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Search Results: 1 - 10 of 464461 matches for " Luisa García-Buey "
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Role of tight junctions in hepatitis C virus infection Implicación de las uniones intercelulares estrechas en la infección por el virus de la hepatitis C
Ignacio Benedicto,Francisca Molina-Jiménez,Luisa García-Buey,Virginia Gondar
Revista Espa?ola de Enfermedades Digestivas , 2012,
Abstract:
Tenofovir treatment of the severe acute hepatitis B Tratamiento con tenofovir de la hepatitis aguda B de evolución grave
Fernando Casals-Seoane,Beatriz Arberas-Díez,Luisa García-Buey
Revista Espa?ola de Enfermedades Digestivas , 2013,
Abstract:
Large asymptomatic type III paraesophageal hernia Gran hernia hiatal paraesofágica tipo III asintomática
Carlos Casta?o-Milla,Enrique de la Fuente-Fernández,Luisa García-Buey
Revista Espa?ola de Enfermedades Digestivas , 2011,
Abstract:
Hepatitis autoinmune
L. García-Buey,R. Moreno-Otero
Revista Espa?ola de Enfermedades Digestivas , 2006,
Abstract:
Angiopoietin-2 Serum Levels Improve Noninvasive Fibrosis Staging in Chronic Hepatitis C: A Fibrogenic-Angiogenic Link
ángel Hernández-Bartolomé, Rosario López-Rodríguez, Yolanda Rodríguez-Mu?oz, Samuel Martín-Vílchez, María Jesús Borque, Luisa García-Buey, Leticia González-Moreno, Yolanda Real, Ricardo Moreno-Otero, Paloma Sanz-Cameno
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066143
Abstract: Aims Accurate liver fibrosis staging is crucial for the management of chronic hepatitis C (CHC). The invasiveness and cost burden of liver biopsy have driven the search for new noninvasive biomarkers of fibrosis. Based on the link between serum angiopoietin-1 and 2 levels and CHC progression, we aimed to determine the value of these angiogenic factors as noninvasive biomarkers of liver fibrosis. Methods Serum levels of angiopoietin-1 and -2 were measured by ELISA in 108 CHC patients who underwent pretreatment liver biopsy. The correlation between angiopoietins and clinical and demographic variables with liver fibrosis was analyzed by univariate regression. Significant factors were then subjected to multivariate analysis, from which we constructed a novel noninvasive liver fibrosis index (AngioScore), whose performance was validated in an independent series of 71 CHC patients. The accuracy of this model was compared with other documented fibrosis algorithms by De Long test. Results Angiopoietins correlated significantly with hepatic fibrosis; however, only angiopoietin-2 was retained in the final model, which also included age, platelets, AST, INR, and GGT. The model was validated and behaved considerably better than other fibrosis indices in discriminating all, significant, moderate and severe liver fibrosis (0.886, 0.920, 0.923). Using clinically relevant cutoffs, we classified CHC patients by discarding significant fibrosis and diagnosing moderate and severe fibrosis with greater accuracy, sensitivity, and specificity. Conclusions Our novel noninvasive liver fibrosis model, based on serum angiopoietin-2 levels, outperforms other indices and should help substantially in managing CHC and monitoring long-term follow-up prognosis.
