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Search Results: 1 - 10 of 55 matches for " Lutfullah TURKMEN "
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A study of prospective Turkish science teachers’ knowledge at the popular biotechnological issues
Emine Selcen DARCIN,Lutfullah TURKMEN
Asia-Pacific Forum on Science Learning and Teaching , 2006,
Abstract: The purpose of this study was to determine the knowledge level of popular biotechnological issues of prospective Turkish science teachers. A questionnaire was administered during 2005-2006 academic year to 194 students in the Department of Science Education of a university in Turkey. The questionnaire covered six biotechnological issues such as biotechnology, agrobiotechnology, human health and pharmacy, environment and biotechnology, and food production with biotechnology. Results showed that whereas department of science education students had an approximate consistent knowledge of describing biotechnology and human health/pharmacy that almost all students had an inadequate knowledge about other biotechnological issues. Finally, the results were compared with other studies in the world.
Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient
Kultigin Turkmen, Lutfullah Altintepe, Ibrahim Guney, et al
International Journal of Nephrology and Renovascular Disease , 2010, DOI: http://dx.doi.org/10.2147/IJNRD.S11077
Abstract: controlled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient Case report (3947) Total Article Views Authors: Kultigin Turkmen, Lutfullah Altintepe, Ibrahim Guney, et al Published Date June 2010 Volume 2010:3 Pages 65 - 68 DOI: http://dx.doi.org/10.2147/IJNRD.S11077 Kultigin Turkmen1, Lutfullah Altintepe2, Ibrahim Guney2, Ismet Aydogdu3, Osman Koc4, Mehmet Ali Erkut5, Halil Zeki Tonbul1 1Department of Nephrology, Meram School of Medicine, Selcuk University, 2Meram Training and Research Hospital, Selcuk University, 3Department of Hematology, Meram School of Medicine, Selcuk University, 4Department of Radiology, Meram School of Medicine, Selcuk University, 5Department of Hematology, Meram Training and Research Hospital, Selcuk University Abstract: Leukemic infiltration of the kidney is usually silent, and the admission of the patients with renal dysfunction or acute kidney injury is uncommon. We present a 34-year old hemodialysis patient with new onset of uncontrolled hypertension, erythropoietin-resistant anemia, thrombocytopenia, and Bell’s palsy. On admission, his blood pressure (BP) was 210/110 mmHg and he had petechiae and purpura at upper and lower extremities. Renal ultrasonography (USG) showed bilaterally enlarged kidneys without hydronephrosis, unlike his previous USG, which determined bilaterally atrophic kidneys. Acute lymphoblastic leukemia, hypertensive crisis due to bilateral leukemic cell infiltration of kidneys, tumor lysis syndrome, and leukemic involvement of the facial nerve were diagnosed. Despite intense antihypertensive management, his BP was not controlled. After prednisolone, daunorubicine, and vincristine therapy, the size of kidneys diminished and his BP dropped under normal range. In conclusion, pathological findings such as uncontrolled hypertension, flank pain, skin rashes, and abnormal blood count should be considered carefully, even in patients with end-stage renal disease receiving renal replacement therapy.
Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient
Kultigin Turkmen,Lutfullah Altintepe,Ibrahim Guney,et al
International Journal of Nephrology and Renovascular Disease , 2010,
Abstract: Kultigin Turkmen1, Lutfullah Altintepe2, Ibrahim Guney2, Ismet Aydogdu3, Osman Koc4, Mehmet Ali Erkut5, Halil Zeki Tonbul11Department of Nephrology, Meram School of Medicine, Selcuk University, 2Meram Training and Research Hospital, Selcuk University, 3Department of Hematology, Meram School of Medicine, Selcuk University, 4Department of Radiology, Meram School of Medicine, Selcuk University, 5Department of Hematology, Meram Training and Research Hospital, Selcuk UniversityAbstract: Leukemic infiltration of the kidney is usually silent, and the admission of the patients with renal dysfunction or acute kidney injury is uncommon. We present a 34-year old hemodialysis patient with new onset of uncontrolled hypertension, erythropoietin-resistant anemia, thrombocytopenia, and Bell’s palsy. On admission, his blood pressure (BP) was 210/110 mmHg and he had petechiae and purpura at upper and lower extremities. Renal ultrasonography (USG) showed bilaterally enlarged kidneys without hydronephrosis, unlike his previous USG, which determined bilaterally atrophic kidneys. Acute lymphoblastic leukemia, hypertensive crisis due to bilateral leukemic cell infiltration of kidneys, tumor lysis syndrome, and leukemic involvement of the facial nerve were diagnosed. Despite intense antihypertensive management, his BP was not controlled. After prednisolone, daunorubicine, and vincristine therapy, the size of kidneys diminished and his BP dropped under normal range. In conclusion, pathological findings such as uncontrolled hypertension, flank pain, skin rashes, and abnormal blood count should be considered carefully, even in patients with end-stage renal disease receiving renal replacement therapy.Keywords: leukemic cell infiltration, uncontrolled hypertension, hemodialysis
Seasonal Variation of Heavy Metals in Shrimp Penaeus kerathurus (Forskal, 1775) from Izmir Bay, Turkey
Gurel Turkmen
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.2839.2844
Abstract: Seasonal changes in heavy metals (Cd, Cu, Fe, Pb, Zn) concentrations in muscle tissues of both male and female caramote shrimp (Penaeus kerathurus) from Izmir bay, Turkey were measured for a year period by using flame and graphite furnace AAS. The relationships in various heavy metal concentrations were compared according to sex and seasons. Heavy metal content varied with type of metals, seasons and sex. The highest concentration of heavy metal in the muscle tissue of P. kerathurus for Cd, Pb, Cu, Fe and Zn was registered in Summer months. Mean Fe level in male shrimps was considerably higher (30.19 compared to 20.23 μg g-1 dry weight) in October. Regarding Cu, the same case could be observed (27.58 μg g-1 dry weight in males compared to 19.02 in females). In the present study, heavy metals accumulated in the shrimp muscle in the order Zn>Fe>Cu>Pb>Cd. Concentrations of metals ranged within the recommended limits for human consumption and not represent a health risk.
