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Search Results: 1 - 10 of 5653 matches for " Luscieti Sara "
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Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome
Luscieti Sara,Tolle Gabriele,Aranda Jessica,Campos Carmen Benet
Orphanet Journal of Rare Diseases , 2013, DOI: 10.1186/1750-1172-8-30
Abstract: Background Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The disease is caused by mutations in the Iron-Responsive Element (IRE) located in the 5′ untranslated region of L-Ferritin (FTL) mRNA, which post-transcriptionally regulates ferritin expression. Methods We describe two families presenting high serum ferritin levels and juvenile cataract with novel mutations in the L-ferritin IRE. The mutations were further characterized by in vitro functional studies. Results We have identified two novel mutations in the IRE of L-Ferritin causing HHCS: the Badalona +36C > U and the Heidelberg +52 G > C mutation. Both mutations conferred reduced binding affinity on recombinant Iron Regulatory Proteins (IPRs) in EMSA experiments. Interestingly, the Badalona +36C > U mutation was found not only in heterozygosity, as expected for an autosomal dominant disease, but also in the homozygous state in some affected subjects. Additionally we report an update of all mutations identified so far to cause HHCS. Conclusions The Badalona +36C > U and Heidelberg +52 G > C mutations within the L-ferritin IRE only mildly alter the binding capacity of the Iron Regulatory Proteins but are still causative for the disease.
Homotopy Perturbation Method for Solving Moving Boundary and Isoperimetric Problems  [PDF]
Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35062
Abstract: In this paper, homotopy perturbation method is applied to solve moving boundary and isoperimetric problems. This method does not depend upon a small parameter in the equation. homotopy is constructed with an imbedding parameter p, which is considered as a “small parameter”. Finally, we use combined homotopy perturbation method and Green’s function method for solving second order problems. Some examples are given to illustrate the effectiveness of methods. The results show that these methods provides a powerful mathematical tools for solving problems.
Creativity at the Crossroad Creative Education as Moral Education?  [PDF]
Sara Nosari
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B015
Abstract:

The man’s action, thanks to its creative capacities, gave a new order to the reality: the “created reality” does not present simply a different order, but is an authentic transformation. Which criteria had directed this transformation? Which will be the criteria of future transformation? The paper presents two possible ideas about creativity and argues in favor of a creative action educated and directed by an ethical criteria.

Using Figurative Language to Assess the Stage of Acceptance of Learning Disability as a Springboard for Treatment of Students with Learning Disabilities  [PDF]
Sara Givon
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.46054
Abstract:

In order to examine the emotional and cognitive processes experienced by adolescents with learning disabilities (LD), twenty tenth grade Israeli students were studied over three years. Data gathered through in-depth interviews underwent an axial-coding process, and a grounded theory model was constructed. The findings revealed various coping styles adopted by students throughout the process of accepting the disability. Participants were asked to use figurative language to describe their method of coping with the disability. Participants’ choice of phrase, metaphor or image characterized the phase of their acceptance as well as their coping style. This can be served as an effective tool of detection. Identifying the stage of students’ acceptance and their coping style may promote optimal treatment for students with LD.

Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials  [PDF]
Mahmoud Saghaei, Sara Saghaei
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.411090
Abstract: Current minimization programs do not permit full control over different aspects of minimization algorithm such as distance or probability measures and may not allow for unequal allocation ratios. This article describes the implementation of “MinimPy” an open-source minimization program in Python programming language, which provides full customizetion of minimization features. MinimPy supports naive and biased coin minimization together with various new and classic distance measures. Data syncing is provided to facilitate minimization of multicenter trial over the network. MinimPy can easily be modified to fit special needs of clinical trials and in particular change it to a pure web application, though it currently supports network syncing of data in multi-center trials using network repositories.
Variational Iterative Method Applied to Variational Problems with Moving Boundaries  [PDF]
Fateme Ghomanjani, Sara Ghaderi
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.35061
Abstract: In this paper, He’s variational iterative method has been applied to give exact solution of the Euler Lagrange equation which arises from the variational problems with moving boundaries and isoperimetric problems. In this method, general Lagrange multipliers are introduced to construct correction functional for the variational problems. The initial approximations can be freely chosen with possible unknown constant, which can be determined by imposing the boundary conditions. Illustrative examples have been presented to demonstrate the efficiency and applicability of the variational iterative method.
Facile Synthesis and Characterization of Nanoporous NiO with Folic Acid as Photodegredation Catalyst for Congo Red  [PDF]
Faezeh Farzaneh, Sara Haghshenas
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.310102
Abstract: In this study nanoporous NiO was prepared using Ni(CH3COO)2,4H2O, folic acid and water as starting material, template and solvent respectively, by sol gel method followed by calcination at 400℃. The solid product was characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) Fourier transform infrared (FT-IR) and photoluminescence (PL) techniques. The particle size of the nanoparticles estimated by XRD was in good agreement with the particle size obtained by TEM analysis (4-5nm). It was also found that the prepared nanoporous NiO show very good activity for photodegredation of dye organic pollutants such as Congo red (91%) during 1.5 hours.
Drilling Operation and Formation Damage  [PDF]
Hooman Fallah, Sara Sheydai
Open Journal of Fluid Dynamics (OJFD) , 2013, DOI: 10.4236/ojfd.2013.32005
Abstract:

Transport of particle suspensions in oil reservoirs is an essential phenomenon in many oil industry processes. Solid and liquid particles dispersed in the drilling fluid (mud) are trapped by the rock (porous medium) and permeability decline takes place during drilling fluid invasion into reservoir resulting in formation damage. The formation damage due to mud filtration is explained by erosion of external filter cake. Nevertheless, the stabilization is observed in core floods, which demonstrates internal erosion. A new mathematical model for detachment of particles is based on mechanical equilibrium of a particle positioned on the internal cake or matrix surface in the pore space. In the current work the analytical solution obtained to mud filtration with one particle capture mechanism with damage stabilization. The particle torque equilibrium is determined by the dimensionless ratio between the drag and normal forces acting on the particle. The maximum retention function of the dimensionless ratio closes system of governing equations for colloid transport through porous medium.

Strategy for Co-Creation of Value with Consumers  [PDF]
Sara J. Garski
Open Journal of Business and Management (OJBM) , 2014, DOI: 10.4236/ojbm.2014.22013
Abstract:

Organizations are seeing the value in comprehensive strategic planning as a result of economic difficulties and the need to become more innovative and viable. The relationship that an organization creates with its customers is the key to its ultimate survival and success. The strategies and tools discussed in this paper provide an overview of what the literature has proven to be some of the most effective ones in today’s competitive environment.

Social Media and On-Line Political Campaigning in Malaysia  [PDF]
Sara Chinnasamy, Izyan Roslan
Advances in Journalism and Communication (AJC) , 2015, DOI: 10.4236/ajc.2015.34014
Abstract: Since the controversies surrounding the 2008 and 2013 Malaysian general elections due to the rising Opposition, social media networks have played a vital role in conveying political messages and debates. In 2014 there were a few state by-elections and they were influenced by the Kuala Lumpur Court of Appeal that found Anwar Ibrahim guilty of sodomy and sentenced him to five years jail (Kajang) on 23 March. He was expected to win, opening the way for him to become the chief minister of Selangor state, the country’s main economic hub surrounding Kuala Lumpur. In another event, a well known Malaysian and opposition politician, Karpal Singh, \"the Tiger of Jelutong\" died tragically following a motor vehicle accident. This paper analyses the influence of Facebook in the Kajang by-election and to what extent the social media impacted on the victory by Dr. Wan Azizah Wan Ismail. Using compliance gaining theory, this paper presents strategies used by the two major political parties, Barisan Nasional (BN) and Pakatan Rakyat (PR) to achieve their electoral goals. Though online political campaigning is not new from a Western perspective it is for Malaysia. To understand how the compliance gaining approach works in practice, selected political parties’ Facebook advertisements were examined within two weeks after nomination day and election observers from diverse backgrounds were interviewed. It can be concluded that since 2008 political messages have been heavily debated through blogs. Independent Internet Media, Facebook and Twitter are very popular among Malaysian political candidates and voters.
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