Maintenance of T1 response as induced during PEG-IFNalpha plus ribavirin therapy controls viral replication in genotype-1 patients with chronic hepatitis C La respuesta inmune T1 inducida durante el tratamiento con PEG-IFNα mαs ribavirina controla la replicaciσn viral en pacientes con hepatitis crónica C
M. Trapero,L. García-Buey,C. Mu?oz,M. Vitón
Revista Espa?ola de Enfermedades Digestivas , 2005,
Abstract: Objectives: to analyze the T1/T2 cytokine profile in CD8 T cells from peripheral blood mononuclear cells from patients with genotype-1 CHC during treatment with pegylated interferon (Peg-IFN) α2a plus ribavirin (RBV). To correlate Th1/Th2 balance with virological response. Patients and methods: in this prospective longitudinal study, a total of 28 na ve genotype-1 CHC patients received Peg-IFNα2a (180 μg/week) plus RBV (1-1.2 g/day) for 48 weeks. All patients (mean age 45 ± 8 years) completed treatment and follow-up: 12 (43%) achieved a sustained virological response (SVR), 13 relapsed after end of treatment (47%), and only 3 (10%) were non-responders. Sixteen healthy controls were also analyzed (mean age 39 ± 17 years). The production of IL-4, IIFNγ, and TTNFα by CD8 T cells was measured by intracytoplasmic detection using flow cytometry in both resting and stimulated cells with a phorbol ester. Statistics: Student's t test for independent values, χ2 test, and ANOVA test were used; relapsers and non-responders were joined to achieve a higher statistical power. Results: at third month during treatment, phorbol ester-stimulated-IL-4 levels tend to be lower in patients who presented with SVR versus those who did not (0.97 vs 2.58; p = 0.1). No statistically significant differences were found in IIFNγ and TTNFα levels at month 3. At EOT, the stimulated-IIFNγ production was significantly higher in patients with SVR (20 vs. 8; p < 0.05). Conversely, IL-4 production was higher in NR patients although these data did not reach statistical significance (p < 0.1). No significant differences were found in TTNFα (14 vs. 7; p < 0.2). Conclusions: Cytokine T1 induced-response maintenance during combination treatment, measured as IIFNgamma production by CD8+ T lymphocytes, is associated with SVR and suggests the replication control and later clearance of patients infected by genotype-1 HCV. Objetivos: analizar el perfil de citocinas T1/T2 producidas por los linfocitos T CD8+ de sangre periférica en pacientes con hepatitis crónica C (HCC) y genotipo 1 durante el tratamiento con interferón pegilado (Peg-IFN) α2a y ribavirina (RBV) y compararlos con controles sanos. Correlacionar el balance T1/T2 con la respuesta virológica al tratamiento combinado. Pacientes y métodos: en este estudio prospectivo longitudinal se incluyeron 28 pacientes na ve con HCC genotipo 1 tratados con Peg-IFNα2a (180 μg/semana) más RBV (1-1,2 g/día) durante 48 semanas. Los 28 pacientes (edad media 45 ± 8 a os) finalizaron el tratamiento y seguimiento: 12 (43%) presentaron respuesta viral sostenida (
Utilidad de los parámetros analíticos en el diagnóstico de las enfermedades hepáticas
Moreno Borque,A.; González Moreno,L.; Mendoza-Jiménez,J.; García-Buey,L.; Moreno Otero,R.;
Anales de Medicina Interna , 2007, DOI: 10.4321/S0212-71992007000100010
Abstract: liver function tests include biochemical parameters (ast, alt, ggt or alkaline phosphatase), bilirrubin and albumin levels and coagulation tests as prothrombin activity. these tests are commonly used in the routine screening even in symptomatic as in asymptomatic patients, and the right evaluation of the results is of vital importance. citolytic elevation in serum aminotransferases: in mild chronic elevation pharmacological toxicity, viral hepatitis, alcoholic and non-alcoholic fatty liver disease and hemochromatosis, should be excluded. cholestatic elevation os serum enzymes: the first option should be to establish the origin of the alkaline phosphatase elevation, with the evaluation of the ggt levels to confirm the hepatic origin. the next step should be to distinguish the presence of an extrahepatic (biliary obstruction) or intrahepatic (pbc, psc, drugs, etc) cholestasis, in these cases the most important test shoul be the abdominal ultrasound, in order to evaluate the biliary system. hyperbilirrubinemia: non conjugated hyperbilirrubinemia (hemolysis, ineffective eritropoyesis, gilbert or criggler-najjar syndromes) and conjugated hyperbilirrubinemia, an unusual situation in wich rotor and dubin-johnson syndromes should be considered. the evaluation of albumin and prothrombin levels evaluates the hepatic function per se, allowing to differentiate between acute and chronic diseases. at present, there are not prospective studies to evaluate the efficacy of the liver function tests. to carry out a complete medical history, an appropiate physical examination and the appropriate application of non-invasive diagnostic test (serology, iron levels, autoimmunity or abdominal ultrasound) allow to perform a right diagnosis in most patients, making more complex tests, including liver biopsy, secondary.