The Protective Effect of mammalian Target of Rapamycin (mTOR) in Cisplatin Induced Nephropathy
Kultigin Turkmen
Iranian Journal of Medical Hypotheses & Ideas , 2009,
Abstract: "nCisplatin, a simple inorganic compound, has been one of the leading antitumor drugs especially for solid tumors for near 30 years. The mechanisms of cisplatin include denaturation of DNA and cell mitochondria, arresting cell cycle in the G2 phase and eventually causing apoptosis, inflammation, necrosis and death in cells. Apoptosis is a process of programmed cell death through cystein proteases named ‘caspases'. Pathways of caspase-mediated apoptosis can classified as ‘mitochondrial' pathway and ‘death receptor' pathway Especially caspase-3 plays a crucial role in cisplatin-induced nephrotoxicity through the pathways of apoptosis. The mammalian target of rapamycin (mTOR), is a serine/threonine kinase that regulates both cell growth and cell cycle progression through the phosphotidyl 3 kinase (PI3K)/protein kinase B (Akt) signaling pathway. mTOR regulates both cell growth, cell cycle progression and angiogenesis. By targeting mTOR, the immunsuppressant and antiproliferative agent Rapamycin inhibits signals required for cell cycle progression, cell growth, cell proliferation and angiogenesis. Angiogenesis is extremely important in tumor progression and metastasis. Although rapamycin is proapoptotic agent especially in cancers, there is an evidence that rapamycin can also have antiapoptotic properties through pleiotropic function in the regulation of cell death depending on the cell type and activation state as well as downstream targets of antiapoptotic molecules such as p53 and Bcl-2 proteins. Activation of caspase signaling pathways and dysregulation of pro- and antiapoptotic Bcl-2 proteins have been described previously. So there are links between the mTOR and caspase signaling pathways. Despite its effectiveness, the dose of cisplatin that can be administered is limited by its nephrotoxicity such as acute tubuler necrosis (ATN) causing acute renal failure (ARF). Several agents have been tested to see whether they could ameliorate or augment the nephrotoxicity of cisplatin. Therefore, we hypothesize that mTOR inhibitor rapamycin can inhibit cisplatin induced ATN and ARF through the mechanisms including PI3K/Akt signaling and mitochondrial cell death pathway by affecting apoptosis. If this hypothesis will be proved by experimental and clinical studies, the patients with solid tumors receiving cisplatin may also be treated with mTOR inhibitors to reduce cisplatin induced nephrotoxicity.
Examining elementary science education teachers disposition after reform
Hakan TURKMEN
Asia-Pacific Forum on Science Learning and Teaching , 2009,
Abstract: The purpose of study was to examine the disposition of in-service teachers at the primary level. 412 science teachers from 72 primary schools, participated by filling out the “Teacher Disposition Index” questionnaire. After factor analyzing the data, Turkish in-service teachers did not fail, but they had doubts in some disposition skills. They were not sure how to maintain and develop their professional skills. They were not seeking out professional growth opportunities, especially in regard to keeping up with current research on teaching practices. Moreover, they had ethical and communication problems with students and parents and their colleagues. Finally they had difficulties selecting proper (relevant and interesting for students) materials for lessons. The most probable reason for these problems is that in-service teachers do not know students both formally (pedagogically) and informally.
