abdolreza Rajaeefard,Abolfazl Mohammad-Beigi,Narges Mohammad-Salehi
Koomesh , 2011,
Abstract: Introduction: The mean age of menopause have been reported at the age of 51 in the world and regarding the increase in life expectancy in many countries more than a third of the life time of women i s in menopause period. The importance of menopause is due to its relationship with various diseases and quality of life. The present study was conducted to estimate the average natural age of menopause in women based on a meta-analysis study. Material and Methods: In a meta-analysis study on all the existing articles in the natural age o f menopause in Iran, 21 articles were selected based on inclusion criteria. Begg and Egger tests fo r publication bias and Cochrane test were used to determine the heterogeneity among samples. ???? estimate of mean calculated based on Random effect model in Stata11 software. Results: The publication bias assumption was rejected by Begg and Egger tests with significant value s equal to 0.174 and 0.446 respectively. There was a heterogeneity among samples (Q=4626.3, df=20 , P<0.001). So based on random effect model the mean age of menopause was calculated as 48.183 with 95 % CI=47.457-48.91. Conclusion: The average age of natural menopause in Iranian women is favorable to some places of Middle East, but is less compared with developed countries and the world mean. Because of the importance of this period in women, educational programs seem to be necessary.
SPE-HPLC method for determination of ketoconazole and clotrimazole residues in cow's milk
Beigi, Farzaneh Ahmad Khan;Imani, Mohammad;Payehghadr, Mahmood;Hosseini, Hedayat;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000900009
Abstract: a simple confirmatory method for hplc-uv determination of ketoconazole and clotrimazole residues in cow's milk after solid phase extraction (spe) is reported in this article. the samples were deprived of proteins and lipids by treating with acetonitrile and consequent extraction in n-hexane. extracts were further cleaned-up and concentrated via solid phase extraction. the analytes were determined quantitatively using a validated high performance liquid chromatography method. the method was linear in the range of 0.1-1.0 μg ml-1 for both analytes. limits of detection and quantification for both analytes were equal to 0.01 and 0.1 μg ml-1, respectively. important parameters influencing the extraction efficiency were investigated and then optimized; the proposed method was applied to the analysis of milk samples. satisfactory recoveries were obtained in the range of 95.9-101.78% using spe.
Polymorphism of Ovar-DRB1 Second Exon with PCR-RFLP Technique in Arabi Sheep Population of Khuzestan Province
Mojtaba Lotfi,Mohammad Taghi Beigi Nassiri,Hedayatollah Roshanfekr,Jamal Fayazi
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.760.762
Abstract: Major Histocompatibility Complex (MHC) plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. The best characterized genetic control of disease resistance and immune response in animals are associated with MHC. Therefore, in this study polymorphism of Ovar-DRB1 in DNA samples of 111 heads Arabi sheep using Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) method was examined. Identities of 18 different patterns and 8 distinct DRB1 alleles among Arabi sheep have been determined. There is not deviation in Ovar-DRB1 gene from Hardy-Weinberg equilibrium in this population, results showed. Obtained results have revealed that the exon 2 region of Ovar-DRB1 was highly polymorphic on Arabi sheep.
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