Maintenance of T1 response as induced during PEG-IFNalpha plus ribavirin therapy controls viral replication in genotype-1 patients with chronic hepatitis C
Trapero,M.; García-Buey,L.; Mu?oz,C.; Vitón,M.; Moreno-Monteagudo,J. A.; Borque,M. J.; Quintana,N. E.; Moreno-Otero,R.;
Revista Espa?ola de Enfermedades Digestivas , 2005, DOI: 10.4321/S1130-01082005000700003
Abstract: objectives: to analyze the t1/t2 cytokine profile in cd8 t cells from peripheral blood mononuclear cells from patients with genotype-1 chc during treatment with pegylated interferon (peg-ifn) α2a plus ribavirin (rbv). to correlate th1/th2 balance with virological response. patients and methods: in this prospective longitudinal study, a total of 28 na?ve genotype-1 chc patients received peg-ifnα2a (180 μg/week) plus rbv (1-1.2 g/day) for 48 weeks. all patients (mean age 45 ± 8 years) completed treatment and follow-up: 12 (43%) achieved a sustained virological response (svr), 13 relapsed after end of treatment (47%), and only 3 (10%) were non-responders. sixteen healthy controls were also analyzed (mean age 39 ± 17 years). the production of il-4, iifnγ, and ttnfα by cd8 t cells was measured by intracytoplasmic detection using flow cytometry in both resting and stimulated cells with a phorbol ester. statistics: student's t test for independent values, χ2 test, and anova test were used; relapsers and non-responders were joined to achieve a higher statistical power. results: at third month during treatment, phorbol ester-stimulated-il-4 levels tend to be lower in patients who presented with svr versus those who did not (0.97 vs 2.58; p = 0.1). no statistically significant differences were found in iifnγ and ttnfα levels at month 3. at eot, the stimulated-iifnγ production was significantly higher in patients with svr (20 vs. 8; p < 0.05). conversely, il-4 production was higher in nr patients although these data did not reach statistical significance (p < 0.1). no significant differences were found in ttnfα (14 vs. 7; p < 0.2). conclusions: cytokine t1 induced-response maintenance during combination treatment, measured as iifng production by cd8+ t lymphocytes, is associated with svr and suggests the replication control and later clearance of patients infected by genotype-1 hcv.
Association between angiogenesis soluble factors and disease progression markers in chronic hepatitis C patients
Salcedo Mora,X.; Sanz-Cameno,P.; Medina,J.; Martín-Vílchez,S.; García-Buey,L.; Borque,M. J.; Moreno-Otero,R.;
Revista Espa?ola de Enfermedades Digestivas , 2005, DOI: 10.4321/S1130-01082005001000003
Abstract: objectives: our objectives were to compare angiogenesis soluble factor (asf) levels in chronic hepatitis c (chc) patients and healthy individuals, and to investigate potential associations between asf levels and both histological and biochemical markers of disease progression. method: thirty-six patients (69% males) positive for hcv-rna by pcr analysis were included in the study. all patients underwent liver biopsy before treatment. serum levels of vascular endothelial growth factor (vegf), soluble flt-1 and flk-1 receptors, placental growth factor (plgf), angiopoietin-2 (ang-2) and soluble tie-2 receptor were determined by elisa. fifteen healthy subjects were used as controls. results: in comparison to healthy individuals, chc patients showed significantly increased serum levels of proangiogenic factors plgf (22 ± 5 vs. 18 ± 8 pg/ml; p < 0.05), ang-2 (1265 ± 385 vs. 833 ± 346 pg/ml; p < 0.005) and sflt-1 (95 ± 22 vs. 72 ± 14 pg/ml; p < 0.0001). interestingly, in chc patients serum levels of vegf and tie-2 correlated with grade of inflammation, plgf correlated with stage of fibrosis, and flt-1 and flk-1 correlated with serum transaminase levels (p < 0.05 in all cases). conclusions: chc patients showed increased serum levels of asf, and a significant correlation was shown between serum levels of selected asfs and grade of inflammation, stage of fibrosis, and transaminase levels.
Etnia goda e iglesia hispana
García Moreno, Luisa A.
Hispania Sacra : Revista de Historia Eclesiástica , 2002,
Abstract: Between the V-VIIth centuries the Visigotic kingdom of Toledo built an ethnic identity very Christian, Hispanic and Goda at the same time. Their memory was entirely keeped after the visigotic′s world destruction by the Arabic conquest. El reino Visigodo de Toledo construyó una identidad étnica, hispana y goda nítidamente cristiana entre los siglos V-VII. Su recuerdo se mantuvo claro tras la destrucción del mundo visigodo por la conquista árabe.
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