Impact of Epidural Analgesia in Labour on Neonatal and Maternal Outcomes  [PDF]
Nora Tawhid S?derholm, Sahruh Turkmen
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.89080
Abstract: Aim: To evaluate the effect of epidural analgesia during labour on neonatal-maternal outcomes. Methods: A retrospective cohort study of nulliparous parturients who gave birth in Vasternorrland County, Sweden, over a 2-year period between 2015 and 2016. Neonatal outcomes (Apgar score at 5 min and umbilical cord arterial blood gases), maternal outcomes (perineal injury, total bleeding volume and maternal satisfaction with birth) and labour parameters (mode of delivery and the durations of labour and postpartum hospital stay) were evaluated. Results: The study cohort consisted of 1449 women with singleton pregnancies. Patients were divided into two groups according to whether during labour they were administered epidural analgesia using bupivacaine and sufentanil (EDA group, n = 615) or not (non-EDA group, n = 834). The rate of assisted vaginal delivery was significantly higher in the EDA group than in the non-EDA group (15.6% and 11.3%, respectively, p < 0.05), whereas the rates of caesarean section were similar. The duration of the active phase of labour was significantly longer in the EDA group than in the non-EDA group (489 ± 217 min versus 371 ± 210 min, respectively, p < 0.001). The Apgar score at 5 min and umbilical cord blood pH were lower and the base deficit greater in the EDA group (p < 0.001, p < 0.001 and p < 0.01, respectively). Bleeding volume was similar between the groups after adjusting for gestational age. Women in the EDA group were more satisfied with their labour experience, as measured by the visual analogue scale (p < 0.05). Conclusion: The results of this study suggest that EDA affects delivery and neonatal-maternal outcomes negatively, but increases the mother’s satisfaction with labour.
METAL CONTAMINATIONS IN FIVE FISH SPECIES FROM BLACK, MARMARA, AEGEAN AND MEDITERRANEAN SEAS, TURKEY
TURKMEN,MUSTAFA; TURKMEN,AYSUN; TEPE,YALQIN;
Journal of the Chilean Chemical Society , 2008, DOI: 10.4067/S0717-97072008000100021
Abstract: the concentrations of cadmium, copper, chromium, copper, iron, manganese, nickel, zinc and lead in muscle and liver tissues of the fish samples collected from seven stations in the coastal waters of turkey and were determined. iron showed the highest levels in both tissues offish and all stations. following fe; zn generally showed the second highest levels. metal concentrations in edible parts offish species were 0.02-0.30 mg kg"' for cadmium, 0.04-0.26 mg kg"' for cobalt, 0.07-1.19 mgkg"' for chromium, 0.34-16.7 mgkg"' for copper, 18.5-72.3 mgkg"' for iron, 0.07-2.58 mgkg"' for manganese, 0.01-2.78 mgkg"'for nickel, 0.04-1.34 mg kg"' for lead, 3.36-42.6 mg kg"' for zinc respectively. in general, metal concentrations in livers were higher than those in muscles. cadmium, chromium and lead concentrations in muscles offish from some stations were higher than permissible safety levels for human uses.
METAL CONTAMINATIONS IN FIVE FISH SPECIES FROM BLACK, MARMARA, AEGEAN AND MEDITERRANEAN SEAS, TURKEY
MUSTAFA TURKMEN,AYSUN TURKMEN,YALQIN TEPE
Journal of the Chilean Chemical Society , 2008,
Abstract: The concentrations of cadmium, copper, chromium, copper, iron, manganese, nickel, zinc and lead in muscle and liver tissues of the fish samples collected from seven stations in the coastal waters of Turkey and were determined. Iron showed the highest levels in both tissues offish and all stations. Following Fe; Zn generally showed the second highest levels. Metal concentrations in edible parts offish species were 0.02-0.30 mg kg"' for cadmium, 0.04-0.26 mg kg"' for cobalt, 0.07-1.19 mgkg"' for chromium, 0.34-16.7 mgkg"' for copper, 18.5-72.3 mgkg"' for iron, 0.07-2.58 mgkg"' for manganese, 0.01-2.78 mgkg"'for nickel, 0.04-1.34 mg kg"' for lead, 3.36-42.6 mg kg"' for zinc respectively. In general, metal concentrations in livers were higher than those in muscles. Cadmium, chromium and lead concentrations in muscles offish from some stations were higher than permissible safety levels for human uses.
Chronobiology and Mood Disorders
Yavuz Selvi,Lutfullah Besiroglu,Adem Aydin
Psikiyatride Guncel Yaklasimlar , 2011,
Abstract: Living organizms show cyclic rhythmicity in a variety of physiological, hormonal, behavioral, and psychological processes. Sleep-wake cycles, body temperature, hormone levels, mood and cognition display a circadian rhythm in humans. Delays, advances or desynchronizations of circadian rhythm are known to be strongly associated with mental illness especially mood disorders such as bipolar disorder, major depression and seasonal affective disorder. Furthermore, some of the mood stabilizers, sleep deprivation and light treatment are employed to treat mood disorders by shifting circadian rhythm. This paper reviews the relationship between mood disorders and circadian rhythm, and describes treatment options by altering circadian rhythm.
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